Protein: POLI
DNA polymerase iota (EC 2.7.7.7) (Eta2) (RAD30 homolog B)

Gene: POLI
Organism: Homo sapiens
Interactions: 41
UniProt ID: Q9UNA4

Gene Ontology (top 5):
GO:0003684 - damaged DNA binding
GO:0003887 - DNA-directed DNA polymerase activity
GO:0005654 - nucleoplasm
GO:0006260 - DNA replication
GO:0006281 - DNA repair

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

551334

PCNA
Proliferating cell nuclear antigen

6

14

Small-scale

0.948

High

508831

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

5

9

Small-scale

0.916

High

1458902

REV1
DNA repair protein REV1

3

13

Small-scale

0.845

High

1462258

POLH
DNA polymerase eta

2

12

Small-scale

0.828

High

1154961

NEDD8
Ubiquitin-like protein NEDD8

1

3

Small-scale

0.724

High

1232751

Q6FI35
Proliferating cell nuclear antigen

1

14

Small-scale

0.713

High

414850

P53
Cellular tumor antigen p53

4

3

Small-scale

0.676

High

507426

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

1

9

Small-scale

0.621

High

1139161

DAZP2
DAZ-associated protein 2

2

0

High-throughput

0.613

High

159920

DVL2
Segment polarity protein dishevelled homolog DVL-2

2

1

High-throughput

0.608

High

1371774

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

1

Small-scale

0.578

High

1449327

HOME3
Homer protein homolog 3

2

1

High-throughput

0.553

High

1067838

EP300
Histone acetyltransferase p300

1

0

Small-scale

0.537

High

1462261

TRAF6
TNF receptor-associated factor 6

1

1

High-throughput

0.523

High

617758

XRCC1
DNA repair protein XRCC1

1

1

Small-scale

0.515

High

1139875

SETB1
Histone-lysine N-methyltransferase SETDB1

1

1

High-throughput

0.515

High

1347415

LMO3
LIM domain only protein 3

1

2

High-throughput

0.515

High

603389

KPCA
Protein kinase C alpha type

1

0

High-throughput

0.493

High

1371333

KAT5
Histone acetyltransferase KAT5

1

0

High-throughput

0.493

High

913093

HNRPF
Heterogeneous nuclear ribonucleoprotein F

1

1

Small-scale

0.479

High

997184

TBA4A
Tubulin alpha-4A chain

1

3

Small-scale

0.479

High

1453799

RAI14
Ankycorbin

1

1

Small-scale

0.479

High

687541

PTBP1
Polypyrimidine tract-binding protein 1

1

0

Small-scale

0.458

High

968485

PP1B
Serine/threonine-protein phosphatase PP1-beta catalytic subunit

1

0

Small-scale

0.458

High

1022807

XIAP
E3 ubiquitin-protein ligase XIAP

1

0

Small-scale

0.458

High

423456

A4
Amyloid-beta precursor protein

1

1

High-throughput

0.457

High

1155206

EREP1
Endosomal transmembrane epsin interactor 1

1

1

Small-scale

0.417

High

1439326

TRI39
E3 ubiquitin-protein ligase TRIM39

2

0

High-throughput

0.334

High

1335961

ZBT44
Zinc finger and BTB domain-containing protein 44

1

0

High-throughput

0.299

High

1359047

TM239
Transmembrane protein 239

1

0

High-throughput

0.299

High

783456

TRI23
E3 ubiquitin-protein ligase TRIM23

1

0

High-throughput

0.292

High

880981

MTR1B
Melatonin receptor type 1B

1

0

High-throughput

0.282

High

1095851

CACO2
Calcium-binding and coiled-coil domain-containing protein 2

1

0

High-throughput

0.282

High

1462260

MFHA1
Malignant fibrous histiocytoma-amplified sequence 1

1

0

High-throughput

0.279

Low

967019

1433G
14-3-3 protein gamma

1

0

High-throughput

0.268

Low

1462259

RNF11
RING finger protein 11

1

0

High-throughput

0.265

Low

456889

ANXA2
Annexin A2

1

0

Small-scale

0.249

Low

555784

ACTN1
Alpha-actinin-1

1

0

Small-scale

0.249

Low

1052125

CALD1
Caldesmon

1

0

Small-scale

0.249

Low

1250803

MPRIP
Myosin phosphatase Rho-interacting protein

1

0

Small-scale

0.249

Low

1433125

CHM4B
Charged multivesicular body protein 4b

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025