Protein: TLR5
Toll-like receptor 5 (Toll/interleukin-1 receptor-like protein 3)

Gene: TLR5
Organism: Homo sapiens
Interactions: 32
UniProt ID: O60602

Gene Ontology (top 5):
GO:0002224 - toll-like receptor signaling pathway
GO:0004888 - transmembrane signaling receptor activity
GO:0005149 - interleukin-1 receptor binding
GO:0005886 - plasma membrane
GO:0006954 - inflammatory response

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

252291

IRAK4
Interleukin-1 receptor-associated kinase 4

2

20

Small-scale

0.754

High

252286

MYD88
Myeloid differentiation primary response protein MyD88

5

20

Small-scale

0.701

High

252288

CNPY3
Protein canopy homolog 3

2

11

High-throughput

0.628

High

126275

TLR4
Toll-like receptor 4

1

16

Small-scale

0.618

High

188584

SIGL5
Sialic acid-binding Ig-like lectin 5

1

20

Small-scale

0.618

High

224532

SIGL6
Sialic acid-binding Ig-like lectin 6

1

20

Small-scale

0.618

High

252275

CD33
Myeloid cell surface antigen CD33

1

20

Small-scale

0.618

High

252276

CD22
B-cell receptor CD22

1

20

Small-scale

0.618

High

252277

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

3

Small-scale

0.618

High

252278

IRAK1
Interleukin-1 receptor-associated kinase 1

1

20

Small-scale

0.618

High

252279

KPCD1
Serine/threonine-protein kinase D1

1

2

Small-scale

0.618

High

252285

SIG11
Sialic acid-binding Ig-like lectin 11

1

20

Small-scale

0.618

High

252292

SIGL7
Sialic acid-binding Ig-like lectin 7

1

20

Small-scale

0.618

High

252294

SIGL9
Sialic acid-binding Ig-like lectin 9

1

20

Small-scale

0.618

High

252271

TLR5
Toll-like receptor 5

1

18

Small-scale

0.590

High

252272

DHRS3
Short-chain dehydrogenase/reductase 3

2

3

High-throughput

0.574

High

252295

DHRS7
Dehydrogenase/reductase SDR family member 7

2

2

High-throughput

0.574

High

252297

SNX14
Sorting nexin-14

2

1

High-throughput

0.574

High

252274

P53
Cellular tumor antigen p53

2

5

Small-scale

0.533

High

252281

TCAM1
TIR domain-containing adapter molecule 1

1

8

Small-scale

0.479

High

252283

PAUF
Pancreatic adenocarcinoma up-regulated factor

1

2

Small-scale

0.479

High

252290

RN216
E3 ubiquitin-protein ligase RNF216

1

5

Small-scale

0.439

High

252289

HOIL1
RanBP-type and C3HC4-type zinc finger-containing protein 1

1

8

High-throughput

0.437

High

249221

MA1A2
Mannosyl-oligosaccharide 1,2-alpha-mannosidase IB

2

0

High-throughput

0.328

High

252273

CNEP1
CTD nuclear envelope phosphatase 1

2

0

High-throughput

0.328

High

252287

PXL2A
Peroxiredoxin-like 2A

2

0

High-throughput

0.328

High

252293

TMX2
Thioredoxin-related transmembrane protein 2

2

0

High-throughput

0.328

High

252296

PTH2
Peptidyl-tRNA hydrolase 2, mitochondrial

2

0

High-throughput

0.328

High

252280

CHSS3
Chondroitin sulfate synthase 3

1

0

High-throughput

0.279

Low

252282

ACO12
Acetyl-coenzyme A thioesterase

1

0

High-throughput

0.279

Low

252284

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025