Protein: APC4
Anaphase-promoting complex subunit 4 (APC4) (Cyclosome subunit 4)

Gene: APC4, ANAPC4
Organism: Homo sapiens
Interactions: 123
UniProt ID: Q9UJX5

Gene Ontology (top 5):
GO:0004842 - ubiquitin-protein transferase activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005680 - anaphase-promoting complex
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1017461

CDC20
Cell division cycle protein 20 homolog

25

7

Small-scale

0.989

High

236990

BUB1B
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta

19

2

Small-scale

0.986

High

1356153

ANC2
Anaphase-promoting complex subunit 2

10

3

Small-scale

0.973

High

1356155

FZR1
Fizzy-related protein homolog

9

7

Small-scale

0.970

High

1356142

APC5
Anaphase-promoting complex subunit 5

9

1

Small-scale

0.967

High

211275

BUB3
Mitotic checkpoint protein BUB3

8

1

Small-scale

0.960

High

1356152

APC4
Anaphase-promoting complex subunit 4

4

1

Small-scale

0.867

High

672919

CDC27
Cell division cycle protein 27 homolog

33

8

Small-scale

0.769

High

1023018

CDC16
Cell division cycle protein 16 homolog

15

11

Small-scale

0.762

High

1029348

MD2L1
Mitotic spindle assembly checkpoint protein MAD2A

15

1

Small-scale

0.760

High

1356134

APC7
Anaphase-promoting complex subunit 7

11

11

Small-scale

0.754

High

1356111

CDC23
Cell division cycle protein 23 homolog

10

11

Small-scale

0.752

High

1328554

APC1
Anaphase-promoting complex subunit 1

10

1

Small-scale

0.749

High

1348494

APC11
Anaphase-promoting complex subunit 11

8

1

Small-scale

0.746

High

1356156

APC10
Anaphase-promoting complex subunit 10

8

3

Small-scale

0.745

High

887629

APC15
Anaphase-promoting complex subunit 15

10

0

Small-scale

0.720

High

1310886

APC13
Anaphase-promoting complex subunit 13

9

0

Small-scale

0.719

High

1246280

CDC26
Anaphase-promoting complex subunit CDC26

9

0

Small-scale

0.717

High

1288138

APC16
Anaphase-promoting complex subunit 16

8

0

Small-scale

0.714

High

851368

NEK2
Serine/threonine-protein kinase Nek2

6

0

Small-scale

0.699

High

211072

BUB1
Mitotic checkpoint serine/threonine-protein kinase BUB1

1

2

High-throughput

0.691

High

1255963

DCA11
DDB1- and CUL4-associated factor 11

1

1

High-throughput

0.691

High

1356154

FBX5
F-box only protein 5

5

0

Small-scale

0.689

High

538623

CCNB1
G2/mitotic-specific cyclin-B1

3

2

Small-scale

0.640

High

590233

CCNA2
Cyclin-A2

3

2

Small-scale

0.640

High

679644

RIR2
Ribonucleoside-diphosphate reductase subunit M2

3

0

High-throughput

0.638

High

1246693

KI18A
Kinesin-like protein KIF18A

2

2

Small-scale

0.628

High

1244553

NUP43
Nucleoporin Nup43

1

1

High-throughput

0.618

High

1305667

LYST
Lysosomal-trafficking regulator

1

1

Small-scale

0.618

High

1117511

ANO6
Anoctamin-6

2

0

High-throughput

0.602

High

295374

RECQ4
ATP-dependent DNA helicase Q4

1

0

High-throughput

0.586

High

1042802

CUL3
Cullin-3

1

0

High-throughput

0.586

High

1219391

CUL9
Cullin-9

1

0

Small-scale

0.586

High

1044249

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

2

1

High-throughput

0.571

High

890886

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

0

Small-scale

0.530

High

391961

H2A1B
Histone H2A type 1-B/E

1

0

High-throughput

0.513

High

739866

SRP14
Signal recognition particle 14 kDa protein

1

0

High-throughput

0.513

High

818584

SOX2
Transcription factor SOX-2

1

0

High-throughput

