Protein: TLR9
Toll-like receptor 9 (CD antigen CD289)

Gene: TLR9
Organism: Homo sapiens
Interactions: 99
UniProt ID: Q9NR96

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0001774 - microglial cell activation
GO:0002224 - toll-like receptor signaling pathway
GO:0002639 - positive regulation of immunoglobulin production
GO:0002730 - regulation of dendritic cell cytokine production

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1054150

BTK
Tyrosine-protein kinase BTK

2

14

Small-scale

0.775

High

891324

GSK3A
Glycogen synthase kinase-3 alpha

1

4

High-throughput

0.691

High

891812

GSK3B
Glycogen synthase kinase-3 beta

1

4

High-throughput

0.691

High

1417800

LRRC3
Leucine-rich repeat-containing protein 3

1

18

High-throughput

0.691

High

1142481

RAGE
Advanced glycosylation end product-specific receptor

1

11

Small-scale

0.665

High

521020

HLAC
HLA class I histocompatibility antigen, C alpha chain

1

0

High-throughput

0.656

High

1407673

MYD88
Myeloid differentiation primary response protein MyD88

3

20

Small-scale

0.650

High

188600

SIGL5
Sialic acid-binding Ig-like lectin 5

1

20

Small-scale

0.618

High

224543

SIGL6
Sialic acid-binding Ig-like lectin 6

1

20

Small-scale

0.618

High

471561

CD14
Monocyte differentiation antigen CD14

1

10

Small-scale

0.618

High

557489

SRC
Proto-oncogene tyrosine-protein kinase Src

1

12

Small-scale

0.618

High

562654

RINI
Ribonuclease inhibitor

1

17

Small-scale

0.618

High

594112

NCK1
SH2/SH3 adapter protein NCK1

1

10

High-throughput

0.618

High

832809

BCL6
B-cell lymphoma 6 protein

1

2

Small-scale

0.618

High

849254

KSYK
Tyrosine-protein kinase SYK

1

20

Small-scale

0.618

High

902227

RAB13
Ras-related protein Rab-13

1

3

Small-scale

0.618

High

905688

IRAK1
Interleukin-1 receptor-associated kinase 1

1

20

Small-scale

0.618

High

981370

RAB1A
Ras-related protein Rab-1A

1

2

Small-scale

0.618

High

1051322

KPCZ
Protein kinase C zeta type

1

6

Small-scale

0.618

High

1051968

KPCD
Protein kinase C delta type

1

6

Small-scale

0.618

High

1097233

PAK2
Serine/threonine-protein kinase PAK 2

1

1

Small-scale

0.618

High

1308487

VRK3
Serine/threonine-protein kinase VRK3

1

1

High-throughput

0.618

High

1352057

MICA1
[F-actin]-monooxygenase MICAL1

1

1

Small-scale

0.618

High

1448073

TLR8
Toll-like receptor 8

1

17

Small-scale

0.618

High

1448079

TBK1
Serine/threonine-protein kinase TBK1

1

4

Small-scale

0.618

High

1448083

SIGL9
Sialic acid-binding Ig-like lectin 9

1

20

Small-scale

0.618

High

1448072

TLR9
Toll-like receptor 9

1

15

Small-scale

0.590

High

1161697

IF16
Gamma-interferon-inducible protein 16

1

0

Small-scale

0.586

High

1369281

SHIP1
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1

1

0

Small-scale

0.586

High

161159

ABCD4
Lysosomal cobalamin transporter ABCD4

1

1

High-throughput

0.536

High

170979

CLGN
Calmegin

1

2

High-throughput

0.536

High

535579

BIP
Endoplasmic reticulum chaperone BiP

1

7

High-throughput

0.536

High

1094990

TRAF3
TNF receptor-associated factor 3

1

13

High-throughput

0.536

High

1323508

S11IP
Serine/threonine-protein kinase 11-interacting protein

1

20

High-throughput

0.536

High

1412989

CNPY3
Protein canopy homolog 3

1

7

High-throughput

0.536

High

1429857

TOLIP
Toll-interacting protein

1

3

High-throughput

0.536

High

1430968

UN93B
Protein unc-93 homolog B1

1

7

High-throughput

0.536

High

1436053

DJC18
DnaJ homolog subfamily C member 18

1

1

High-throughput

0.536

High

1448080

KCNG1
Voltage-gated potassium channel regulatory subunit KCNG1

1

3

High-throughput

0.536

High

1448086

SNX14
Sorting nexin-14

1

1

High-throughput

0.536

High

794639

RBMX
RNA-binding motif protein, X chromosome

1

2

High-throughput

0.515

High

243833

ADCY3
Adenylate cyclase type 3

1

0

High-throughput

0.513

High

1103593

PDE3B
cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B

1

0

High-throughput

0.513

High

1212309

TM63B
Mechanosensitive cation channel TMEM63B

1

0

High-throughput

0.513

High

1214131

DIK1A
Divergent protein kinase domain 1A

1

0

High-throughput

0.513

High

1337687

PDZD8
PDZ domain-containing protein 8

1

0

High-throughput

0.513

High

1445987

ABCB9
