Protein: PGES2
Prostaglandin E synthase 2 (EC 5.3.99.3) (Membrane-associated prostaglandin E synthase-2) (mPGE synthase-2) (Microsomal prostaglandin E synthase 2) (mPGES-2) (Prostaglandin-H(2) E-isomerase) [Cleaved into: Prostaglandin E synthase 2 truncated form]

Gene: PGES2, PTGES2
Organism: Homo sapiens
Interactions: 99
UniProt ID: Q9H7Z7

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0001516 - prostaglandin biosynthetic process
GO:0003677 - DNA binding
GO:0005576 - extracellular region
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1248475

SHSA2
Protein shisa-2 homolog

3

1

High-throughput

0.609

High

169016

QCR8
Cytochrome b-c1 complex subunit 8

2

0

High-throughput

0.602

High

1322866

EID3
EP300-interacting inhibitor of differentiation 3

2

0

High-throughput

0.585

High

848567

MAGA8
Melanoma-associated antigen 8

2

0

High-throughput

0.576

High

1383472

PBIP1
Pre-B-cell leukemia transcription factor-interacting protein 1

2

0

High-throughput

0.576

High

1435973

PGES2
Prostaglandin E synthase 2

1

1

Small-scale

0.575

High

49545

SHSA3
Protein shisa-3 homolog

2

1

High-throughput

0.549

High

543595

ERR1
Steroid hormone receptor ERR1

1

1

High-throughput

0.536

High

651877

QCR2
Cytochrome b-c1 complex subunit 2, mitochondrial

1

1

High-throughput

0.536

High

728825

QCR1
Cytochrome b-c1 complex subunit 1, mitochondrial

1

1

High-throughput

0.536

High

458487

ADRB2
Beta-2 adrenergic receptor

1

0

High-throughput

0.518

High

876726

HSP13
Heat shock 70 kDa protein 13

1

0

High-throughput

0.518

High

156207

CO72L
Cytochrome c oxidase subunit 7A2-like, mitochondrial

1

0

High-throughput

0.513

High

165851

OPLA
5-oxoprolinase

1

0

High-throughput

0.513

High

244498

MGRN1
E3 ubiquitin-protein ligase MGRN1

1

0

High-throughput

0.513

High

251253

RNBP6
Ran-binding protein 6

1

0

High-throughput

0.513

High

280956

HYPM
Huntingtin-interacting protein M

1

0

High-throughput

0.513

High

317220

UBP1
Ubiquitin carboxyl-terminal hydrolase 1

1

0

High-throughput

0.513

High

339352

MET18
Histidine protein methyltransferase 1 homolog

1

0

High-throughput

0.513

High

357863

CYB
Cytochrome b

1

0

High-throughput

0.513

High

373163

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.513

High

377724

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

0

High-throughput

0.513

High

471696

CY1
Cytochrome c1, heme protein, mitochondrial

1

0

High-throughput

0.513

High

578010

QCR7
Cytochrome b-c1 complex subunit 7

1

0

High-throughput

0.513

High

591842

H2AX
Histone H2AX

1

0

High-throughput

0.513

High

637955

NF1
Neurofibromin

1

0

High-throughput

0.513

High

869240

UCRI
Cytochrome b-c1 complex subunit Rieske, mitochondrial

1

0

High-throughput

0.513

High

922777

CCHL
Holocytochrome c-type synthase

1

0

High-throughput

0.513

High

1060918

LRP1
Prolow-density lipoprotein receptor-related protein 1

1

0

High-throughput

0.513

High

1139907

MLC1
Membrane protein MLC1

1

0

High-throughput

0.513

High

1214376

SYT6
Synaptotagmin-6

1

0

High-throughput

0.513

High

1310413

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.513

High

1347154

WDR48
WD repeat-containing protein 48

1

0

High-throughput

0.513

High

1400391

PUS7
Pseudouridylate synthase 7 homolog

1

0

High-throughput

0.513

High

1414395

PDC10
Programmed cell death protein 10

1

0

High-throughput

0.513

High

1435975

CHM1A
Charged multivesicular body protein 1a

1

0

High-throughput

0.513

High

1435977

QCR9
Cytochrome b-c1 complex subunit 9

1

0

High-throughput

0.513

High

1435982

SBDS
Ribosome maturation protein SBDS

1

0

High-throughput

0.513

High

1435984

STK24
Serine/threonine-protein kinase 24

1

0

High-throughput

0.513

High

843989

HD
Huntingtin

1

0

High-throughput

0.493

High

1032245

EXOSX
Exosome complex component 10

1

0

High-throughput

0.486

High

256989

H2B1K
Histone H2B type 1-K

1

2

High-throughput

0.479

High

981102

H2B1C
Histone H2B type 1-C/E/F/G/I

1

2

High-throughput

0.479

High

998816

H31
Histone H3.1

1

1

High-throughput

0.479

High

1258946

H32
Histone H3.2

1

1

High-throughput

0.479

High

1367289

ESR2
Estrogen receptor beta

1

1

