Protein: AT1B1
Sodium/potassium-transporting ATPase subunit beta-1 (Sodium/potassium-dependent ATPase subunit beta-1)

Gene: AT1B1, ATP1B1
Organism: Homo sapiens
Interactions: 134
UniProt ID: P05026

Gene Ontology (top 5):
GO:0001666 - response to hypoxia
GO:0001671 - ATPase activator activity
GO:0005391 - P-type sodium:potassium-exchanging transporter activity
GO:0005886 - plasma membrane
GO:0005890 - sodium:potassium-exchanging ATPase complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

420297

AT1A1
Sodium/potassium-transporting ATPase subunit alpha-1

7

16

Small-scale

0.963

High

420765

ATP4A
Potassium-transporting ATPase alpha chain 1

2

16

Small-scale

0.789

High

420761

AT1A3
Sodium/potassium-transporting ATPase subunit alpha-3

2

16

High-throughput

0.776

High

420777

AT12A
Potassium-transporting ATPase alpha chain 2

1

16

High-throughput

0.691

High

124671

PLM
Phospholemman

1

0

Small-scale

0.586

High

420769

AGTR1
Type-1 angiotensin II receptor

1

1

High-throughput

0.582

High

388351

B3AT
Band 3 anion transport protein

1

0

Small-scale

0.576

High

395311

ESR1
Estrogen receptor

2

1

High-throughput

0.571

High

240474

PRKN
E3 ubiquitin-protein ligase parkin

2

0

High-throughput

0.559

High

362578

EGFR
Epidermal growth factor receptor

1

3

Small-scale

0.554

High

420831

NED4L
E3 ubiquitin-protein ligase NEDD4-like

1

1

Small-scale

0.552

High

420853

NDRG2
Protein NDRG2

1

4

Small-scale

0.552

High

420775

5HT2B
5-hydroxytryptamine receptor 2B

1

1

High-throughput

0.541

High

186398

TM9S1
Transmembrane 9 superfamily member 1

1

4

High-throughput

0.536

High

222342

TSN6
Tetraspanin-6

1

6

High-throughput

0.536

High

269826

IGSF3
Immunoglobulin superfamily member 3

1

2

High-throughput

0.536

High

323955

CSTN1
Calsyntenin-1

1

1

High-throughput

0.536

High

420756

HLAC
HLA class I histocompatibility antigen, C alpha chain

1

2

High-throughput

0.536

High

420758

BIP
Endoplasmic reticulum chaperone BiP

1

2

High-throughput

0.536

High

420788

STX4
Syntaxin-4

1

1

High-throughput

0.536

High

420798

P2RY6
P2Y purinoceptor 6

1

4

High-throughput

0.536

High

420801

SGCB
Beta-sarcoglycan

1

4

High-throughput

0.536

High

420804

TBB8
Tubulin beta-8 chain

1

2

High-throughput

0.536

High

420825

SPP2B
Signal peptide peptidase-like 2B

1

1

High-throughput

0.536

High

420826

NDRG1
Protein NDRG1

1

4

High-throughput

0.536

High

420834

SCN2A
Sodium channel protein type 2 subunit alpha

1

5

High-throughput

0.536

High

420836

TM9S2
Transmembrane 9 superfamily member 2

1

4

High-throughput

0.536

High

420839

UN93B
Protein unc-93 homolog B1

1

1

High-throughput

0.536

High

420840

TBB1
Tubulin beta-1 chain

1

1

High-throughput

0.536

High

420845

TM9S3
Transmembrane 9 superfamily member 3

1

4

High-throughput

0.536

High

420848

RTN4
Reticulon-4

1

4

High-throughput

0.536

High

420850

NDRG3
Protein NDRG3

1

4

High-throughput

0.536

High

105106

APRIO
Alternative prion protein

2

1

High-throughput

0.533

High

295904

SC5D
Lathosterol oxidase

1

0

High-throughput

0.513

High

324325

SLIK5
SLIT and NTRK-like protein 5

1

0

High-throughput

0.513

High

420819

K319L
Dyslexia-associated protein KIAA0319-like protein

1

0

High-throughput

0.513

High

420821

CISD2
CDGSH iron-sulfur domain-containing protein 2

1

0

High-throughput

0.513

High

420833

PANX1
Pannexin-1

1

0

High-throughput

0.513

High

420837

TX101
Testis-expressed protein 101

1

0

High-throughput

0.513

High

420843

AGRL3
Adhesion G protein-coupled receptor L3

1

0

High-throughput

0.513

High

301300

WFS1
Wolframin

1

0

Small-scale

0.506

High

420820

KIRR3
Kin of IRRE-like protein 3

1

1

Small-scale

0.506

High

185347

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