0.513

High

828935

SRP09
Signal recognition particle 9 kDa protein

1

0

High-throughput

0.513

High

880329

TCL1A
T-cell leukemia/lymphoma protein 1A

1

0

High-throughput

0.513

High

929102

SKP1
S-phase kinase-associated protein 1

1

0

High-throughput

0.513

High

1087469

H2B2E
Histone H2B type 2-E

1

0

High-throughput

0.513

High

1131425

HP1B3
Heterochromatin protein 1-binding protein 3

1

0

High-throughput

0.513

High

1221254

KLHL7
Kelch-like protein 7

1

0

High-throughput

0.513

High

1306735

TCPH
T-complex protein 1 subunit eta

1

0

High-throughput

0.513

High

1348376

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

0

High-throughput

0.513

High

943808

CCNA1
Cyclin-A1

1

2

Small-scale

0.501

High

559285

H15
Histone H1.5

1

0

High-throughput

0.493

High

687308

P5CR1
Pyrroline-5-carboxylate reductase 1, mitochondrial

1

1

High-throughput

0.489

High

1176355

KNDC1
Kinase non-catalytic C-lobe domain-containing protein 1

1

1

High-throughput

0.489

High

1286380

P5CR2
Pyrroline-5-carboxylate reductase 2

1

1

High-throughput

0.489

High

330214

PTTG1
Securin

1

0

Small-scale

0.480

High

930445

UBC9
SUMO-conjugating enzyme UBC9

1

0

Small-scale

0.480

High

1062975

MD2BP
MAD2L1-binding protein

1

0

Small-scale

0.480

High

1086941

UBE2S
Ubiquitin-conjugating enzyme E2 S

1

0

Small-scale

0.480

High

163439

XPO1
Exportin-1

1

1

High-throughput

0.479

High

309341

KIF4A
Chromosome-associated kinesin KIF4A

1

2

Small-scale

0.479

High

381324

TBB4A
Tubulin beta-4A chain

1

1

Small-scale

0.479

High

509743

UBL4A
Ubiquitin-like protein 4A

1

1

Small-scale

0.479

High

783591

EIF1
Eukaryotic translation initiation factor 1

1

1

Small-scale

0.479

High

897326

CSN2
COP9 signalosome complex subunit 2

1

1

Small-scale

0.479

High

1019167

TP53B
TP53-binding protein 1

1

1

High-throughput

0.479

High

1057019

MDC1
Mediator of DNA damage checkpoint protein 1

1

2

High-throughput

0.479

High

1173270

PAXI1
PAX-interacting protein 1

1

1

High-throughput

0.479

High

1205427

KI18B
Kinesin-like protein KIF18B

1

1

Small-scale

0.479

High

1305488

KIF2C
Kinesin-like protein KIF2C

1

3

Small-scale

0.479

High

1313690

TBB2B
Tubulin beta-2B chain

1

1

Small-scale

0.479

High

224550

RAD21
Double-strand-break repair protein rad21 homolog

1

0

High-throughput

0.458

High

319372

BRD1
Bromodomain-containing protein 1

1

0

High-throughput

0.458

High

415097

CDK1
Cyclin-dependent kinase 1

1

0

Small-scale

0.458

High

656333

PSA5
Proteasome subunit alpha type-5

1

0

Small-scale

0.458

High

721735

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.458

High

723720

HXD13
Homeobox protein Hox-D13

1

0

Small-scale

0.458

High

749941

BRCA1
Breast cancer type 1 susceptibility protein

1

0

High-throughput

0.458

High

819853

PSMD8
26S proteasome non-ATPase regulatory subunit 8

1

0

Small-scale

0.458

High

840226

MXI1
Max-interacting protein 1

1

0

Small-scale

0.458

High

848503

IRAK1
Interleukin-1 receptor-associated kinase 1

1

0

High-throughput

0.458

High

858068

NUP98
Nuclear pore complex protein Nup98-Nup96

1

0

Small-scale

0.458

High

931036

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

1

0

Small-scale

0.458

High

941565

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.458

High

968004

PO5F1
POU domain, class 5, transcription factor 1

1

0

High-throughput

0.458

High

974267

