Protein: PI42A
Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha (EC 2.7.1.149) (1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha) (Diphosphoinositide kinase 2-alpha) (PIP5KIII) (Phosphatidylinositol 5-Phosphate 4-Kinase) (PI5P4Kalpha) (Phosphatidylinositol 5-phosphate 4-kinase type II alpha) (PI(5)P 4-kinase type II alpha) (PIP4KII-alpha) (PtdIns(4)P-5-kinase B isoform) (PtdIns(4)P-5-kinase C isoform) (PtdIns(5)P-4-kinase isoform 2-alpha)

Gene: PI42A, PIP4K2A
Organism: Homo sapiens
Interactions: 218
UniProt ID: P48426

Gene Ontology (top 5):
GO:0001750 - photoreceptor outer segment
GO:0001917 - photoreceptor inner segment
GO:0005524 - ATP binding
GO:0005654 - nucleoplasm
GO:0005764 - lysosome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

871983

PI42C
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma

6

14

High-throughput

0.945

High

871921

PI42B
Phosphatidylinositol 5-phosphate 4-kinase type-2 beta

4

14

High-throughput

0.900

High

872008

PI51A
Phosphatidylinositol 4-phosphate 5-kinase type-1 alpha

3

14

High-throughput

0.855

High

259604

BRD4
Bromodomain-containing protein 4

5

11

High-throughput

0.712

High

229978

SAHH2
S-adenosylhomocysteine hydrolase-like protein 1

4

6

High-throughput

0.697

High

871942

STK11
Serine/threonine-protein kinase STK11

4

4

High-throughput

0.697

High

329710

ZRAB2
Zinc finger Ran-binding domain-containing protein 2

4

2

High-throughput

0.691

High

872000

EAF1
ELL-associated factor 1

4

4

High-throughput

0.691

High

251533

CCNT1
Cyclin-T1

3

2

High-throughput

0.675

High

625245

CSK22
Casein kinase II subunit alpha'