2

High-throughput

0.501

High

420753

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.493

High

420805

MBRL
Membralin

1

1

High-throughput

0.489

High

420806

MKS3
Meckelin

1

1

High-throughput

0.489

High

420829

TXD15
Thioredoxin domain-containing protein 15

1

2

High-throughput

0.489

High

350272

DDAH2
Putative hydrolase DDAH2

1

0

High-throughput

0.486

High

420787

PSME1
Proteasome activator complex subunit 1

1

0

High-throughput

0.486

High

420766

CD9
CD9 antigen

1

7

High-throughput

0.484

High

420773

BRCA1
Breast cancer type 1 susceptibility protein

1

3

High-throughput

0.481

High

420794

TRI14
Tripartite motif-containing protein 14

1

3

High-throughput

0.481

High

420835

BARD1
BRCA1-associated RING domain protein 1

1

2

High-throughput

0.481

High

156836

CTRO
Citron Rho-interacting kinase

1

1

High-throughput

0.479

High

178144

NPC1
NPC intracellular cholesterol transporter 1

1

3

High-throughput

0.479

High

217707

TGON2
Trans-Golgi network integral membrane protein 2

1

1

High-throughput

0.479

High

380243

DRA
HLA class II histocompatibility antigen, DR alpha chain

1

8

Small-scale

0.479

High

403728

GCR
Glucocorticoid receptor

1

1

High-throughput

0.479

High

411172

NTRK1
High affinity nerve growth factor receptor

1

3

High-throughput

0.479

High

420755

RHOC
Rho-related GTP-binding protein RhoC

1

10

High-throughput

0.479

High

420762

DRB4
HLA class II histocompatibility antigen, DR beta 4 chain

1

8

Small-scale

0.479

High

420763

RAC2
Ras-related C3 botulinum toxin substrate 2

1

9

High-throughput

0.479

High

420771

PHB1
Prohibitin 1

1

3

High-throughput

0.479

High

420782

RHOB
Rho-related GTP-binding protein RhoB

1

12

High-throughput

0.479

High

420783

RAC1
Ras-related C3 botulinum toxin substrate 1

1

11

High-throughput

0.479

High

420785

DRB3
HLA class II histocompatibility antigen, DR beta 3 chain

1

8

Small-scale

0.479

High

420786

VIGLN
Vigilin

1

1

High-throughput

0.479

High

420790

TRAF3
TNF receptor-associated factor 3

1

2

Small-scale

0.479

High

420791

TADBP
TAR DNA-binding protein 43

1

3

Small-scale

0.479

High

420803

DRB5
HLA class II histocompatibility antigen, DR beta 5 chain

1

8

Small-scale

0.479

High

420814

TM11B
Transmembrane protease serine 11B

1

3

High-throughput

0.479

High

420817

S15A3
Solute carrier family 15 member 3

1

3

High-throughput

0.479

High

420822

RN149
E3 ubiquitin-protein ligase RNF149

1

2

High-throughput

0.479

High

420841

RHOJ
Rho-related GTP-binding protein RhoJ

1

13

High-throughput

0.479

High

420842

PKHA4
Pleckstrin homology domain-containing family A member 4

1

2

High-throughput

0.479

High

420844

RHOF
Rho-related GTP-binding protein RhoF

1

14

High-throughput

0.479

High

420851

S12A6
Solute carrier family 12 member 6

1

4

Small-scale

0.479

High

420854

TRAF6
TNF receptor-associated factor 6

1

2

Small-scale

0.479

High

420852

KMT2B
Histone-lysine N-methyltransferase 2B

1

1

High-throughput

0.464

High

420796

T132D
Transmembrane protein 132D

1

0

Small-scale

0.460

High

162312

PDCD5
Programmed cell death protein 5

1

0

Small-scale

0.458

High

400099

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

High-throughput

0.458

High

420797

MLC1
Membrane protein MLC1

1

0

Small-scale

0.458

High

420802

CAH9
Carbonic anhydrase 9

1

0

High-throughput

0.458

High

420827

HAVR1
Hepatitis A virus cellular receptor 1

1

0

Small-scale

0.458

High

420838

CCDC8
Coiled-coil domain-containing protein 8

1

0

High-throughput

0.458

High

104092

F5H1C8
Solute carrier family 15 member 3

1

3

High-throughput

0.445

High

254728

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

1

High-throughput

0.445

High

404619

PRIO
Major prion protein

