Protein: OPLA
5-oxoprolinase (EC 3.5.2.9) (5-oxo-L-prolinase) (5-OPase) (Pyroglutamase)

Gene: OPLA, OPLAH
Organism: Homo sapiens
Interactions: 14
UniProt ID: O14841

Gene Ontology (top 5):
GO:0005524 - ATP binding
GO:0005829 - cytosol
GO:0006749 - glutathione metabolic process
GO:0017168 - 5-oxoprolinase (ATP-hydrolyzing) activity
GO:0042802 - identical protein binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

165841

OPLA
5-oxoprolinase

2

0

High-throughput

0.742

High

165850

TPK1
Thiamine pyrophosphokinase 1

2

0

High-throughput

0.580

High

165844

TAU
Microtubule-associated protein tau

1

0

High-throughput

0.513

High

165851

PGES2
Prostaglandin E synthase 2

1

0

High-throughput

0.513

High

165843

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

1

High-throughput

0.501

High

165845

GLPK
Glycerol kinase

1

0

High-throughput

0.460

High

165842

RECQ4
ATP-dependent DNA helicase Q4

1

0

High-throughput

0.458

High

165852

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

165849

NUDC1
NudC domain-containing protein 1

1

0

High-throughput

0.426

High

165847

PO6F2
POU domain, class 6, transcription factor 2

2

0

High-throughput

0.316

High

165846

HXA1
Homeobox protein Hox-A1

1

0

High-throughput

0.282

High

165853

ZN451
E3 SUMO-protein ligase ZNF451

1

0

High-throughput

0.251

Low

165848

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025