Protein: INT4
Integrator complex subunit 4 (Int4)

Gene: INT4, INTS4
Organism: Homo sapiens
Interactions: 111
UniProt ID: Q96HW7

Gene Ontology (top 5):
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005730 - nucleolus
GO:0005737 - cytoplasm
GO:0016180 - snRNA processing

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

994338

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

3

1

High-throughput

0.871

High

1393578

INT9
Integrator complex subunit 9

3

3

Small-scale

0.861

High

717937

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

3

0

High-throughput

0.827

High

1215003

INT11
Integrator complex subunit 11

2

3

Small-scale

0.776

High

1393577

BMP2K
BMP-2-inducible protein kinase

2

0

High-throughput

0.770

High

1323827

INT1
Integrator complex subunit 1

2

0

High-throughput

0.716

High

977563

PP2AB
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform

1

1

High-throughput

0.691

High

218627

TGON2
Trans-Golgi network integral membrane protein 2

4

0

High-throughput

0.661

High

1386318

FAF2
FAS-associated factor 2

3

0

High-throughput

0.638

High

1393591

VSIG4
V-set and immunoglobulin domain-containing protein 4

4

1

High-throughput

0.630

High

1293890

VSIG1
V-set and immunoglobulin domain-containing protein 1

3

1

High-throughput

0.604

High

1330730

SIGL1
SIGLEC family-like protein 1

3

1

High-throughput

0.604

High

1243322

INT5
Integrator complex subunit 5

1

0

High-throughput

0.586

High

130576

SPT5H
Transcription elongation factor SPT5

2

0

High-throughput

0.585

High

1393572

MEIS3
Homeobox protein Meis3

2

0

High-throughput

0.580

High

1393584

LHX3
LIM/homeobox protein Lhx3

2

0

High-throughput

0.580

High

344769

AP2A1
AP-2 complex subunit alpha-1

2

1

High-throughput

0.574

High

1349408

ADA32
Disintegrin and metalloproteinase domain-containing protein 32

2

1

High-throughput

0.574

High

1393585

CLC2D
C-type lectin domain family 2 member D

2

2

High-throughput

0.574

High

1393580

INT10
Integrator complex subunit 10

2

0

Small-scale

0.559

High

1393587

INT6
Integrator complex subunit 6

2

0

Small-scale

0.559

High

1101299

SLAF1
Signaling lymphocytic activation molecule

2

1

High-throughput

0.558

High

1290263

Q86V94
LOC554223 protein

2

2

High-throughput

0.558

High

1338543

ZMIZ2
Zinc finger MIZ domain-containing protein 2

1

0

High-throughput

0.549

High

954729

SEM1
26S proteasome complex subunit SEM1

2

0

Small-scale

0.547

High

539627

PYGM
Glycogen phosphorylase, muscle form

1

0

High-throughput

0.518

High

157732

CTRO
Citron Rho-interacting kinase

1

0

High-throughput

0.517

High

231002

TYOBP
TYRO protein tyrosine kinase-binding protein

1

0

High-throughput

0.513

High

484201

PGFRB
Platelet-derived growth factor receptor beta

1

0

High-throughput

0.513

High

486603

TACD2
Tumor-associated calcium signal transducer 2

1

0

High-throughput

0.513

High

621935

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

1

0

High-throughput

0.513

High

723051

RPB2
DNA-directed RNA polymerase II subunit RPB2

1

0

High-throughput

0.513

High

923522

RPAB4
DNA-directed RNA polymerases I, II, and III subunit RPABC4

1

0

High-throughput

0.513

High

959028

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

1

0

High-throughput

0.513

High

968650

NCS1
Neuronal calcium sensor 1

1

0

High-throughput

0.513

High

1022935

EFNB1
Ephrin-B1

1

0

High-throughput

0.513

High

1065360

SSRP1
FACT complex subunit SSRP1

1

0

High-throughput

0.513

High

1199818

AGK
Acylglycerol kinase, mitochondrial

1

0

High-throughput

0.513

High

1393570

INT14
Integrator complex subunit 14

1

0

High-throughput

0.513

High

1393574

SOSB1
SOSS complex subunit B1

1

0

High-throughput

0.513

High

380123

HLAB
HLA class I histocompatibility antigen, B alpha chain

2

1

High-throughput

0.504

High

188597

SIGL5
Sialic acid-binding Ig-like lectin 5

1

1

High-throughput

0.489

High

270219

ADA11
Disintegrin and metalloproteinase domain-containing protein 11

1

1

High-throughput

0.489

High

323767

AP2A2
AP-2 complex subunit alpha-2

1

1

High-throughput

0.489

High

380651

DQB1
HLA class II histocompatibility antigen, DQ beta 1 chain

1

2

High-throughput

0.489

High

520966

HLAC
HLA class I histocompatibility antigen, C alpha chain

1

1

High-throughput

0.489

High

1090107

KLRB1
Killer cell lectin-like receptor subfamily B member 1

1

3

High-throughput

0.489

High

1355998

CLC4C
C-type lectin domain family 4 member C

1

2

High-throughput

0.489

High

1393588

CLC4E
C-type lectin domain family 4 member E

1

2

High-throughput

0.489

High

520288

ANDR
Androgen receptor

1

1

High-throughput

0.479

High

1048061

TLE3
Transducin-like enhancer protein 3

1

1

High-throughput

0.479

High

1340779

COP1
E3 ubiquitin-protein ligase COP1