3

11

High-throughput

0.667

High

674106

BRD2
Bromodomain-containing protein 2

3

10

High-throughput

0.667

High

273499

DJC13
DnaJ homolog subfamily C member 13

3

5

High-throughput

0.662

High

331722

MTMR5
Myotubularin-related protein 5

3

8

High-throughput

0.662

High

871922

ENL
Protein ENL

3

1

High-throughput

0.662

High

871926

TCOF
Treacle protein

3

3

High-throughput

0.662

High

871928

MTMR1
Phosphatidylinositol-3-phosphate phosphatase MTMR1

3

4

High-throughput

0.662

High

871937

NOLC1
Nucleolar and coiled-body phosphoprotein 1

3

4

High-throughput

0.662

High

871940

RNPS1
RNA-binding protein with serine-rich domain 1

3

4

High-throughput

0.662

High

871945

CHD9
Chromodomain-helicase-DNA-binding protein 9

3

3

High-throughput

0.662

High

871953

JMJD6
Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6

3

3

High-throughput

0.662

High

871955

EDC4
Enhancer of mRNA-decapping protein 4

3

2

High-throughput

0.662

High

871960

MEX3B
RNA-binding protein MEX3B

3

2

High-throughput

0.662

High

871964

STRAA
STE20-related kinase adapter protein alpha

3

7

High-throughput

0.662

High

871975

PLCD3
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3

3

3

High-throughput

0.662

High

871989

RTF1
RNA polymerase-associated protein RTF1 homolog

3

1

High-throughput

0.662

High

871998

SAHH3
Adenosylhomocysteinase 3

3

6

High-throughput

0.662

High

871999

NAF1
H/ACA ribonucleoprotein complex non-core subunit NAF1

3

1

High-throughput

0.662

High

872023

PININ
Pinin

3

1

High-throughput

0.662

High

872025

WDR26
WD repeat-containing protein 26

3

6

High-throughput

0.662

High

872029

CWC22
Pre-mRNA-splicing factor CWC22 homolog

3

1

High-throughput

0.662

High

872045

AFF4
AF4/FMR2 family member 4

3

4

High-throughput

0.662

High

872048

ACINU
Apoptotic chromatin condensation inducer in the nucleus

3

1

High-throughput

0.662

High

872052

SRRM2
Serine/arginine repetitive matrix protein 2

3

1

High-throughput

0.662

High

872057

CAB39
Calcium-binding protein 39

3

1

High-throughput

0.662

High

871914

UBE2H
Ubiquitin-conjugating enzyme E2 H

3

4

High-throughput

0.650

High

871974

CLASR
CLK4-associating serine/arginine rich protein

3

0

High-throughput

0.634

High

871984

PNISR
Arginine/serine-rich protein PNISR

3

0

High-throughput

0.634

High

872033

RAD18
E3 ubiquitin-protein ligase RAD18

3

0

High-throughput

0.634

High

137320

ELL2
RNA polymerase II elongation factor ELL2

2

2

High-throughput

0.628

High

230620

PRIC3
Prickle planar cell polarity protein 3

2

2

High-throughput

0.628

High

269748

CAPON
Carboxyl-terminal PDZ ligand of neuronal nitric oxide synthase protein

2

3

High-throughput

0.628

High

604617

UBF1
Nucleolar transcription factor 1

2

2

High-throughput

0.628

High

839866

AF9
Protein AF-9

2

1

High-throughput

0.628

High

871908

AFF3
AF4/FMR2 family member 3

2

3

High-throughput

0.628

High

871909

ELL
RNA polymerase II elongation factor ELL

2

2

High-throughput

0.628

High

871910

BRPF1
Peregrin

2

2

High-throughput

0.628

High

871925

PPIG
Peptidyl-prolyl cis-trans isomerase G

2

1

High-throughput

0.628

High

871935

KANK1
KN motif and ankyrin repeat domain-containing protein 1

2

4

High-throughput

0.628

High

871949

PPRC1
Peroxisome proliferator-activated receptor gamma coactivator-related protein 1

