Protein: SIR4
NAD-dependent protein lipoamidase sirtuin-4, mitochondrial (EC 2.3.1.-) (NAD-dependent ADP-ribosyltransferase sirtuin-4) (EC 2.4.2.-) (NAD-dependent protein biotinylase sirtuin-4) (EC 2.3.1.-) (NAD-dependent protein deacetylase sirtuin-4) (EC 2.3.1.286) (Regulatory protein SIR2 homolog 4) (SIR2-like protein 4)

Gene: SIR4, SIRT4
Organism: Homo sapiens
Interactions: 115
UniProt ID: Q9Y6E7

Gene Ontology (top 5):
GO:0000820 - regulation of glutamine family amino acid metabolic process
GO:0003950 - NAD+ ADP-ribosyltransferase activity
GO:0004407 - histone deacetylase activity
GO:0005634 - nucleus
GO:0005739 - mitochondrion

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1345685

SIR3
NAD-dependent protein deacetylase sirtuin-3, mitochondrial

1

11

Small-scale

0.691

High

500259

CH60
60 kDa heat shock protein, mitochondrial

4

5

High-throughput

0.691

High

539871

IDE
Insulin-degrading enzyme

3

8

Small-scale

0.650

High

489844

ODP2
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial

1

5

High-throughput

0.586

High

890918

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

4

Small-scale

0.561

High

1031311

SKP2
S-phase kinase-associated protein 2

1

4

Small-scale

0.561

High

235013

SNX3
Sorting nexin-3

2

4

High-throughput

0.558

High

126290

ODPX
Pyruvate dehydrogenase protein X component, mitochondrial

1

5

High-throughput

0.550

High

397557

ADT2
ADP/ATP translocase 2

1

6

Small-scale

0.515

High

518545

ADT3
ADP/ATP translocase 3

1

6

Small-scale

0.515

High

176662

FANCA
Fanconi anemia group A protein

1

1

Small-scale

0.479

High

325957

LATS1
Serine/threonine-protein kinase LATS1

1

4

Small-scale

0.479

High

177587

BCAT2
Branched-chain-amino-acid aminotransferase, mitochondrial

1

0

Small-scale

0.458

High

59373

VWA8
von Willebrand factor A domain-containing protein 8

1

4

High-throughput

0.445

High

265096

MPPB
Mitochondrial-processing peptidase subunit beta

1

7

High-throughput

0.445

High

282174

CLPX
ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial

1

1

High-throughput

0.445

High

316533

ETHE1
Persulfide dioxygenase ETHE1, mitochondrial

1

1

High-throughput

0.445

High

330753

TOM40
Mitochondrial import receptor subunit TOM40 homolog

1

2

High-throughput

0.445

High

335225

DHE3
Glutamate dehydrogenase 1, mitochondrial

1

3

High-throughput

0.445

High

396514

ALDH2
Aldehyde dehydrogenase, mitochondrial

1

7

High-throughput

0.445

High

398317

PCCA
Propionyl-CoA carboxylase alpha chain, mitochondrial

1

14

High-throughput

0.445

High

451989

CN37
2',3'-cyclic-nucleotide 3'-phosphodiesterase

1

2

High-throughput

0.445

High

452934

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

1

High-throughput

0.445

High

505929

ODPB
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial

1

2

High-throughput

0.445

High

506090

ODB2
Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial

1

5

High-throughput

0.445

High

513653

PYC
Pyruvate carboxylase, mitochondrial

1

15

High-throughput

0.445

High

520774

ODBA
2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial

1

3

High-throughput

0.445

High

526470

HEM1
5-aminolevulinate synthase, non-specific, mitochondrial

1

4

High-throughput

0.445

High

615574

MAOM
NAD-dependent malic enzyme, mitochondrial

1

2

High-throughput

0.445

High

624013

THIL
Acetyl-CoA acetyltransferase, mitochondrial

1

1

High-throughput

0.445

High

642876

IVD
Isovaleryl-CoA dehydrogenase, mitochondrial

1

5

High-throughput

0.445

High

658200

NDUS1
NADH-ubiquinone oxidoreductase 75 kDa subunit, mitochondrial

1

2

High-throughput

0.445

High

666201

SHC1
SHC-transforming protein 1

1

2

High-throughput

0.445

High

671040

PRDX3
Thioredoxin-dependent peroxide reductase, mitochondrial

