Protein: SPG21
Maspardin (Acid cluster protein 33) (Spastic paraplegia 21 autosomal recessive Mast syndrome protein) (Spastic paraplegia 21 protein)

Gene: SPG21
Organism: Homo sapiens
Interactions: 194
UniProt ID: Q9NZD8

Gene Ontology (top 5):
GO:0005794 - Golgi apparatus
GO:0005829 - cytosol
GO:0007173 - epidermal growth factor receptor signaling pathway
GO:0007626 - locomotory behavior
GO:0010008 - endosome membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

124657

EYA2
Protein phosphatase EYA2

2

0

High-throughput

0.742

High

1090953

TRAF2
TNF receptor-associated factor 2

5

2

High-throughput

0.722

High

1328076

ATPF2
ATP synthase mitochondrial F1 complex assembly factor 2

6

0

High-throughput

0.712

High

1279585

SPRE2
Sprouty-related, EVH1 domain-containing protein 2

4

1

High-throughput

0.698

High

954631

PRPS1
Ribose-phosphate pyrophosphokinase 1

5

0

High-throughput

0.691

High

1247423

ATRAP
Type-1 angiotensin II receptor-associated protein

5

0

High-throughput

0.689

High

1449607

CUTC
Copper homeostasis protein cutC homolog

5

0

High-throughput

0.687

High

1453222

PRAF1
Prenylated Rab acceptor protein 1

4

0

High-throughput

0.675

High

1093981

TRAF1
TNF receptor-associated factor 1

3

1

High-throughput

0.675

High

1350952

DTX3L
E3 ubiquitin-protein ligase DTX3L

3

1

High-throughput

0.675

High

384568

CRYAA
Alpha-crystallin A chain

4

0

High-throughput

0.668

High

407724

S100B
Protein S100-B

4

0

High-throughput

0.668

High

1309994

NXP20
Protein NOXP20

4

0

High-throughput

0.668

High

1289321

DTX2
Probable E3 ubiquitin-protein ligase DTX2

5

1

High-throughput

0.658

High

1129131

PLSI
Plastin-1

1

0

High-throughput

0.656

High

901624

RAB7A
Ras-related protein Rab-7a

3

1

Small-scale

0.656

High

1453219

PEF1
Peflin

2

0

High-throughput

0.655

High

1139291

AR6P1
ADP-ribosylation factor-like protein 6-interacting protein 1

3

0

High-throughput

0.646

High

1367814

TFG
Protein TFG

3

0

High-throughput

0.646

High

1453225

IKZF3
Zinc finger protein Aiolos

3

0

High-throughput

0.646

High

1453224

GGA2
ADP-ribosylation factor-binding protein GGA2

3

0

High-throughput

0.639

High

1384767

ARL8A
ADP-ribosylation factor-like protein 8A

4

1

High-throughput

0.629

High

1403950

HTF4
Transcription factor 12

2

1

High-throughput

0.628

High

1049035

REL
Proto-oncogene c-Rel

3

0

High-throughput

0.622

High

1448428

PYRG2
CTP synthase 2

2

0

High-throughput

0.618

High

1419243

TRI54
Tripartite motif-containing protein 54

3

3

High-throughput

0.616

High

1420542

TRIM9
E3 ubiquitin-protein ligase TRIM9

3

4

High-throughput

0.616

High

1453223

TRIM1
Probable E3 ubiquitin-protein ligase MID2

3

3

High-throughput

0.616

High

228928

CF410
Cilia- and flagella-associated protein 410

2

1

High-throughput

0.606

High

361931

HPRT
Hypoxanthine-guanine phosphoribosyltransferase

2

1

High-throughput

0.606

High

475709

K1C19
Keratin, type I cytoskeletal 19

2

3

High-throughput

0.606

High

566318

K1C13
Keratin, type I cytoskeletal 13

2

2

High-throughput

0.606

High

1063657

GOGA2
Golgin subfamily A member 2

2

1

High-throughput

0.606

High

1146197

K1H1
Keratin, type I cuticular Ha1

2

3

High-throughput

0.606

High

1279776

SPRE1
Sprouty-related, EVH1 domain-containing protein 1

2

1

High-throughput

0.606

High

1448451

PRDC1
Phosphoribosyltransferase domain-containing protein 1

2

1

High-throughput

0.606

High

1453215

SPG21
Maspardin

1

0

High-throughput

0.589

High

155362

CDKA1
Cyclin-dependent kinase 2-associated protein 1

2

0

High-throughput

0.580

High

167130

GEMI2
Gem-associated protein 2

2

0

High-throughput

0.580

High

213495

CTIF
CBP80/20-dependent translation initiation factor

2

0

High-throughput

0.580

High

219097

RA51C
DNA repair protein RAD51 homolog 3

2

0

High-throughput

0.580

High

250351

VINEX
Vinexin

2

0

High-throughput

0.580

High

303023

PDE5A
cGMP-specific 3',5'-cyclic phosphodiesterase

2

0

High-throughput

0.580

High

353754

DRC4
Dynein regulatory complex subunit 4

2

0

High-throughput

0.580

High

528365

THIO
Thioredoxin

2

0

High-throughput

0.580

High

591431

NQO2
Ribosyldihydronicotinamide dehydrogenase [quinone]

