Protein: ACSL1
Long-chain-fatty-acid--CoA ligase 1 (EC 6.2.1.3) (Acyl-CoA synthetase 1) (ACS1) (Arachidonate--CoA ligase) (EC 6.2.1.15) (Long-chain acyl-CoA synthetase 1) (LACS 1) (Long-chain acyl-CoA synthetase 2) (LACS 2) (Long-chain fatty acid-CoA ligase 2) (Palmitoyl-CoA ligase 1) (Palmitoyl-CoA ligase 2) (Phytanate--CoA ligase) (EC 6.2.1.24)

Gene: ACSL1
Organism: Homo sapiens
Interactions: 63
UniProt ID: P33121

Gene Ontology (top 5):
GO:0000038 - very long-chain fatty acid metabolic process
GO:0001676 - long-chain fatty acid metabolic process
GO:0004467 - long-chain fatty acid-CoA ligase activity
GO:0005524 - ATP binding
GO:0005739 - mitochondrion

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

702609

FAS
Fatty acid synthase

1

0

High-throughput

0.656

High

226653

PRKN
E3 ubiquitin-protein ligase parkin

2

8

Small-scale

0.584

High

171944

GP182
G-protein coupled receptor 182

1

4

High-throughput

0.536

High

382584

DPB1
HLA class II histocompatibility antigen, DP beta 1 chain

1

3

High-throughput

0.536

High

644705

NKG2D
NKG2-D type II integral membrane protein

1

6

High-throughput

0.536

High

702608

EAA3
Excitatory amino acid transporter 3

1

4

High-throughput

0.536

High

702626

F174A
Membrane protein FAM174A

1

1

High-throughput

0.536

High

702630

AQP3
Aquaporin-3

1

3

High-throughput

0.536

High

702632

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

2

High-throughput

0.536

High

702625

MFD4A
Major facilitator superfamily domain-containing protein 4A

1

0

High-throughput

0.513

High

702627

HUMMR
Protein MGARP

1

0

High-throughput

0.513

High

156799

FFAR1
Free fatty acid receptor 1

1

5

High-throughput

0.489

High

245315

RAMP3
Receptor activity-modifying protein 3

1

1

High-throughput

0.489

High

644542

NKG2A
NKG2-A/NKG2-B type II integral membrane protein

1

6

High-throughput

0.489

High

686603

CCR1
C-C chemokine receptor type 1

1

2

High-throughput

0.489

High

702606

APJ
Apelin receptor

1

2

High-throughput

0.489

High

702611

CCG7
Voltage-dependent calcium channel gamma-7 subunit

1

1

High-throughput

0.489

High

702618

LRAD1
Low-density lipoprotein receptor class A domain-containing protein 1

1

1

High-throughput

0.489

High

702620

T150A
Transmembrane protein 150A

1

1

High-throughput

0.489

High

702621

P2RY8
P2Y purinoceptor 8

1

3

High-throughput

0.489

High

702623

S22A9
Organic anion transporter 7

1

2

High-throughput

0.489

High

702634

BRNP2
BMP/retinoic acid-inducible neural-specific protein 2

1

1

High-throughput

0.489

High

702639

CCG4
Voltage-dependent calcium channel gamma-4 subunit

1

1

High-throughput

0.489

High

702640

B3GN3
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 3

1

1

High-throughput

0.489

High

702641

GPR55
G-protein coupled receptor 55

1

7

High-throughput

0.489

High

702642

CTDP1
RNA polymerase II subunit A C-terminal domain phosphatase

1

1

High-throughput

0.489

High

702643

GPR45
Probable G-protein coupled receptor 45

1

3

High-throughput

0.489

High

437627

MCR
Mineralocorticoid receptor

1

6

High-throughput

0.481

High

130448

NDUA4
Cytochrome c oxidase subunit NDUFA4

1

1

High-throughput

0.479

High

196270

PJA2
E3 ubiquitin-protein ligase Praja-2

1

1

Small-scale

0.479

High

258412

COQ9
Ubiquinone biosynthesis protein COQ9, mitochondrial

1

3

High-throughput

0.479

High

377134

GCR
Glucocorticoid receptor

1

6

Small-scale

0.479

High

384363

NTRK1
High affinity nerve growth factor receptor

1

10

High-throughput

0.479

High

569280

CEBPB
CCAAT/enhancer-binding protein beta

1

2

High-throughput

0.479

High

594712

ATP4A
Potassium-transporting ATPase alpha chain 1

1

3

Small-scale

0.479

High

668466

PML
Protein PML

1

2

High-throughput

0.479

High

702612

BDH
D-beta-hydroxybutyrate dehydrogenase, mitochondrial

1

1

High-throughput

0.479

High

702628

RBCC1
RB1-inducible coiled-coil protein 1

1

3

High-throughput

0.479

High

702631

ARMC5
Armadillo repeat-containing protein 5

1

1

High-throughput

0.479

High

702638

WWOX
WW domain-containing oxidoreductase

1

2

High-throughput

0.479

High

702622

PLD3
5'-3' exonuclease PLD3

1

0

High-throughput

0.458

High

702624

PLD6
Mitochondrial cardiolipin hydrolase

1

0

High-throughput

0.458

High

354324

HLAB
HLA class I histocompatibility antigen, B alpha chain

1

1

High-throughput

0.445

High

528648

CFTR
Cystic fibrosis transmembrane conductance regulator

1

2

High-throughput

0.445

High

702615

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

1

High-throughput

0.445

High

702613

FMR1
Fragile X messenger ribonucleoprotein 1

1

0

High-throughput

0.438

High

346061

MYC
Myc proto-oncogene protein

1

2

High-throughput

0.437

High

552052

RFA2
Replication protein A 32 kDa subunit

1

4

High-throughput

0.437

High

650482

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

4

High-throughput

0.437

High

702605

RFA3
Replication protein A 14 kDa subunit

1

3

High-throughput

0.437

High

702607

CCNF
Cyclin-F

1

1

High-throughput

0.437

High

702617

DUS7
Dual specificity protein phosphatase 7

1

1

High-throughput

0.437

High

702619

TRI67
Tripartite motif-containing protein 67

1

4

High-throughput

0.437

High

702633

NMES1
Normal mucosa of esophagus-specific gene 1 protein

1

1

High-throughput

0.437

High

702635

EGLN3
Prolyl hydroxylase EGLN3

1

1

High-throughput

0.437

High

702636

ECT2
Protein ECT2

1

2

High-throughput

0.437

High

702637

TLS1
Splicing factor C9orf78

1

1

High-throughput

0.437

High

702610

CEBPA
CCAAT/enhancer-binding protein alpha

1

2

High-throughput

0.373

High

271916

FCN3
Ficolin-3

1

0

High-throughput

0.279

Low

686267

VIPR1
Vasoactive intestinal polypeptide receptor 1

1

0

High-throughput

0.279

Low

702614

MESP2
Mesoderm posterior protein 2

1

0

High-throughput

0.279

Low

702616

SGCA
Alpha-sarcoglycan

1

0

High-throughput

0.279

Low

702629

ITLN1
Intelectin-1

1

0

High-throughput

0.279

Low


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Last updated: 15 Jul 2024