1

2

High-throughput

0.445

High

671552

ECHM
Enoyl-CoA hydratase, mitochondrial

1

5

High-throughput

0.445

High

687317

P5CR1
Pyrroline-5-carboxylate reductase 1, mitochondrial

1

3

High-throughput

0.445

High

713657

GLYM
Serine hydroxymethyltransferase, mitochondrial

1

1

High-throughput

0.445

High

729235

HMGCL
Hydroxymethylglutaryl-CoA lyase, mitochondrial

1

3

High-throughput

0.445

High

737543

LONM
Lon protease homolog, mitochondrial

1

2

High-throughput

0.445

High

739369

ODO2
Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex, mitochondrial

1

5

High-throughput

0.445

High

778349

ECHA
Trifunctional enzyme subunit alpha, mitochondrial

1

5

High-throughput

0.445

High

790105

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

2

High-throughput

0.445

High

822533

IDHP
Isocitrate dehydrogenase [NADP], mitochondrial

1

2

High-throughput

0.445

High

827677

EFTU
Elongation factor Tu, mitochondrial

1

6

High-throughput

0.445

High

832955

ACADV
Very long-chain specific acyl-CoA dehydrogenase, mitochondrial

1

5

High-throughput

0.445

High

873506

P5CS
Delta-1-pyrroline-5-carboxylate synthase

1

9

High-throughput

0.445

High

948774

RT09
Small ribosomal subunit protein uS9m

1

2

High-throughput

0.445

High

969562

ODO1
2-oxoglutarate dehydrogenase complex component E1

1

2

High-throughput

0.445

High

1014561

MPPA
Mitochondrial-processing peptidase subunit alpha

1

7

High-throughput

0.445

High

1020624

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

3

High-throughput

0.445

High

1022643

ECH1
Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial

1

5

High-throughput

0.445

High

1087893

PCKGM
Phosphoenolpyruvate carboxykinase [GTP], mitochondrial

1

1

High-throughput

0.445

High

1110329

AL1L2
Mitochondrial 10-formyltetrahydrofolate dehydrogenase

1

7

High-throughput

0.445

High

1116918

ACSF3
Malonate--CoA ligase ACSF3, mitochondrial

1

2

High-throughput

0.445

High

1127423

PREP
Presequence protease, mitochondrial

1

8

High-throughput

0.445

High

1128304

SYAM
Alanine--tRNA ligase, mitochondrial

1

2

High-throughput

0.445

High

1164737

C1TM
Monofunctional C1-tetrahydrofolate synthase, mitochondrial

1

1

High-throughput

0.445

High

1184114

DHX30
ATP-dependent RNA helicase DHX30

1

13

High-throughput

0.445

High

1185427

FAKD5
FAST kinase domain-containing protein 5, mitochondrial

1

1

High-throughput

0.445

High

1200105

NLRX1
NLR family member X1

1

3

High-throughput

0.445

High

1204155

NIT1
Deaminated glutathione amidase

1

1

High-throughput

0.445

High

1273140

GCDH
Glutaryl-CoA dehydrogenase, mitochondrial

1

5

High-throughput

0.445

High

1282906

FAKD4
FAST kinase domain-containing protein 4

1

1

High-throughput

0.445

High

1286387

P5CR2
Pyrroline-5-carboxylate reductase 2

1

3

High-throughput

0.445

High

1286929

ACSF2
Medium-chain acyl-CoA ligase ACSF2, mitochondrial

1

2

High-throughput

0.445

High

1290685

PTCD3
Small ribosomal subunit protein mS39

1

1

High-throughput

0.445

High

1294428

SUCB2
Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial

1

4

High-throughput

0.445

High

1301307

MCCA
Methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial

1

16

High-throughput

0.445

High

1305868

HCD2
3-hydroxyacyl-CoA dehydrogenase type-2

1

1

High-throughput

0.445

High

1333425

ACAD9
Complex I assembly factor ACAD9, mitochondrial

1

5

High-throughput

0.445

High

1335937

MCCB
Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial

1

5

High-throughput

0.445

High

1342459

SYSM
Serine--tRNA ligase, mitochondrial

1

3

High-throughput

0.445

High

1345566

SYIM
Isoleucine--tRNA ligase, mitochondrial

1

2

High-throughput

0.445

High

1349584

