Protein: 2A5D
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform (PP2A B subunit isoform B'-delta) (PP2A B subunit isoform B56-delta) (PP2A B subunit isoform PR61-delta) (PP2A B subunit isoform R5-delta)

Gene: 2A5D, PPP2R5D
Organism: Homo sapiens
Interactions: 126
UniProt ID: Q14738

Gene Ontology (top 5):
GO:0000159 - protein phosphatase type 2A complex
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005829 - cytosol
GO:0007165 - signal transduction

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

717811

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

12

20

Small-scale

0.982

High

977492

PP2AB
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform

8

20

High-throughput

0.975

High

994222

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

7

20

Small-scale

0.972

High

951976

PP4C
Serine/threonine-protein phosphatase 4 catalytic subunit

5

20

Small-scale

0.930

High

718121

2AAB
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform

5

20

Small-scale

0.925

High

1131716

PPME1
Protein phosphatase methylesterase 1

3

1

High-throughput

0.861

High

1095531

LIPA1
Liprin-alpha-1

3

5

High-throughput

0.687

High

1131667

SGO1
Shugoshin 1

4

4

Small-scale

0.679

High

909274

CCNG1
Cyclin-G1

3

13

High-throughput

0.667

High

931189

BCAT1
Branched-chain-amino-acid aminotransferase, cytosolic

3

0

High-throughput

0.638

High

1131693

RPGF5
Rap guanine nucleotide exchange factor 5

2

4

High-throughput

0.628

High

1131704

PRR14
Proline-rich protein 14

2

3

High-throughput

0.628

High

967731

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

17

Small-scale

0.618

High

840708

RS27
Small ribosomal subunit protein eS27

2

1

High-throughput

0.611

High

1131664

CCNG2
Cyclin-G2

2

13

High-throughput

0.611

High

942153

WNT3A
Protein Wnt-3a

3

4

High-throughput

0.609

High

1131682

FA43A
Protein FAM43A

3

4

High-throughput

0.609

High

1131691

DNS2B
Deoxyribonuclease-2-beta

3

2

High-throughput

0.609

High

946487

YBEY
Endoribonuclease YbeY

2

0

High-throughput

0.602

High

1131699

BTBD6
BTB/POZ domain-containing protein 6

2

0

High-throughput

0.602

High

1131714

FBXL3
F-box/LRR-repeat protein 3

2

0

High-throughput

0.602

High

1131659

2A5A
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform

1

8

Small-scale

0.590

High

51417

FSD2
Fibronectin type III and SPRY domain-containing protein 2

1

4

High-throughput

0.573

High

1131666

SGO2
Shugoshin 2

2

2

Small-scale

0.562

High

719326

MPIP3
M-phase inducer phosphatase 3

2

0

Small-scale

0.559

High

354981

CHK2
Serine/threonine-protein kinase Chk2

1

6

Small-scale

0.552

High

729841

1433B
14-3-3 protein beta/alpha

1

6

High-throughput

0.536

High

872332

SOX2
Transcription factor SOX-2

1

1

High-throughput

0.536

High

1091047

FOXF1
Forkhead box protein F1

1

1

High-throughput

0.536

High

1131660

TEBP
Prostaglandin E synthase 3

1

2

High-throughput

0.536

High

1131679

DNJB7
DnaJ homolog subfamily B member 7

1

1

High-throughput

0.536

High

1131708

KLH14
Kelch-like protein 14

1

3

High-throughput

0.536

High

960651

HAND2
Heart- and neural crest derivatives-expressed protein 2

1

1

Small-scale

0.527

High

1131684

USBP1
Harmonin-binding protein USHBP1

1

1

High-throughput

0.523

High

347026

BAG2
BAG family molecular chaperone regulator 2

1

0

High-throughput

0.513

High

611869

RL35A
Large ribosomal subunit protein eL33

1

0

High-throughput

0.513

High

642550

TGM2
Protein-glutamine gamma-glutamyltransferase 2

1

0

High-throughput

0.513

High

1131673

RAD9B
Cell cycle checkpoint control protein RAD9B

1

0

High-throughput

