Protein: DEDD2
DNA-binding death effector domain-containing protein 2 (DED-containing protein FLAME-3) (FADD-like anti-apoptotic molecule 3)

Gene: DEDD2
Organism: Homo sapiens
Interactions: 18
UniProt ID: Q8WXF8

Gene Ontology (top 5):
GO:0003677 - DNA binding
GO:0005654 - nucleoplasm
GO:0005730 - nucleolus
GO:0006396 - RNA processing
GO:0008625 - extrinsic apoptotic signaling pathway via death domain receptors

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

289089

DEDD
Death effector domain-containing protein

2

2

Small-scale

0.843

High

193030

CFLAR
CASP8 and FADD-like apoptosis regulator

2

5

Small-scale

0.834

High

1132399

CASP8
Caspase-8

2

5

Small-scale

0.819

High

1360595

DEDD2
DNA-binding death effector domain-containing protein 2

2

2

Small-scale

0.789

High

1025397

CDK6
Cyclin-dependent kinase 6

1

1

Small-scale

0.710

High

1360596

CASPA
Caspase-10

1

5

Small-scale

0.595

High

1360600

TF3C3
General transcription factor 3C polypeptide 3

1

2

Small-scale

0.561

High

1244807

FBX38
F-box only protein 38

2

1

Small-scale

0.533

High

211377

RFOX2
RNA binding protein fox-1 homolog 2

1

0

High-throughput

0.518

High

1360598

ROAA
Heterogeneous nuclear ribonucleoprotein A/B

1

0

High-throughput

0.518

High

1360601

NR2E3
Photoreceptor-specific nuclear receptor

1

0

High-throughput

0.518

High

831138

CCNF
Cyclin-F

1

2

High-throughput

0.479

High

1360597

CDA7L
Cell division cycle-associated 7-like protein

1

0

High-throughput

0.460

High

1056882

FMR1
Fragile X messenger ribonucleoprotein 1

1

0

High-throughput

0.438

High

1227158

A16L1
Autophagy-related protein 16-1

2

0

Small-scale

0.319

High

1360599

RHXF2
Rhox homeobox family member 2

1

0

High-throughput

0.282

High

1226481

DCA15
DDB1- and CUL4-associated factor 15

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025