2

2

High-throughput

0.628

High

871957

RFWD3
E3 ubiquitin-protein ligase RFWD3

2

2

High-throughput

0.628

High

871967

RHG22
Rho GTPase-activating protein 22

2

4

High-throughput

0.628

High

871995

EAF2
ELL-associated factor 2

2

4

High-throughput

0.628

High

872006

MINT
Msx2-interacting protein

2

1

High-throughput

0.628

High

872009

LZTS2
Leucine zipper putative tumor suppressor 2

2

4

High-throughput

0.628

High

872010

SRSF8
Serine/arginine-rich splicing factor 8

2

3

High-throughput

0.628

High

872019

STRAB
STE20-related kinase adapter protein beta

2

8

High-throughput

0.628

High

872027

ELL3
RNA polymerase II elongation factor ELL3

2

2

High-throughput

0.628

High

872031

E41L5
Band 4.1-like protein 5

2

6

High-throughput

0.628

High

872051

SET1B
Histone-lysine N-methyltransferase SETD1B

2

3

High-throughput

0.628

High

871920

CSK21
Casein kinase II subunit alpha

2

8

High-throughput

0.611

High

871938

BRD3
Bromodomain-containing protein 3

3

11

High-throughput

0.609

High

871950

AR6P4
ADP-ribosylation factor-like protein 6-interacting protein 4

3

2

High-throughput

0.609

High

871966

HDGR2
Hepatoma-derived growth factor-related protein 2

3

2

High-throughput

0.604

High

872001

LENG8
Leukocyte receptor cluster member 8

3

1

High-throughput

0.604

High

872047

GPTC8
G patch domain-containing protein 8

3

2

High-throughput

0.604

High

587346

SIAT1
Beta-galactoside alpha-2,6-sialyltransferase 1

2

0

High-throughput

0.602

High

770351

T2FA
General transcription factor IIF subunit 1

2

0

High-throughput

0.602

High

871927

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

2

0

High-throughput

0.602

High

872040

CXXC1
CXXC-type zinc finger protein 1

2

0

High-throughput

0.602

High

872041

IKBL1
NF-kappa-B inhibitor-like protein 1

2

0

High-throughput

0.602

High

872056

AP3M1
AP-3 complex subunit mu-1

2

0

High-throughput

0.602

High

529319

TAU
Microtubule-associated protein tau

2

5

High-throughput

0.601

High

732479

ARRB2
Beta-arrestin-2

2

1

High-throughput

0.601

High

245793

PI51C
Phosphatidylinositol 4-phosphate 5-kinase type-1 gamma

1

14

High-throughput

0.575

High

126074

AP3B1
AP-3 complex subunit beta-1

2

5

High-throughput

0.574

High

155555

NEMP1
Nuclear envelope integral membrane protein 1

2

1

High-throughput

0.574

High

871907

AFF1
AF4/FMR2 family member 1

2

3

High-throughput

0.574

High

871947

MEX3C
RNA-binding E3 ubiquitin-protein ligase MEX3C

2

2

High-throughput

0.574

High

871991

C102A
Coiled-coil domain-containing protein 102A

2

1

High-throughput

0.574

High

871993

ZN428
Zinc finger protein 428

2

2

High-throughput

0.574

High

871994

CSTOS
Protein CUSTOS

2

1

High-throughput

0.574

High

872028

GPBL1
Vasculin-like protein 1

2

2

High-throughput

0.574

High

872044

SUN2
SUN domain-containing protein 2

2

2

High-throughput

0.574

High

872053

DIP2C
Disco-interacting protein 2 homolog C

2

1

High-throughput

0.574

High

872007

MEIS3
Homeobox protein Meis3

2

1

High-throughput

0.553

High

608234

EGLN
Endoglin

1

1

High-throughput

0.536

High

659181

SP100
Nuclear autoantigen Sp-100

1

5

High-throughput

0.536

High

718375

CD6
T-cell differentiation antigen CD6

1

3

High-throughput

0.536

High

871912

MAX
Protein max

1

5

High-throughput

0.536

High

871924

TP53B
TP53-binding protein 1

1

1

High-throughput

0.536

High

871932

SCRIB
Protein scribble homolog

1

2

High-throughput

0.536

High

871959

RFIP1
Rab11 family-interacting protein 1

1

2

High-throughput

0.536

High

871987

MADD
MAP kinase-activating death domain protein

1

5

High-throughput

0.536

High

872005

IWS1
Protein IWS1 homolog

1

1

High-throughput

0.536

High

872015

SETD2
Histone-lysine N-methyltransferase SETD2

1

2

High-throughput

0.536

High

872018

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

3

High-throughput

0.536

High

872021

NUAK2
NUAK family SNF1-like kinase 2

1

2

High-throughput

0.536

High

872030

CHD8
Chromodomain-helicase-DNA-binding protein 8

1

3

High-throughput

0.536

High

872032

MED4
Mediator of RNA polymerase II transcription subunit 4

1

3

High-throughput

0.536

High

872049

TAOK2
Serine/threonine-protein kinase TAO2

1

5

High-throughput

0.536

High

872054

E41L3
Band 4.1-like protein 3

1

4

High-throughput

0.536

High

105546

APRIO
Alternative prion protein

2

1

High-throughput

0.533

High

872055

GSTK1
Glutathione S-transferase kappa 1

1

0

High-throughput

0.518

High

871911

CXCR4
C-X-C chemokine receptor type 4

1

0

High-throughput

0.513

High

871915

RS14
Small ribosomal subunit protein uS11

1

0