0.513

High

1131686

SERB1
SERPINE1 mRNA-binding protein 1

1

0

High-throughput

0.513

High

1131692

S39A7
Zinc transporter SLC39A7

1

0

High-throughput

0.513

High

1131694

TANK
TRAF family member-associated NF-kappa-B activator

1

0

High-throughput

0.513

High

1131698

UBP47
Ubiquitin carboxyl-terminal hydrolase 47

1

0

High-throughput

0.513

High

1131700

LURA1
Leucine rich adaptor protein 1

1

0

High-throughput

0.513

High

1131703

PTN18
Tyrosine-protein phosphatase non-receptor type 18

1

0

High-throughput

0.513

High

1131706

RDH8
Retinol dehydrogenase 8

1

0

High-throughput

0.513

High

1131717

WIF1
Wnt inhibitory factor 1

1

0

High-throughput

0.513

High

902779

RORG
Nuclear receptor ROR-gamma

1

1

High-throughput

0.508

High

995035

CSK2B
Casein kinase II subunit beta

1

3

High-throughput

0.508

High

1088769

NMDE1
Glutamate receptor ionotropic, NMDA 2A

1

2

High-throughput

0.489

High

1101487

GPR17
Uracil nucleotide/cysteinyl leukotriene receptor

1

1

High-throughput

0.489

High

1131670

TTC27
Tetratricopeptide repeat protein 27

1

3

High-throughput

0.489

High

1131689

DUS19
Dual specificity protein phosphatase 19

1

1

High-throughput

0.489

High

192922

CLOCK
Circadian locomoter output cycles protein kaput

1

1

High-throughput

0.481

High

251759

BUB1B
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta

1

7

Small-scale

0.481

High

354057

HAND1
Heart- and neural crest derivatives-expressed protein 1

1

2

Small-scale

0.481

High

885777

KC1E
Casein kinase I isoform epsilon

1

2

High-throughput

0.481

High

1131663

CRY1
Cryptochrome-1

1

3

High-throughput

0.481

High

1131665

CRY2
Cryptochrome-2

1

3

High-throughput

0.481

High

241697

PRKN
E3 ubiquitin-protein ligase parkin

1

3

High-throughput

0.479

High

345829

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

1

High-throughput

0.479

High

588707

RFA2
Replication protein A 32 kDa subunit

1

2

High-throughput

0.479

High

695471

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

2

High-throughput

0.479

High

701982

TMOD1
Tropomodulin-1

1

1

High-throughput

0.479

High

768205

RFA3
Replication protein A 14 kDa subunit

1

2

High-throughput

0.479

High

1004569

RNF4
E3 ubiquitin-protein ligase RNF4

1

2

High-throughput

0.479

High

1045293

TF65
Transcription factor p65

1

1

High-throughput

0.479

High

1105924

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

1

High-throughput

0.479

High

1131661

KS6A2
Ribosomal protein S6 kinase alpha-2

1

3

High-throughput

0.479

High

1131671

CTR9
RNA polymerase-associated protein CTR9 homolog

1

3

High-throughput

0.479

High

1131672

LMBRL
Protein LMBR1L

1

1

High-throughput

0.479

High

1131688

CCHCR
Coiled-coil alpha-helical rod protein 1

1

2

High-throughput

0.479

High

1131695

ARHG2
Rho guanine nucleotide exchange factor 2

1

3

Small-scale

0.479

High

1131696

OPTN
Optineurin

1

1

High-throughput

0.479

High

1131707

TLS1
Splicing factor C9orf78

1

3

High-throughput

0.479

High

1131710

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

129085

MEN1
Menin

1

0

High-throughput

0.458

High

459592

PROF1
Profilin-1

1

0

High-throughput

0.458

High

830743

CCNF
Cyclin-F

1

0

High-throughput

0.458

High

891555

GSK3B
Glycogen synthase kinase-3 beta

1

0

Small-scale

0.458

High

1039219

RL6
Large ribosomal subunit protein eL6

1

0

High-throughput

0.458

High

1094175

ACACA
Acetyl-CoA carboxylase 1

1

0

Small-scale

0.458

High

1107721

SQSTM
Sequestosome-1

1

0

High-throughput

0.458

High

1131657

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

0

High-throughput

