Protein: TRM5
tRNA (guanine(37)-N(1))-methyltransferase (EC 2.1.1.228) (M1G-methyltransferase) (tRNA [GM37] methyltransferase) (tRNA methyltransferase 5 homolog)

Gene: TRM5, TRMT5
Organism: Homo sapiens
Interactions: 41
UniProt ID: Q32P41

Gene Ontology (top 5):
GO:0002939 - tRNA N1-guanine methylation
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005739 - mitochondrion
GO:0005759 - mitochondrial matrix

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

241850

PRKN
E3 ubiquitin-protein ligase parkin

2

0

High-throughput

0.559

High

431149

LA
Lupus La protein

1

0

High-throughput

0.513

High

1181459

FAHD1
Oxaloacetate tautomerase FAHD1, mitochondrial

1

0

High-throughput

0.513

High

944811

PCBP3
Poly(rC)-binding protein 3

1

0

High-throughput

0.493

High

185747

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

0

High-throughput

0.480

High

287300

RF1M
Peptide chain release factor 1, mitochondrial

1

1

High-throughput

0.479

High

1090417

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

1

High-throughput

0.479

High

1181470

RF1ML
Peptide chain release factor 1-like, mitochondrial

1

1

High-throughput

0.479

High

129139

MEN1
Menin

1

0

High-throughput

0.458

High

279776

CISY
Citrate synthase, mitochondrial

1

0

High-throughput

0.458

High

471052

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

0

High-throughput

0.458

High

519124

COX8A
Cytochrome c oxidase subunit 8A, mitochondrial

1

0

High-throughput

0.458

High

532625

CH60
60 kDa heat shock protein, mitochondrial

1

0

High-throughput

0.458

High

695605

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

828789

MDHM
Malate dehydrogenase, mitochondrial

1

0

High-throughput

0.458

High

841763

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

0

High-throughput

0.458

High

851903

EFTS
Elongation factor Ts, mitochondrial

1

0

High-throughput

0.458

High

882695

EFTU
Elongation factor Tu, mitochondrial

1

0

High-throughput

0.458

High

980806

H2B1C
Histone H2B type 1-C/E/F/G/I

1

0

High-throughput

0.458

High

1058046

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

0

High-throughput

0.458

High

1113244

CUL3
Cullin-3

1

0

High-throughput

0.458

High

1117743

AUHM
Methylglutaconyl-CoA hydratase, mitochondrial

1

0

High-throughput

0.458

High

1142556

PDK1
[Pyruvate dehydrogenase

1

0

High-throughput

0.458

High

1162347

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

1

0

High-throughput

0.458

High

1181457

SYAM
Alanine--tRNA ligase, mitochondrial

1

0

High-throughput

0.458

High

1181458

MRM1
rRNA methyltransferase 1, mitochondrial

1

0

High-throughput

0.458

High

1181460

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.458

High

1181461

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.458

High

1181462

CGAS
Cyclic GMP-AMP synthase

1

0

Small-scale

0.458

High

1181463

TMM70
Transmembrane protein 70, mitochondrial

1

0

High-throughput

0.458

High

1181464

TR61B
tRNA

1

0

High-throughput

0.458

High

1181465

CC90B
Coiled-coil domain-containing protein 90B, mitochondrial

1

0

High-throughput

0.458

High

1181466

IF3M
Translation initiation factor IF-3, mitochondrial

1

0

High-throughput

0.458

High

1181467

MET17
Ribosome assembly protein METTL17, mitochondrial

1

0

High-throughput

0.458

High

1181468

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

0

High-throughput

0.458

High

1181469

MRES1
Mitochondrial transcription rescue factor 1

1

0

High-throughput

0.458

High

1103974

RM49
Large ribosomal subunit protein mL49

1

0

High-throughput

0.426

High

1098620

SBP1
Methanethiol oxidase

1

0

High-throughput

0.279

Low

768332

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

1015480

RHOG
Rho-related GTP-binding protein RhoG

1

0

High-throughput

0.249

Low

330172

VENTX
Homeobox protein VENTX

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025