ABC-type oligopeptide transporter ABCB9

1

0

High-throughput

0.513

High

1448077

UGGG1
UDP-glucose:glycoprotein glucosyltransferase 1

1

0

High-throughput

0.513

High

1448081

PALD
Paladin

1

0

High-throughput

0.513

High

844277

MTHR
Methylenetetrahydrofolate reductase

1

1

High-throughput

0.489

High

1034975

GCYB1
Guanylate cyclase soluble subunit beta-1

1

1

High-throughput

0.489

High

186052

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

1

Small-scale

0.479

High

243743

SMCA5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5

1

2

Small-scale

0.479

High

481391

HMGB1
High mobility group protein B1

1

6

Small-scale

0.479

High

537968

HSP7C
Heat shock cognate 71 kDa protein

1

5

Small-scale

0.479

High

578316

ETS2
Protein C-ets-2

1

4

Small-scale

0.479

High

600944

HSP76
Heat shock 70 kDa protein 6

1

5

Small-scale

0.479

High

622481

ELK1
ETS domain-containing protein Elk-1

1

3

Small-scale

0.479

High

887252

CEBPA
CCAAT/enhancer-binding protein alpha

1

3

Small-scale

0.479

High

1292748

TRI69
E3 ubiquitin-protein ligase TRIM69

1

3

Small-scale

0.479

High

1407170

PI51A
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha

1

2

Small-scale

0.479

High

1432933

UN45A
Protein unc-45 homolog A

1

6

Small-scale

0.479

High

1448082

CHIP
E3 ubiquitin-protein ligase CHIP

1

4

Small-scale

0.479

High

1448084

TRAF6
TNF receptor-associated factor 6

1

10

Small-scale

0.479

High

1448085

RN115
E3 ubiquitin-protein ligase RNF115

1

4

Small-scale

0.479

High

1448075

RN216
E3 ubiquitin-protein ligase RNF216

1

5

Small-scale

0.464

High

123844

MYO1C
Unconventional myosin-Ic

1

0

Small-scale

0.458

High

138321

PSDE
26S proteasome non-ATPase regulatory subunit 14

1

0

High-throughput

0.458

High

246976

KDM1A
Lysine-specific histone demethylase 1A

1

0

Small-scale

0.458

High

593229

CREB1
Cyclic AMP-responsive element-binding protein 1

1

0

Small-scale

0.458

High

639316

TNAP3
Tumor necrosis factor alpha-induced protein 3

1

0

Small-scale

0.458

High

659707

NFYA
Nuclear transcription factor Y subunit alpha

1

0

Small-scale

0.458

High

837864

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

0

Small-scale

0.458

High

993346

ACTG
Actin, cytoplasmic 2

1

0

Small-scale

0.458

High

1005971

GTF2I
General transcription factor II-I

1

0

Small-scale

0.458

High

1195335

TPRN
Taperin

1

0

Small-scale

0.458

High

1288267

LYRIC
Protein LYRIC

1

0

Small-scale

0.458

High

1316466

XRN1
5'-3' exoribonuclease 1

1

0

Small-scale

0.458

High

1356797

STYX
Serine/threonine/tyrosine-interacting protein

1

0

High-throughput

0.458

High

1370130

RENT1
Regulator of nonsense transcripts 1

1

0

Small-scale

0.458

High

1391516

BSCL2
Seipin

1

0

Small-scale

0.458

High

761896

HSP74
Heat shock 70 kDa protein 4

1

7

Small-scale

0.437

High

1326104

RYBP
RING1 and YY1-binding protein

1

0

High-throughput

0.426

High

866838

CAZA2
F-actin-capping protein subunit alpha-2

1

1

High-throughput

0.381

High

915196

CAZA1
F-actin-capping protein subunit alpha-1

1

1

High-throughput

0.381

High

1448078

ARP3B
Actin-related protein 3B

1

1

High-throughput

0.381

High

1307204

RB6I2
ELKS/Rab6-interacting/CAST family member 1

1

0

High-throughput

0.365

High

1415851

ELOV1
Very long chain fatty acid elongase 1

1

0

High-throughput

0.365

High

1448076

LYAR
Cell growth-regulating nucleolar protein

1

0

High-throughput

0.365

High

300604

KRT36
Keratin, type I cuticular Ha6

1

3

High-throughput

0.348

High

1007545

KRT85
Keratin, type II cuticular Hb5

1

2

High-throughput

0.348

High

1146180

K1H1
Keratin, type I cuticular Ha1

1

3

High-throughput

0.348

High

1448074

KRT82
Keratin, type II cuticular Hb2

1

2

High-throughput

0.348

High

139616

PESC
Pescadillo homolog

1

0

Small-scale

0.249

Low

633343

MSH3
DNA mismatch repair protein Msh3

1

0

Small-scale

0.249

Low

948515

ELOF1
Transcription elongation factor 1 homolog

1

0

Small-scale

0.249

Low

1413468

MCMBP
Mini-chromosome maintenance complex-binding protein

1

0

Small-scale

0.249

Low

867445

CAPZB
F-actin-capping protein subunit beta

1

0

High-throughput

0.198

Low


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Last updated: 11Aug2025