Protein: T22D1
TSC22 domain family protein 1 (Cerebral protein 2) (HUCEP-2) (Regulatory protein TSC-22) (TGFB-stimulated clone 22 homolog) (Transforming growth factor beta-1-induced transcript 4 protein)

Gene: T22D1, TSC22D1
Organism: Homo sapiens
Interactions: 199
UniProt ID: Q15714

Gene Ontology (top 5):
GO:0003713 - transcription coactivator activity
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005739 - mitochondrion
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1152503

T22D4
TSC22 domain family protein 4

4

14

High-throughput

0.892

High

1152461

T22D3
TSC22 domain family protein 3

3

10

High-throughput

0.861

High

1152424

T22D1
TSC22 domain family protein 1

2

16

High-throughput

0.801

High

1152490

NRBP
Nuclear receptor-binding protein

6

18

Small-scale

0.734

High

1152455

NTAQ1
Protein N-terminal glutamine amidohydrolase

4

0

High-throughput

0.668

High

1152479

CAH10
Carbonic anhydrase-related protein 10

4

1

High-throughput

0.630

High

907317

APLP1
Amyloid beta precursor like protein 1

2

4

High-throughput

0.620

High

1139713

SETB1
Histone-lysine N-methyltransferase SETDB1

2

14

High-throughput

0.620

High

1152467

CC90B
Coiled-coil domain-containing protein 90B, mitochondrial

2

0

High-throughput

0.594

High

1147164

ELOB
Elongin-B

2

2

High-throughput

0.584

High

787399

TGFR1
TGF-beta receptor type-1

1

6

Small-scale

0.573

High

1152472

GORS2
Golgi reassembly-stacking protein 2

2

7

High-throughput

0.553

High

413903

P53
Cellular tumor antigen p53

1

13

Small-scale

0.552

High

567407

TCTP
Translationally-controlled tumor protein

1

0

Small-scale

0.549

High

563819

CFTR
Cystic fibrosis transmembrane conductance regulator

1

5

High-throughput

0.541

High

1087708

M3K12
Mitogen-activated protein kinase kinase kinase 12

1

18

High-throughput

0.541

High

1152497

COR2B
Coronin-2B

1

20

High-throughput

0.541

High

390052

ALBU
Albumin

1

1

High-throughput

0.536

High

764782

CTNB1
Catenin beta-1

1

19

High-throughput

0.536

High

944388

SYJ2B
Synaptojanin-2-binding protein

1

6

High-throughput

0.536

High

1152464

GNL3
Guanine nucleotide-binding protein-like 3

1

1

Small-scale

0.536

High

1152468

ADA19
Disintegrin and metalloproteinase domain-containing protein 19

1

9

High-throughput

0.536

High

1152480

NRBP2
Nuclear receptor-binding protein 2

1

20

High-throughput

0.536

High

1061668

RGS1
Regulator of G-protein signaling 1

1

0

High-throughput

0.518

High

1108784

ASAH1
Acid ceramidase

1

0

High-throughput

0.518

High

667874

CDK2
Cyclin-dependent kinase 2

1

4

High-throughput

0.515

High

773517

COPB2
Coatomer subunit beta'

