Protein: MBIP1
MAP3K12-binding inhibitory protein 1 (MAPK upstream kinase-binding inhibitory protein) (MUK-binding inhibitory protein)

Gene: MBIP1, MBIP
Organism: Homo sapiens
Interactions: 186
UniProt ID: Q9NS73

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0004860 - protein kinase inhibitor activity
GO:0005654 - nucleoplasm
GO:0005730 - nucleolus
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

965267

WDR5
WD repeat-containing protein 5

11

2

Small-scale

0.760

High

1436231

CSR2B
Cysteine-rich protein 2-binding protein

10

3

High-throughput

0.759

High

1389695

SGF29
SAGA-associated factor 29

8

1

Small-scale

0.750

High

283556

TAD2A
Transcriptional adapter 2-alpha

7

3

Small-scale

0.742

High

284888

TADA3
Transcriptional adapter 3

7

2

Small-scale

0.742

High

1369167

KAT2A
Histone acetyltransferase KAT2A

7

4

Small-scale

0.742

High

1449160

YETS2
YEATS domain-containing protein 2

7

2

Small-scale

0.742

High

1315061

ZZZ3
ZZ-type zinc finger-containing protein 3

6

1

High-throughput

0.729

High

1369215

KAT2B
Histone acetyltransferase KAT2B

6

4

Small-scale

0.729

High

1031962

NC2B
Protein Dr1

4

2

Small-scale

0.694

High

681936

RBTN2
Rhombotin-2

3

2

High-throughput

0.683

High

960581

PSME3
Proteasome activator complex subunit 3

3

1

High-throughput

0.667

High

1243868

CTR9
RNA polymerase-associated protein CTR9 homolog

3

1

High-throughput

0.667

High

1402180

PRPK
EKC/KEOPS complex subunit TP53RK

4

0

High-throughput

0.661

High

1449168

TPRKB
EKC/KEOPS complex subunit TPRKB

4

0

High-throughput

0.661

High

1145539

RBBP5
Retinoblastoma-binding protein 5

3

3

High-throughput

0.656

High

900531

FXR2
RNA-binding protein FXR2

2

1

High-throughput

0.640

High

1449146

MBIP1
MAP3K12-binding inhibitory protein 1

2

1

High-throughput

0.640

High

610486

PRS6A
26S proteasome regulatory subunit 6A

3

0

High-throughput

0.638

High

913814

ZN131
Zinc finger protein 131

3

0

High-throughput

0.638

High

1243725

RFWD3
E3 ubiquitin-protein ligase RFWD3

3

0

High-throughput

0.638

High

1449164

CARD8
Caspase recruitment domain-containing protein 8

3

0

High-throughput

0.638

High

1325256

TXLNB
Beta-taxilin

4

1

High-throughput

0.637

High

1446319

OSGEP
tRNA N6-adenosine threonylcarbamoyltransferase

3

0

High-throughput

0.634

High

658510

MYF6
Myogenic factor 6

2

1

High-throughput

0.628

High

1315136

EXOC8
Exocyst complex component 8

2

0

High-throughput

0.623

High

756371

MCM7
DNA replication licensing factor MCM7

2

0

High-throughput

0.618

High

911879

GDS1
Rap1 GTPase-GDP dissociation stimulator 1

2

0

High-throughput

0.618

High

1428199

NDEL1
Nuclear distribution protein nudE-like 1

2

0

High-throughput

0.618

High

1449156

VPS28
Vacuolar protein sorting-associated protein 28 homolog

2

1

High-throughput

0.613

High

1095599

LIPA1
Liprin-alpha-1

2

0

High-throughput

0.613

High

66672

CC85C
Coiled-coil domain-containing protein 85C

3

1

High-throughput

0.609

High

292033

CRTAP
Cartilage-associated protein

3

1

High-throughput

0.609

High

1162754

KAT1
Kynurenine--oxoglutarate transaminase 1

2

0

High-throughput

0.602

High

1233803

CNDH2
Condensin-2 complex subunit H2

2

0

High-throughput

0.602

High

1434723

IKZF5
Zinc finger protein Pegasus

2

0

High-throughput

0.602

High

1449152

ASH2L
Set1/Ash2 histone methyltransferase complex subunit ASH2

2

3

High-throughput

0.584

High

1449167

E41L3
Band 4.1-like protein 3

2

1

High-throughput

0.584

High

1364885

P55G
Phosphatidylinositol 3-kinase regulatory subunit gamma

2

1

High-throughput

0.576

High

821208

TXLNA
Alpha-taxilin

1

1

High-throughput

0.573

High

870169

LIMS1
LIM and senescent cell antigen-like-containing domain protein 1

1

1

High-throughput

0.560

High

373257

MYC
Myc proto-oncogene protein

2

0

High-throughput

0.559

High

1181437

P3H1
