Protein: HAND2
Heart- and neural crest derivatives-expressed protein 2 (Class A basic helix-loop-helix protein 26) (bHLHa26) (Deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2) (dHAND)

Gene: HAND2
Organism: Homo sapiens
Interactions: 31
UniProt ID: P61296

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0000977 - RNA polymerase II transcription regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001223 - transcription coactivator binding
GO:0001228 - DNA-binding transcription activator activity, RNA polymerase II-specific

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

960659

HTF4
Transcription factor 12

3

20

High-throughput

0.858

High

587041

ITF2
Transcription factor 4

2

20

High-throughput

0.831

High

587436

TFE2
Transcription factor E2-alpha

2

20

Small-scale

0.793

High

165155

PHX2A
Paired mesoderm homeobox protein 2A

1

8

Small-scale

0.724

High

960646

HAND2
Heart- and neural crest derivatives-expressed protein 2

1

18

Small-scale

0.647

High

405966

MYCN
N-myc proto-oncogene protein

1

10

High-throughput

0.618

High

771575

HXD13
Homeobox protein Hox-D13

1

20

Small-scale

0.618

High

238462

RAD21
Double-strand-break repair protein rad21 homolog

2

1

High-throughput

0.601

High

960649

RIPP1
Protein ripply1

2

0

High-throughput

0.580

High

851486

GATA4
Transcription factor GATA-4

1

9

Small-scale

0.561

High

960653

KANK2
KN motif and ankyrin repeat domain-containing protein 2

2

9

High-throughput

0.553

High

960654

F90A1
Protein FAM90A1

2

1

High-throughput

0.553

High

960664

UBP20
Ubiquitin carboxyl-terminal hydrolase 20

2

4

High-throughput

0.553

High

960651

2A5D
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform

1

1

Small-scale

0.527

High

960658

OPTN
Optineurin

1

2

High-throughput

0.515

High

603223

KPCA
Protein kinase C alpha type

1

2

Small-scale

0.501

High

605621

KAPCA
cAMP-dependent protein kinase catalytic subunit alpha

1

2

Small-scale

0.501

High

960648

EP300
Histone acetyltransferase p300

1

20

Small-scale

0.501

High

960662

DNM3L
DNA

1

2

Small-scale

0.501

High

446830

NPM
Nucleophosmin

1

1

Small-scale

0.481

High

960650

SMC1A
Structural maintenance of chromosomes protein 1A

1

1

High-throughput

0.479

High

960655

STAG2
Cohesin subunit SA-2

1

1

High-throughput

0.479

High

960656

STAG1
Cohesin subunit SA-1

1

1

High-throughput

0.479

High

960660

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

1

High-throughput

0.479

High

960661

XPO7
Exportin-7

1

2

High-throughput

0.479

High

960663

SMC3
Structural maintenance of chromosomes protein 3

1

1

High-throughput

0.479

High

451494

CENPB
Major centromere autoantigen B

1

0

Small-scale

0.460

High

960657

CSN5
COP9 signalosome complex subunit 5

1

0

Small-scale

0.460

High

960647

RS24
Small ribosomal subunit protein eS24

1

0

High-throughput

0.458

High

960652

SPXN3
Sperm protein associated with the nucleus on the X chromosome N3

2

0

High-throughput

0.316

High


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Last updated: 11Aug2025