HitPredict

Interactor 1: HDAC1 (Q13547)
Histone deacetylase 1 (HD1) (EC 3.5.1.98) (Protein deacetylase HDAC1) (EC 3.5.1.-) (Protein decrotonylase HDAC1) (EC 3.5.1.-)
Gene: HDAC1

Interactor 2: PF21A (Q96BD5)
PHD finger protein 21A (BHC80a) (BRAF35-HDAC complex protein BHC80)
Gene: PHF21A

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.94	0.60	0.752

Property	Details
Experiments	12032298, 34709266, 26496610, 28514442, 15325272, 33961781, 35271311, 23752268
Identification Methods	biochemical, proximity labelling technology, affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	association, physical association, direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000118 - histone deacetylase complex GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005654 - nucleoplasm GO:0006325 - chromatin organization
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 482 Hs			1 680
+	Hs
		170356 HDAC1_HUMAN (1-482): 0: 668: 100.00		TIF1A_HUMAN (2-647): 1.34e-77: 270: 14.56
+	Hs
		170436 HDAC2_HUMAN (1-478): 0: 666: 85.92		TIF1A_HUMAN (2-647): 1.34e-77: 270: 14.56
+	Hs
		1038782 HDAC1_HUMAN (1-482): 0: 668: 100.00		KDM5B_HUMAN (147-656): 5.55e-61: 224: 13.90
+	Mm
		140293 HDAC1_MOUSE (1-482): 0: 672: 99.38		KDM5B_MOUSE (139-656): 9.66e-59: 217: 14.83
+	Hs
		782341 HDAC1_HUMAN (1-482): 0: 668: 100.00		KDM5C_HUMAN (169-655): 3.08e-60: 221: 15.75
+	Hs
		782369 HDAC2_HUMAN (1-478): 0: 666: 85.92		KDM5C_HUMAN (169-655): 3.08e-60: 221: 15.75
+	Hs
		666529 HDAC1_HUMAN (1-482): 0: 668: 100.00		KDM5A_HUMAN (211-656): 1.39e-54: 204: 16.12
+	Hs
		666546 HDAC2_HUMAN (1-478): 0: 666: 85.92		KDM5A_HUMAN (211-656): 1.39e-54: 204: 16.12
+	Hs
		1038791 HDAC1_HUMAN (1-482): 0: 668: 100.00		BAZ2A_HUMAN (4-648): 1.81e-50: 192: 11.71
+	Mm
		56897 HDAC1_MOUSE (1-482): 0: 672: 99.38		CHD5_MOUSE (255-617): 1.37e-48: 186: 16.33
+	Hs
		1038563 HDAC1_HUMAN (1-482): 0: 668: 100.00		CHD5_HUMAN (255-617): 2.01e-43: 170: 16.79
+	Mm
		140286 HDAC1_MOUSE (1-482): 0: 672: 99.38		CHD4_MOUSE (324-650): 3.17e-41: 164: 16.04
+	Hs
		1038382 HDAC1_HUMAN (1-482): 0: 668: 100.00		CHD4_HUMAN (324-650): 1.2e-41: 165: 16.04
+	Hs
		1018465 HDAC1_HUMAN (1-482): 0: 668: 100.00		CHD3_HUMAN (298-617): 4.98e-41: 163: 15.21
+	Hs
		331809 HDAC1_HUMAN (1-482): 0: 668: 100.00		NSD2_HUMAN (77-547): 1.68e-36: 149: 11.77
+	Hs
		331858 HDAC2_HUMAN (1-478): 0: 666: 85.92		NSD2_HUMAN (77-547): 1.68e-36: 149: 11.77
+	Hs
		1038620 HDAC1_HUMAN (1-482): 0: 668: 100.00		PF21B_HUMAN (190-668): 6.44e-36: 144: 25.30
+	Hs
		217477 HDAC1_HUMAN (1-482): 0: 668: 100.00		AIRE_HUMAN (472-538): 1.24e-19: 94.9: 43.06
+	Hs
		217495 HDAC2_HUMAN (1-478): 0: 666: 85.92		AIRE_HUMAN (472-538): 1.24e-19: 94.9: 43.06
+	Hs
		1038642 HDAC1_HUMAN (1-482): 0: 668: 100.00		PHF12_HUMAN (462-541): 1.99e-13: 76: 31.71