Protein: PKHG4
Puratrophin-1 (Pleckstrin homology domain-containing family G member 4) (PH domain-containing family G member 4) (Purkinje cell atrophy-associated protein 1)

Gene: PKHG4, PLEKHG4
Organism: Homo sapiens
Interactions: 162
UniProt ID: Q58EX7

Gene Ontology (top 5):
GO:0005085 - guanyl-nucleotide exchange factor activity
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0007411 - axon guidance

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

894092

CDC42
Cell division control protein 42 homolog

3

20

Small-scale

0.829

High

1123328

DOCK5
Dedicator of cytokinesis protein 5

2

2

High-throughput

0.811

High

442840

HCK
Tyrosine-protein kinase HCK

2

15

High-throughput

0.783

High

1016128

ARHG5
Rho guanine nucleotide exchange factor 5

2

14

High-throughput

0.783

High

1123274

FGD2
FYVE, RhoGEF and PH domain-containing protein 2

2

14

High-throughput

0.783

High

856540

EFNB2
Ephrin-B2

3

1

High-throughput

0.667

High

900546

RHOA
Transforming protein RhoA

1

20

High-throughput

0.647

High

793106

PE2R3
Prostaglandin E2 receptor EP3 subtype

3

0

High-throughput

0.638

High

1123321

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

2

3

High-throughput

0.628

High

545418

RAC2
Ras-related C3 botulinum toxin substrate 2

1

20

High-throughput

0.618

High

892408

RAC3
Ras-related C3 botulinum toxin substrate 3

1

20

High-throughput

0.618

High

925330

RAC1
Ras-related C3 botulinum toxin substrate 1

1

20

High-throughput

0.618

High

1108956

PKHG6
Pleckstrin homology domain-containing family G member 6

1

20

High-throughput

0.618

High

271109

UBP2
Ubiquitin carboxyl-terminal hydrolase 2

2

1

High-throughput

0.606

High

318819

K2C75
Keratin, type II cytoskeletal 75

2

2

High-throughput

0.606

High

517759

K2C3
Keratin, type II cytoskeletal 3

2

2

High-throughput

0.606

High

555736

F261
6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 1

2

1

High-throughput

0.606

High

594549

PSB1
Proteasome subunit beta type-1

2

5

High-throughput

0.606

High

790984

CDN2C
Cyclin-dependent kinase 4 inhibitor C

2

10

High-throughput

0.606

High

862946

MAP11
Methionine aminopeptidase 1

2

1

High-throughput

0.606

High

1044776

RIN1
Ras and Rab interactor 1

2

4

High-throughput

0.606

High

1123295

TFG
Protein TFG

2

3

High-throughput

0.606

High

1123312

PKP2
Plakophilin-2

2

6

High-throughput

0.606

High

1123314

DCNL5
DCN1-like protein 5

2

1

High-throughput

0.606

High

1123326

SH24A
SH2 domain-containing protein 4A

2

20

High-throughput

0.606

High

1123331

A1CF
APOBEC1 complementation factor

2

1

High-throughput

0.606

High

1123332

TNR19
Tumor necrosis factor receptor superfamily member 19

2

0

High-throughput

0.602

High

231548

KIF1B
Kinesin-like protein KIF1B

1

5

High-throughput

0.594

High

211720

MAAI
Maleylacetoacetate isomerase

2

0

High-throughput

0.580

High

620511

GATA3
Trans-acting T-cell-specific transcription factor GATA-3

2

0

High-throughput

0.580

High

836399

MCSP
Sperm mitochondrial-associated cysteine-rich protein

2

0

High-throughput

0.580

High

1031878

MTA1
Metastasis-associated protein MTA1

2

0

High-throughput

0.580

High

1074450

SIX1
Homeobox protein SIX1

2

0

High-throughput

0.580

High

1123269

DPPA3
Developmental pluripotency-associated protein 3

2

0

High-throughput

0.580

High

1123273

SAXO4
Stabilizer of axonemal microtubules 4

2

0

High-throughput

0.580

High