1

6

High-throughput

0.515

High

856707

BAG6
Large proline-rich protein BAG6

1

14

High-throughput

0.515

High

910529

HNRPM
Heterogeneous nuclear ribonucleoprotein M

1

6

High-throughput

0.515

High

945800

EPIPL
Epiplakin

1

4

High-throughput

0.515

High

1123912

DYHC1
Cytoplasmic dynein 1 heavy chain 1

1

2

High-throughput

0.515

High

1152441

NUP93
Nuclear pore complex protein Nup93

1

1

High-throughput

0.515

High

1152449

GCN1
Stalled ribosome sensor GCN1

1

8

High-throughput

0.515

High

1152473

GHC1
Mitochondrial glutamate carrier 1

1

1

High-throughput

0.515

High

1152474

SFXN1
Sideroflexin-1

1

1

High-throughput

0.515

High

1152506

SRPRB
Signal recognition particle receptor subunit beta

1

1

High-throughput

0.515

High

422156

A4
Amyloid-beta precursor protein

1

5

High-throughput

0.515

High

139710

CAC1A
Voltage-dependent P/Q-type calcium channel subunit alpha-1A

1

1

High-throughput

0.508

High

163641

GNB5
Guanine nucleotide-binding protein subunit beta-5

1

13

High-throughput

0.508

High

245702

GANP
Germinal-center associated nuclear protein

1

10

High-throughput

0.508

High

284950

TAF5L
TAF5-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 5L

1

18

High-throughput

0.508

High

285304

EED
Polycomb protein EED

1

20

High-throughput

0.508

High

344941

WIZ
Protein Wiz

1

1

High-throughput

0.508

High

350295

DDAH2
Putative hydrolase DDAH2

1

1

High-throughput

0.508

High

474698

VIME
Vimentin

1

6

High-throughput

0.508

High

539183

ODPB
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial

1

2

High-throughput

0.508

High

835679

KPCI
Protein kinase C iota type

1

9

High-throughput

0.508

High

859297

RL5
Large ribosomal subunit protein uL18

1

3

High-throughput

0.508

High

868174

SYQ
Glutamine--tRNA ligase

1

1

High-throughput

0.508

High

906671

UB2D1
Ubiquitin-conjugating enzyme E2 D1

1

3

High-throughput

0.508

High

984122

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

13

High-throughput

0.508

High

1047826

TLE1
Transducin-like enhancer protein 1

1

19

High-throughput

0.508

High

1088365

CHD3
Chromodomain-helicase-DNA-binding protein 3

1

6

High-throughput

0.508

High

1123197

DPYL1
Dihydropyrimidinase-related protein 1

1

4

High-throughput

0.508

High

1152436

SPRE1
Sprouty-related, EVH1 domain-containing protein 1

1

1

High-throughput

0.508

High

1152445

KMT2C
Histone-lysine N-methyltransferase 2C

1

20

High-throughput

0.508

High

1152476

SP110
Sp110 nuclear body protein

1

20

High-throughput

0.508

High

1152493

KMT2B
Histone-lysine N-methyltransferase 2B

1

20

High-throughput

0.508

High

1152496

FAF1
FAS-associated factor 1

1

2

High-throughput

0.508

High

1152426

NDUA9
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9, mitochondrial

1

0

High-throughput

0.493

High

1152438

DAAF5
Dynein axonemal assembly factor 5

1

0

High-throughput

0.493

High

1152463

METH
Methionine synthase

1

0

High-throughput

0.493

High

1152500

GSTK1
Glutathione S-transferase kappa 1

1

0

High-throughput

0.493

High

1105129

U119A
Protein unc-119 homolog A

1

0

High-throughput

0.486

High

1152433

WDR73
Integrator complex assembly factor WDR73

1

0

High-throughput

0.486

High

1152437

ZC3C1
Zinc finger C3HC-type protein 1

1

0

High-throughput

0.486

High

1152453

SACA9
Sperm acrosome-associated protein 9

1

0

High-throughput

0.486

High

1152454

OTUB1
Ubiquitin thioesterase OTUB1

1

0

High-throughput

0.486

High

1152487

DNM3B
DNA

1

0

High-throughput

0.486

High

1152502

CHSP1
Calcium-regulated heat-stable protein 1

1

0

High-throughput

0.486

High

407455

K2C1
Keratin, type II cytoskeletal 1

1

1

Small-scale

0.484

High

1152470

WNK1
Serine/threonine-protein kinase WNK1

1

20

High-throughput

0.481

High

60141

A2J422
Anti-HER3 scFv

1

1

High-throughput

0.479

High

124357

HAX1
HCLS1-associated protein X-1

1

1

High-throughput

0.479

High

128536

BMR1B
Bone morphogenetic protein receptor type-1B

1

7

Small-scale

0.479

High

177685

SMAD7
Mothers against decapentaplegic homolog 7

1

15

Small-scale

0.479

High

215570

EMC8
ER membrane protein complex subunit 8

1

1

High-throughput

0.479

High

219865

SMAD6
Mothers against decapentaplegic homolog 6

1

15

Small-scale

0.479

