Protein: MSH5
MutS protein homolog 5 (hMSH5)

Gene: MSH5
Organism: Homo sapiens
Interactions: 35
UniProt ID: O43196

Gene Ontology (top 5):
GO:0003690 - double-stranded DNA binding
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0006298 - mismatch repair
GO:0030983 - mismatched DNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

191252

MSH4
MutS protein homolog 4

8

14

Small-scale

0.967

High

210447

ABL1
Tyrosine-protein kinase ABL1

3

1

Small-scale

0.694

High

210451

MLH1
DNA mismatch repair protein Mlh1

1

20

Small-scale

0.647

High

210470

MLH3
DNA mismatch repair protein Mlh3

1

20

Small-scale

0.647

High

210455

GPS2
G protein pathway suppressor 2

1

1

Small-scale

0.586

High

210449

XRCC5
X-ray repair cross-complementing protein 5

1

3

High-throughput

0.536

High

210471

SPG7
Mitochondrial inner membrane m-AAA protease component paraplegin

1

1

High-throughput

0.536

High

160662

TOR1A
Torsin-1A

1

3

High-throughput

0.515

High

210444

PEX1
Peroxisomal ATPase PEX1

1

2

High-throughput

0.515

High

210454

MECP2
Methyl-CpG-binding protein 2

1

1

High-throughput

0.515

High

210457

SMN
Survival motor neuron protein

1

1

High-throughput

0.515

High

129838

GET1
Guided entry of tail-anchored proteins factor 1

1

0

High-throughput

0.513

High

210460

BORA
Protein aurora borealis

1

0

High-throughput

0.513

High

210472

TPRKB
EKC/KEOPS complex subunit TPRKB

1

0

High-throughput

0.513

High

210452

HD
Huntingtin

1

0

High-throughput

0.493

High

210464

GDAP1
Ganglioside-induced differentiation-associated protein 1

1

0

High-throughput

0.493

High

210468

SGTB
Small glutamine-rich tetratricopeptide repeat-containing protein beta

1

4

High-throughput

0.489

High

187421

FANCA
Fanconi anemia group A protein

1

1

Small-scale

0.479

High

210456

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

2

High-throughput

0.479

High

210453

DYN2
Dynamin-2

1

1

High-throughput

0.470

High

172286

XPO1
Exportin-1

1

0

High-throughput

0.458

High

210461

SLN11
Schlafen family member 11

1

0

High-throughput

0.458

High

210458

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

2

High-throughput

0.445

High

210469

TRI54
Tripartite motif-containing protein 54

1

3

High-throughput

0.439

High

210459

A16L1
Autophagy-related protein 16-1

1

1

High-throughput

0.407

High

210446

PDE5A
cGMP-specific 3',5'-cyclic phosphodiesterase

1

0

High-throughput

0.279

Low

210448

NU1M
NADH-ubiquinone oxidoreductase chain 1

1

0

High-throughput

0.279

Low

210462

PLD6
Mitochondrial cardiolipin hydrolase

1

0

High-throughput

0.279

Low

210463

MCU
Calcium uniporter protein, mitochondrial

1

0

High-throughput

0.279

Low

210465

CANT1
Soluble calcium-activated nucleotidase 1

1

0

High-throughput

0.279

Low

210466

EDEM1
ER degradation-enhancing alpha-mannosidase-like protein 1

1

0

High-throughput

0.279

Low

210467

GSLG1
Golgi apparatus protein 1

1

0

High-throughput

0.279

Low

116840

I6L9F6
NEFL protein

1

0

High-throughput

0.268

Low

210445

WFS1
Wolframin

1

0

High-throughput

0.268

Low

210450

GRN
Progranulin

1

0

High-throughput

0.268

Low


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Last updated: 11Aug2025