Protein: MP2K4
Dual specificity mitogen-activated protein kinase kinase 4 (MAP kinase kinase 4) (MAPKK 4) (EC 2.7.12.2) (JNK-activating kinase 1) (MAPK/ERK kinase 4) (MEK 4) (SAPK/ERK kinase 1) (SEK1) (Stress-activated protein kinase kinase 1) (SAPK kinase 1) (SAPKK-1) (SAPKK1) (c-Jun N-terminal kinase kinase 1) (JNKK)

Gene: MP2K4, MAP2K4
Organism: Homo sapiens
Interactions: 66
UniProt ID: P45985

Gene Ontology (top 5):
GO:0000165 - MAPK cascade
GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity
GO:0004708 - MAP kinase kinase activity
GO:0004713 - protein tyrosine kinase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

853616

MK08
Mitogen-activated protein kinase 8

14

20

Small-scale

0.985

High

853887

M3K1
Mitogen-activated protein kinase kinase kinase 1

11

20

Small-scale

0.981

High

853765

MK09
Mitogen-activated protein kinase 9

6

20

Small-scale

0.940

High

853905

M3K5
Mitogen-activated protein kinase kinase kinase 5

5

19

Small-scale

0.920

High

853915

M3K4
Mitogen-activated protein kinase kinase kinase 4

3

18

Small-scale

0.853

High

853914

M3K2
Mitogen-activated protein kinase kinase kinase 2

3

18

Small-scale

0.840

High

853880

MK10
Mitogen-activated protein kinase 10

3

20

Small-scale

0.834

High

728097

AKT1
RAC-alpha serine/threonine-protein kinase

2

17

Small-scale

0.834

High

853891

MK14
Mitogen-activated protein kinase 14

2

20

Small-scale

0.812

High

853907

M3K3
Mitogen-activated protein kinase kinase kinase 3

2

19

Small-scale

0.812

High

213856

M3K7
Mitogen-activated protein kinase kinase kinase 7

2

20

Small-scale

0.768

High

853890

NBR1
Next to BRCA1 gene 1 protein

1

2

Small-scale

0.724

High

853876

MP2K4
Dual specificity mitogen-activated protein kinase kinase 4

1

18

Small-scale

0.710

High

853883

KPCZ
Protein kinase C zeta type

1

18

High-throughput

0.691

High

161962

MP2K7
Dual specificity mitogen-activated protein kinase kinase 7

1

17

Small-scale

0.665

High

853895

ZDH17
Palmitoyltransferase ZDHHC17

1

10

Small-scale

0.648

High

507657

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

13

High-throughput

0.647

High

703482

MK01
Mitogen-activated protein kinase 1

1

20

Small-scale

0.647

High

834737

M3K8
Mitogen-activated protein kinase kinase kinase 8

1

18

Small-scale

0.647

High

853879

MP2K6
Dual specificity mitogen-activated protein kinase kinase 6

1

18

Small-scale

0.647

High

853882

M3K10
Mitogen-activated protein kinase kinase kinase 10

1

20

Small-scale

0.647

High

853884

M4K2
Mitogen-activated protein kinase kinase kinase kinase 2

1

18

Small-scale

0.647

High

853885

M3K12
Mitogen-activated protein kinase kinase kinase 12

1

19

Small-scale

0.647

High

853892

M3K11
Mitogen-activated protein kinase kinase kinase 11

1

15

Small-scale

0.647

High

853893

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

20

Small-scale

0.647

High

177819

IKKA
Inhibitor of nuclear factor kappa-B kinase subunit alpha

1

20

Small-scale

0.618

High

192994

CFLAR
CASP8 and FADD-like apoptosis regulator

1

12

Small-scale

0.618

High

362942

EGFR
Epidermal growth factor receptor

1

20

High-throughput

0.618

High

424644

KPCG
Protein kinase C gamma type

1

17

Small-scale

0.618

High

853903

TRIB1
Tribbles homolog 1

1

18

Small-scale

0.618

High

732470

ARRB2
Beta-arrestin-2

2

10

Small-scale

0.595

High

853898

GEMI5
Gem-associated protein 5

1

11

Small-scale

0.578

High

853901

ITCH
E3 ubiquitin-protein ligase Itchy homolog

1

18

Small-scale

0.578

High

776936

PPM1A
Protein phosphatase 1A

1

9

Small-scale

0.575

High

853886

STK4
Serine/threonine-protein kinase 4

1

19

High-throughput

0.575

High

853911

M3K20
Mitogen-activated protein kinase kinase kinase 20

1

17

Small-scale

0.575

High

853889

FLNC
Filamin-C

1

12

Small-scale

0.573

High

853894

TRI67
Tripartite motif-containing protein 67

1

20

High-throughput

0.553

High

853909

PKHA4
Pleckstrin homology domain-containing family A member 4

1

20

High-throughput

0.553

High

421187

ALDOB
Fructose-bisphosphate aldolase B

1

5

High-throughput

0.541

High

853896

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

7

High-throughput

0.536

High

853899

BLNK
B-cell linker protein

1

8

Small-scale

0.536

High

853904

CDC5L
Cell division cycle 5-like protein

1

11

High-throughput

0.536

High

853913

JIP3
C-Jun-amino-terminal kinase-interacting protein 3

2

20

Small-scale

0.533

High

144134

F16P2
Fructose-1,6-bisphosphatase isozyme 2

1

0

High-throughput

0.518

High

853881

STX17
Syntaxin-17

1

0

High-throughput

0.518

High

853888

CYLC2
Cylicin-2

1

0

High-throughput

0.518

High

853906

CTIP
DNA endonuclease RBBP8

1

0

High-throughput

0.518

High

853902

CNDP2
Cytosolic non-specific dipeptidase

1

0

High-throughput

0.513

High

853908

PUS3
tRNA pseudouridine(38/39) synthase

1

0

High-throughput

0.513

High

421682

A4
Amyloid-beta precursor protein

1

13

High-throughput

0.501

High

429479

JUN
Transcription factor Jun

1

7

Small-scale

0.501

High

853877

ARRB1
Beta-arrestin-1

1

10

Small-scale

0.501

High

243907

JIP4
C-Jun-amino-terminal kinase-interacting protein 4

1

20

Small-scale

0.479

High

278034

FLNB
Filamin-B

1

12

Small-scale

0.479

High

621832

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

1

1

High-throughput

0.479

High

694851

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

10

High-throughput

0.479

High

721702

GCH1
GTP cyclohydrolase 1

1

1

Small-scale

0.479

High

853910

SAR1A
Small COPII coat GTPase SAR1A

1

15

High-throughput

0.479

High

853912

ZRAN1
Ubiquitin thioesterase ZRANB1

1

9

High-throughput

0.479

High

853878

RPAB3
DNA-directed RNA polymerases I, II, and III subunit RPABC3

1

0

High-throughput

0.458

High

105521

APRIO
Alternative prion protein

1

5

High-throughput

0.437

High

767627

RFA3
Replication protein A 14 kDa subunit

1

7

High-throughput

0.437

High

853897

SH3R3
E3 ubiquitin-protein ligase SH3RF3

1

20

Small-scale

0.437

High

853900

TP8L1
Tumor necrosis factor alpha-induced protein 8-like protein 1

1

1

Small-scale

0.437

High


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Last updated: 11Aug2025