HitPredict - High confidence protein-protein interactions

Protein: IRAK3
Interleukin-1 receptor-associated kinase 3 (IRAK-3) (IL-1 receptor-associated kinase M) (IRAK-M) (Inactive IL-1 receptor-associated kinase 3)

Gene: IRAK3
Organism: Mus musculus
Interactions: 9
UniProt ID: Q8K4B2

Gene Ontology (top 5):
GO:0000287 - magnesium ion binding
GO:0001819 - positive regulation of cytokine production
GO:0001960 - negative regulation of cytokine-mediated signaling pathway
GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity

Download interactions: TXT MITAB-2.5

Interaction	Interactor	Experiments	Homologs	Category	Interaction Score	Confidence
1224127	IRAK1 Interleukin-1 receptor-associated kinase 1	2	20	Small-scale	0.754	High
999872	TRAF6 TNF receptor-associated factor 6	3	12	Small-scale	0.629	High
1298411	IRAK2 Interleukin-1 receptor-associated kinase-like 2	1	20	Small-scale	0.618	High
1317413	IRAK4 Interleukin-1 receptor-associated kinase 4	1	19	Small-scale	0.618	High
648070	MYD88 Myeloid differentiation primary response protein MyD88	1	20	Small-scale	0.575	High
1317412	IRAK3 Interleukin-1 receptor-associated kinase 3	1	16	Small-scale	0.575	High
148135	CASP6 Caspase-6	1	1	Small-scale	0.561	High
1230522	UBP7 Ubiquitin carboxyl-terminal hydrolase 7	1	2	High-throughput	0.479	High

Service provided by Combinatics, Japan

Last updated: 11Aug2025