Protein: GRP3
Ras guanyl-releasing protein 3 (Calcium and DAG-regulated guanine nucleotide exchange factor III) (Guanine nucleotide exchange factor for Rap1)

Gene: GRP3, RASGRP3
Organism: Homo sapiens
Interactions: 19
UniProt ID: Q8IV61

Gene Ontology (top 5):
GO:0000165 - MAPK cascade
GO:0005085 - guanyl-nucleotide exchange factor activity
GO:0005096 - GTPase activator activity
GO:0005509 - calcium ion binding
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

436699

KPCB
Protein kinase C beta type

2

8

Small-scale

0.778

High

1308457

DYL2
Dynein light chain 2, cytoplasmic

1

1

High-throughput

0.740

High

1051943

KPCD
Protein kinase C delta type

1

8

Small-scale

0.724

High

691213

1433T
14-3-3 protein theta

1

20

High-throughput

0.665

High

605744

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

1

7

Small-scale

0.647

High

1035005

KPCE
Protein kinase C epsilon type

1

8

Small-scale

0.647

High

1048288

KPCT
Protein kinase C theta type

1

8

Small-scale

0.647

High

297086

DGKI
Diacylglycerol kinase iota

1

5

Small-scale

0.618

High

374736

RASH
GTPase HRas

1

20

Small-scale

0.618

High

958143

ARP3
Actin-related protein 3

1

1

Small-scale

0.553

High

422511

A4
Amyloid-beta precursor protein

1

7

High-throughput

0.501

High

839044

PK3CA
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

1

2

Small-scale

0.501

High

132940

ST1C2
Sulfotransferase 1C2

1

1

High-throughput

0.494

High

186560

TRI18
E3 ubiquitin-protein ligase Midline-1

1

3

Small-scale

0.479

High

1141757

EEA1
Early endosome antigen 1

1

3

High-throughput

0.479

High

1308458

ZDH15
Palmitoyltransferase ZDHHC15

1

0

Small-scale

0.458

High

1126467

CAPR1
Caprin-1

1

4

High-throughput

0.437

High

129875

GET1
Guided entry of tail-anchored proteins factor 1

2

0

High-throughput

0.316

High

1308456

DHB11
Estradiol 17-beta-dehydrogenase 11

2

0

High-throughput

0.316

High


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Last updated: 11Aug2025