Protein: JIP2
C-Jun-amino-terminal kinase-interacting protein 2 (JIP-2) (JNK-interacting protein 2) (Islet-brain-2) (IB-2) (JNK MAP kinase scaffold protein 2) (Mitogen-activated protein kinase 8-interacting protein 2)

Gene: JIP2, MAPK8IP2
Organism: Homo sapiens
Interactions: 121
UniProt ID: Q13387

Gene Ontology (top 5):
GO:0000165 - MAPK cascade
GO:0001540 - amyloid-beta binding
GO:0001662 - behavioral fear response
GO:0005078 - MAP-kinase scaffold activity
GO:0005198 - structural molecule activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

363228

EGFR
Epidermal growth factor receptor

4

20

High-throughput

0.887

High

1103743

JIP1
C-Jun-amino-terminal kinase-interacting protein 1

3

11

Small-scale

0.879

High

181990

UBD
Ubiquitin D

2

10

High-throughput

0.819

High

422056

A4
Amyloid-beta precursor protein

2

19

Small-scale

0.754

High

889272

NUMB
Protein numb homolog

2

3

High-throughput

0.743

High

1038570

M3K10
Mitogen-activated protein kinase kinase kinase 10

1

13

Small-scale

0.724

High

1087706

M3K12
Mitogen-activated protein kinase kinase kinase 12

1

19

Small-scale

0.724

High

1103696

M3K11
Mitogen-activated protein kinase kinase kinase 11

1

10

Small-scale

0.724

High

961169

FGF12
Fibroblast growth factor 12

4

8

Small-scale

0.685

High

1103721

FGF13
Fibroblast growth factor 13

4

8

Small-scale

0.685

High

1103742

JIP3
C-Jun-amino-terminal kinase-interacting protein 3

3

9

Small-scale

0.670

High

1103686

ASPP2
Apoptosis-stimulating of p53 protein 2

1

9

High-throughput

0.656

High

1103694

ITSN1
Intersectin-1

1

12

High-throughput

0.656

High

161984

MP2K7
Dual specificity mitogen-activated protein kinase kinase 7

2

15

Small-scale

0.629

High

1091389

ANK3
Ankyrin-3

1

8

High-throughput

0.618

High

1103684

JIP2
C-Jun-amino-terminal kinase-interacting protein 2

1

13

Small-scale

0.618

High

1103732

DUS16
Dual specificity protein phosphatase 16

2

4

Small-scale

0.611

High

725049

HXC8
Homeobox protein Hox-C8

3

20

High-throughput

0.607

High

131060

TULP2
Tubby-related protein 2

2

0

High-throughput

0.602

High

1103687

LRP8
Low-density lipoprotein receptor-related protein 8

2

20

Small-scale

0.594

High

184630

MK13
Mitogen-activated protein kinase 13

2

12

Small-scale

0.584

High

858645

MP2K3
Dual specificity mitogen-activated protein kinase kinase 3

2

13

Small-scale

0.584

High

1103692

ANGP1
Angiopoietin-1

2

5

High-throughput

0.579

High

410815

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

19

High-throughput

0.579

High

1103693

TRBP2
RISC-loading complex subunit TARBP2

2

3

High-throughput

0.576

High

1103714

DUS18
Dual specificity protein phosphatase 18

2

4

High-throughput

0.576

High

1103730

RBM4
RNA-binding protein 4

2

2

High-throughput

0.576

High

1103720

RPGF5
Rap guanine nucleotide exchange factor 5

2

2

High-throughput

0.574

High

853790

MK09
Mitogen-activated protein kinase 9

1

12

Small-scale

0.561

High

1022604

LRP2
Low-density lipoprotein receptor-related protein 2

2

20

Small-scale

0.556

High

1092427

TIAM1
Rho guanine nucleotide exchange factor TIAM1

1

8

Small-scale

0.553

High

1103716

SH3R3
E3 ubiquitin-protein ligase SH3RF3

1

20

Small-scale

0.553

High

458391

ADRB2
Beta-2 adrenergic receptor

1

1

Small-scale

0.552

High

892857

MRE11
Double-strand break repair protein MRE11

2

0

High-throughput

0.551

High

967146

UBP46
Ubiquitin carboxyl-terminal hydrolase 46

2

0

High-throughput

0.551

High

1103710