2

0

High-throughput

0.580

High

685365

PAX6
Paired box protein Pax-6

2

0

High-throughput

0.580

High

700963

PSB4
Proteasome subunit beta type-4

2

0

High-throughput

0.580

High

729482

HNRH1
Heterogeneous nuclear ribonucleoprotein H

2

0

High-throughput

0.580

High

809889

RS19
Small ribosomal subunit protein eS19

2

0

High-throughput

0.580

High

842936

CDN2B
Cyclin-dependent kinase 4 inhibitor B

2

0

High-throughput

0.580

High

944580

GEMI4
Gem-associated protein 4

2

0

High-throughput

0.580

High

1050876

DCE2
Glutamate decarboxylase 2

2

0

High-throughput

0.580

High

1140153

IQCB1
IQ calmodulin-binding motif-containing protein 1

2

0

High-throughput

0.580

High

1140273

IF4H
Eukaryotic translation initiation factor 4H

2

0

High-throughput

0.580

High

1238977

UFSP1
Ufm1-specific protease 1

2

0

High-throughput

0.580

High

1279384

DHB13
17-beta-hydroxysteroid dehydrogenase 13

2

0

High-throughput

0.580

High

1280824

S35E3
Solute carrier family 35 member E3

2

0

High-throughput

0.580

High

1294332

TRI50
E3 ubiquitin-protein ligase TRIM50

2

0

High-throughput

0.580

High

1336007

SMIP6
Sperm microtubule inner protein 6

2

0

High-throughput

0.580

High

1347471

CEP76
Centrosomal protein of 76 kDa

2

0

High-throughput

0.580

High

1350731

CCHCR
Coiled-coil alpha-helical rod protein 1

2

0

High-throughput

0.580

High

1357641

SFT2A
Vesicle transport protein SFT2A

2

0

High-throughput

0.580

High

1394756

COG3
Conserved oligomeric Golgi complex subunit 3

2

0

High-throughput

0.580

High

1402059

TRIB3
Tribbles homolog 3

2

0

High-throughput

0.580

High

1404683

PFD5
Prefoldin subunit 5

2

0

High-throughput

0.580

High

1408379

SH3G1
Endophilin-A2

2

0

High-throughput

0.580

High

1411124

VPS25
Vacuolar protein-sorting-associated protein 25

2

0

High-throughput

0.580

High

1413811

TM208
Transmembrane protein 208

2

0

High-throughput

0.580

High

1433877

FBX44
F-box only protein 44

2

0

High-throughput

0.580

High

1435558

DCTP1
dCTP pyrophosphatase 1

2

0

High-throughput

0.580

High

1446509

ACO13
Acyl-coenzyme A thioesterase 13

2

0

High-throughput

0.580

High

1451608

TXN4B
Thioredoxin-like protein 4B

2

0

High-throughput

0.580

High

1453221

CIDEB
Lipid transferase CIDEB

2

0

High-throughput

0.580

High

1453227

GOT1B
Vesicle transport protein GOT1B

2

0

High-throughput

0.580

High

1453228

CEPT1
Choline/ethanolaminephosphotransferase 1

2

0

High-throughput

0.580

High

618123

K1C15
Keratin, type I cytoskeletal 15

1

2

High-throughput

0.573

High

74374

ZBT42
Zinc finger and BTB domain-containing protein 42

2

2

High-throughput

0.553

High

210131

CRX
Cone-rod homeobox protein

2

1

High-throughput

0.553

High

226380

SNG1
Synaptogyrin-1

2

1

High-throughput

0.553

High

226496

SNG3
Synaptogyrin-3

2

1

High-throughput

0.553

High

551299

PCNA
Proliferating cell nuclear antigen

2

1

High-throughput

0.553

High

1050070

PLP2
Proteolipid protein 2

2

3

High-throughput

0.553

High

1121352

TRI14
