Protein: POLH
DNA polymerase eta (EC 2.7.7.7) (RAD30 homolog A) (Xeroderma pigmentosum variant type protein)

Gene: POLH
Organism: Homo sapiens
Interactions: 83
UniProt ID: Q9Y253

Gene Ontology (top 5):
GO:0000731 - DNA synthesis involved in DNA repair
GO:0003684 - damaged DNA binding
GO:0003887 - DNA-directed DNA polymerase activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

551341

PCNA
Proliferating cell nuclear antigen

20

14

Small-scale

0.988

High

1458903

REV1
DNA repair protein REV1

8

13

Small-scale

0.973

High

1462258

POLI
DNA polymerase iota

2

12

Small-scale

0.828

High

1449255

RAD18
E3 ubiquitin-protein ligase RAD18

7

2

Small-scale

0.743

High

508852

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

6

9

Small-scale

0.734

High

1232752

Q6FI35
Proliferating cell nuclear antigen

1

14

Small-scale

0.713

High

1371791

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

2

1

Small-scale

0.634

High

953193

ACTB
Actin, cytoplasmic 1

2

2

High-throughput

0.628

High

1490501

LSM5
U6 snRNA-associated Sm-like protein LSm5

2

0

High-throughput

0.602

High

1490500

POLH
DNA polymerase eta

1

13

Small-scale

0.590

High

1399869

ZN363
RING finger and CHY zinc finger domain-containing protein 1

2

0

Small-scale

0.585

High

462059

HS90A
Heat shock protein HSP 90-alpha

2

5

Small-scale

0.584

High

1453342

DTL
Denticleless protein homolog

1

1

Small-scale

0.578

High

507003

POTEI
POTE ankyrin domain family member I

2

1

High-throughput

0.574

High

1201095

ACTBL
Beta-actin-like protein 2

2

1

High-throughput

0.574

High

904417

BRCA2
Breast cancer type 2 susceptibility protein

1

0

Small-scale

0.571

High

1294969

PALB2
Partner and localizer of BRCA2

1

0

Small-scale

0.561

High

1028455

MDM2
E3 ubiquitin-protein ligase Mdm2

2

0

Small-scale

0.559

High

1416107

TRAIP
E3 ubiquitin-protein ligase TRAIP

1

3

Small-scale

0.552

High

827524

MLH1
DNA mismatch repair protein Mlh1

1

0

Small-scale

0.549

High

1157998

DDB1
DNA damage-binding protein 1

1

0

Small-scale

0.537

High

997193

TBA4A
Tubulin alpha-4A chain

1

3

High-throughput

0.536

High

520467

ANDR
Androgen receptor

1

1

High-throughput

0.534

High

878290

DPOD2
DNA polymerase delta subunit 2

1

2

Small-scale

0.527

High

238970

DHX16
Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16

1

0

High-throughput

0.513

High

553098

PIP
Prolactin-inducible protein

1

0

High-throughput

0.513

High

883965

CENPF
Centromere protein F

1

0

High-throughput

0.513

High

1068338

AHNK
Neuroblast differentiation-associated protein AHNAK

1

0

High-throughput

0.513

High

1089134

HYAL2
Hyaluronidase-2

1

0

High-throughput

0.513

High

1339897

KNL1
Outer kinetochore KNL1 complex subunit KNL1

1

0

High-throughput

0.513

High

1448248

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

0

High-throughput

0.513

High

1461207

PACN3
Protein kinase C and casein kinase substrate in neurons protein 3

1

0

High-throughput

0.513

High

423479

A4
Amyloid-beta precursor protein

1

1

High-throughput

0.501

High

1416461

GTPB2
GTP-binding protein 2

1

1

High-throughput

0.489

High

159926

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

1

High-throughput

0.479

High

186131

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

1

Small-scale

0.479

High

297715

PIAS1
E3 SUMO-protein ligase PIAS1

1

3

Small-scale

0.479

High

468929

HS90B
Heat shock protein HSP 90-beta

1

5

Small-scale

0.479

High

755823

MCM4
DNA replication licensing factor MCM4

1

3

Small-scale

