Protein: DI3L2
DIS3-like exonuclease 2 (hDIS3L2) (EC 3.1.13.-)

Gene: DI3L2, DIS3L2
Organism: Homo sapiens
Interactions: 29
UniProt ID: Q8IYB7

Gene Ontology (top 5):
GO:0000175 - 3'-5'-RNA exonuclease activity
GO:0000278 - mitotic cell cycle
GO:0000287 - magnesium ion binding
GO:0000932 - P-body
GO:0000956 - nuclear-transcribed mRNA catabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

428857

RLA0
Large ribosomal subunit protein uL10

1

3

High-throughput

0.536

High

1314770

LN28A
Protein lin-28 homolog A

1

5

High-throughput

0.536

High

474812

VIME
Vimentin

1

0

High-throughput

0.518

High

1272478

CSN6
COP9 signalosome complex subunit 6

1

0

High-throughput

0.518

High

1314767

FEZ1
Fasciculation and elongation protein zeta-1

1

0

High-throughput

0.518

High

1314768

RTP3
Receptor-transporting protein 3

1

0

High-throughput

0.513

High

502423

H2A1
Histone H2A type 1

1

3

High-throughput

0.489

High

1099430

SRSF6
Serine/arginine-rich splicing factor 6

1

3

High-throughput

0.489

High

1132214

CBX2
Chromobox protein homolog 2

1

2

High-throughput

0.489

High

1314766

CCG8
Voltage-dependent calcium channel gamma-8 subunit

1

1

High-throughput

0.489

High

302891

CIAO1
Probable cytosolic iron-sulfur protein assembly protein CIAO1

1

3

High-throughput

0.479

High

412233

NTRK1
High affinity nerve growth factor receptor

1

1

High-throughput

0.479

High

414181

P53
Cellular tumor antigen p53

1

1

High-throughput

0.479

High

1254567

TRI67
Tripartite motif-containing protein 67

1

2

High-throughput

0.479

High

1314764

XRN1
5'-3' exoribonuclease 1

1

2

High-throughput

0.479

High

1314765

NUDC2
NudC domain-containing protein 2

1

1

High-throughput

0.479

High

717535

PDIA3
Protein disulfide-isomerase A3

1

1

High-throughput

0.470

High

1045494

TF65
Transcription factor p65

1

0

Small-scale

0.458

High

1106600

SMAD4
Mothers against decapentaplegic homolog 4

1

0

High-throughput

0.458

High

129767

CBX4
E3 SUMO-protein ligase CBX4

1

2

High-throughput

0.437

High

372532

MYC
Myc proto-oncogene protein

1

4

High-throughput

0.437

High

406373

MYCN
N-myc proto-oncogene protein

1

4

High-throughput

0.437

High

765693

BMI1
Polycomb complex protein BMI-1

1

1

High-throughput

0.437

High

1155529

EZH2
Histone-lysine N-methyltransferase EZH2

1

1

High-throughput

0.437

High

1102493

IFIT5
Interferon-induced protein with tetratricopeptide repeats 5

1

0

High-throughput

0.426

High

1201226

SPIN4
Spindlin-4

1

0

High-throughput

0.426

High

142368

PEX7
Peroxisomal targeting signal 2 receptor

1

6

High-throughput

0.407

High

1314769

NAT10
RNA cytidine acetyltransferase

1

3

High-throughput

0.407

High

1307135

TCAM1
TIR domain-containing adapter molecule 1

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025