Tripartite motif-containing protein 14

2

1

High-throughput

0.553

High

1316824

CKLF4
CKLF-like MARVEL transmembrane domain-containing protein 4

2

3

High-throughput

0.553

High

1451904

CKLF6
CKLF-like MARVEL transmembrane domain-containing protein 6

2

3

High-throughput

0.553

High

1453216

ZN581
Zinc finger protein 581

2

1

High-throughput

0.553

High

1450628

ARL8B
ADP-ribosylation factor-like protein 8B

1

1

High-throughput

0.536

High

587239

ITF2
Transcription factor 4

1

1

High-throughput

0.523

High

891334

GSK3A
Glycogen synthase kinase-3 alpha

1

0

Small-scale

0.518

High

1400890

MTMR9
Myotubularin-related protein 9

1

0

High-throughput

0.518

High

156359

G3PT
Glyceraldehyde-3-phosphate dehydrogenase, testis-specific

1

0

High-throughput

0.513

High

557497

SRC
Proto-oncogene tyrosine-protein kinase Src

1

0

High-throughput

0.513

High

893024

KHK
Ketohexokinase

1

0

High-throughput

0.513

High

908055

VAMP7
Vesicle-associated membrane protein 7

1

0

High-throughput

0.513

High

1219789

RRAGB
Ras-related GTP-binding protein B

1

0

High-throughput

0.513

High

1352062

MICA1
[F-actin]-monooxygenase MICAL1

1

0

High-throughput

0.513

High

1400934

VPS35
Vacuolar protein sorting-associated protein 35

1

0

High-throughput

0.513

High

1414682

MIC26
MICOS complex subunit MIC26

1

0

High-throughput

0.513

High

1453218

VPS29
Vacuolar protein sorting-associated protein 29

1

0

High-throughput

0.513

High

374245

RASN
GTPase NRas

1

1

High-throughput

0.479

High

376028

RASK
GTPase KRas

1

1

High-throughput

0.479

High

902112

RAB9A
Ras-related protein Rab-9A

1

1

High-throughput

0.479

High

46623

A0A286YEY3
SLIT-ROBO Rho GTPase activating protein 2B

1

1

High-throughput

0.470

High

386310

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

0

High-throughput

0.460

High

178426

NPC1
NPC intracellular cholesterol transporter 1

1

0

High-throughput

0.458

High

1335011

SERB1
SERPINE1 mRNA-binding protein 1

1

0

High-throughput

0.458

High

47280

A0A6Q8KRG2
Golgin subfamily A member 2

1

1

High-throughput

0.457

High

516076

SRG2B
SLIT-ROBO Rho GTPase-activating protein 2B

1

1

High-throughput

0.439

High

1239322

ARMC6
Armadillo repeat-containing protein 6

1

0

High-throughput

0.426

High

1199895

AKIR2
Akirin-2

7

0

High-throughput

0.389

High

1393458

REEP6
Receptor expression-enhancing protein 6

4

0

High-throughput

0.364

High

1081500

INCA1
Protein INCA1

3

0

High-throughput

0.352

High

1206442

EFHC2
EF-hand domain-containing family member C2

3

0

High-throughput

0.352

High

1228730

C102B
Coiled-coil domain-containing protein 102B

3

0

High-throughput

0.352

High

1388211

CKLF5
CKLF-like MARVEL transmembrane domain-containing protein 5

3

0

High-throughput

0.352

High

1206009

MTUS2
Microtubule-associated tumor suppressor candidate 2

3

0

High-throughput

0.339

High

1446932

RTN4
Reticulon-4

2

0

High-throughput

0.317

High

143938

NDKM
Nucleoside diphosphate kinase, mitochondrial

2

0

High-throughput

0.316

High

175998

