Protein: PFKA1
ATP-dependent 6-phosphofructokinase subunit alpha (EC 2.7.1.11) (ATP-dependent 6-phosphofructokinase) (ATP-PFK) (Phosphofructokinase 1) (Phosphohexokinase)

Gene: PFKA1, PFK1
Organism: Saccharomyces cerevisiae S288C
Interactions: 181
UniProt ID: P16861

Gene Ontology (top 5):
GO:0003872 - 6-phosphofructokinase activity
GO:0005524 - ATP binding
GO:0005737 - cytoplasm
GO:0005739 - mitochondrion
GO:0005741 - mitochondrial outer membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

562174

PFKA2
ATP-dependent 6-phosphofructokinase subunit beta

11

13

Small-scale

0.976

High

562173

PFKA1
ATP-dependent 6-phosphofructokinase subunit alpha

3

13

Small-scale

0.828

High

562263

TBG
Tubulin gamma chain

2

3

High-throughput

0.621

High

510163

SSB1
Ribosome-associated molecular chaperone SSB1

2

5

High-throughput

0.611

High

440855

ARO1
Pentafunctional AROM polypeptide [Includes: 3-dehydroquinate synthase

2

0

High-throughput

0.602

High

490244

HSP71
Heat shock protein SSA1

2

6

High-throughput

0.601

High

454161

TBA1
Tubulin alpha-1 chain

2

3

Small-scale

0.594

High

562300

LKHA4
Leucine aminopeptidase 2

2

2

High-throughput

0.588

High

562252

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

2

2

High-throughput

0.584

High

562270

2ABA
Protein phosphatase PP2A regulatory subunit B

2

0

High-throughput

0.576

High

562287

ARPC3
Actin-related protein 2/3 complex subunit 3

2

0

High-throughput

0.576

High

562190

RAD51
DNA repair protein RAD51

2

0

High-throughput

0.563

High

562213

PP2C3
Protein phosphatase 2C homolog 3

2

0

High-throughput

0.563

High

562290

CFT1
Protein CFT1

2

0

High-throughput

0.563

High

562205

RSSA1
Small ribosomal subunit protein uS2A

2

1

High-throughput

0.558

High

477863

HSP77
Import motor subunit, mitochondrial

2

5

High-throughput

0.552

High

562187

SIS1
Protein SIS1

2

2

High-throughput

0.549

High

562204

SLA1
Actin cytoskeleton-regulatory complex protein SLA1

1

1

High-throughput

0.541

High

562237

RV167
Reduced viability upon starvation protein 167

1

2

High-throughput

0.541

High

562253

LSB3
LAS seventeen-binding protein 3

1

2

High-throughput

0.541

High

409593

KAPC
cAMP-dependent protein kinase type 3

1

5

High-throughput

0.536

High

498427

METK1
S-adenosylmethionine synthase 1

1

1

High-throughput

0.536

High

562186

GRR1
SCF E3 ubiquitin ligase complex F-box protein GRR1

1

1

High-throughput

0.536

High

562199

MKK2
MAP kinase kinase MKK2/SSP33

1

7

High-throughput

0.536

High

562211

HSP78
Heat shock protein 78, mitochondrial

1

3

High-throughput

0.536

High

562216

EF1G2
Elongation factor 1-gamma 2

1

1

High-throughput

0.536

High

562227

KIC1
Serine/threonine-protein kinase KIC1

1

1

High-throughput

0.536

High

562229

DBP8
ATP-dependent RNA helicase DBP8

1

2

High-throughput

0.536

High

562264

BRE5
UBP3-associated protein BRE5

1

2

High-throughput

0.536

High

562272

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

3

High-throughput

0.536

High

562284

SML1
Ribonucleotide reductase inhibitor protein SML1

1

1

High-throughput

0.536

High

562293

RBX1
RING-box protein HRT1

1

2

High-throughput

0.536

High

562306

PRP46
Pre-mRNA-splicing factor PRP46

1

5

High-throughput

0.536

High

562307

AHA1
Hsp90 co-chaperone AHA1

1

1

High-throughput

0.536

High

562285

CYK2
Cytokinesis protein 2

1

0

High-throughput

0.518

High

562292

HRD1
ERAD-associated E3 ubiquitin-protein ligase HRD1

1

3

High-throughput

0.515

High

562245

MOB1
DBF2 kinase activator protein MOB1

1

0

High-throughput

0.513

High

