Protein: PDE5A
cGMP-specific 3',5'-cyclic phosphodiesterase (EC 3.1.4.35) (cGMP-binding cGMP-specific phosphodiesterase) (CGB-PDE)

Gene: PDE5A
Organism: Homo sapiens
Interactions: 16
UniProt ID: O76074

Gene Ontology (top 5):
GO:0004114 - 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0004115 - 3',5'-cyclic-AMP phosphodiesterase activity
GO:0005829 - cytosol
GO:0019933 - cAMP-mediated signaling
GO:0030553 - cGMP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

303024

AIPL1
Aryl-hydrocarbon-interacting protein-like 1

2

5

High-throughput

0.628

High

303023

SPG21
Maspardin

2

0

High-throughput

0.580

High

303015

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

3

High-throughput

0.536

High

303011

RHBT1
Rho-related BTB domain-containing protein 1

2

3

Small-scale

0.533

High

303016

KGP1
cGMP-dependent protein kinase 1

1

6

Small-scale

0.500

High

303019

H2B1H
Histone H2B type 1-H

1

0

High-throughput

0.493

High

303020

WDR24
GATOR2 complex protein WDR24

1

3

High-throughput

0.479

High

303022

MIOS
GATOR2 complex protein MIOS

1

1

High-throughput

0.479

High

303012

CEP43
Centrosomal protein 43

1

0

High-throughput

0.458

High

303013

BLM
RecQ-like DNA helicase BLM

1

0

High-throughput

0.458

High

303017

ITPR1
Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1

1

3

Small-scale

0.457

High

303014

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

2

High-throughput

0.445

High

303018

FKB15
FK506-binding protein 15

1

1

High-throughput

0.437

High

210446

MSH5
MutS protein homolog 5

1

0

High-throughput

0.279

Low

130332

SPT5H
Transcription elongation factor SPT5

1

0

High-throughput

0.249

Low

303021

PATZ1
POZ-, AT hook-, and zinc finger-containing protein 1

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025