Prolyl 3-hydroxylase 1

2

1

High-throughput

0.558

High

1430807

CAD19
Cadherin-19

2

1

High-throughput

0.558

High

363913

EGFR
Epidermal growth factor receptor

1

0

Small-scale

0.558

High

180411

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

1

0

High-throughput

0.549

High

666916

CCNC
Cyclin-C

1

0

High-throughput

0.549

High

1307246

TF2LY
Homeobox protein TGIF2LY

1

0

High-throughput

0.549

High

1361587

ING5
Inhibitor of growth protein 5

1

0

High-throughput

0.549

High

1385147

MOAP1
Modulator of apoptosis 1

1

0

High-throughput

0.549

High

1449147

MS18A
Protein Mis18-alpha

1

0

High-throughput

0.549

High

634659

LMNB1
Lamin-B1

1

1

High-throughput

0.541

High

900186

FXR1
RNA-binding protein FXR1

1

1

High-throughput

0.541

High

682626

S100P
Protein S100-P

1

1

High-throughput

0.536

High

953132

ACTB
Actin, cytoplasmic 1

1

1

High-throughput

0.536

High

1054652

PSME1
Proteasome activator complex subunit 1

1

1

High-throughput

0.536

High

1123145

FHL2
Four and a half LIM domains protein 2

1

1

High-throughput

0.536

High

1447934

DPOE4
DNA polymerase epsilon subunit 4

1

1

High-throughput

0.536

High

1393299

Q96HL7
EPB41L3 protein

2

1

High-throughput

0.533

High

1087711

M3K12
Mitogen-activated protein kinase kinase kinase 12

1

0

Small-scale

0.529

High

1086709

SNF5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1

1

0

High-throughput

0.518

High

1119094

RPGF1
Rap guanine nucleotide exchange factor 1

1

0

High-throughput

0.518

High

1161232

MK06
Mitogen-activated protein kinase 6

1

0

High-throughput

0.518

High

1365006

TSC1
Hamartin

1

0

High-throughput

0.518

High

1398371

CEP63
Centrosomal protein of 63 kDa

1

0

High-throughput

0.518

High

1407675

MYD88
Myeloid differentiation primary response protein MyD88

1

0

High-throughput

0.518

High

1413204

CSN4
COP9 signalosome complex subunit 4

1

0

High-throughput

0.518

High

1417964

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

1

0

High-throughput

0.518

High

1445994

VTA1
Vacuolar protein sorting-associated protein VTA1 homolog

1

0

High-throughput

0.518

High

1449165

NINL
Ninein-like protein

1

0

High-throughput

0.518

High

995843

ACTC
Actin, alpha cardiac muscle 1

1

1

High-throughput

0.515

High

451282

NFL
Neurofilament light polypeptide

1

1

High-throughput

0.515

High

475020

VIME
Vimentin

1

1

High-throughput

0.515

High

1200654

Q548N1
Vacuolar protein sorting-associated protein 28 homolog

1

1

High-throughput

0.515

High

570995

MIF
Macrophage migration inhibitory factor

1

0

High-throughput

0.513

High

718016

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

1

0

High-throughput

0.513

High

931130

HSP72
Heat shock-related 70 kDa protein 2

1

0

High-throughput

0.513

High

961647

PHS
Pterin-4-alpha-carbinolamine dehydratase

1

0

High-throughput

0.513

High

997154

TBA4A
Tubulin alpha-4A chain

1

0

High-throughput

0.513

High

1013113

HMGN5
High mobility group nucleosome-binding domain-containing protein 5

1

0

High-throughput

0.513

High

1099795

MD2L1
Mitotic spindle assembly checkpoint protein MAD2A

1

0

High-throughput

0.513

High

1156337

HSPB2
Heat shock protein beta-2

1

0

High-throughput

0.513

High

1163237

H2B2E
Histone H2B type 2-E

1

0

High-throughput

0.513

High

1324599

PIAS4
E3 SUMO-protein ligase PIAS4

1

0

High-throughput

0.513

High

1357214

BRK1
Protein BRICK1

1

0

High-throughput

0.513

High

1367908

THRSP
Thyroid hormone-inducible hepatic protein

1

0

High-throughput

0.513

High

1439489

BRMS1
Breast cancer metastasis-suppressor 1

1

0

High-throughput

0.513

High

1449163

RUVB2
RuvB-like 2

1

0

High-throughput

0.513

High

1449171

RPC8
DNA-directed RNA polymerase III subunit RPC8

1

0

High-throughput

0.513

High

1154599

CC85B
Coiled-coil domain-containing protein 85B

1

1

High-throughput