High-throughput

0.513

High

871916

RS23
Small ribosomal subunit protein uS12

1

0

High-throughput

0.513

High

871918

RL30
Large ribosomal subunit protein eL30

1

0

High-throughput

0.513

High

871976

NKAP
NF-kappa-B-activating protein

1

0

High-throughput

0.513

High

872042

EIF3K
Eukaryotic translation initiation factor 3 subunit K

1

0

High-throughput

0.513

High

658578

KS6B1
Ribosomal protein S6 kinase beta-1

1

4

Small-scale

0.501

High

871982

ZCH10
Zinc finger CCHC domain-containing protein 10

1

2

High-throughput

0.489

High

871996

ATG4C
Cysteine protease ATG4C

1

2

High-throughput

0.489

High

872002

CC85A
Coiled-coil domain-containing protein 85A

1

3

High-throughput

0.489

High

209214

PRP4
U4/U6 small nuclear ribonucleoprotein Prp4

1

2

High-throughput

0.479

High

215050

PRPF3
U4/U6 small nuclear ribonucleoprotein Prp3

1

1

High-throughput

0.479

High

241041

PRKN
E3 ubiquitin-protein ligase parkin

1

6

High-throughput

0.479

High

279304

TULP3
Tubby-related protein 3

1

2

High-throughput

0.479

High

345507

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

1

High-throughput

0.479

High

371443

MYC
Myc proto-oncogene protein

1

6

High-throughput

0.479

High

540354

LAMP1
Lysosome-associated membrane glycoprotein 1

1

4

High-throughput

0.479

High

552528

IMDH2
Inosine-5'-monophosphate dehydrogenase 2

1

2

High-throughput

0.479

High

612929

EGR1
Early growth response protein 1

1

1

High-throughput

0.479

High

675408

TYY1
Transcriptional repressor protein YY1

1

1

High-throughput

0.479

High

694883

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.479

High

720442

AMRP
Alpha-2-macroglobulin receptor-associated protein

1

1

High-throughput

0.479

High

761963

GRK5
G protein-coupled receptor kinase 5

1

3

High-throughput

0.479

High

767657

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.479

High

871900

KC1A
Casein kinase I isoform alpha

1

9

High-throughput

0.479

High

871901

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

2

High-throughput

0.479

High

871903

KC1E
Casein kinase I isoform epsilon

1

11

High-throughput

0.479

High

871905

RBP2
E3 SUMO-protein ligase RanBP2

1

2

High-throughput

0.479

High

871913

WDR5
WD repeat-containing protein 5

1

3

High-throughput

0.479

High

871919

RS21
Small ribosomal subunit protein eS21

1

1

High-throughput

0.479

High

871923

CKAP4
Cytoskeleton-associated protein 4

1

2

High-throughput

0.479

High

871929

CUL4B
Cullin-4B

1

2

Small-scale

0.479

High

871930

PTC1
Protein patched homolog 1

1

3

Small-scale

0.479

High

871933

ELOA1
Elongin-A

1

1

High-throughput

0.479

High

871934

SRC8
Src substrate cortactin

1

1

High-throughput

0.479

High

871941

SF3B4
Splicing factor 3B subunit 4

1

2

High-throughput

0.479

High

871971

PHF6
PHD finger protein 6

1

2

High-throughput

0.479

High

871978

KC1AL
Casein kinase I isoform alpha-like

1

9

High-throughput

0.479

High

871979

PR38A
Pre-mRNA-splicing factor 38A

1

1

High-throughput

0.479

High

871981

CSK23
Casein kinase II subunit alpha 3

1

8

High-throughput

0.479

High

872003

PP1RA
Serine/threonine-protein phosphatase 1 regulatory subunit 10

1

1

High-throughput

0.479

High

872013

RIOK2
Serine/threonine-protein kinase RIO2

1

1

High-throughput

0.479

High

872016

GTPB4
GTP-binding protein 4

1

2

High-throughput

0.479

High

872034

DCA13
DDB1- and CUL4-associated factor 13

1

4

High-throughput

0.479

High

872036

SLTM
SAFB-like transcription modulator

1

2

High-throughput

0.479

High

872039

DDX56
Probable ATP-dependent RNA helicase DDX56

1

1

High-throughput

0.479

High

872043

ZRAN1
Ubiquitin thioesterase ZRANB1

1

6

High-throughput

0.479

High

228203

CPSF5
Cleavage and polyadenylation specificity factor subunit 5

1

0

High-throughput

0.458

High

317554

SLIT2
Slit homolog 2 protein

1

0

High-throughput

0.458

High

359616

DHE3
Glutamate dehydrogenase 1, mitochondrial

1

0

High-throughput

0.458

High

367574

CAH2
Carbonic anhydrase 2

1

0

High-throughput

0.458

High

476595

RSSA
Small ribosomal subunit protein uS2

1

0

High-throughput

0.458

High

588160

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.458

High

649763

SPR2E
Small proline-rich protein 2E

1

0

High-throughput

0.458

High

871906

MECP2
Methyl-CpG-binding protein 2

1

0

High-throughput

0.458

High

871936

RRP1B
Ribosomal RNA processing protein 1 homolog B

1

0

High-throughput

0.458

High

871939

PDIA6
Protein disulfide-isomerase A6

1

0

High-throughput

0.458

High

871943

IF16
Gamma-interferon-inducible protein 16

1

0

High-throughput

0.458

High

871954

TAF2