High

227883

MYO1B
Unconventional myosin-Ib

1

9

High-throughput

0.479

High

255429

SNX2
Sorting nexin-2

1

2

High-throughput

0.479

High

255638

DPM1
Dolichol-phosphate mannosyltransferase subunit 1

1

3

High-throughput

0.479

High

274593

DNJB6
DnaJ homolog subfamily B member 6

1

2

High-throughput

0.479

High

281212

CDC45
Cell division control protein 45 homolog

1

2

High-throughput

0.479

High

318327

MYO1D
Unconventional myosin-Id

1

9

High-throughput

0.479

High

415592

HSPB1
Heat shock protein beta-1

1

3

High-throughput

0.479

High

551060

PCNA
Proliferating cell nuclear antigen

1

3

High-throughput

0.479

High

633690

PSB1
Proteasome subunit beta type-1

1

6

High-throughput

0.479

High

651339

CBL
E3 ubiquitin-protein ligase CBL

1

12

High-throughput

0.479

High

669909

MCM3
DNA replication licensing factor MCM3

1

2

High-throughput

0.479

High

786103

LONM
Lon protease homolog, mitochondrial

1

5

High-throughput

0.479

High

787170

BMR1A
Bone morphogenetic protein receptor type-1A

1

6

Small-scale

0.479

High

787299

ACV1B
Activin receptor type-1B

1

6

Small-scale

0.479

High

788459

ACVL1
Activin receptor type-1-like

1

6

Small-scale

0.479

High

788928

TGFR2
TGF-beta receptor type-2

1

6

Small-scale

0.479

High

829088

RFC5
Replication factor C subunit 5

1

3

High-throughput

0.479

High

834456

SYIC
Isoleucine--tRNA ligase, cytoplasmic

1

3

High-throughput

0.479

High

860213

RS9
Small ribosomal subunit protein uS4

1

1

High-throughput

0.479

High

883906

CENPF
Centromere protein F

1

16

High-throughput

0.479

High

925540

MOT1
Monocarboxylate transporter 1

1

1

High-throughput

0.479

High

972423

RS14
Small ribosomal subunit protein uS11

1

2

High-throughput

0.479

High

991995

RL38
Large ribosomal subunit protein eL38

1

1

High-throughput

0.479

High

1004610

RNF4
E3 ubiquitin-protein ligase RNF4

1

4

High-throughput

0.479

High

1010993

CRUM1
Protein crumbs homolog 1

1

6

High-throughput

0.479

High

1048358

ACVR1
Activin receptor type-1

1

6

Small-scale

0.479

High

1113192

CUL3
Cullin-3

1

13

High-throughput

0.479

High

1114842

CUL4A
Cullin-4A

1

13

High-throughput

0.479

High

1143129

PLEC
Plectin

1

3

High-throughput

0.479

High

1146679

PCBP1
Poly(rC)-binding protein 1

1

6

High-throughput

0.479

High

1147034

ELOC
Elongin-C

1

2

High-throughput

0.479

High

1152425

DDB1
DNA damage-binding protein 1

1

4

High-throughput

0.479

High

1152427

TIM50
Mitochondrial import inner membrane translocase subunit TIM50

1

1

High-throughput

0.479

High

1152432

SFXN4
Sideroflexin-4

1

1

High-throughput

0.479

High

1152447

RBCC1
RB1-inducible coiled-coil protein 1

1

19

High-throughput

0.479

High

1152451

USP9X
Ubiquitin carboxyl-terminal hydrolase 9X

1

9

High-throughput

0.479

High

1152452

FAKD4
FAST kinase domain-containing protein 4

1

1

High-throughput

0.479

High

1152458

IPO9
Importin-9

1

2

High-throughput

0.479

High

1152460

MMS19
MMS19 nucleotide excision repair protein homolog

1

1

High-throughput

0.479

High

1152462

PHB2
Prohibitin-2

1

3

High-throughput

0.479

High

1152469

EHD4
EH domain-containing protein 4

1

3

High-throughput

0.479

High

1152475

XPO5
Exportin-5

1

9

High-throughput

0.479

High

1152483

RFOX1
RNA binding protein fox-1 homolog 1

1

9

High-throughput

0.479

High

1152484

FAKD2
FAST kinase domain-containing protein 2, mitochondrial

1

1

High-throughput

0.479

High

1152488

DIC
Mitochondrial dicarboxylate carrier

1

1

High-throughput

0.479

High

1152491

XPO7
Exportin-7

1

8

High-throughput

0.479

High

1152494

PRP19
Pre-mRNA-processing factor 19

1

16

High-throughput

0.479

High

1152495

MAGD2
Melanoma-associated antigen D2

1

6

High-throughput

0.479

High

1152505

LAS1L
Ribosomal biogenesis protein LAS1L

1

1

High-throughput

0.479

High

1152508

COPG1
Coatomer subunit gamma-1

1

11

High-throughput

0.479

High

768282

RFA3
Replication protein A 14 kDa subunit

1

8

High-throughput

0.470

High

1152444

EMC1
ER membrane protein complex subunit 1

1

1

High-throughput

0.470

High

1152429

LRIF1
Ligand-dependent nuclear receptor-interacting factor 1

1

1

High-throughput

0.464

High

1152435

FBN3
Fibrillin-3 [Cleaved into: Fibrillin-3 C-terminal peptide]

