Protein: TPIS
Triosephosphate isomerase (TIM) (EC 5.3.1.1) (Methylglyoxal synthase) (EC 4.2.3.3) (Triose-phosphate isomerase)

Gene: TPIS, TPI1
Organism: Homo sapiens
Interactions: 175
UniProt ID: P60174

Gene Ontology (top 5):
GO:0004807 - triose-phosphate isomerase activity
GO:0005615 - extracellular space
GO:0005634 - nucleus
GO:0005829 - cytosol
GO:0006094 - gluconeogenesis

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

888142

TPIS
Triosephosphate isomerase

1

6

Small-scale

0.710

High

227011

PRKN
E3 ubiquitin-protein ligase parkin

3

1

High-throughput

0.656

High

336435

SODC
Superoxide dismutase [Cu-Zn]

2

1

High-throughput

0.611

High

528858

CFTR
Cystic fibrosis transmembrane conductance regulator

2

1

High-throughput

0.601

High

888223

HYPK
Huntingtin-interacting protein K

2

0

Small-scale

0.585

High

338210

EGFR
Epidermal growth factor receptor

2

0

Small-scale

0.582

High

329557

AGR2
Anterior gradient protein 2 homolog

2

0

Small-scale

0.576

High

888171

EZH2
Histone-lysine N-methyltransferase EZH2

2

0

High-throughput

0.576

High

888214

DDX24
ATP-dependent RNA helicase DDX24

2

1

High-throughput

0.561

High

373965

RAF1
RAF proto-oncogene serine/threonine-protein kinase

2

0

High-throughput

0.559

High

779120

CCNF
Cyclin-F

2

0

High-throughput

0.559

High

454817

FGR
Tyrosine-protein kinase Fgr

2

0

High-throughput

0.547

High

888148

RAC1
Ras-related C3 botulinum toxin substrate 1

2

0

High-throughput

0.547

High

888174

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

2

0

High-throughput

0.547

High

888196

DOCK8
Dedicator of cytokinesis protein 8

2

0

High-throughput

0.547

High

869589

TERF1
Telomeric repeat-binding factor 1

1

0

High-throughput

0.543

High

888169

SETB1
Histone-lysine N-methyltransferase SETDB1

1

1

High-throughput

0.541

High

435025

SP1
Transcription factor Sp1

1

0

High-throughput

0.537

High

517158

PCNA
Proliferating cell nuclear antigen

1

0

Small-scale

0.537

High

170313

TIF1A
Transcription intermediary factor 1-alpha

1

1

High-throughput

0.536

High

808066

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

1

High-throughput

0.536

High

888203

PARK7
Parkinson disease protein 7

1

1

High-throughput

0.536

High

128513

DNM1L
Dynamin-1-like protein

1

0

High-throughput

0.513

High

547762

ATF2
Cyclic AMP-dependent transcription factor ATF-2

1

0

High-throughput

0.513

High

601193

VDAC1
Voltage-dependent anion-selective channel protein 1

1

0

High-throughput

0.513

High

739048

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

0

High-throughput

0.513

High

888170

IQCB1
IQ calmodulin-binding motif-containing protein 1

1

0

High-throughput

0.513

High

888197

PHOP1
Phosphoethanolamine/phosphocholine phosphatase

1

0

High-throughput

0.513

High

888205

HCD2
3-hydroxyacyl-CoA dehydrogenase type-2

1

0

High-throughput

0.513

High

888206

ARI3A
AT-rich interactive domain-containing protein 3A

1

0

High-throughput

0.513

High

888218

MED20
Mediator of RNA polymerase II transcription subunit 20

1

0

High-throughput

0.513

High

888234

GOT1B
Vesicle transport protein GOT1B

1

0

High-throughput

0.513

