Protein: M3K12
Mitogen-activated protein kinase kinase kinase 12 (EC 2.7.11.25) (Dual leucine zipper bearing kinase) (DLK) (Leucine-zipper protein kinase) (ZPK) (MAPK-upstream kinase) (MUK) (Mixed lineage kinase)

Gene: M3K12, MAP3K12
Organism: Homo sapiens
Interactions: 18
UniProt ID: Q12852

Gene Ontology (top 5):
GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity
GO:0004709 - MAP kinase kinase kinase activity
GO:0005524 - ATP binding
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

363199

EGFR
Epidermal growth factor receptor

2

20

Small-scale

0.825

High

161982

MP2K7
Dual specificity mitogen-activated protein kinase kinase 7

1

19

Small-scale

0.724

High

1087706

JIP2
C-Jun-amino-terminal kinase-interacting protein 2

1

19

Small-scale

0.724

High

1087713

JIP1
C-Jun-amino-terminal kinase-interacting protein 1

1

20

Small-scale

0.724

High

1087709

MK06
Mitogen-activated protein kinase 6

1

16

High-throughput

0.656

High

853885

MP2K4
Dual specificity mitogen-activated protein kinase kinase 4

1

19

Small-scale

0.647

High

461411

HS90A
Heat shock protein HSP 90-alpha

1

20

High-throughput

0.618

High

468311

HS90B
Heat shock protein HSP 90-beta

1

20

High-throughput

0.618

High

690953

1433T
14-3-3 protein theta

1

20

High-throughput

0.618

High

1038610

FKBP4
Peptidyl-prolyl cis-trans isomerase FKBP4

1

18

Small-scale

0.618

High

1087707

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

1

18

Small-scale

0.618

High

391238

FRIL
Ferritin light chain

1

3

High-throughput

0.541

High

1061667

RGS1
Regulator of G-protein signaling 1

1

3

High-throughput

0.541

High

1087708

T22D1
TSC22 domain family protein 1

1

18

High-throughput

0.541

High

1087711

MBIP1
MAP3K12-binding inhibitory protein 1

1

0

Small-scale

0.529

High

1087712

FKBPL
FK506-binding protein-like

1

18

Small-scale

0.479

High

1037471

RL18A
Large ribosomal subunit protein eL20

1

1

High-throughput

0.457

High

1087710

F10C1
Protein FRA10AC1

1

0

High-throughput

0.288

High


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Last updated: 11Aug2025