562282

SEN15
tRNA-splicing endonuclease subunit SEN15

1

0

High-throughput

0.513

High

562305

SMT3
Ubiquitin-like protein SMT3

1

4

High-throughput

0.504

High

420009

STE7
Serine/threonine-protein kinase STE7

1

5

High-throughput

0.501

High

562185

MEK1
Meiosis-specific serine/threonine-protein kinase MEK1

1

4

High-throughput

0.501

High

562203

IME2
Meiosis induction protein kinase IME2/SME1

1

7

High-throughput

0.501

High

562208

SWE1
Mitosis inhibitor protein kinase SWE1

1

8

High-throughput

0.501

High

562220

AKL1
Serine/threonine-protein kinase AKL1

1

2

High-throughput

0.501

High

562302

RTK1
Probable serine/threonine-protein kinase RTK1

1

10

High-throughput

0.501

High

367701

EF1A
Elongation factor 1-alpha

1

1

High-throughput

0.500

High

423750

ATPA
ATP synthase subunit alpha, mitochondrial

1

1

High-throughput

0.500

High

562178

FKBP
FK506-binding protein 1

1

1

High-throughput

0.500

High

562179

PP11
Serine/threonine-protein phosphatase PP1-1

1

4

High-throughput

0.500

High

562188

MSH3
DNA mismatch repair protein MSH3

1

1

High-throughput

0.500

High

562197

ARP2
Actin-related protein 2

1

2

High-throughput

0.500

High

562202

RPD3
Histone deacetylase RPD3

1

6

Small-scale

0.500

High

562210

CBF5
H/ACA ribonucleoprotein complex subunit CBF5

1

1

High-throughput

0.500

High

562231

UTP9
U3 small nucleolar RNA-associated protein 9

1

1

High-throughput

0.489

High

562234

TEM1
Protein TEM1

1

1

High-throughput

0.489

High

562180

MDHC
Malate dehydrogenase, cytoplasmic

1

0

High-throughput

0.479

High

562200

EI2BB
Translation initiation factor eIF2B subunit beta

1

0

High-throughput

0.479

High

141131

RS9A
Small ribosomal subunit protein uS4A

1

1

High-throughput

0.479

High

339416

CDK1
Cyclin-dependent kinase 1

1

3

High-throughput

0.479

High

340002

KPYK1
Pyruvate kinase 1

1

1

High-throughput

0.479

High

343523

PMG1
Phosphoglycerate mutase 1

1

1

High-throughput

0.479

High

365740

HSP82
ATP-dependent molecular chaperone HSP82

1

5

High-throughput

0.479

High

375257

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

1

High-throughput

0.479

High

402875

ERF3
Eukaryotic peptide chain release factor GTP-binding subunit

1

2

Small-scale

0.479

High

419791

SNF1
Carbon catabolite-derepressing protein kinase

1

2

Small-scale

0.479

High

425585

KAPR
cAMP-dependent protein kinase regulatory subunit

1

2

Small-scale

0.479

High

543132

HSC82
ATP-dependent molecular chaperone HSC82

1

5

High-throughput

0.479

High

562177

HSP60
Heat shock protein 60, mitochondrial

1

1

Small-scale

0.479

High

562181

XRN1
5'-3' exoribonuclease 1

1

1

High-throughput

0.479

High

562184

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

1

High-throughput

0.479

High

562194

TF2B
Transcription initiation factor IIB

1

1

High-throughput

0.479

High

562196

HS104
Heat shock protein 104

1

3

High-throughput

0.479

High

562198

HOG1
Mitogen-activated protein kinase HOG1

1

10

High-throughput

0.479

High

562206

SMY2
Protein SMY2

1

1

High-throughput

0.479

High

562209

PRS6A
26S proteasome regulatory subunit 6A

1

1

High-throughput

0.479

High

562215

RS27A
Small ribosomal subunit protein eS27A

1

2

High-throughput

0.479

High

562219

GBLP
Small ribosomal subunit protein RACK1

1

5

High-throughput

0.479

High

562224

AIM4
Altered inheritance of mitochondria protein 4

1

1

High-throughput

0.479

High

562228

RS20
Small ribosomal subunit protein uS10

1

1

High-throughput

0.479

High

562230

RPN1
26S proteasome regulatory subunit RPN1

1