1123277

DTX2
Probable E3 ubiquitin-protein ligase DTX2

2

0

High-throughput

0.580

High

1123280

MSRB3
Methionine-R-sulfoxide reductase B3

2

0

High-throughput

0.580

High

1123300

MASU1
Mitochondrial assembly of ribosomal large subunit protein 1

2

0

High-throughput

0.580

High

1123306

TSSK3
Testis-specific serine/threonine-protein kinase 3

2

0

High-throughput

0.580

High

1123316

BEX2
Protein BEX2

2

0

High-throughput

0.580

High

1123323

SMG9
Nonsense-mediated mRNA decay factor SMG9

2

0

High-throughput

0.580

High

1123338

MYEF2
Myelin expression factor 2

2

0

High-throughput

0.580

High

1123339

DS13B
Dual specificity protein phosphatase 13B

2

0

High-throughput

0.580

High

1123341

CHIC2
Cysteine-rich hydrophobic domain-containing protein 2

2

0

High-throughput

0.580

High

1123270

PKHG7
Pleckstrin homology domain-containing family G member 7

1

17

High-throughput

0.575

High

327873

TBX18
T-box transcription factor TBX18

2

2

High-throughput

0.553

High

567850

HXB9
Homeobox protein Hox-B9

2

1

High-throughput

0.553

High

678927

HXC8
Homeobox protein Hox-C8

2

2

High-throughput

0.553

High

793991

MATR3
Matrin-3

2

1

High-throughput

0.553

High

1123267

TTC23
Tetratricopeptide repeat protein 23

2

1

High-throughput

0.553

High

1123271

SHSA6
Protein shisa-6

2

2

High-throughput

0.553

High

1123291

PRP31
U4/U6 small nuclear ribonucleoprotein Prp31

2

1

High-throughput

0.553

High

1123292

ZCH14
Zinc finger CCHC domain-containing protein 14

2

1

High-throughput

0.553

High

1123302

CC120
Coiled-coil domain-containing protein 120

2

1

High-throughput

0.553

High

1123320

SETD5
Histone-lysine N-methyltransferase SETD5

2

2

High-throughput

0.553

High

1123343

ZN148
Zinc finger protein 148

2

1

High-throughput

0.553

High

1123311

MDFI
MyoD family inhibitor

1

0

High-throughput

0.549

High

1123318

TRI55
Tripartite motif-containing protein 55

1

10

High-throughput

0.541

High

126598

P2Y10
Putative P2Y purinoceptor 10

1

6

High-throughput

0.536

High

172022

GP182
G-protein coupled receptor 182

1

4

High-throughput

0.536

High

200391

HS12A
Heat shock 70 kDa protein 12A

1

1

High-throughput

0.536

High

598951

FPR1
fMet-Leu-Phe receptor

1

2

High-throughput

0.536

High

672674

CD6
T-cell differentiation antigen CD6

1

3

High-throughput

0.536

High

895640

CXCR4
C-X-C chemokine receptor type 4

1

2

High-throughput

0.536

High

957845

EFNB1
Ephrin-B1

1

1

High-throughput

0.536

High

1123296

FGF14
Fibroblast growth factor 14

1

2

High-throughput

0.536

High

1123313

NAA11
N-alpha-acetyltransferase 11

1

1

High-throughput

0.536

High

1123319

UBXN6
UBX domain-containing protein 6

1

1

High-throughput

0.536

High

1123324

SENP3
Sentrin-specific protease 3

1

1

High-throughput

0.536

High

1123340

HSPB8
Heat shock protein beta-8

1

4

High-throughput

0.536

High

1123346

NPTN
Neuroplastin

1

4

High-throughput

0.536

High

265526

ERN1
Serine/threonine-protein kinase/endoribonuclease IRE1

1

7

High-throughput

0.515

High

388489

HSPB1
Heat shock protein beta-1

1

4

High-throughput

0.515

High

527497

LAMP2
Lysosome-associated membrane glycoprotein 2

1

2

High-throughput

0.515

High

871596

HSP72
Heat shock-related 70 kDa protein 2

1

2

High-throughput

0.515

High

877054

CASP6
Caspase-6

1

2

High-throughput

0.515

High

893367

PRPS1
Ribose-phosphate pyrophosphokinase 1

1

4

High-throughput

