Protein: KGP1
cGMP-dependent protein kinase 1 (cGK 1) (cGK1) (EC 2.7.11.12) (cGMP-dependent protein kinase I) (cGKI)

Gene: KGP1, PRKG1
Organism: Homo sapiens
Interactions: 52
UniProt ID: Q13976

Gene Ontology (top 5):
GO:0001669 - acrosomal vesicle
GO:0001764 - neuron migration
GO:0004672 - protein kinase activity
GO:0004692 - cGMP-dependent protein kinase activity
GO:0005246 - calcium channel regulator activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1119633

KGP1
cGMP-dependent protein kinase 1

3

18

Small-scale

0.854

High

1050989

FAK1
Focal adhesion kinase 1

2

20

High-throughput

0.811

High

1119634

ITPR1
Inositol 1,4,5-trisphosphate-gated calcium channel ITPR1

2

10

Small-scale

0.799

High

1119642

RBAK
RB-associated KRAB zinc finger protein

2

0

High-throughput

0.742

High

600415

ZKSC1
Zinc finger protein with KRAB and SCAN domains 1

2

1

High-throughput

0.726

High

174439

ZN646
Zinc finger protein 646

2

1

High-throughput

0.725

High

833411

RGS2
Regulator of G-protein signaling 2

1

4

Small-scale

0.724

High

681812

RBTN2
Rhombotin-2

4

12

High-throughput

0.698

High

1119635

SAFB1
Scaffold attachment factor B1

1

10

High-throughput

0.691

High

1119646

TNIK
TRAF2 and NCK-interacting protein kinase

1

20

High-throughput

0.691

High

1118365

BMPR2
Bone morphogenetic protein receptor type-2

1

7

Small-scale

0.665

High

568558

TNNT1
Troponin T, slow skeletal muscle

2

1

Small-scale

0.649

High

1119648

IRAG1
Inositol 1,4,5-triphosphate receptor associated 1

2

1

Small-scale

0.649

High

171242

MYPT1
Protein phosphatase 1 regulatory subunit 12A

1

9

Small-scale

0.647

High

715061

OAS2
2'-5'-oligoadenylate synthase 2

2

1

High-throughput

0.628

High

968913

PRS8
26S proteasome regulatory subunit 8

2

9

High-throughput

0.628

High

1119647

COR2B
Coronin-2B

2

12

High-throughput

0.628

High

239312

MYPT2
Protein phosphatase 1 regulatory subunit 12B

1

9

Small-scale

0.621

High

591202

ANPRA
Atrial natriuretic peptide receptor 1

1

2

Small-scale

0.621

High

822657

VHL
von Hippel-Lindau disease tumor suppressor

1

5

Small-scale

0.621

High

302518

RNF8
E3 ubiquitin-protein ligase RNF8

1

10

Small-scale

0.618

High

400812

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

20

Small-scale

0.618

High

324294

ARHGF
Rho guanine nucleotide exchange factor 15

2

13

High-throughput

0.606

High

1119639

MEP50
Methylosome protein WDR77

1

11

Small-scale

0.578

High

1096427

PAK1
Serine/threonine-protein kinase PAK 1

1

17

Small-scale

0.575

High

1005864

GTF2I
General transcription factor II-I

1

2

Small-scale

0.561

High

1119640

TRI54
Tripartite motif-containing protein 54

1

19

High-throughput

0.541

High

122766

KIF2A
Kinesin-like protein KIF2A

1

6

High-throughput

0.536

High

144264

ACACB
Acetyl-CoA carboxylase 2

1

12

High-throughput

0.536

High

415555

HSPB1
Heat shock protein beta-1

1

14

High-throughput

0.536

High

542505

TOP2A
DNA topoisomerase 2-alpha

1

6

High-throughput

0.536

High

912057

RPAB3
DNA-directed RNA polymerases I, II, and III subunit RPABC3

1

2

High-throughput

0.536

High

1097282

CBX3
Chromobox protein homolog 3

1

3

High-throughput

0.536

High

1119638

NGDN
Neuroguidin

1

2

High-throughput

0.536

High

1119641

DDX31
ATP-dependent DNA helicase DDX31

1

11

High-throughput

0.536

High

1119643

H2AW
Core histone macro-H2A.2

1

19

High-throughput

0.536

High

297981

SPF27
Pre-mRNA-splicing factor SPF27

1

0

High-throughput

0.513

High

520030

ANDR
Androgen receptor

1

19

Small-scale

0.501

High

570762

LYAM1
L-selectin

1

4

Small-scale

0.501

High

593105

CREB1
Cyclic AMP-responsive element-binding protein 1

1

4

Small-scale

0.501

High

627970

ANXA7
Annexin A7

1

8

Small-scale

0.501

High

1109710

HDAC1
Histone deacetylase 1

1

8

Small-scale

0.501

High

303016

PDE5A
cGMP-specific 3',5'-cyclic phosphodiesterase

1

6

Small-scale

0.500

High

1179

A0A096LP39
Ribonuclease P/MRP subunit p21

1

8

Small-scale

0.481

High

893856

MEOX2
Homeobox protein MOX-2

1

6

High-throughput

0.481

High

1106529

SMAD4
Mothers against decapentaplegic homolog 4

1

14

Small-scale

0.479

High

1119645

HECW2
E3 ubiquitin-protein ligase HECW2

1

20

High-throughput

0.479

High

1119636

Q6FHY5
MEOX2 protein

1

6

High-throughput

0.470

High

1119644

STIM2
Stromal interaction molecule 2

1

0

High-throughput

0.458

High

1119637

F124A
Protein FAM124A

2

0

High-throughput

0.327

High

517306

GAGE1
G antigen 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025