0.494

High

1347393

LMO3
LIM domain only protein 3

1

2

High-throughput

0.494

High

1417710

DGC6L
Protein DGCR6L

1

2

High-throughput

0.494

High

1419303

TRI55
Tripartite motif-containing protein 55

1

1

High-throughput

0.494

High

231767

PEX1
Peroxisomal ATPase PEX1

1

0

High-throughput

0.493

High

301721

WFS1
Wolframin

1

0

High-throughput

0.493

High

593793

PECA1
Platelet endothelial cell adhesion molecule

1

0

High-throughput

0.493

High

631504

RAB5A
Ras-related protein Rab-5A

1

0

High-throughput

0.493

High

706329

S10A2
Protein S100-A2

1

1

High-throughput

0.489

High

71477

P20L1
PHD finger protein 20-like protein 1

1

2

High-throughput

0.479

High

175934

SET1A
Histone-lysine N-methyltransferase SETD1A

1

3

High-throughput

0.479

High

194618

KDM6A
Lysine-specific demethylase 6A

1

1

High-throughput

0.479

High

284987

TAF5L
TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L

1

3

High-throughput

0.479

High

581735

MYOD1
Myoblast determination protein 1

1

1

High-throughput

0.479

High

789582

PPARG
Peroxisome proliferator-activated receptor gamma

1

1

High-throughput

0.479

High

905494

HCFC1
Host cell factor 1

1

2

High-throughput

0.479

High

928353

ATN1
Atrophin-1

1

1

High-throughput

0.479

High

944752

KLF3
Krueppel-like factor 3

1

1

High-throughput

0.479

High

1041606

KMT2A
Histone-lysine N-methyltransferase 2A

1

3

High-throughput

0.479

High

1159339

TAF9
Transcription initiation factor TFIID subunit 9

1

1

High-throughput

0.479

High

1241510

EDC4
Enhancer of mRNA-decapping protein 4

1

1

High-throughput

0.479

High

1287327

TAD2B
Transcriptional adapter 2-beta

1

3

High-throughput

0.479

High

1338989

NUP43
Nucleoporin Nup43

1

3

High-throughput

0.479

High

1379957

LHX4
LIM/homeobox protein Lhx4

1

1

High-throughput

0.479

High

1415295

PHF20
PHD finger protein 20

1

3

High-throughput

0.479

High

1438398

TAF9B
Transcription initiation factor TFIID subunit 9B

1

1

High-throughput

0.479

High

1449148

CXXC1
CXXC-type zinc finger protein 1

1

2

High-throughput

0.479

High

1449149

KANL3
KAT8 regulatory NSL complex subunit 3

1

1

High-throughput

0.479

High

1449151

RERE
Arginine-glutamic acid dipeptide repeats protein

1

3

High-throughput

0.479

High

1449157

RCOR1
REST corepressor 1

1

1

High-throughput

0.479

High

1449161

KMT2B
Histone-lysine N-methyltransferase 2B

1

3

High-throughput

0.479

High

1449162

SET1B
Histone-lysine N-methyltransferase SETD1B

1

3

High-throughput

0.479

High

1449170

KLF12
Krueppel-like factor 12

1

1

High-throughput

0.479

High

1449173

HCFC2
Host cell factor 2

1

2

High-throughput

0.479

High

272759

BRE1B
E3 ubiquitin-protein ligase BRE1B

1

0

High-throughput

0.458

High

283627

SUPT3
Transcription initiation protein SPT3 homolog

1

0

High-throughput

0.458

High

319177

ST65G
STAGA complex 65 subunit gamma

1

0

High-throughput

0.458

High

577503

ETS1
Protein C-ets-1

1

0

High-throughput

0.458

High

590500

GATA1
Erythroid transcription factor

1

0

High-throughput

0.458

High

675700

TYY1
Transcriptional repressor protein YY1

1

0

High-throughput

0.458

High

834069

HNF4A
Hepatocyte nuclear factor 4-alpha

1

0

High-throughput

0.458

High

867450

CAPZB
F-actin-capping protein subunit beta

1

0

High-throughput

0.458

High

881612

CDK8
Cyclin-dependent kinase 8

1

0

High-throughput

0.458

High

961858

RL37A
Large ribosomal subunit protein eL43

1

0

High-throughput

0.458

High

980404

H4
Histone H4

1

0

High-throughput

0.458

High

1029160

E2F1
Transcription factor E2F1

1

0

High-throughput

0.458

High

1033263

EWS
RNA-binding protein EWS

1

0

High-throughput

0.458

High

1110117

HDAC1
Histone deacetylase 1

1

0

High-throughput

0.458

High

1133690

NFIX
Nuclear factor 1 X-type

1

0

High-throughput

0.458

High

1276109

KANL1
KAT8 regulatory NSL complex subunit 1