MSRB3
Methionine-R-sulfoxide reductase B3

2

0

High-throughput

0.551

High

1103712

RYBP
RING1 and YY1-binding protein

2

0

High-throughput

0.551

High

1103701

RBG1L
Rab GTPase-activating protein 1-like

1

0

High-throughput

0.546

High

1103703

CV039
Synaptic plasticity regulator PANTS

2

3

High-throughput

0.542

High

407852

SEMG1
Semenogelin-1

1

1

High-throughput

0.536

High

1103711

ASPM
Abnormal spindle-like microcephaly-associated protein

1

5

High-throughput

0.536

High

1103722

FGF11
Fibroblast growth factor 11

1

8

High-throughput

0.536

High

1103723

FGF14
Fibroblast growth factor 14

1

8

High-throughput

0.536

High

1060868

LRP1
Prolow-density lipoprotein receptor-related protein 1

1

20

Small-scale

0.527

High

164858

SH21B
SH2 domain-containing protein 1B

2

9

High-throughput

0.526

High

344537

LSM8
U6 snRNA-associated Sm-like protein LSm8

2

3

High-throughput

0.526

High

833101

MNDA
Myeloid cell nuclear differentiation antigen

2

1

High-throughput

0.526

High

1103705

SPSB3
SPRY domain-containing SOCS box protein 3

2

7

High-throughput

0.526

High

1103725

S39AD
Zinc transporter ZIP13

2

1

High-throughput

0.526

High

1103728

SCLT1
Sodium channel and clathrin linker 1

2

8

High-throughput

0.526

High

1103729

ZN670
Zinc finger protein 670

2

3

High-throughput

0.526

High

1103731

C1QT3
Complement C1q tumor necrosis factor-related protein 3

2

3

High-throughput

0.526

High

1103736

RPA12
DNA-directed RNA polymerase I subunit RPA12

2

1

High-throughput

0.526

High

1103741

ING4
Inhibitor of growth protein 4

2

2

High-throughput

0.526

High

431800

ITB1
Integrin beta-1

1

15

High-throughput

0.515

High

570416

GFAP
Glial fibrillary acidic protein

1

8

High-throughput

0.515

High

605664

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

1

9

High-throughput

0.515

High

699734

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

5

High-throughput

0.515

High

988334

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.515

High

1103744

KCC2A
Calcium/calmodulin-dependent protein kinase type II subunit alpha

1

2

High-throughput

0.515

High

629836

BTF3
Transcription factor BTF3

1

0

High-throughput

0.513

High

1103704

INT5
Integrator complex subunit 5

1

0

High-throughput

0.513

High

736917

GBP2
Guanylate-binding protein 2

1

1

High-throughput

0.508

High

1086573

SNF5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1

1

1

High-throughput

0.508

High

1103708

RAI1
Retinoic acid-induced protein 1

1

6

High-throughput

0.508

High

1103717

SYNE2
Nesprin-2

1

5

High-throughput

0.508

High

1103724

KIFC2
Kinesin-like protein KIFC2

1

3

High-throughput

0.508

High

1103737

KS6B2
Ribosomal protein S6 kinase beta-2

1

7

High-throughput

0.508

High

923385

MK10
Mitogen-activated protein kinase 10

1

12

Small-scale

0.501

High

1103709

VRK2
Serine/threonine-protein kinase VRK2

1

5

Small-scale

0.501

High

1103719

RSPH1
Radial spoke head 1 homolog

1

1

High-throughput

0.494

High

580626

AMPN
Aminopeptidase N

1

0

High-throughput

0.493

High

712859

CASP1
Caspase-1

1

0

High-throughput

0.493

High

760437

SDC2
Syndecan-2

1

0

High-throughput

0.493

High

1036565

SEMG2
Semenogelin-2

1

1

High-throughput

0.489

High

1103690

TTLL4
Tubulin monoglutamylase TTLL4

1

1

High-throughput

0.489

High

1103691

RRP5
Protein RRP5 homolog

1

2

High-throughput

0.489

High

1103726

SENP5
Sentrin-specific protease 5

1

1

High-throughput

0.489