1

1

High-throughput

0.445

High

420757

TAU
Microtubule-associated protein tau

1

7

High-throughput

0.445

High

420759

GTR1
Solute carrier family 2, facilitated glucose transporter member 1

1

4

High-throughput

0.445

High

420767

GTR5
Solute carrier family 2, facilitated glucose transporter member 5

1

4

High-throughput

0.445

High

420779

CD81
CD81 antigen

1

7

High-throughput

0.445

High

420793

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

5

High-throughput

0.445

High

420795

NTCP
Hepatic sodium/bile acid cotransporter

1

1

High-throughput

0.445

High

420811

GTR7
Solute carrier family 2, facilitated glucose transporter member 7

1

4

High-throughput

0.445

High

420815

RIMS1
Regulating synaptic membrane exocytosis protein 1

1

1

High-throughput

0.445

High

420823

MFSD8
Major facilitator superfamily domain-containing protein 8

1

1

High-throughput

0.445

High

420847

SO1B3
Solute carrier organic anion transporter family member 1B3

1

1

High-throughput

0.445

High

420789

UBP4
Ubiquitin carboxyl-terminal hydrolase 4

1

2

Small-scale

0.439

High

420813

PAXI1
PAX-interacting protein 1

1

1

High-throughput

0.439

High

420754

S10A9
Protein S100-A9

1

0

Small-scale

0.438

High

420808

RIF1
Telomere-associated protein RIF1

1

0

High-throughput

0.438

High

125140

LEG9
Galectin-9

1

2

High-throughput

0.437

High

293047

CD123
Translation initiation factor eIF2 assembly protein

1

1

High-throughput

0.437

High

420764

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.437

High

420768

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.437

High

420772

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.437

High

420784

RNF4
E3 ubiquitin-protein ligase RNF4

1

1

High-throughput

0.437

High

420792

APR
Phorbol-12-myristate-13-acetate-induced protein 1

1

1

High-throughput

0.437

High

420809

VIR
Protein virilizer homolog

1

1

High-throughput

0.437

High

420812

TRI67
Tripartite motif-containing protein 67

1

5

High-throughput

0.437

High

420849

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.437

High

337058

NPT2B
Sodium-dependent phosphate transport protein 2B

1

0

High-throughput

0.426

High

420760

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.426

High

420778

TERA
Transitional endoplasmic reticulum ATPase

1

0

High-throughput

0.426

High

420780

SNP25
Synaptosomal-associated protein 25

1

0

Small-scale

0.426

High

420816

OSTA
Organic solute transporter subunit alpha

1

0

High-throughput

0.426

High

420824

S35B2
Adenosine 3'-phospho 5'-phosphosulfate transporter 1

1

0

High-throughput

0.426

High

420830

S35E1
Solute carrier family 35 member E1

1

0

High-throughput

0.426

High

420832

SYGP1
Ras/Rap GTPase-activating protein SynGAP

1

0

High-throughput

0.426

High

420846

S40A1
Ferroportin

1

0

High-throughput

0.426

High

420828

OMA1
Metalloendopeptidase OMA1, mitochondrial

1

0

High-throughput

0.279

Low

420776

CRIP2
Cysteine-rich protein 2

1

0

High-throughput

0.265

Low

420800

EZH2
Histone-lysine N-methyltransferase EZH2

1

0

High-throughput

0.265

Low

420818

TRM2A
tRNA

1

0

High-throughput

0.265

Low

273249

T22D2
TSC22 domain family protein 2

1

0

Small-scale

0.251

Low

420770

GCH1
GTP cyclohydrolase 1

1

0

Small-scale

0.251

Low

420807

LRIF1
Ligand-dependent nuclear receptor-interacting factor 1

1

0

High-throughput

0.251

Low

352834

AGR2
Anterior gradient protein 2 homolog

1

0

High-throughput

0.249

Low

420774

CCNF
Cyclin-F

1

0

High-throughput

0.249

Low

420781

SMS
Somatostatin

1

0

Small-scale

0.249

Low

420799

SMAD2
Mothers against decapentaplegic homolog 2

1

0

High-throughput

0.249

Low

420810

ZNT6
Zinc transporter 6

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025