1

0

High-throughput

0.458

High

1290496

IQGA3
Ras GTPase-activating-like protein IQGAP3

1

0

High-throughput

0.458

High

1337588

SP20H
Transcription factor SPT20 homolog

1

0

High-throughput

0.458

High

1384453

PF21A
PHD finger protein 21A

1

0

High-throughput

0.458

High

1384792

TADA1
Transcriptional adapter 1

1

0

High-throughput

0.458

High

1390174

MCRS1
Microspherule protein 1

1

0

High-throughput

0.458

High

1428985

WWTR1
WW domain-containing transcription regulator protein 1

1

0

High-throughput

0.458

High

1435956

KAT8
Histone acetyltransferase KAT8

1

0

High-throughput

0.458

High

1437159

KANL2
KAT8 regulatory NSL complex subunit 2

1

0

High-throughput

0.458

High

1449150

HECW2
E3 ubiquitin-protein ligase HECW2

1

0

High-throughput

0.458

High

1449158

ZN608
Zinc finger protein 608

1

0

High-throughput

0.458

High

1449159

MED23
Mediator of RNA polymerase II transcription subunit 23

1

0

High-throughput

0.458

High

1449169

TRRAP
Transformation/transcription domain-associated protein

1

0

High-throughput

0.458

High

1449175

TAF6L
TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L

1

0

High-throughput

0.458

High

1324820

Q8N381
Phosphatidylinositol 3-kinase regulatory subunit gamma

1

1

High-throughput

0.451

High

1120881

DGCR6
Protein DGCR6

1

2

High-throughput

0.439

High

1380863

TRI63
E3 ubiquitin-protein ligase TRIM63

1

1

High-throughput

0.439

High

185241

FANCG
Fanconi anemia group G protein

1

0

High-throughput

0.438

High

1392929

NTAQ1
Protein N-terminal glutamine amidohydrolase

1

0

High-throughput

0.438

High

1449166

WDR37
WD repeat-containing protein 37

1

3

High-throughput

0.437

High

827494

MLH1
DNA mismatch repair protein Mlh1

1

0

High-throughput

0.426

High

903582

IDH3G
Isocitrate dehydrogenase [NAD] subunit gamma, mitochondrial

1

0

High-throughput

0.426

High

1449176

X5DP20
DiGeorge syndrome critical region 6 isoform D

1

2

High-throughput

0.417

High

1396488

Q96KY9
CDH19 protein

1

1

High-throughput

0.407

High

1436608

PKHF2
Pleckstrin homology domain-containing family F member 2

3

0

High-throughput

0.358

High

1200015

KLH26
Kelch-like protein 26

3

0

High-throughput

0.347

High

1237929

PHLB3
Pleckstrin homology-like domain family B member 3

3

0

High-throughput

0.347

High

1244013

F199X
Protein FAM199X

3

0

High-throughput

0.347

High

1257303

STXB4
Syntaxin-binding protein 4

3

0

High-throughput

0.347

High

1394269

GMCL1
Germ cell-less protein-like 1

3

0

High-throughput

0.347

High

1108861

BFSP2
Phakinin

2

0

High-throughput

0.341

High

51648

CBAR1
CBY1-interacting BAR domain-containing protein 1

2

0

High-throughput

0.328

High

1332441

CBY2
Protein chibby homolog 2

2

0

High-throughput

0.328

High

286729

STX11
Syntaxin-11

1

0

High-throughput

0.299

High

1130722

DIP2A
Disco-interacting protein 2 homolog A

1

0

High-throughput

0.299

High

1242700

KLC3
Kinesin light chain 3

1

0

High-throughput

0.299

High

1314290

DRC7
Dynein regulatory complex subunit 7

1

0

High-throughput

0.299

High

1323706

CRBG2
Beta/gamma crystallin domain-containing protein 2

1

0

High-throughput

0.279

Low

1402718

TCPQM
T-complex protein 1 subunit theta-like 2

1

0

High-throughput

0.279

Low

1431479

CAD23
Cadherin-23

1

0

High-throughput

0.279

Low

246154

KIF1B
Kinesin-like protein KIF1B

1

0

High-throughput

0.268

Low

650441

FGFR3
Fibroblast growth factor receptor 3

1

0

High-throughput

0.268

Low

1449174

Q9Y649
GW128

1

0

High-throughput

0.268

Low

1449155

XPO7
Exportin-7

1

0

High-throughput

0.249

Low

1449172

CD2AP
CD2-associated protein

1

0

High-throughput

0.238

Low

1449153

CLIP2
CAP-Gly domain-containing linker protein 2

1

0

High-throughput

0.232

Low

1449154

SEPT3
Neuronal-specific septin-3

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025