1

4

High-throughput

0.464

High

1152489

HMGX4
HMG domain-containing protein 4

1

20

High-throughput

0.464

High

1152492

ERG28
Ergosterol biosynthetic protein 28 homolog

1

1

High-throughput

0.464

High

636736

PTN
Pleiotrophin

1

0

High-throughput

0.460

High

137722

NDUA4
Cytochrome c oxidase subunit NDUFA4

1

0

High-throughput

0.458

High

211794

ZW10
Centromere/kinetochore protein zw10 homolog

1

0

High-throughput

0.458

High

299652

ATP5L
ATP synthase F(0) complex subunit g, mitochondrial

1

0

High-throughput

0.458

High

301901

CLPX
ATP-dependent clpX-like chaperone, mitochondrial

1

0

High-throughput

0.458

High

467499

4F2
Amino acid transporter heavy chain SLC3A2

1

0

High-throughput

0.458

High

873234

COPD
Coatomer subunit delta

1

0

High-throughput

0.458

High

944480

GEMI4
Gem-associated protein 4

1

0

High-throughput

0.458

High

1122008

EFR3A
Protein EFR3 homolog A

1

0

High-throughput

0.458

High

1135966

MELT
Ventricular zone-expressed PH domain-containing protein homolog 1

1

0

High-throughput

0.458

High

1152430

MIC13
MICOS complex subunit MIC13

1

0

High-throughput

0.458

High

1152434

C1TM
Monofunctional C1-tetrahydrofolate synthase, mitochondrial

1

0

High-throughput

0.458

High

1152439

MFN1
Mitofusin-1

1

0

High-throughput

0.458

High

1152448

MAIP1
m-AAA protease-interacting protein 1, mitochondrial

1

0

High-throughput

0.458

High

1152456

ATPMK
ATP synthase F(0) complex subunit k, mitochondrial

1

0

High-throughput

0.458

High

1152459

OR4CC
Olfactory receptor 4C12

1

0

High-throughput

0.458

High

1152466

UCK2
Uridine-cytidine kinase 2

1

0

High-throughput

0.458

High

1152482

FANCI
Fanconi anemia group I protein

1

0

High-throughput

0.458

High

1152499

HIG1A
HIG1 domain family member 1A, mitochondrial

1

0

High-throughput

0.458

High

1152501

PDIP2
Polymerase delta-interacting protein 2

1

0

High-throughput

0.458

High

1152504

TELO2
Telomere length regulation protein TEL2 homolog

1

0

High-throughput

0.458

High

1152507

GMPPB
Mannose-1-phosphate guanylyltransferase catalytic subunit beta

1

0

High-throughput

0.458

High

993587

UBC9
SUMO-conjugating enzyme UBC9

1

6

High-throughput

0.457

High

485165

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

10

Small-scale

0.445

High

521709

H14
Histone H1.4

1

6

Small-scale

0.445

High

529860

TAU
Microtubule-associated protein tau

1

20

High-throughput

0.445

High

586713

RS2
Small ribosomal subunit protein uS5

1

1

Small-scale

0.445

High

592844

CBR1
Carbonyl reductase [NADPH] 1

1

2

Small-scale

0.445

High

596120

H12
Histone H1.2

1

6

Small-scale

0.445

High

634459

LMNB1
Lamin-B1

1

7

Small-scale

0.445

High

649323

H1T
Histone H1t

1

6

Small-scale

0.445

High

688010

EF1G
Elongation factor 1-gamma

1