0.515

High

179188

COPT1
High affinity copper uptake protein 1

1

0

High-throughput

0.513

High

277310

ST1C4
Sulfotransferase 1C4

1

0

High-throughput

0.513

High

335267

DYR
Dihydrofolate reductase

1

0

High-throughput

0.513

High

1123266

FAXC
Failed axon connections homolog

1

0

High-throughput

0.513

High

1123276

ISCA2
Iron-sulfur cluster assembly 2 homolog, mitochondrial

1

0

High-throughput

0.513

High

1123282

PIAS4
E3 SUMO-protein ligase PIAS4

1

0

High-throughput

0.513

High

1123293

BSND
Barttin

1

0

High-throughput

0.513

High

1123299

EFMT3
EEF1A lysine methyltransferase 3

1

0

High-throughput

0.513

High

1123301

AB17A
Alpha/beta hydrolase domain-containing protein 17A

1

0

High-throughput

0.513

High

1123304

LURA1
Leucine rich adaptor protein 1

1

0

High-throughput

0.513

High

750295

COIL
Coilin

1

1

High-throughput

0.508

High

157919

KLF11
Krueppel-like factor 11

1

0

High-throughput

0.493

High

660535

GRN
Progranulin

1

0

High-throughput

0.493

High

877618

FOXG1
Forkhead box protein G1

1

2

High-throughput

0.489

High

1021074

FOXF2
Forkhead box protein F2

1

3

High-throughput

0.489

High

1100047

INF2
Inverted formin-2

1

1

High-throughput

0.489

High

1123305

HS12B
Heat shock 70 kDa protein 12B

1

1

High-throughput

0.489

High

1123307

TCPQM
T-complex protein 1 subunit theta-like 2

1

1

High-throughput

0.489

High

1123310

NPAS1
Neuronal PAS domain-containing protein 1

1

2

High-throughput

0.489

High

1123297

TRI63
E3 ubiquitin-protein ligase TRIM63

1

10

High-throughput

0.481

High

117154

DX39A
ATP-dependent RNA helicase DDX39A

1

5

High-throughput

0.479

High

198904

RFOX2
RNA binding protein fox-1 homolog 2

1

7

High-throughput

0.479

High

320867

HS74L
Heat shock 70 kDa protein 4L

1

4

High-throughput

0.479

High

346969

MYC
Myc proto-oncogene protein

1

12

High-throughput

0.479

High

381220

TBB4A
Tubulin beta-4A chain

1

7

High-throughput

0.479

High

390271

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

2

High-throughput

0.479

High

866955

MOT1
Monocarboxylate transporter 1

1

2

High-throughput

0.479

High

875986

ECHB
Trifunctional enzyme subunit beta, mitochondrial

1

1

High-throughput

0.479

High

911015

RS29
Small ribosomal subunit protein uS14

1

2

High-throughput

0.479

High

911862

RUXF
Small nuclear ribonucleoprotein F

1

4

High-throughput

0.479

High

950500

ARF1
ADP-ribosylation factor 1

1

4

High-throughput

0.479

High

1075413

NHRF2
Na(+)/H(+) exchange regulatory cofactor NHE-RF2

1

12

High-throughput

0.479

High

1080941

SEPT7
Septin-7

1

1

High-throughput

0.479

High

1123278

P2RY8
P2Y purinoceptor 8

1

5

High-throughput

0.479

High

1123294

GCN1
Stalled ribosome sensor GCN1

1

7

High-throughput

0.479

High

1123327

AAMDC
Mth938 domain-containing protein

1

1

High-throughput

0.479

High

1123334

FANCI
Fanconi anemia group I protein

1

1

High-throughput

0.479

High

1123342

AKP8L
A-kinase anchor protein 8-like

1

1

High-throughput

0.479

High

1123344

RUVB1
RuvB-like 1

1

2

High-throughput

0.479

High

281661

WFS1
Wolframin

1

1

High-throughput

0.470

High

601634

PGS1
Biglycan

1

1

High-throughput

0.470

High

1012401

Q0VDC6
peptidylprolyl isomerase

1

1

High-throughput

0.470

High

403250

LA
Lupus La protein

1

0

High-throughput

0.458

High

1123272

BT2A1
Butyrophilin subfamily 2 member A1

1

0

High-throughput

0.458