High

888172

MK06
Mitogen-activated protein kinase 6

1

1

High-throughput

0.508

High

646762

1433T
14-3-3 protein theta

1

4

High-throughput

0.501

High

888236

UCHL5
Ubiquitin carboxyl-terminal hydrolase isozyme L5

1

1

Small-scale

0.501

High

791433

HD
Huntingtin

1

0

High-throughput

0.493

High

394439

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.480

High

282589

RNF8
E3 ubiquitin-protein ligase RNF8

1

1

High-throughput

0.479

High

417213

ENOA
Alpha-enolase

1

3

High-throughput

0.479

High

538176

ENPL
Endoplasmin

1

3

High-throughput

0.479

High

569479

CEBPB
CCAAT/enhancer-binding protein beta

1

2

High-throughput

0.479

High

601027

ZP3
Zona pellucida sperm-binding protein 3

1

1

Small-scale

0.479

High

618036

COF1
Cofilin-1

1

1

Small-scale

0.479

High

668556

PML
Protein PML

1

2

High-throughput

0.479

High

808439

YAP1
Transcriptional coactivator YAP1

1

2

High-throughput

0.479

High

888145

SUMO2
Small ubiquitin-related modifier 2

1

1

High-throughput

0.479

High

888147

RL40
Ubiquitin-ribosomal protein eL40 fusion protein

1

2

Small-scale

0.479

High

888149

1433Z
14-3-3 protein zeta/delta

1

3

High-throughput

0.479

High

888152

VIGLN
Vigilin

1

1

High-throughput

0.479

High

888155

SOS2
Son of sevenless homolog 2

1

1

High-throughput

0.479

High

888166

TRI25
E3 ubiquitin/ISG15 ligase TRIM25

1

1

High-throughput

0.479

High

888177

A16L1
Autophagy-related protein 16-1

1

1

High-throughput

0.479

High

888198

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

1

High-throughput

0.479

High

888199

REQU
Zinc finger protein ubi-d4

1

1

High-throughput

0.479

High

888202

RING2
E3 ubiquitin-protein ligase RING2

1

2

High-throughput

0.479

High

888207

ANM1
Protein arginine N-methyltransferase 1

1

1

High-throughput

0.479

High

888210

FACD2
Fanconi anemia group D2 protein

1

1

High-throughput

0.479

High

888213

RHG39
Rho GTPase-activating protein 39

1

1

High-throughput

0.479

High

888215

RNF38
E3 ubiquitin-protein ligase RNF38

1

1

Small-scale

0.479

High

888225

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

1

1

High-throughput

0.479

High

888226

HDAC6
Histone deacetylase 6

1

1

High-throughput

0.479

High

888230

HDAC5
Histone deacetylase 5

1

1

High-throughput

0.479

High

214165

SPOP
Speckle-type POZ protein

1

0

High-throughput

0.458

High

244188

BRD4
Bromodomain-containing protein 4

1

0

High-throughput

0.458

High

255632

OBSL1
Obscurin-like protein 1

1

0

High-throughput

0.458

High

278012

PIAS1
E3 SUMO-protein ligase PIAS1

1

0

High-throughput

0.458

High

294597

RECQ4
ATP-dependent DNA helicase Q4

1

0

High-throughput

0.458

High

298333

UFL1
E3 UFM1-protein ligase 1

1

0

High-throughput

0.458

High

303062

HEXI1
Protein HEXIM1

1

0

High-throughput

0.458

High

346363

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.458

High

375918

ALDOA
Fructose-bisphosphate aldolase A

1

0

High-throughput

0.458

High

384581

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.458

High

414601

PTMA
Prothymosin alpha [Cleaved into: Prothymosin alpha, N-terminally processed; Thymosin alpha-1]