High

138378

ZN593
Zinc finger protein 593

1

0

High-throughput

0.486

High

660052

COF1
Cofilin-1

1

0

High-throughput

0.486

High

934563

TERA
Transitional endoplasmic reticulum ATPase

1

0

High-throughput

0.486

High

983787

RBX1
E3 ubiquitin-protein ligase RBX1

1

0

High-throughput

0.486

High

1103697

FSCN1
Fascin

1

0

High-throughput

0.486

High

1103707

ASGL1
Isoaspartyl peptidase/L-asparaginase

1

0

High-throughput

0.486

High

1103733

VP33B
Vacuolar protein sorting-associated protein 33B

1

0

High-throughput

0.486

High

1103735

YYAP1
YY1-associated protein 1

1

0

High-throughput

0.486

High

1103702

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

10

Small-scale

0.479

High

1103738

FBW1B
F-box/WD repeat-containing protein 11

1

7

High-throughput

0.479

High

586982

CHIN
N-chimaerin

1

3

High-throughput

0.464

High

907901

PLXA3
Plexin-A3

1

2

High-throughput

0.464

High

1103695

EZH2
Histone-lysine N-methyltransferase EZH2

1

8

High-throughput

0.464

High

1103713

ZN784
Zinc finger protein 784

1

5

High-throughput

0.464

High

1103727

MAGD4
Melanoma-associated antigen D4

1

5

High-throughput

0.464

High

1103699

Q53HF2
Heat shock 70kDa protein 8 isoform 2 variant

1

1

High-throughput

0.462

High

520830

HLAC
HLA class I histocompatibility antigen, C alpha chain

1

1

High-throughput

0.439

High

305852

O78179
HLA-C protein

1

1

High-throughput

0.417

High

66073

IGIP
IgA-inducing protein homolog

2

0

High-throughput

0.310

High

1103700

TM128
Transmembrane protein 128

2

0

High-throughput

0.310

High

1103734

CH033
UPF0488 protein C8orf33

2

0

High-throughput

0.310

High

131040

LFTY2
Left-right determination factor 2

2

0

High-throughput

0.300

High

388526

CRP

2

0

High-throughput

0.300

High

399408

SLPI
Antileukoproteinase

2

0

High-throughput

0.300

High

479413

SRP19
Signal recognition particle 19 kDa protein

2

0

High-throughput

0.300

High

628580

ISK2
Serine protease inhibitor Kazal-type 2

2

0

High-throughput

0.300

High

1103689

GALT3
Polypeptide N-acetylgalactosaminyltransferase 3

2

0

High-throughput

0.300

High

1103718

CTBL1
Beta-catenin-like protein 1

2

0

High-throughput

0.300

High

1103740

APC10
Anaphase-promoting complex subunit 10

2

0

High-throughput

0.300

High

85257

RBG10
Rab GTPase-activating protein 1-like, isoform 10

1

0

High-throughput

0.288

High

326254

PRS23
Serine protease 23

1

0

High-throughput

0.282

High

702945

DPOD1
DNA polymerase delta catalytic subunit

1

0

High-throughput

0.279

Low

1103698

CF184
Cilia- and flagella-associated protein 184

1

0

High-throughput

0.279

Low

1103706

INT8
Integrator complex subunit 8

1

0

High-throughput

0.279

Low

278660

NDUS6
NADH dehydrogenase [ubiquinone] iron-sulfur protein 6, mitochondrial

1

0

High-throughput

0.265

Low

877456

MASP1
Mannan-binding lectin serine protease 1

1

0

High-throughput

0.265

Low

914048

SPSY
Spermine synthase

1

0

High-throughput

0.265

Low

1103685

U119A
Protein unc-119 homolog A

1

0

High-throughput

0.265

Low

1103688

DPYL1
Dihydropyrimidinase-related protein 1

1

0

High-throughput

0.265

Low

1103715

BBS10
BBSome complex assembly protein BBS10

1

0

High-throughput

0.265

Low

1103739

ERG28
Ergosterol biosynthetic protein 28 homolog

1

0

High-throughput

0.265

Low

1103745

AFG32
Mitochondrial inner membrane m-AAA protease component AFG3L2

1

0

High-throughput

0.265

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025