1

1

High-throughput

0.479

High

1367016

ESR2
Estrogen receptor beta

1

1

High-throughput

0.479

High

1143472

PCM1
Pericentriolar material 1 protein

1

0

High-throughput

0.460

High

350107

SNAI1
Zinc finger protein SNAI1

1

0

High-throughput

0.458

High

402657

ALDOA
Fructose-bisphosphate aldolase A

1

0

High-throughput

0.458

High

775257

FUS
RNA-binding protein FUS

1

0

High-throughput

0.458

High

905032

MECP2
Methyl-CpG-binding protein 2

1

0

High-throughput

0.458

High

980139

H4
Histone H4

1

0

High-throughput

0.458

High

1124393

ELOA1
Elongin-A

1

0

Small-scale

0.458

High

1128084

DHX8
ATP-dependent RNA helicase DHX8

1

0

High-throughput

0.458

High

1155660

EZH2
Histone-lysine N-methyltransferase EZH2

1

0

High-throughput

0.458

High

1229189

INT3
Integrator complex subunit 3

1

0

High-throughput

0.458

High

1255067

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.458

High

1313031

RPAP2
Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2

1

0

High-throughput

0.458

High

1387490

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

0

High-throughput

0.458

High

1393579

INT13
Integrator complex subunit 13

1

0

Small-scale

0.458

High

1393581

TLS1
Splicing factor C9orf78

1

0

High-throughput

0.458

High

1393583

HECW2
E3 ubiquitin-protein ligase HECW2

1

0

High-throughput

0.458

High

638497

FPR1
fMet-Leu-Phe receptor

1

1

High-throughput

0.445

High

1292862

STING
Stimulator of interferon genes protein

1

0

Small-scale

0.426

High

1340501

DNJB8
DnaJ homolog subfamily B member 8

1

0

High-throughput

0.426

High

1393571

S1PR3
Sphingosine 1-phosphate receptor 3

1

0

High-throughput

0.426

High

262285

SCN2B
Sodium channel regulatory subunit beta-2

1

1

High-throughput

0.407

High

1153425

CD226
CD226 antigen

1

1

High-throughput

0.407

High

169701

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

3

0

High-throughput

0.352

High

749259

CD70
CD70 antigen

2

0

High-throughput

0.328

High

821756

CD79B
B-cell antigen receptor complex-associated protein beta chain

2

0

High-throughput

0.328

High

829916

PMEL
Melanocyte protein PMEL

2

0

High-throughput

0.328

High

1142519

PDCD1
Programmed cell death protein 1

2

0

High-throughput

0.328

High

1393575

GORS1
Golgi reassembly-stacking protein 1

2

0

High-throughput

0.328

High

139289

UPK2
Uroplakin-2

2

0

High-throughput

0.313

High

1330056

USBP1
Harmonin-binding protein USHBP1

1

0

High-throughput

0.299

High

71239

HIDE1
Protein HIDE1

1

0

High-throughput

0.279

Low

378646

IL2RA
Interleukin-2 receptor subunit alpha

1

0

High-throughput

0.279

Low

634793

GRAH
Granzyme H

1

0

High-throughput

0.279

Low

733049

VIPR1
Vasoactive intestinal polypeptide receptor 1

1

0

High-throughput

0.279

Low

774164

ADDB
Beta-adducin

1

0

High-throughput

0.279

Low

847791

SSRB
Translocon-associated protein subunit beta

1

0

High-throughput

0.279

Low

1159223

SGCA
Alpha-sarcoglycan

1

0

High-throughput

0.279

Low

1249831

BTNL9
Butyrophilin-like protein 9

1

0

High-throughput

0.279

Low

1286741

CLC14
C-type lectin domain family 14 member A

1

0

High-throughput

0.279

Low

1291656

CMTD1
Catechol O-methyltransferase domain-containing protein 1

1

0

High-throughput

0.279

Low

1324843

LRC25
Leucine-rich repeat-containing protein 25

1

0

High-throughput

0.279

Low

1350859

HUMMR
Protein MGARP

1

0

High-throughput

0.279

Low

1393573

KI2L4
Killer cell immunoglobulin-like receptor 2DL4

1

0

High-throughput

0.279

Low

1393582

TMEM9
Proton-transporting V-type ATPase complex assembly regulator TMEM9

1

0

High-throughput

0.279

Low

1393586

CC018
Uncharacterized protein C3orf18

1

0

High-throughput

0.279

Low

1393589

PCDAC
Protocadherin alpha-12

1

0

High-throughput

0.279

Low

1393590

LAMP3
Lysosome-associated membrane glycoprotein 3

1

0

High-throughput

0.279

Low

1393592

PCDB3
Protocadherin beta-3

1

0

High-throughput

0.279

Low

154861

ISLR
Immunoglobulin superfamily containing leucine-rich repeat protein

1

0

High-throughput

0.249

Low

412436

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.249

Low

1256920

SEML
Putative protein SEM1, isoform 2

1

0

High-throughput

0.249

Low

640263

EPHA1
Ephrin type-A receptor 1

1

0

High-throughput

0.232

Low

669352

ACKR3
Atypical chemokine receptor 3

1

0

High-throughput

0.232

Low

683313

TNR5
Tumor necrosis factor receptor superfamily member 5

1

0

High-throughput

0.232

Low

704058

5HT1E
5-hydroxytryptamine receptor 1E

1

0

High-throughput

0.232

Low

1232110

VASN
Vasorin

1

0

High-throughput

0.232

Low

1279074

RIC3
Protein RIC-3

1

0

High-throughput

0.232

Low

1393576

S4A5
Electrogenic sodium bicarbonate cotransporter 4

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025