0.458

High

1131662

EZH2
Histone-lysine N-methyltransferase EZH2

1

0

High-throughput

0.458

High

1131678

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.458

High

1131687

BICD2
Protein bicaudal D homolog 2

1

0

High-throughput

0.458

High

1131711

XPO7
Exportin-7

1

0

High-throughput

0.458

High

154979

BHE40
Class E basic helix-loop-helix protein 40

1

2

High-throughput

0.457

High

1131681

DZIP1
Cilium assembly protein DZIP1

1

9

Small-scale

0.457

High

1131701

NEK1
Serine/threonine-protein kinase Nek1

1

4

Small-scale

0.457

High

59228

A2ABH1
Coiled-coil alpha-helical rod protein 1

1

1

High-throughput

0.445

High

262232

SCN2B
Sodium channel regulatory subunit beta-2

1

6

High-throughput

0.445

High

529806

TAU
Microtubule-associated protein tau

1

6

High-throughput

0.445

High

1131702

M3K3
Mitogen-activated protein kinase kinase kinase 3

1

4

Small-scale

0.445

High

1131709

DEC1
Deleted in esophageal cancer 1

1

1

High-throughput

0.439

High

1131674

TRI67
Tripartite motif-containing protein 67

1

4

High-throughput

0.437

High

1131705

PKHA4
Pleckstrin homology domain-containing family A member 4

1

5

High-throughput

0.437

High

1131713

DJC12
DnaJ homolog subfamily C member 12

1

1

High-throughput

0.437

High

783099

ARL2
ADP-ribosylation factor-like protein 2

1

0

Small-scale

0.426

High

835271

VIPR2
Vasoactive intestinal polypeptide receptor 2

1

0

High-throughput

0.426

High

1099674

MD2L1
Mitotic spindle assembly checkpoint protein MAD2A

1

0

Small-scale

0.426

High

1131680

VSIG1
V-set and immunoglobulin domain-containing protein 1

1

3

High-throughput

0.407

High

1131683

Q8N5D4
Cyclin-G2

1

13

High-throughput

0.407

High

1131718

NPTN
Neuroplastin

1

3

High-throughput

0.407

High

186909

GPR37
Prosaposin receptor GPR37

2

0

High-throughput

0.328

High

479054

CEL3A
Chymotrypsin-like elastase family member 3A

2

0

High-throughput

0.328

High

1131685

GALD1
Glutamine amidotransferase-like class 1 domain-containing protein 1

2

0

High-throughput

0.328

High

1131658

PON2
Serum paraoxonase/arylesterase 2

2

0

High-throughput

0.318

High

1131690

DYDC1
DPY30 domain-containing protein 1

2

0

High-throughput

0.316

High

380289

DRA
HLA class II histocompatibility antigen, DR alpha chain

1

0

High-throughput

0.279

Low

611731

BMP7
Bone morphogenetic protein 7

1

0

High-throughput

0.279

Low

1022387

IDD
Integral membrane protein DGCR2/IDD

1

0

High-throughput

0.279

Low

1131668

VWA2
von Willebrand factor A domain-containing protein 2

1

0

High-throughput

0.279

Low

1131669

SPRY7
SPRY domain-containing protein 7

1

0

High-throughput

0.279

Low

1131675

TPGS1
Tubulin polyglutamylase complex subunit 1

1

0

High-throughput

0.279

Low

1131676

LHPL2
LHFPL tetraspan subfamily member 2 protein

1

0

High-throughput

0.279

Low

1131715

NTNG1
Netrin-G1

1

0

High-throughput

0.279

Low

1131719

CCD61
Centrosomal protein CCDC61

1

0

High-throughput

0.279

Low

105939

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

130097

PGRC1
Membrane-associated progesterone receptor component 1

1

0

Small-scale

0.249

Low

208505

PJA2
E3 ubiquitin-protein ligase Praja-2

1

0

Small-scale

0.249

Low

411941

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.249

Low

642873

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

0

High-throughput

0.249

Low

1131677

ATG9A
Autophagy-related protein 9A

1

0

High-throughput

0.249

Low

1131697

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.249

Low

1131712

HOOK1
Protein Hook homolog 1

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025