1

High-throughput

0.479

High

562235

DHH1
ATP-dependent RNA helicase DHH1

1

1

High-throughput

0.479

High

562243

MLP2
Protein MLP2

1

3

High-throughput

0.479

High

562244

TM108
Protein TMA108

1

2

High-throughput

0.479

High

562251

OTU1
Ubiquitin thioesterase OTU1

1

1

High-throughput

0.479

High

562258

RS12
Small ribosomal subunit protein eS12

1

1

High-throughput

0.479

High

562259

VATG
V-type proton ATPase subunit G

1

1

High-throughput

0.479

High

562262

PIL1
Sphingolipid long chain base-responsive protein PIL1

1

1

High-throughput

0.479

High

562268

SAM50
Sorting assembly machinery 50 kDa subunit

1

1

High-throughput

0.479

High

562276

TOM1
E3 ubiquitin-protein ligase TOM1

1

3

High-throughput

0.479

High

562279

RUVB1
RuvB-like protein 1

1

3

High-throughput

0.479

High

562280

CTK1
CTD kinase subunit alpha

1

7

High-throughput

0.479

High

562294

SGO1
Shugoshin

1

1

High-throughput

0.479

High

562295

MCA1
Metacaspase-1

1

2

High-throughput

0.479

High

562301

TMA46
Translation machinery-associated protein 46

1

1

High-throughput

0.479

High

562308

RUVB2
RuvB-like protein 2

1

3

High-throughput

0.479

High

562309

SMC6
Structural maintenance of chromosomes protein 6

1

1

High-throughput

0.479

High

420216

CALM
Calmodulin

1

9

High-throughput

0.470

High

562260

UBP8
Ubiquitin carboxyl-terminal hydrolase 8

1

2

High-throughput

0.464

High

406754

RS3
Small ribosomal subunit protein uS3

1

0

High-throughput

0.458

High

407701

RS13
Small ribosomal subunit protein uS15

1

0

High-throughput

0.458

High

410890

PDC1
Pyruvate decarboxylase isozyme 1

1

0

High-throughput

0.458

High

482058

RS18A
Small ribosomal subunit protein uS13A

1

0

High-throughput

0.458

High

520664

REV1
DNA repair protein REV1

1

0

High-throughput

0.458

High

524145

CAF20
Cap-associated protein CAF20

1

0

High-throughput

0.458

High

562189

RS2
Small ribosomal subunit protein uS5

1

0

High-throughput

0.458

High

562201

NAB2
Nuclear polyadenylated RNA-binding protein NAB2

1

0

High-throughput

0.458

High

562214

FAB1
1-phosphatidylinositol 3-phosphate 5-kinase FAB1

1

0

High-throughput

0.458

High

562218

LONM
Lon protease homolog, mitochondrial

1

0

High-throughput

0.458

High

562223

PHO88
SRP-independent targeting protein 3

1

0

High-throughput

0.458

High

562238

IF4F1
Eukaryotic initiation factor 4F subunit p150

1

0

High-throughput

0.458

High

562250

UTP10
U3 small nucleolar RNA-associated protein 10

1

0

High-throughput

0.458

High

562256

MPS3
Spindle pole body assembly component MPS3

1

0

High-throughput

0.458

High

562261

DUO1
DASH complex subunit DUO1

1

0

High-throughput

0.458

High

562269

ACT
Actin

1

0

Small-scale

0.458

High

562271

MCE1
mRNA-capping enzyme subunit alpha

1

0

High-throughput

0.458

High

562273

RS15
Small ribosomal subunit protein uS19

1

0

High-throughput

0.458

High

562283

COX20
Cytochrome c oxidase assembly protein COX20, mitochondrial

1

0

High-throughput

0.458

High

562291

VAM6
Vacuolar morphogenesis protein 6

1

0

Small-scale

0.458

High

562296

RDL2
Thiosulfate sulfurtransferase RDL2, mitochondrial

1

0

High-throughput

0.458

High

562274

UBC7
Ubiquitin-conjugating enzyme E2 7

1

1

High-throughput

0.457

High

562286

CIAO1
Cytosolic iron-sulfur protein assembly protein 1

1

6

High-throughput

0.457

High

429615

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

1

3

High-throughput

0.457

High

562176

PRP6
Pre-mRNA-splicing factor 6

1

1

High-throughput

0.457

High

562248

COPB2
Coatomer subunit beta'