N4BP3
NEDD4-binding protein 3

2

0

High-throughput

0.316

High

178849

SCAM1
Secretory carrier-associated membrane protein 1

2

0

High-throughput

0.316

High

254651

EIF1B
Eukaryotic translation initiation factor 1b

2

0

High-throughput

0.316

High

329674

LERL1
Leptin receptor overlapping transcript-like 1

2

0

High-throughput

0.316

High

339295

MPC2
Mitochondrial pyruvate carrier 2

2

0

High-throughput

0.316

High

387602

APOC1
Apolipoprotein C-I

2

0

High-throughput

0.316

High

469561

SYPH
Synaptophysin

2

0

High-throughput

0.316

High

581796

MYOG
Myogenin

2

0

High-throughput

0.316

High

631846

NR1D1
Nuclear receptor subfamily 1 group D member 1

2

0

High-throughput

0.316

High

682114

RBTN1
Rhombotin-1

2

0

High-throughput

0.316

High

938081

TPD52
Tumor protein D52

2

0

High-throughput

0.316

High

940698

ATP5I
ATP synthase F(0) complex subunit e, mitochondrial

2

0

High-throughput

0.316

High

1032787

SATB1
DNA-binding protein SATB1

2

0

High-throughput

0.316

High

1061904

TLE5
TLE family member 5

2

0

High-throughput

0.316

High

1144592

PTPA
Serine/threonine-protein phosphatase 2A activator

2

0

High-throughput

0.316

High

1152967

NAB2
NGFI-A-binding protein 2

2

0

High-throughput

0.316

High

1165260

RTL8B
Retrotransposon Gag-like protein 8B

2

0

High-throughput

0.316

High

1179418

VMAC
Vimentin-type intermediate filament-associated coiled-coil protein

2

0

High-throughput

0.316

High

1179940

TXIP1
Translin-associated factor X-interacting protein 1

2

0

High-throughput

0.316

High

1187700

T10IP
Testis-specific protein 10-interacting protein

2

0

High-throughput

0.316

High

1193102

DRC12
Dynein regulatory complex protein 12

2

0

High-throughput

0.316

High

1205809

PPM1J
Protein phosphatase 1J

2

0

High-throughput

0.316

High

1214862

ARM12
Armadillo repeat-containing protein 12

2

0

High-throughput

0.316

High

1238954

SWAP1
ATPase SWSAP1

2

0

High-throughput

0.316

High

1244163

TT23L
Tetratricopeptide repeat protein 23-like

2

0

High-throughput

0.316

High

1271421

KCTD9
BTB/POZ domain-containing protein KCTD9

2

0

High-throughput

0.316

High

1276174

NUP54
Nucleoporin p54

2

0

High-throughput

0.316

High

1322573

LSME2
Leucine-rich single-pass membrane protein 2

2

0

High-throughput

0.316

High

1323245

NDUF2
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 2

2

0

High-throughput

0.316

High

1329134

CPSF7
Cleavage and polyadenylation specificity factor subunit 7

2

0

High-throughput

0.316

High

1330102

USBP1
Harmonin-binding protein USHBP1

2

0

High-throughput

0.316

High

1330621

CLD22
Claudin-22

2

0

High-throughput

0.316

High

1331435

MB213
Protein mab-21-like 3

2

0

High-throughput

0.316

High

1348548

LNX1
E3 ubiquitin-protein ligase LNX

2

0

High-throughput

0.316

High

1356627

CT55
Cancer/testis antigen 55

2

0

High-throughput

0.316

High

1358940

SMIP5
Sperm-associated microtubule inner protein 5

2

0

High-throughput

0.316

High

1359005

TEKT4
Tektin-4

2

0

High-throughput

0.316

