Protein: RIR2
Ribonucleoside-diphosphate reductase subunit M2 (EC 1.17.4.1) (Ribonucleotide reductase small chain) (Ribonucleotide reductase small subunit)

Gene: RIR2, RRM2
Organism: Homo sapiens
Interactions: 77
UniProt ID: P31350

Gene Ontology (top 5):
GO:0001824 - blastocyst development
GO:0004748 - ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
GO:0005634 - nucleus
GO:0005829 - cytosol
GO:0005971 - ribonucleoside-diphosphate reductase complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

621223

RIR1
Ribonucleoside-diphosphate reductase large subunit

10

13

Small-scale

0.976

High

679622

RIR2B
Ribonucleoside-diphosphate reductase subunit M2 B

3

15

High-throughput

0.861

High

679646

FZR1
Fizzy-related protein homolog

5

3

Small-scale

0.718

High

176392

SHIP2
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2

3

1

High-throughput

0.667

High

672774

CDC27
Cell division cycle protein 27 homolog

3

2

High-throughput

0.667

High

679605

CCNF
Cyclin-F

4

0

Small-scale

0.664

High

503525

HSP7C
Heat shock cognate 71 kDa protein

3

1

High-throughput

0.650

High

679600

RIR2
Ribonucleoside-diphosphate reductase subunit M2

1

15

Small-scale

0.647

High

679644

APC4
Anaphase-promoting complex subunit 4

3

0

High-throughput

0.638

High

132750

SDCB1
Syntenin-1

2

0

High-throughput

0.580

High

229631

JIP4
C-Jun-amino-terminal kinase-interacting protein 4

1

1

High-throughput

0.536

High

323607

BAG2
BAG family molecular chaperone regulator 2

1

1

High-throughput

0.536

High

679612

CDC16
Cell division cycle protein 16 homolog

1

2

High-throughput

0.536

High

679643

CDC23
Cell division cycle protein 23 homolog

1

2

High-throughput

0.536

High

679613

SKP2
S-phase kinase-associated protein 2

1

0

Small-scale

0.529

High

386176

P53
Cellular tumor antigen p53

1

1

Small-scale

0.523

High

274184

STK16
Serine/threonine-protein kinase 16

1

0

High-throughput

0.513

High

506524

BCR
Breakpoint cluster region protein

1

0

High-throughput

0.513

High

528632

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.513

High

556789

CREB1
Cyclic AMP-responsive element-binding protein 1

1

0

High-throughput

0.513

High

679608

APC15
Anaphase-promoting complex subunit 15

1

0

High-throughput

0.513

High

679618

NCBP3
Nuclear cap-binding protein subunit 3

1

0

High-throughput

0.513

High

679621

FBX50
F-box only protein 50

1

0

High-throughput

0.513

High

679623

HORN
Hornerin

1

0

High-throughput

0.513

High

679633

PITH1
PITH domain-containing protein 1

1

0

High-throughput

0.513

High

679635

SLK
STE20-like serine/threonine-protein kinase

1

0

High-throughput

0.513

High

679640

SDHF2
Succinate dehydrogenase assembly factor 2, mitochondrial

1

0

High-throughput

0.513

High

679647

M3K2
Mitogen-activated protein kinase kinase kinase 2

1

0

High-throughput

0.513

High

414772

CDK1
Cyclin-dependent kinase 1

1

1

Small-scale

0.501

High

679628

KAT5
Histone acetyltransferase KAT5

1

1

Small-scale

0.501

High

128462

DNM1L
Dynamin-1-like protein

1

0

Small-scale

0.486

High

679636

PLK3
Serine/threonine-protein kinase PLK3

1

3

Small-scale

0.481

High

328744

TOP3B
DNA topoisomerase 3-beta-1

1

1

High-throughput

0.479

High

384350

NTRK1
High affinity nerve growth factor receptor

1

3

High-throughput

0.479

High

431570

HS90A
Heat shock protein HSP 90-alpha

1

5

High-throughput

0.479

High

679602

HSP74
Heat shock 70 kDa protein 4

1

3

High-throughput

0.479

High

679604

GRP75
Stress-70 protein, mitochondrial

1

3

High-throughput

0.479

High

679606

PLK1
Serine/threonine-protein kinase PLK1

1

3

High-throughput

0.479

High

679609

1433G
14-3-3 protein gamma

1

1

High-throughput

0.479

High

679611

1433F
14-3-3 protein eta

1

1

High-throughput

0.479

High

679614

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

1

High-throughput

0.479

High

679624

SIR6
NAD-dependent protein deacylase sirtuin-6

1

1

High-throughput

0.479

High

679626

NUP43
Nucleoporin Nup43

1

1

High-throughput

0.479

High

226634

PRKN
E3 ubiquitin-protein ligase parkin

1

0

High-throughput

0.458

High

272498

OFD1
Centriole and centriolar satellite protein OFD1

1

0

High-throughput

0.458

High

346040

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.458

High

359694

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

0

High-throughput

0.458

High

487168

ANDR
Androgen receptor

1

0

High-throughput

0.458

High

552036

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.458

High

569264

CEBPB
CCAAT/enhancer-binding protein beta

1

0

High-throughput

0.458

High

650464

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

668463

PML
Protein PML

1

0

High-throughput

0.458

High

679601

STIP1
Stress-induced-phosphoprotein 1

1

0

High-throughput

0.458

High

679607

TERA
Transitional endoplasmic reticulum ATPase

1

0

High-throughput

0.458

High

679616

PCM1
Pericentriolar material 1 protein

1

0

High-throughput

0.458

High

679617

STIL
SCL-interrupting locus protein

1

0

High-throughput

0.458

High

679619

CE170
Centrosomal protein of 170 kDa

1

0

High-throughput

0.458

High

679627

BICD2
Protein bicaudal D homolog 2

1

0

High-throughput

0.458

High

679630

SCLT1
Sodium channel and clathrin linker 1

1

0

High-throughput

0.458

High

679634

TOLIP
Toll-interacting protein

1

0

High-throughput

0.458

High

679641

MKS1
Tectonic-like complex member MKS1

1

0

High-throughput

0.458

High

679642

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

679632

TS101
Tumor susceptibility gene 101 protein

1

0

High-throughput

0.438

High

434142

RET
Proto-oncogene tyrosine-protein kinase receptor Ret

1

3

High-throughput

0.437

High

607894

FGFR4
Fibroblast growth factor receptor 4

1

3

High-throughput

0.437

High

679620

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.437

High

679645

CLC4E
C-type lectin domain family 4 member E

1

2

High-throughput

0.437

High

679610

E2F1
Transcription factor E2F1

1

0

High-throughput

0.426

High

679629

FAF2
FAS-associated factor 2

4

0

High-throughput

0.362

High

679639

TM248
Transmembrane protein 248

1

0

High-throughput

0.279

Low

679603

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

679615

RBM39
RNA-binding protein 39

1

0

High-throughput

0.249

Low

679625

POC1A
POC1 centriolar protein homolog A

1

0

High-throughput

0.249

Low

679631

NR1H4
Bile acid receptor

1

0

Small-scale

0.249

Low

679637

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.249

Low

679638

KBTB4
Kelch repeat and BTB domain-containing protein 4

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024