1

2

High-throughput

0.457

High

410300

SC160
Protein SCP160

1

1

High-throughput

0.445

High

493120

HSP72
Heat shock protein SSA2

1

6

High-throughput

0.445

High

562182

NPR1
Nitrogen permease reactivator protein

1

15

High-throughput

0.445

High

562195

MCM5
Minichromosome maintenance protein 5

1

4

High-throughput

0.445

High

562221

SEA4
SEH-associated protein 4

1

1

High-throughput

0.445

High

562226

YM8C
Uncharacterized deoxyribonuclease YMR262W

1

1

High-throughput

0.445

High

562239

HSP7E
Heat shock protein SSC3, mitochondrial

1

5

High-throughput

0.445

High

562265

HCH1
Hsp90 co-chaperone HCH1

1

1

High-throughput

0.445

High

562266

JJJ1
J protein JJJ1

1

1

High-throughput

0.445

High

562267

CRZ1
Transcriptional regulator CRZ1

1

1

High-throughput

0.445

High

382927

RL25
Large ribosomal subunit protein uL23

1

1

High-throughput

0.437

High

405404

RL26A
Large ribosomal subunit protein uL24A

1

1

High-throughput

0.437

High

413281

RS14A
Small ribosomal subunit protein uS11A

1

1

High-throughput

0.437

High

470839

RS22A
Small ribosomal subunit protein uS8A

1

1

High-throughput

0.437

High

471997

RL31A
Large ribosomal subunit protein eL31A

1

1

High-throughput

0.437

High

480455

RS8A
Small ribosomal subunit protein eS8A

1

1

High-throughput

0.437

High

562192

RL16A
Large ribosomal subunit protein uL13A

1

1

High-throughput

0.437

High

562212

RS3A1
Small ribosomal subunit protein eS1A

1

1

High-throughput

0.437

High

562222

GID4
Vacuolar import and degradation protein 24

1

1

High-throughput

0.437

High

562233

RPN10
26S proteasome regulatory subunit RPN10

1

1

High-throughput

0.437

High

562236

LAA1
AP-1 accessory protein LAA1

1

1

High-throughput

0.437

High

562247

RLP7
Ribosome biogenesis protein RLP7

1

1

High-throughput

0.437

High

562255

NU192
Nucleoporin NUP192

1

1

High-throughput

0.437

High

562289

URN1
Pre-mRNA-splicing factor URN1

1

1

High-throughput

0.437

High

562297

RS10A
Small ribosomal subunit protein eS10A

1

1

High-throughput

0.437

High

562299

AP3D
AP-3 complex subunit delta

1

1

High-throughput

0.437

High

562303

RRP6
Exosome complex exonuclease RRP6

1

1

High-throughput

0.437

High

389841

VDAC1
Mitochondrial outer membrane protein porin 1

1

0

High-throughput

0.426

High

561207

APA1
Protein APA1 [Includes: Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase 1

1

0

High-throughput

0.426

High

562257

JSN1
Protein JSN1

1

0

High-throughput

0.426

High

562241

JEM1
DnaJ-like chaperone JEM1

1

4

High-throughput

0.407

High

562277

GCN5
Histone acetyltransferase GCN5

1

2

High-throughput

0.407

High

562278

WDR59
Maintenance of telomere capping protein 5

1

8

High-throughput

0.407

High

562304

CENPH
Inner kinetochore subunit MCM16

1

1

High-throughput

0.407

High

356227

H4
Histone H4

2

0

High-throughput

0.307

High

562225

ATG12
Ubiquitin-like protein ATG12

1

0

High-throughput

0.279

Low

562240

SHO1
High osmolarity signaling protein SHO1

1

0

Small-scale

0.269

Low

562207

SUI1
Eukaryotic translation initiation factor eIF-1

1

0

High-throughput

0.261

Low

357860

RS17A
Small ribosomal subunit protein eS17A

1

0

High-throughput

0.249

Low

425738

RS19A
Small ribosomal subunit protein eS19A

1

0

High-throughput

0.249

Low

479899

RS6A
Small ribosomal subunit protein eS6A

1

0

High-throughput

0.249

Low

562191

SGF29
SAGA-associated factor 29

1

0

Small-scale

0.249

Low

562193

RS7A
Small ribosomal subunit protein eS7A

1

0

High-throughput

0.249

Low

562217

CENPA
Histone H3-like centromeric protein CSE4

1

0

High-throughput

0.249

Low

562249

MID1
Stretch-activated cation channel MID1

1

0

Small-scale

0.249

Low

562281

PDS5
Sister chromatid cohesion protein PDS5

1

0

High-throughput

0.249

Low

562298

RSA1
Ribosome assembly 1 protein

1

0

High-throughput

0.249

Low

562310

ENV10
SRP-independent targeting protein 2

1

0

High-throughput

0.249

Low

562175

ERD2
ER lumen protein-retaining receptor

1

0

High-throughput

0.232

Low

562183

SEC15
Exocyst complex component SEC15

1

0

High-throughput

0.232

Low

562232

RIX1
Pre-rRNA-processing protein RIX1

1

0

High-throughput

0.232

Low

562242

PSF2
DNA replication complex GINS protein PSF2

1

0

High-throughput

0.232

Low

562246

DSN1
Kinetochore-associated protein DSN1

1

0

High-throughput

0.232

Low

562254

GWT1
GPI-anchored wall transfer protein 1

1

0

High-throughput

0.232

Low

562275

NUP49
Nucleoporin NUP49/NSP49

1

0

High-throughput

0.232

Low

562288

COG4
Conserved oligomeric Golgi complex subunit 4

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024