High

1359046

TM239
Transmembrane protein 239

2

0

High-throughput

0.316

High

1361965

BSND
Barttin

2

0

High-throughput

0.316

High

1392356

BORC6
BLOC-1-related complex subunit 6

2

0

High-throughput

0.316

High

1399148

TOX2
TOX high mobility group box family member 2

2

0

High-throughput

0.316

High

1400231

PNMA5
Paraneoplastic antigen-like protein 5

2

0

High-throughput

0.316

High

1400508

FACC1
Flagellum-associated coiled-coil domain-containing protein 1

2

0

High-throughput

0.316

High

1406709

SEPT5
Septin-5

2

0

High-throughput

0.316

High

1416158

SSBP4
Single-stranded DNA-binding protein 4

2

0

High-throughput

0.316

High

1419201

PBX4
Pre-B-cell leukemia transcription factor 4

2

0

High-throughput

0.316

High

1428860

NIF3L
NIF3-like protein 1

2

0

High-throughput

0.316

High

1429736

ZMY12
Zinc finger MYND domain-containing protein 12

2

0

High-throughput

0.316

High

1430246

PHS2
Pterin-4-alpha-carbinolamine dehydratase 2

2

0

High-throughput

0.316

High

1435031

ARMC7
Armadillo repeat-containing protein 7

2

0

High-throughput

0.316

High

1435947

NRDE2
Nuclear exosome regulator NRDE2

2

0

High-throughput

0.316

High

1437634

ROP1A
Ropporin-1A

2

0

High-throughput

0.316

High

1437807

GRPE1
GrpE protein homolog 1, mitochondrial

2

0

High-throughput

0.316

High

1447092

RPR1B
Regulation of nuclear pre-mRNA domain-containing protein 1B

2

0

High-throughput

0.316

High

1450672

F86C1
Putative protein FAM86C1P

2

0

High-throughput

0.316

High

1453217

TFP11
Tuftelin-interacting protein 11

2

0

High-throughput

0.316

High

1453220

ZN629
Zinc finger protein 629

2

0

High-throughput

0.316

High

1453226

COG6
Conserved oligomeric Golgi complex subunit 6

2

0

High-throughput

0.316

High

783435

TRI23
E3 ubiquitin-protein ligase TRIM23

1

0

High-throughput

0.299

High

378881

CD4
T-cell surface glycoprotein CD4

1

0

Small-scale

0.288

High

171935

ZN263
Zinc finger protein 263

1

0

High-throughput

0.282

High

720704

AGTR1
Type-1 angiotensin II receptor

1

0

High-throughput

0.282

High

618488

GNAZ
Guanine nucleotide-binding protein G(z) subunit alpha

1

0

High-throughput

0.279

Low

1125781

FA50A
Protein FAM50A

1

0

High-throughput

0.279

Low

1333450

XXLT1
Xyloside xylosyltransferase 1

1

0

High-throughput

0.279

Low

1412001

PXL2A
Peroxiredoxin-like 2A

1

0

High-throughput

0.279

Low

1437897

MYG1
MYG1 exonuclease

1

0

High-throughput

0.268

Low

959543

YPEL3
Protein yippee-like 3

1

0

High-throughput

0.251

Low

1328414

CCD33
Coiled-coil domain-containing protein 33

1

0

High-throughput

0.251

Low

1217946

MYOM3
Myomesin-3

1

0

High-throughput

0.249

Low

1233534

LTOR1
Ragulator complex protein LAMTOR1

1

0

High-throughput

0.249

Low

1126009

LRC32
Transforming growth factor beta activator LRRC32

1

0

High-throughput

0.232

Low

1366277

LPAR1
Lysophosphatidic acid receptor 1

1

0

High-throughput

0.232

Low

1430157

TKTL2
Transketolase-like protein 2

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025