HHEX
Hematopoietically-expressed homeobox protein HHEX

1

0

Small-scale

0.458

High

992052

BAX
Apoptosis regulator BAX

1

0

Small-scale

0.458

High

1072984

DHC24
Delta(24)-sterol reductase

1

0

Small-scale

0.458

High

1135159

ACBD5
Acyl-CoA-binding domain-containing protein 5

1

0

High-throughput

0.458

High

1175236

TBA1A
Tubulin alpha-1A chain

1

0

Small-scale

0.458

High

1198288

UBP37
Ubiquitin carboxyl-terminal hydrolase 37

1

0

Small-scale

0.458

High

1200737

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

1221817

SMC5
Structural maintenance of chromosomes protein 5

1

0

High-throughput

0.458

High

1236562

SIR6
NAD-dependent protein deacylase sirtuin-6

1

0

High-throughput

0.458

High

1242020

SMG8
Nonsense-mediated mRNA decay factor SMG8

1

0

Small-scale

0.458

High

1242688

TNR6A
Trinucleotide repeat-containing gene 6A protein

1

0

Small-scale

0.458

High

1243990

FBX22
F-box only protein 22

1

0

High-throughput

0.458

High

1244744

NUP35
Nucleoporin NUP35

1

0

Small-scale

0.458

High

1269884

ESR2
Estrogen receptor beta

1

0

High-throughput

0.458

High

1285219

SH3K1
SH3 domain-containing kinase-binding protein 1

1

0

High-throughput

0.458

High

1327804

RGAP1
Rac GTPase-activating protein 1

1

0

Small-scale

0.458

High

1334436

NANOG
Homeobox protein NANOG

1

0

High-throughput

0.458

High

1334854

PKHA5
Pleckstrin homology domain-containing family A member 5

1

0

Small-scale

0.458

High

1343898

GEPH
Gephyrin [Includes: Molybdopterin adenylyltransferase

1

0

Small-scale

0.458

High

1350499

HECW2
E3 ubiquitin-protein ligase HECW2

1

0

High-throughput

0.458

High

1354426

CSN7A
COP9 signalosome complex subunit 7a

1

0

Small-scale

0.458

High

1356158

TRI33
E3 ubiquitin-protein ligase TRIM33

1

0

Small-scale

0.458

High

1356159

PHF8
Histone lysine demethylase PHF8

1

0

Small-scale

0.458

High

1135066

Q5T8C6
Cell division cycle 16

1

10

High-throughput

0.445

High

1286489

DCPS
m7GpppX diphosphatase

1

0

Small-scale

0.426

High

327756

TTLL1
Polyglutamylase complex subunit TTLL1

3

0

High-throughput

0.347

High

351629

PENK
Proenkephalin-A [Cleaved into: Synenkephalin; Met-enkephalin

3

0

High-throughput

0.347

High

1332589

MAGIX
PDZ domain-containing protein MAGIX

3

0

High-throughput

0.347

High

1161484

CP087
UPF0547 protein C16orf87

2

0

High-throughput

0.328

High

1244901

GP156
Probable G-protein coupled receptor 156

2

0

High-throughput

0.328

High

473075

BNIP5
Protein BNIP5

1

0

High-throughput

0.279

Low

1103306

FHOD3
FH1/FH2 domain-containing protein 3

1

0

High-throughput

0.279

Low

1127368

CX066
Uncharacterized protein CXorf66

1

0

High-throughput

0.279

Low

1260796

DEP1B
DEP domain-containing protein 1B

1

0

High-throughput

0.279

Low

1350226

CFA97
Cilia- and flagella-associated protein 97

1

0

High-throughput

0.279

Low

1356157

PCDA4
Protocadherin alpha-4

1

0

High-throughput

0.279

Low

49618

LNP1
Leukemia NUP98 fusion partner 1

1

0

Small-scale

0.249

Low

1145646

F91A1
Protein FAM91A1

1

0

Small-scale

0.249

Low

1172193

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

1356160

TIM13
Mitochondrial import inner membrane translocase subunit Tim13

1

0

Small-scale

0.249

Low

1156231

SCMC1
Mitochondrial adenyl nucleotide antiporter SLC25A24

1

0

Small-scale

0.232

Low


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Last updated: 15 Jul 2024