High

1123347

TX264
Testis-expressed protein 264

1

0

High-throughput

0.458

High

1123285

MOT11
Monocarboxylate transporter 11

1

2

High-throughput

0.445

High

158655

TIM23
Mitochondrial import inner membrane translocase subunit Tim23

1

1

High-throughput

0.437

High

847282

SSRD
Translocon-associated protein subunit delta

1

1

High-throughput

0.437

High

1054367

RBM39
RNA-binding protein 39

1

2

High-throughput

0.437

High

1074132

SF3A1
Splicing factor 3A subunit 1

1

4

High-throughput

0.437

High

1123268

RL22L
Ribosomal protein eL22-like

1

3

High-throughput

0.437

High

1123290

TM263
Transmembrane protein 263

1

4

High-throughput

0.437

High

1123298

UTP4
U3 small nucleolar RNA-associated protein 4 homolog

1

6

High-throughput

0.437

High

1123308

YMEL1
ATP-dependent zinc metalloprotease YME1L1

1

1

High-throughput

0.437

High

1123317

RT26
Small ribosomal subunit protein mS26

1

1

High-throughput

0.437

High

1123322

SLIRP
SRA stem-loop-interacting RNA-binding protein, mitochondrial

1

7

High-throughput

0.437

High

1123329

GHC1
Mitochondrial glutamate carrier 1

1

6

High-throughput

0.437

High

1123335

GAR1
H/ACA ribonucleoprotein complex subunit 1

1

2

High-throughput

0.437

High

1123336

TECR
Very-long-chain enoyl-CoA reductase

1

2

High-throughput

0.437

High

1123345

VDAC3
Voltage-dependent anion-selective channel protein 3

1

4

High-throughput

0.437

High

1123303

F167A
Protein FAM167A

2

0

High-throughput

0.328

High

60589

VP37C
Vacuolar protein sorting-associated protein 37C

2

0

High-throughput

0.316

High

270988

GCM2
Chorion-specific transcription factor GCMb

2

0

High-throughput

0.316

High

686459

OTX1
Homeobox protein OTX1

2

0

High-throughput

0.316

High

1107867

F161A
Protein FAM161A

2

0

High-throughput

0.316

High

1123265

ZN648
Zinc finger protein 648

2

0

High-throughput

0.316

High

1123275

AP2D
Transcription factor AP-2-delta

2

0

High-throughput

0.316

High

1123279

Q8IVT4
Hypothetical MGC50722

2

0

High-throughput

0.316

High

1123281

SAXO1
Stabilizer of axonemal microtubules 1

2

0

High-throughput

0.316

High

1123284

NATD1
Protein NATD1

2

0

High-throughput

0.316

High

1123286

TET5D
Terminal nucleotidyltransferase 5D

2

0

High-throughput

0.316

High

1123309

PRP18
Pre-mRNA-splicing factor 18

2

0

High-throughput

0.316

High

1123315

TEKT3
Tektin-3

2

0

High-throughput

0.316

High

1123325

ARMC7
Armadillo repeat-containing protein 7

2

0

High-throughput

0.316

High

1123330

MYOZ1
Myozenin-1

2

0

High-throughput

0.316

High

1123333

TB22B
TBC1 domain family member 22B

2

0

High-throughput

0.316

High

1123337

ZN319
Zinc finger protein 319

2

0

High-throughput

0.316

High

1123264

SNPC4
snRNA-activating protein complex subunit 4

1

0

High-throughput

0.279

Low

1123283

D2HDH
D-2-hydroxyglutarate dehydrogenase, mitochondrial

1

0

High-throughput

0.279

Low

1123288

ZCH10
Zinc finger CCHC domain-containing protein 10

1

0

High-throughput

0.279

Low

1123289

NPRL2
GATOR1 complex protein NPRL2

1

0

High-throughput

0.279

Low

1123287

COQ8A
Atypical kinase COQ8A, mitochondrial

1

0

High-throughput

0.268

Low

174091

SPTC1
Serine palmitoyltransferase 1

1

0

High-throughput

0.249

Low

532971

PRG2
Bone marrow proteoglycan

1

0

High-throughput

0.249

Low

1001523

ZNFS1
Putative uncharacterized protein ZNF252P-AS1

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024