Protein: CASPA
Caspase-10 (CASP-10) (EC 3.4.22.63) (Apoptotic protease Mch-4) (FAS-associated death domain protein interleukin-1B-converting enzyme 2) (FLICE2) (ICE-like apoptotic protease 4) [Cleaved into: Caspase-10 subunit p23/17; Caspase-10 subunit p12]

Gene: CASPA, CASP10
Organism: Homo sapiens
Interactions: 53
UniProt ID: Q92851

Gene Ontology (top 5):
GO:0004197 - cysteine-type endopeptidase activity
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0006508 - proteolysis
GO:0006915 - apoptotic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1132403

CASP8
Caspase-8

11

17

Small-scale

0.974

High

1096916

FADD
FAS-associated death domain protein

7

20

Small-scale

0.968

High

193031

CFLAR
CASP8 and FADD-like apoptosis regulator

5

18

Small-scale

0.932

High

1022760

XIAP
E3 ubiquitin-protein ligase XIAP

3

20

Small-scale

0.883

High

1369555

CASPA
Caspase-10

3

20

Small-scale

0.857

High

1369557

M3K14
Mitogen-activated protein kinase kinase kinase 14

2

7

Small-scale

0.776

High

840079

CASP3
Caspase-3

2

17

Small-scale

0.755

High

675097

TNR6
Tumor necrosis factor receptor superfamily member 6

4

16

Small-scale

0.666

High

712883

CASP1
Caspase-1

1

17

Small-scale

0.647

High

840120

CASP2
Caspase-2

1

20

Small-scale

0.647

High

885704

CASP4
Caspase-4

1

17

Small-scale

0.647

High

936924

CASP7
Caspase-7

1

19

Small-scale

0.647

High

936961

CASP9
Caspase-9

1

20

Small-scale

0.647

High

937079

CASP6
Caspase-6

1

17

Small-scale

0.647

High

161831

RIOK3
Serine/threonine-protein kinase RIO3

2

0

Small-scale

0.634

High

289090

DEDD
Death effector domain-containing protein

1

5

Small-scale

0.618

High

729597

CASPE
Caspase-14

1

17

Small-scale

0.618

High

1107076

BIRC3
Baculoviral IAP repeat-containing protein 3

1

20

Small-scale

0.618

High

1107441

BIRC2
Baculoviral IAP repeat-containing protein 2

1

20

Small-scale

0.618

High

1109639

RIPK1
Receptor-interacting serine/threonine-protein kinase 1

2

8

Small-scale

0.601

High

1360596

DEDD2
DNA-binding death effector domain-containing protein 2

1

5

Small-scale

0.595

High

716332

PRDX6
Peroxiredoxin-6

1

1

Small-scale

0.582

High

853720

MK08
Mitogen-activated protein kinase 8

1

11

Small-scale

0.575

High

127711

TR10A
Tumor necrosis factor receptor superfamily member 10A

2

16

Small-scale

0.571

High

163339

TR10B
Tumor necrosis factor receptor superfamily member 10B

2

16

Small-scale

0.571

High

622654

TNR1A
Tumor necrosis factor receptor superfamily member 1A

2

16

Small-scale

0.571

High

869509

TNFL6
Tumor necrosis factor ligand superfamily member 6

2

13

Small-scale

0.571

High

1369556

RNF34
E3 ubiquitin-protein ligase RNF34

1

20

Small-scale

0.552

High

518749

GRAB
Granzyme B

2

12

Small-scale

0.552

High

1369560

BCLF1
Bcl-2-associated transcription factor 1

1

1

Small-scale

0.515

High

1369563

C8AP2
CASP8-associated protein 2

1

1

Small-scale

0.508

High

442779

RB
Retinoblastoma-associated protein

1

5

Small-scale

0.501

High

1093900

TRAF1
TNF receptor-associated factor 1

1

18

Small-scale

0.501

High

138255

PSDE
26S proteasome non-ATPase regulatory subunit 14

1

1

High-throughput

0.479

High

895498

SPB9
Serpin B9

1

8

Small-scale

0.479

High

1326019

RYBP
RING1 and YY1-binding protein

1

1

Small-scale

0.479

High

1369558

TNR27
Tumor necrosis factor receptor superfamily member 27

1

1

Small-scale

0.479

High

1369559

IFT57
Intraflagellar transport protein 57 homolog

1

2

Small-scale

0.479

High

1369561

BFAR
Bifunctional apoptosis regulator

1

10

Small-scale

0.479

High

582908

EZRI
Ezrin

1

4

Small-scale

0.445

High

683877

MOES
Moesin

1

4

Small-scale

0.445

High

897150

TNF10
Tumor necrosis factor ligand superfamily member 10

1

13

Small-scale

0.445

High

912591

GDIR1
Rho GDP-dissociation inhibitor 1

1

8

Small-scale

0.445

High

939641

BID
BH3-interacting domain death agonist

1

4

Small-scale

0.445

High

962345

RHOA
Transforming protein RhoA

1

3

Small-scale

0.445

High

1369564

TRRAP
Transformation/transcription domain-associated protein

1

2

High-throughput

0.437

High

71461

P20L1
PHD finger protein 20-like protein 1

1

0

High-throughput

0.282

High

217168

MS18B
Protein Mis18-beta

1

0

High-throughput

0.282

High

1369562

IKBL1
NF-kappa-B inhibitor-like protein 1

1

0

High-throughput

0.282

High

640247

EPHA1
Ephrin type-A receptor 1

1

0

High-throughput

0.249

Low

1279415

DPOLN
DNA polymerase nu

1

0

High-throughput

0.249

Low

516912

EFCE2
EEF1AKMT4-ECE2 readthrough transcript protein

1

0

High-throughput

0.238

Low


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Last updated: 11Aug2025