1

0

High-throughput

0.458

High

430112

PROF1
Profilin-1

1

0

High-throughput

0.458

High

444870

ANXA5
Annexin A5

1

0

High-throughput

0.458

High

453243

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

0

High-throughput

0.458

High

500930

MCF2
Proto-oncogene DBL

1

0

High-throughput

0.458

High

509219

G6PD
Glucose-6-phosphate 1-dehydrogenase

1

0

High-throughput

0.458

High

519155

KCRB
Creatine kinase B-type

1

0

High-throughput

0.458

High

535823

MIF
Macrophage migration inhibitory factor

1

0

High-throughput

0.458

High

552372

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.458

High

590755

BTF3
Transcription factor BTF3

1

0

High-throughput

0.458

High

625275

CDK2
Cyclin-dependent kinase 2

1

0

High-throughput

0.458

High

637827

PSA3
Proteasome subunit alpha type-3

1

0

Small-scale

0.458

High

641688

U2AF2
Splicing factor U2AF 65 kDa subunit

1

0

High-throughput

0.458

High

650818

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

653536

CALR
Calreticulin

1

0

High-throughput

0.458

High

669950

MARCS
Myristoylated alanine-rich C-kinase substrate

1

0

High-throughput

0.458

High

671769

PDIA3
Protein disulfide-isomerase A3

1

0

High-throughput

0.458

High

714801

GPC1
Glypican-1 [Cleaved into: Secreted glypican-1]