PDP1
[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial

1

4

High-throughput

0.445

High

1350553

SUCB1
Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial

1

4

High-throughput

0.445

High

1354188

HDAC6
Histone deacetylase 6

1

9

High-throughput

0.445

High

1355559

NB5R1
NADH-cytochrome b5 reductase 1

1

2

High-throughput

0.445

High

1356215

STML2
Stomatin-like protein 2, mitochondrial

1

1

High-throughput

0.445

High

1378177

RT18B
Small ribosomal subunit protein mS40

1

1

High-throughput

0.445

High

233798

NDK8
Putative nucleoside diphosphate kinase

1

0

High-throughput

0.426

High

259195

NDUS2
NADH dehydrogenase [ubiquinone] iron-sulfur protein 2, mitochondrial

1

0

High-throughput

0.426

High

324945

DCMC
Malonyl-CoA decarboxylase, mitochondrial

1

0

High-throughput

0.426

High

422649

GPX1
Glutathione peroxidase 1

1

0

High-throughput

0.426

High

533573

ETFA
Electron transfer flavoprotein subunit alpha, mitochondrial

1

0

High-throughput

0.426

High

670871

PRDX5
Peroxiredoxin-5, mitochondrial

1

0

High-throughput

0.426

High

736196

HEM6
Oxygen-dependent coproporphyrinogen-III oxidase, mitochondrial

1

0

High-throughput

0.426

High

782975

GARS
Glycine--tRNA ligase

1

0

High-throughput

0.426

High

835282

NDUV1
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial

1

0

High-throughput

0.426

High

846286

RT29
Small ribosomal subunit protein mS29

1

0

High-throughput

0.426

High

947022

RT22
Small ribosomal subunit protein mS22

1

0

High-throughput

0.426

High

1024003

RM28
Large ribosomal subunit protein bL28m

1

0

High-throughput

0.426

High

1116683

NAKD2
NAD kinase 2, mitochondrial

1

0

High-throughput

0.426

High

1132584

SYRM
Probable arginine--tRNA ligase, mitochondrial

1

0

High-throughput

0.426

High

1133212

CAF17
Putative transferase CAF17, mitochondrial

1

0

High-throughput

0.426

High

1154313

PDE12
2',5'-phosphodiesterase 12

1

0

High-throughput

0.426

High

1217575

MMAA
Methylmalonic aciduria type A protein, mitochondrial

1

0

High-throughput

0.426

High

1244351

FAD1
FAD synthase

1

0

High-throughput

0.426

High

1254457

ALAT2
Alanine aminotransferase 2

1

0

High-throughput

0.426

High

1288740

RM38
Large ribosomal subunit protein mL38

1

0

High-throughput

0.426

High

1306472

MIPEP
Mitochondrial intermediate peptidase

1

0

High-throughput

0.426

High

1311365

CQ080
Mitochondrial nucleoid-associated protein 1

1

0

High-throughput

0.426

High

1315846

HDHD5
Haloacid dehalogenase-like hydrolase domain-containing 5

1

0

High-throughput

0.426

High

1316650

RM01
Large ribosomal subunit protein uL1m

1

0

High-throughput

0.426

High

1317877

RM37
Large ribosomal subunit protein mL37

1

0

High-throughput

0.426

High

1329707

IPYR2
Inorganic pyrophosphatase 2, mitochondrial

1

0

High-throughput

0.426

High

1334344

RM44
Large ribosomal subunit protein mL44

1

0

High-throughput

0.426

High

1342501

RT30
Large ribosomal subunit protein mL65

1

0

High-throughput

0.426

High

1348565

RM39
Large ribosomal subunit protein mL39

1

0

High-throughput

0.426

High

1356805

DNPEP
Aspartyl aminopeptidase

1

0

High-throughput

0.426

High

1377494

ACOT9
Acyl-coenzyme A thioesterase 9, mitochondrial

1

0

High-throughput

0.426

High

1377680

RT23
Small ribosomal subunit protein mS23

1

0

High-throughput

0.426

High

277222

AL1L1
Cytosolic 10-formyltetrahydrofolate dehydrogenase

1

7

High-throughput

0.407

High

1200807

NT5D3
5'-nucleotidase domain-containing protein 3

1

1

High-throughput

0.407

High

1333446

NT5D2
5'-nucleotidase domain-containing protein 2

1

1

High-throughput

0.407

High

1223455

THNS1
Threonine synthase-like 1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024