Protein: TLR8
Toll-like receptor 8 (CD antigen CD288)

Gene: TLR8
Organism: Homo sapiens
Interactions: 21
UniProt ID: Q9NR97

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0002224 - toll-like receptor signaling pathway
GO:0003677 - DNA binding
GO:0003723 - RNA binding
GO:0003725 - double-stranded RNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1448087

TLR8
Toll-like receptor 8

3

17

Small-scale

0.858

High

1054151

BTK
Tyrosine-protein kinase BTK

2

14

Small-scale

0.775

High

188601

SIGL5
Sialic acid-binding Ig-like lectin 5

1

20

Small-scale

0.618

High

224544

SIGL6
Sialic acid-binding Ig-like lectin 6

1

20

Small-scale

0.618

High

471562

CD14
Monocyte differentiation antigen CD14

1

10

Small-scale

0.618

High

699869

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

3

Small-scale

0.618

High

838184

STAT1
Signal transducer and activator of transcription 1-alpha/beta

1

1

Small-scale

0.618

High

1397000

SIG10
Sialic acid-binding Ig-like lectin 10

1

20

Small-scale

0.618

High

1448073

TLR9
Toll-like receptor 9

1

17

Small-scale

0.618

High

1448089

TLR7
Toll-like receptor 7

1

18

Small-scale

0.618

High

1448090

SIGL9
Sialic acid-binding Ig-like lectin 9

1

20

Small-scale

0.618

High

1430969

UN93B
Protein unc-93 homolog B1

2

7

Small-scale

0.611

High

1372401

AT2A3
Sarcoplasmic/endoplasmic reticulum calcium ATPase 3

1

2

High-throughput

0.536

High

1412990

CNPY3
Protein canopy homolog 3

1

7

High-throughput

0.536

High

414691

P53
Cellular tumor antigen p53

1

5

Small-scale

0.479

High

607141

CEBPB
CCAAT/enhancer-binding protein beta

1

2

Small-scale

0.479

High

1062670

DHX9
ATP-dependent RNA helicase A

1

2

Small-scale

0.479

High

1407674

MYD88
Myeloid differentiation primary response protein MyD88

1

20

Small-scale

0.457

High

887471

CEBPD
CCAAT/enhancer-binding protein delta

1

3

Small-scale

0.437

High

1448088

RN216
E3 ubiquitin-protein ligase RNF216

1

5

Small-scale

0.437

High


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Last updated: 11Aug2025