1

0

High-throughput

0.458

High

749297

BRCA1
Breast cancer type 1 susceptibility protein

1

0

High-throughput

0.458

High

777519

MDHM
Malate dehydrogenase, mitochondrial

1

0

High-throughput

0.458

High

807659

MAP1B
Microtubule-associated protein 1B

1

0

High-throughput

0.458

High

815202

TISD
mRNA decay activator protein ZFP36L2

1

0

High-throughput

0.458

High

817848

SOX2
Transcription factor SOX-2

1

0

High-throughput

0.458

High

821646

K2C6C
Keratin, type II cytoskeletal 6C

1

0

Small-scale

0.458

High

832282

MCM2
DNA replication licensing factor MCM2

1

0

High-throughput

0.458

High

836807

DNLI4
DNA ligase 4

1

0

High-throughput

0.458

High

842301

PPT1
Palmitoyl-protein thioesterase 1

1

0

High-throughput

0.458

High

868101

ATX3
Ataxin-3

1

0

High-throughput

0.458

High

874746

TERA
Transitional endoplasmic reticulum ATPase

1

0

High-throughput

0.458

High

888143

UBC12
NEDD8-conjugating enzyme Ubc12

1

0

High-throughput

0.458

High

888144

CH10
10 kDa heat shock protein, mitochondrial

1

0

High-throughput

0.458

High

888146

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.458

High

888150

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.458

High

888151

BASP1
Brain acid soluble protein 1

1

0

High-throughput

0.458

High

888153

EWS
RNA-binding protein EWS

1

0

High-throughput

0.458

High

888154

PRDX1
Peroxiredoxin-1

1

0

High-throughput

0.458

High

888156

FOXO1
Forkhead box protein O1

1

0

High-throughput

0.458

High

888157

TFCP2
Alpha-globin transcription factor CP2

1

0

High-throughput

0.458

High

888159

ILF3
Interleukin enhancer-binding factor 3

1

0

Small-scale

0.458

High

888160

TADBP
TAR DNA-binding protein 43

1

0

High-throughput

0.458

High

888161

AIMP2
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

1

0

High-throughput

0.458

High

888162

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.458

High

888163

SQSTM
Sequestosome-1

1

0

Small-scale

0.458

High

888164

CUL1
Cullin-1

1

0

High-throughput

0.458

High

888167

CUL7
Cullin-7

1

0

High-throughput

0.458

High

888168

SUZ12
Polycomb protein SUZ12

1

0

High-throughput

0.458

High

888175

TET5C
Terminal nucleotidyltransferase 5C

1

0

High-throughput

0.458

High

888178

VIR
Protein virilizer homolog

1

0

High-throughput

0.458

High

888179

PRP8
Pre-mRNA-processing-splicing factor 8

1

0

High-throughput

0.458

High

888180

RICTR
Rapamycin-insensitive companion of mTOR

1

0

High-throughput

0.458

High

888181

FGD5
FYVE, RhoGEF and PH domain-containing protein 5

1

0

High-throughput

0.458

High

888183

MOB3C
MOB kinase activator 3C

1

0

High-throughput

0.458

High

888184

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

888187

SLX4
Structure-specific endonuclease subunit SLX4

1

0

High-throughput

0.458

High

888188

RPTOR
Regulatory-associated protein of mTOR

1

0

High-throughput

0.458

High

888193

F184A
Protein FAM184A

1

0

High-throughput

0.458

High

888194

NHLC2
NHL repeat-containing protein 2

1

0

High-throughput

0.458

High

888200

CDCA5
Sororin

1

0

Small-scale

0.458

High

888204

NECD
Necdin

1

0

High-throughput

0.458

High

888209

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

0

High-throughput

0.458

High

888211

ACE2
Angiotensin-converting enzyme 2

1

0

Small-scale

0.458

High

888216

SHRPN
Sharpin

1

0

Small-scale

0.458

High

888217

CCDC8
Coiled-coil domain-containing protein 8

1

0

High-throughput

0.458

High

888219

NANOG
Homeobox protein NANOG

1

0

High-throughput

0.458

High

888220

ANLN
Anillin

1

0

High-throughput

0.458

High

888222

PIHD1
PIH1 domain-containing protein 1

1

0

High-throughput

0.458

High

888227

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

888228

PRP19
Pre-mRNA-processing factor 19

1

0

High-throughput

0.458

High

888229

SMC3
Structural maintenance of chromosomes protein 3

1

0

High-throughput

0.458

High

888232

NINL
Ninein-like protein

1

0

High-throughput

0.458

High

888235

LOXL2
Lysyl oxidase homolog 2

1

0

High-throughput

0.458

High

306051

GBRAP
Gamma-aminobutyric acid receptor-associated protein

1

3

High-throughput

0.445

High

496677

TAU
Microtubule-associated protein tau

1

1

High-throughput

0.445

High

717609

BMI1
Polycomb complex protein BMI-1

1

2

High-throughput

0.445

High

849508

CCL11
Eotaxin

1

0

High-throughput

0.438

High

888231

LIPT
Lipoyl amidotransferase LIPT1, mitochondrial

1

0

High-throughput

0.438

High

888158

ZP4
Zona pellucida sperm-binding protein 4

1

1

Small-scale

0.437

High

888182

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.437

High

888186

GOLI
E3 ubiquitin-protein ligase RNF130

1

1

High-throughput

0.437

High

888195

RN149
E3 ubiquitin-protein ligase RNF149

1

2

High-throughput

0.437

High

230594

KATIP
Katanin-interacting protein

1

0

High-throughput

0.426

High

888165

DAG1
Dystroglycan 1

1

0

Small-scale

0.426

High

888176

RNLS
Renalase

1

0

Small-scale

0.426

High

831155

CEBPA
CCAAT/enhancer-binding protein alpha

1

2

High-throughput

0.408

High

888189

RHG24
Rho GTPase-activating protein 24

2

0

High-throughput

0.298

High

658217

5HT2C
5-hydroxytryptamine receptor 2C

1

0

High-throughput

0.282

High

673753

BKRB2
B2 bradykinin receptor

1

0

High-throughput

0.282

High

888221

POTE1
Protection of telomeres protein 1

1

0

High-throughput

0.282

High

677914

SDHA
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

1

0

High-throughput

0.279

Low

725750

SOAT1
Sterol O-acyltransferase 1

1

0

High-throughput

0.279

Low

888208

PYGO2
Pygopus homolog 2

1

0

High-throughput

0.279

Low

225578

PCDH7
Protocadherin-7

1

0

High-throughput

0.249

Low

720104

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

888173

TGO1
Transport and Golgi organization protein 1 homolog

1

0

High-throughput

0.249

Low

888185

ZCH18
Zinc finger CCCH domain-containing protein 18

1

0

High-throughput

0.249

Low

888190

EMC5
ER membrane protein complex subunit 5

1

0

High-throughput

0.249

Low

888191

EMC1
ER membrane protein complex subunit 1

1

0

High-throughput

0.249

Low

888192

ARL10
ADP-ribosylation factor-like protein 10

1

0

High-throughput

0.249

Low

888201

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.249

Low

888224

B3GN2
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

1

0

High-throughput

0.249

Low

888233

AAR2
Protein AAR2 homolog

1

0

High-throughput

0.249

Low

888212

ZDHC5
Palmitoyltransferase ZDHHC5

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024