High-throughput

0.479

High

1381862

H2B1A
Histone H2B type 1-A

1

2

High-throughput

0.479

High

1435976

BIRC6
Dual E2 ubiquitin-conjugating enzyme/E3 ubiquitin-protein ligase BIRC6

1

1

Small-scale

0.479

High

137819

NDUA4
Cytochrome c oxidase subunit NDUFA4

1

0

High-throughput

0.458

High

164444

NRP1
Neuropilin-1

1

0

High-throughput

0.458

High

275105

COQ9
Ubiquinone biosynthesis protein COQ9, mitochondrial

1

0

High-throughput

0.458

High

292229

S2512
Electrogenic aspartate/glutamate antiporter SLC25A12, mitochondrial

1

0

High-throughput

0.458

High

386238

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

0

High-throughput

0.458

High

567486

TCTP
Translationally-controlled tumor protein

1

0

High-throughput

0.458

High

589703

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.458

High

696521

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

942893

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

0

High-throughput

0.458

High

980333

H4
Histone H4

1

0

High-throughput

0.458

High

1106708

SMAD4
Mothers against decapentaplegic homolog 4

1

0

High-throughput

0.458

High

1141310

BRD3
Bromodomain-containing protein 3

1

0

High-throughput

0.458

High

1156861

E2F4
Transcription factor E2F4

1

0

High-throughput

0.458

High

1229682

VIR
Protein virilizer homolog

1

0

High-throughput

0.458

High

1334928

SERB1
SERPINE1 mRNA-binding protein 1

1

0

High-throughput

0.458

High

1339177

NUP35
Nucleoporin NUP35

1

0

High-throughput

0.458

High

1420422

NMES1
Normal mucosa of esophagus-specific gene 1 protein

1

0

High-throughput

0.458

High

1435974

SFXN1
Sideroflexin-1

1

0

High-throughput

0.458

High

1435979

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

1435980

MD2L2
Mitotic spindle assembly checkpoint protein MAD2B

1

0

Small-scale

0.458

High

1435981

FZR1
Fizzy-related protein homolog

1

0

High-throughput

0.458

High

1412965

FUZZY
Protein fuzzy homolog

1

1

High-throughput

0.437

High

598775

ANFB
Natriuretic peptides B

1

0

High-throughput

0.426

High

653571

HEMH
Ferrochelatase, mitochondrial

1

0

High-throughput

0.426

High

1093577

TRDN
Triadin

1

0

High-throughput

0.426

High

1227474

A16L1
Autophagy-related protein 16-1

1

0

High-throughput

0.426

High

1389593

SAAL1
Protein SAAL1

1

0

High-throughput

0.426

High

1420112

CHIA
Acidic mammalian chitinase

1

0

High-throughput

0.426

High

97015

E9PK12
Fuzzy planar cell polarity protein

1

1

High-throughput

0.407

High

1139575

S39AE
Metal cation symporter ZIP14

1

1

High-throughput

0.407

High

1404948

S1PR3
Sphingosine 1-phosphate receptor 3

1

1

High-throughput

0.407

High

1421352

S39A8
Metal cation symporter ZIP8

1

1

High-throughput

0.407

High

1435978

ABCF2
ATP-binding cassette sub-family F member 2

2

0

High-throughput

0.328

High

961569

VA0D1
V-type proton ATPase subunit d 1

2

0

High-throughput

0.318

High

1010105

DLK1
Protein delta homolog 1

2

0

High-throughput

0.318

High

1218124

CP141
Cilia- and flagella-associated protein 141

1

0

High-throughput

0.299

High

296378

ATRN
Attractin

1

0

High-throughput

0.279

Low

1081677

TM267
Transmembrane protein 267

1

0

High-throughput

0.279

Low

1101422

SG2A2
Mammaglobin-A

1

0

High-throughput

0.279

Low

1230762

HEAT6
HEAT repeat-containing protein 6

1

0

High-throughput

0.279

Low

1315180

CPNE9
Copine-9

1

0

High-throughput

0.279

Low

1333637

SUMF1
Formylglycine-generating enzyme

1

0

High-throughput

0.279

Low

1395606

BT3L4
Transcription factor BTF3 homolog 4

1

0

High-throughput

0.279

Low

294333

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.249

Low

1255564

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

1330397

EMC1
ER membrane protein complex subunit 1

1

0

High-throughput

0.249

Low

1278570

P4HA3
Prolyl 4-hydroxylase subunit alpha-3

1

0

High-throughput

0.232

Low

1356709

TGFA1
Transforming growth factor-beta receptor-associated protein 1

1

0

High-throughput

0.232

Low

1415042

EDEM2
ER degradation-enhancing alpha-mannosidase-like protein 2

1

0

High-throughput

0.232

Low

1435983

NPTN
Neuroplastin

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025