Protein: HES1
Transcription factor HES-1 (Class B basic helix-loop-helix protein 39) (bHLHb39) (Hairy and enhancer of split 1) (Hairy homolog) (Hairy-like protein) (hHL)

Gene: HES1
Organism: Homo sapiens
Interactions: 47
UniProt ID: Q14469

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001222 - transcription corepressor binding
GO:0001227 - DNA-binding transcription repressor activity, RNA polymerase II-specific

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1054251

HEY1
Hairy/enhancer-of-split related with YRPW motif protein 1

4

18

Small-scale

0.893

High

1054244

HES6
Transcription cofactor HES-6

2

17

Small-scale

0.789

High

1054239

HES1
Transcription factor HES-1

2

17

Small-scale

0.737

High

971833

HEN2
Helix-loop-helix protein 2

1

20

Small-scale

0.724

High

980604

TLE1
Transducin-like enhancer protein 1

5

20

Small-scale

0.711

High

1044537

FHL1
Four and a half LIM domains protein 1

1

1

High-throughput

0.656

High

1054249

HEY2
Hairy/enhancer-of-split related with YRPW motif protein 2

1

18

Small-scale

0.647

High

986907

SUH
Recombining binding protein suppressor of hairless

3

1

Small-scale

0.633

High

1054241

LMO3
LIM domain only protein 3

1

4

Small-scale

0.618

High

1054245

FANCE
Fanconi anemia group E protein

3

0

Small-scale

0.613

High

174394

FANCG
Fanconi anemia group G protein

2

0

Small-scale

0.593

High

176602

FANCA
Fanconi anemia group A protein

2

0

Small-scale

0.593

High

1054246

FANCF
Fanconi anemia group F protein

2

0

Small-scale

0.593

High

776683

STAT3
Signal transducer and activator of transcription 3

1

3

Small-scale

0.578

High

1054243

SIR1
NAD-dependent protein deacetylase sirtuin-1

1

5

Small-scale

0.578

High

1047410

RUNX2
Runt-related transcription factor 2

2

0

Small-scale

0.569

High

414286

RB
Retinoblastoma-associated protein

1

0

Small-scale

0.537

High

1054247

FANCL
E3 ubiquitin-protein ligase FANCL

1

0

Small-scale

0.529

High

980686

TLE2
Transducin-like enhancer protein 2

1

20

Small-scale

0.527

High

611440

NR4A1
Nuclear receptor subfamily 4immunitygroup A member 1

1

3

High-throughput

0.508

High

830357

KC1E
Casein kinase I isoform epsilon

1

3

High-throughput

0.508

High

983613

FAK1
Focal adhesion kinase 1

1

2

High-throughput

0.508

High

1054248

HDAC6
Histone deacetylase 6

1

7

High-throughput

0.508

High

329103

NUDT3
Diphosphoinositol polyphosphate phosphohydrolase 1

1

0

High-throughput

0.486

High

362430

SAMP
Serum amyloid P-component

1

0

High-throughput

0.486

High

381983

G3P
Glyceraldehyde-3-phosphate dehydrogenase

1

0

High-throughput

0.486

High

683345

1433B
14-3-3 protein beta/alpha

1

0

High-throughput

0.486

High

1054242

APH1A
Gamma-secretase subunit APH-1A

1

1

High-throughput

0.481

High

238409

JAK2
Tyrosine-protein kinase JAK2

1

2

Small-scale

0.479

High

431854

HS90A
Heat shock protein HSP 90-alpha

1

2

Small-scale

0.479

High

455436

PARP1
Poly [ADP-ribose] polymerase 1

1

1

Small-scale

0.479

High

569724

CEBPB
CCAAT/enhancer-binding protein beta

1

5

Small-scale

0.479

High

714224

HSP74
Heat shock 70 kDa protein 4

1

4

Small-scale

0.479

High

928909

SKP1
S-phase kinase-associated protein 1

1

2

Small-scale

0.479

High

1038375

HDAC1
Histone deacetylase 1

1

6

Small-scale

0.479

High

1054240

FXL14
F-box/LRR-repeat protein 14

1

1

Small-scale

0.479

High

303237

HEXI1
Protein HEXIM1

1

0

High-throughput

0.458

High

475756

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

0

Small-scale

0.458

High

960689

FANCC
Fanconi anemia group C protein

1

0

Small-scale

0.458

High

1037932

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

1

0

Small-scale

0.458

High

1040979

CUL1
Cullin-1

1

0

Small-scale

0.458

High

1054250

ALK
ALK tyrosine kinase receptor

1

1

Small-scale

0.457

High

1045409

SPTN1
Spectrin alpha chain, non-erythrocytic 1

1

1

Small-scale

0.437

High

729217

HMGCL
Hydroxymethylglutaryl-CoA lyase, mitochondrial

1

0

High-throughput

0.265

Low

426831

ASGR2
Asialoglycoprotein receptor 2

1

0

High-throughput

0.251

Low

738664

TNR3
Tumor necrosis factor receptor superfamily member 3

1

0

High-throughput

0.251

Low


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Last updated: 15 Jul 2024