0.479

High

756412

MCM7
DNA replication licensing factor MCM7

1

3

Small-scale

0.479

High

799589

BRCA1
Breast cancer type 1 susceptibility protein

1

3

Small-scale

0.479

High

846702

MSH2
DNA mismatch repair protein Msh2

1

4

Small-scale

0.479

High

986824

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

1

High-throughput

0.479

High

991000

UBE2B
Ubiquitin-conjugating enzyme E2 B

1

1

Small-scale

0.479

High

1017313

H33
Histone H3.3

1

4

High-throughput

0.479

High

1048139

TLE3
Transducin-like enhancer protein 3

1

1

High-throughput

0.479

High

1339046

NUP43
Nucleoporin Nup43

1

2

High-throughput

0.479

High

1340843

COP1
E3 ubiquitin-protein ligase COP1

1

2

High-throughput

0.479

High

1351204

SP7
Transcription factor Sp7

1

2

High-throughput

0.479

High

1364310

TOPB1
DNA topoisomerase 2-binding protein 1

1

2

High-throughput

0.479

High

1387650

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

2

High-throughput

0.479

High

1416960

KLF16
Krueppel-like factor 16

1

1

High-throughput

0.479

High

1417526

FACD2
Fanconi anemia group D2 protein

1

1

Small-scale

0.479

High

1460255

MD2L2
Mitotic spindle assembly checkpoint protein MAD2B

1

7

Small-scale

0.479

High

1460307

XPO7
Exportin-7

1

1

High-throughput

0.479

High

1381253

WBP2
WW domain-binding protein 2

1

0

Small-scale

0.460

High

247468

PHLP1
PH domain leucine-rich repeat-containing protein phosphatase 1

1

0

High-throughput

0.458

High

326102

UBR5
E3 ubiquitin-protein ligase UBR5

1

0

Small-scale

0.458

High

331430

KI20A
Kinesin-like protein KIF20A

1

0

High-throughput

0.458

High

419280

H2A1B
Histone H2A type 1-B/E

1

0

Small-scale

0.458

High

457779

TBB5
Tubulin beta chain

1

0

Small-scale

0.458

High

775936

HNF1B
Hepatocyte nuclear factor 1-beta

1

0

High-throughput

0.458

High

892964

MRE11
Double-strand break repair protein MRE11

1

0

Small-scale

0.458

High

1008943

RED1
Double-stranded RNA-specific editase 1

1

0

High-throughput

0.458

High

1110205

HDAC1
Histone deacetylase 1

1

0

High-throughput

0.458

High

1137198

SART3
Spliceosome associated factor 3, U4/U6 recycling protein

1

0

Small-scale

0.458

High

1159053

RBBP7
Histone-binding protein RBBP7

1

0

High-throughput

0.458

High

1313542

SMC5
Structural maintenance of chromosomes protein 5

1

0

High-throughput

0.458

High

1347672

NPL4
Nuclear protein localization protein 4 homolog

1

0

Small-scale

0.458

High

1357613

DCAF4
DDB1- and CUL4-associated factor 4

1

0

High-throughput

0.458

High

1370001

UFD1
Ubiquitin recognition factor in ER-associated degradation protein 1

1

0

Small-scale

0.458

High

1384485

PF21A
PHD finger protein 21A

1

0

High-throughput

0.458

High

1385127

MOB3A
MOB kinase activator 3A

1

0

High-throughput

0.458

High

1403619

MMS19
MMS19 nucleotide excision repair protein homolog

1

0

Small-scale

0.458

High

1429399

SPRTN
DNA-dependent metalloprotease SPRTN

1

0

Small-scale

0.458

High

1461140

RCOR1
REST corepressor 1

1

0

High-throughput

0.458

High

996896

TBA1B
Tubulin alpha-1B chain

1

3

Small-scale

0.437

High

1155208

EREP1
Endosomal transmembrane epsin interactor 1

1

1

Small-scale

0.417

High

321944

FRYL
Protein furry homolog-like

1

0

High-throughput

0.279

Low

683763

PTX3
Pentraxin-related protein PTX3

1

0

High-throughput

0.279

Low

1103810

PLD1
Phospholipase D1

1

0

High-throughput

0.279

Low

1416703

LGR4
Leucine-rich repeat-containing G-protein coupled receptor 4

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025