Protein: MAPK2
MAP kinase-activated protein kinase 2 (MAPK-activated protein kinase 2) (MAPKAP kinase 2) (MAPKAP-K2) (MAPKAPK-2) (MK-2) (MK2) (EC 2.7.11.1)

Gene: MAPK2, MAPKAPK2
Organism: Homo sapiens
Interactions: 113
UniProt ID: P49137

Gene Ontology (top 5):
GO:0000165 - MAPK cascade
GO:0002224 - toll-like receptor signaling pathway
GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity
GO:0004683 - calcium/calmodulin-dependent protein kinase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

879723

MK14
Mitogen-activated protein kinase 14

20

20

Small-scale

0.991

High

879722

MK11
Mitogen-activated protein kinase 11

5

20

Small-scale

0.925

High

879697

MAPK2
MAP kinase-activated protein kinase 2

4

16

Small-scale

0.879

High

703494

MK01
Mitogen-activated protein kinase 1

4

20

Small-scale

0.878

High

728110

AKT1
RAC-alpha serine/threonine-protein kinase

2

15

Small-scale

0.834

High

879724

MAPK3
MAP kinase-activated protein kinase 3

2

17

High-throughput

0.811

High

879736

PHC2
Polyhomeotic-like protein 2

2

4

Small-scale

0.800

High

691673

MK03
Mitogen-activated protein kinase 3

2

20

Small-scale

0.767

High

415427

HSPB1
Heat shock protein beta-1

17

9

Small-scale

0.764

High

241058

PRKN
E3 ubiquitin-protein ligase parkin

2

13

High-throughput

0.754

High

879701

PLK1
Serine/threonine-protein kinase PLK1

1

19

Small-scale

0.724

High

879705

CSK2B
Casein kinase II subunit beta

1

4

Small-scale

0.713

High

879734

MAPK5
MAP kinase-activated protein kinase 5

1

16

Small-scale

0.713

High

879702

LIMK1
LIM domain kinase 1

1

20

Small-scale

0.710

High

636050

CD11B
Cyclin-dependent kinase 11B

1

10

High-throughput

0.691

High

879715

PRP4K
Serine/threonine-protein kinase PRP4 homolog

1

8

High-throughput

0.691

High

879719

DHX8
ATP-dependent RNA helicase DHX8

1

1

High-throughput

0.691

High

879720

ZN638
Zinc finger protein 638

1

1

High-throughput

0.691

High

879721

SAFB1
Scaffold attachment factor B1

1

2

High-throughput

0.691

High

879737

SREK1
Splicing regulatory glutamine/lysine-rich protein 1

1

1

High-throughput

0.691

High

879758

SLTM
SAFB-like transcription modulator

1

3

High-throughput

0.691

High

879761

CDK12
Cyclin-dependent kinase 12

1

17

High-throughput

0.691

High

550175

PABP1
Polyadenylate-binding protein 1

1

1

Small-scale

0.647

High

719198

MPIP2
M-phase inducer phosphatase 2

1

2

Small-scale

0.647

High

879700

MP2K6
Dual specificity mitogen-activated protein kinase kinase 6

1

14

Small-scale

0.647

High

879713

ROA0
Heterogeneous nuclear ribonucleoprotein A0

1

5

Small-scale

0.647

High

157088

CTRO
Citron Rho-interacting kinase

1

7

High-throughput

0.618

High

879706

HSF1
Heat shock factor protein 1

1

1

Small-scale

0.604

High

688224

TTP
mRNA decay activator protein ZFP36

2

2

Small-scale

0.602

High

879707

MDM2
E3 ubiquitin-protein ligase Mdm2

2

2

Small-scale

0.602

High

879710

TISB
mRNA decay activator protein ZFP36L1

2

2

Small-scale

0.602

High

827700

STAT3
Signal transducer and activator of transcription 3

2

3

High-throughput

0.594

High

488207

LOX5
Polyunsaturated fatty acid 5-lipoxygenase

2

1

Small-scale

0.585

High

879744

SIR1
NAD-dependent protein deacetylase sirtuin-1

2

0

High-throughput

0.576

High

231550

PRKY
Putative serine/threonine-protein kinase PRKY

1

12

High-throughput

0.575

High

719116

MPIP1
M-phase inducer phosphatase 1

1

2

Small-scale

0.575

High

728561

AKT2
RAC-beta serine/threonine-protein kinase

1

15

Small-scale

0.575

High

711279

SHC1
SHC-transforming protein 1

1

7

Small-scale

0.573

High

608496

DDX5
Probable ATP-dependent RNA helicase DDX5

1

2

Small-scale

0.561

High

569295

MTDC
Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial [Includes: NAD-dependent methylenetetrahydrofolate dehydrogenase