3

Small-scale

0.445

High

772003

K1C9
Keratin, type I cytoskeletal 9

1

1

Small-scale

0.445

High

934661

TERA
Transitional endoplasmic reticulum ATPase

1

3

High-throughput

0.445

High

952841

ACTB
Actin, cytoplasmic 1

1

17

Small-scale

0.445

High

978963

RS6
Small ribosomal subunit protein eS6

1

3

Small-scale

0.445

High

1007701

RAE1L
mRNA export factor RAE1

1

16

High-throughput

0.445

High

1152428

KLH22
Kelch-like protein 22

1

5

High-throughput

0.445

High

1152450

RND1
Rho-related GTP-binding protein Rho6

1

18

Small-scale

0.445

High

1152457

UBP47
Ubiquitin carboxyl-terminal hydrolase 47

1

10

Small-scale

0.445

High

1152465

CHM4A
Charged multivesicular body protein 4a

1

3

Small-scale

0.445

High

1152471

PKHG2
Pleckstrin homology domain-containing family G member 2

1

4

Small-scale

0.445

High

1152481

DDX28
Probable ATP-dependent RNA helicase DDX28

1

6

High-throughput

0.445

High

418147

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

1

High-throughput

0.437

High

963068

S61A1
Protein transport protein Sec61 subunit alpha isoform 1

1

1

High-throughput

0.437

High

1152431

TTC27
Tetratricopeptide repeat protein 27

1

16

High-throughput

0.437

High

1152486

HACD3
Very-long-chain

1

1

High-throughput

0.437

High

1152498

DHDH
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase

1

1

High-throughput

0.437

High

408894

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

0

Small-scale

0.426

High

643861

FBRL
rRNA 2'-O-methyltransferase fibrillarin

1

0

Small-scale

0.426

High

835252

PACR
Pituitary adenylate cyclase-activating polypeptide type I receptor

1

0

Small-scale

0.426

High

1131940

PTCA
Protein tyrosine phosphatase receptor type C-associated protein

1

0

Small-scale

0.426

High

1152442

FA24B
Protein FAM24B

1

0

High-throughput

0.279

Low

369676

A2MG
Alpha-2-macroglobulin

1

0

High-throughput

0.265

Low

1152440

FA20C
Extracellular serine/threonine protein kinase FAM20C

1

0

High-throughput

0.265

Low

1152477

NCOA5
Nuclear receptor coactivator 5

1

0

High-throughput

0.265

Low

895562

SERPH
Serpin H1

1

0

High-throughput

0.249

Low

903705

SSRD
Translocon-associated protein subunit delta

1

0

High-throughput

0.249

Low

944260

TMM33
Transmembrane protein 33

1

0

High-throughput

0.249

Low

1152443

KTAP2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit KCP2

1

0

High-throughput

0.249

Low

1152446

TOIP2
Torsin-1A-interacting protein 2

1

0

High-throughput

0.249

Low

1152478

OSTC
Oligosaccharyltransferase complex subunit OSTC

1

0

High-throughput

0.249

Low

1152485

TAP26
Thyroid transcription factor 1-associated protein 26

1

0

High-throughput

0.249

Low

1010626

DCD
Dermcidin

1

0

Small-scale

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025