Transcription initiation factor TFIID subunit 2

1

0

High-throughput

0.458

High

871965

NUFP2
FMR1-interacting protein NUFIP2

1

0

High-throughput

0.458

High

871968

DDX42
ATP-dependent RNA helicase DDX42

1

0

High-throughput

0.458

High

871977

CPSF7
Cleavage and polyadenylation specificity factor subunit 7

1

0

High-throughput

0.458

High

871985

PPIL4
Peptidyl-prolyl cis-trans isomerase-like 4

1

0

High-throughput

0.458

High

871986

PSPC1
Paraspeckle component 1

1

0

High-throughput

0.458

High

871988

H1X
Histone H1.10

1

0

High-throughput

0.458

High

871997

TMA16
Translation machinery-associated protein 16

1

0

High-throughput

0.458

High

872022

NSRP1
Nuclear speckle splicing regulatory protein 1

1

0

High-throughput

0.458

High

872038

LYAR
Cell growth-regulating nucleolar protein

1

0

High-throughput

0.458

High

258802

DNJA2
DnaJ homolog subfamily A member 2

1

3

High-throughput

0.445

High

352694

NUDT3
Diphosphoinositol polyphosphate phosphohydrolase 1

1

1

High-throughput

0.445

High

713946

PML
Protein PML

1

3

High-throughput

0.445

High

848761

MAGAA
Melanoma-associated antigen 10

1

4

High-throughput

0.445

High

871902

ARRB1
Beta-arrestin-1

1

1

High-throughput

0.445

High

871904

NUMB
Protein numb homolog

1

3

High-throughput

0.445

High

871951

A16L1
Autophagy-related protein 16-1

1

5

High-throughput

0.445

High

871958

RBP10
Ran-binding protein 10

1

2

High-throughput

0.445

High

871963

MAEA
E3 ubiquitin-protein transferase MAEA

1

4

High-throughput

0.445

High

872004

S38A2
Sodium-coupled neutral amino acid symporter 2

1

2

High-throughput

0.445

High

872017

OSBL6
Oxysterol-binding protein-related protein 6

1

1

High-throughput

0.445

High

872024

OSBL3
Oxysterol-binding protein-related protein 3

1

1

High-throughput

0.445

High

872026

RMD5A
E3 ubiquitin-protein transferase RMND5A

1

3

High-throughput

0.445

High

872035

EXOC1
Exocyst complex component 1

1

2

High-throughput

0.445

High

872037

GID8
Glucose-induced degradation protein 8 homolog

1

4

High-throughput

0.445

High

872050

CSN3
COP9 signalosome complex subunit 3

1

2

High-throughput

0.445

High

533620

CLUS
Clusterin

1

0

High-throughput

0.438

High

871944

KNOP1
Lysine-rich nucleolar protein 1

1

1

High-throughput

0.437

High

871946

SPOUT
28S rRNA

1

1

High-throughput

0.437

High

871956

FBX42
F-box only protein 42

1

4

High-throughput

0.437

High

871961

TRI67
Tripartite motif-containing protein 67

1

7

High-throughput

0.437

High

871990

EDEM1
ER degradation-enhancing alpha-mannosidase-like protein 1

1

2

High-throughput

0.437

High

872060

MAFB
Transcription factor MafB

1

3

High-throughput

0.437

High

134603

SAP18
Histone deacetylase complex subunit SAP18

1

0

High-throughput

0.426

High

429501

JUN
Transcription factor Jun

1

0

High-throughput

0.426

High

657216

KALM
Anosmin-1

1

0

High-throughput

0.426

High

666080

PPAC
Low molecular weight phosphotyrosine protein phosphatase

1

0

High-throughput

0.426

High

871931

CAC1C
Voltage-dependent L-type calcium channel subunit alpha-1C

1

0

High-throughput

0.426

High

871952

RPGP2
Rap1 GTPase-activating protein 2

1

0

High-throughput

0.426

High

871970

ARMC8
Armadillo repeat-containing protein 8

1

0

High-throughput

0.426

High

872020

PIP30
PSME3-interacting protein

1

0

High-throughput

0.426

High

871972

GPAM1
GPALPP motifs-containing protein 1

3

0

High-throughput

0.345

High

871992

ARK2N
Protein ARK2N

3

0

High-throughput

0.345

High

871973

SELH
Selenoprotein H

2

0

High-throughput

0.328

High

871969

F90A1
Protein FAM90A1

1

0

High-throughput

0.279

Low

872059

CCDC9
Coiled-coil domain-containing protein 9

1

0

High-throughput

0.279

Low

277280

PITX3
Pituitary homeobox 3

1

0

Small-scale

0.249

Low

634833

HXA5
Homeobox protein Hox-A5

1

0

High-throughput

0.249

Low

871948

PR38B
Pre-mRNA-splicing factor 38B

1

0

High-throughput

0.249

Low

871962

MEPCE
7SK snRNA methylphosphate capping enzyme

1

0

High-throughput

0.249

Low

871980

FA98A
Protein FAM98A

1

0

High-throughput

0.249

Low

872011

TACO1
Translational activator of cytochrome c oxidase 1

1

0

High-throughput

0.249

Low

872012

MMTA2
Multiple myeloma tumor-associated protein 2

1

0

High-throughput

0.249

Low

872014

NUSAP
Nucleolar and spindle-associated protein 1

1

0

High-throughput

0.249

Low

872046

ATIF1
ATPase inhibitor, mitochondrial

1

0

High-throughput

0.249

Low

872058

LC7L2
Putative RNA-binding protein Luc7-like 2

1

0

High-throughput

0.249

Low

871917

YPEL5
Protein yippee-like 5

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025