2

1

High-throughput

0.549

High

879704

1433Z
14-3-3 protein zeta/delta

1

20

Small-scale

0.536

High

280545

PR40A
Pre-mRNA-processing factor 40 homolog A

1

2

High-throughput

0.536

High

340733

CPSF4
Cleavage and polyadenylation specificity factor subunit 4

1

1

High-throughput

0.536

High

395684

ESR1
Estrogen receptor

1

7

High-throughput

0.536

High

875587

PRC2A
Protein PRRC2A

1

2

High-throughput

0.536

High

879698

YLPM1
YLP motif-containing protein 1

1

1

High-throughput

0.536

High

879716

CUL3
Cullin-3

1

4

High-throughput

0.536

High

879728

DDX46
Probable ATP-dependent RNA helicase DDX46

1

2

High-throughput

0.536

High

879731

RBBP6
E3 ubiquitin-protein ligase RBBP6

1

2

High-throughput

0.536

High

879739

PHF3
PHD finger protein 3

1

3

High-throughput

0.536

High

879741

CSN5
COP9 signalosome complex subunit 5

1

2

High-throughput

0.536

High

879746

PP1RA
Serine/threonine-protein phosphatase 1 regulatory subunit 10

1

1

High-throughput

0.536

High

879747

MAGI1
Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 1

1

11

High-throughput

0.536

High

879748

SCAFB
Protein SCAF11

1

1

High-throughput

0.536

High

879749

DIDO1
Death-inducer obliterator 1

1

8

High-throughput

0.536

High

879753

WDR33
pre-mRNA 3' end processing protein WDR33

1

1

High-throughput

0.536

High

879755

BRD9
Bromodomain-containing protein 9

1

6

High-throughput

0.536

High

879757

DDX21
Nucleolar RNA helicase 2

1

4

High-throughput

0.536

High

879762

ACINU
Apoptotic chromatin condensation inducer in the nucleus

1

1

High-throughput

0.536

High

879765

ZC3H4
Zinc finger CCCH domain-containing protein 4

1

1

High-throughput

0.536

High

879768

PRC2C
Protein PRRC2C

1

4

High-throughput

0.536

High

192696

ARPC5
Actin-related protein 2/3 complex subunit 5

1

0

Small-scale

0.513

High

244659

ZC3H1
Zinc finger C3H1 domain-containing protein

1

0

High-throughput

0.513

High

769945

RFC1
Replication factor C subunit 1

1

0

High-throughput

0.513

High

879712

SFSWA
Splicing factor, suppressor of white-apricot homolog

1

0

High-throughput

0.513

High

879730

HDGR2
Hepatoma-derived growth factor-related protein 2

1

0

High-throughput

0.513

High

879732

CIR1
Corepressor interacting with RBPJ 1

1

0

High-throughput

0.513

High

879733

SPAS2
Spermatogenesis-associated serine-rich protein 2

1

0

High-throughput

0.513

High

879735

SUGP2
SURP and G-patch domain-containing protein 2

1

0

High-throughput

0.513

High

879752

UT14A
U3 small nucleolar RNA-associated protein 14 homolog A

1

0

High-throughput

0.513

High

879766

WBP11
WW domain-binding protein 11

1

0

High-throughput

0.513

High

879769

PAXB1
PAX3- and PAX7-binding protein 1

1

0

High-throughput

0.513

High

587429

TFE2
Transcription factor E2-alpha

1

1

Small-scale

0.501

High

617086

ATF1
Cyclic AMP-dependent transcription factor ATF-1

1

9

Small-scale

0.501

High

750499

LSP1
Lymphocyte-specific protein 1

1

1

Small-scale

0.501

High

879699

ETV1
ETS translocation variant 1

1

2

Small-scale

0.501

High

879711

B2CL1
Bcl-2-like protein 1

1

1

Small-scale

0.501

High

879718

BECN1
Beclin-1

1

1

Small-scale

0.501

High

879725

CPZIP
CapZ-interacting protein

1

1

Small-scale

0.501

High

879738

WASF1
Actin-binding protein WASF1

1

6

Small-scale

0.501

High

879763

AGO2
Protein argonaute-2

1

1

Small-scale

0.501

High

879764

CP131
Centrosomal protein of 131 kDa

1

2

Small-scale

0.501

High

879767

UB2J1
Ubiquitin-conjugating enzyme E2 J1

1

3

Small-scale

0.501

High

879756

MTD2L
Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2, mitochondrial

1

1

High-throughput

0.489

High

297775

PIAS2
E3 SUMO-protein ligase PIAS2

1

0

Small-scale

0.480

High

337321

PARN
Poly(A)-specific ribonuclease PARN

1

0

Small-scale

0.480

High

879714

TIF1B
Transcription intermediary factor 1-beta

1

0

Small-scale

0.480

High

172574

XPO1
Exportin-1

1

3

High-throughput

0.479

High

215791

P52K
52 kDa repressor of the inhibitor of the protein kinase

1

1

Small-scale

0.479

High

298495

SPF30
Survival of motor neuron-related-splicing factor 30

1

1

High-throughput

0.479

High

516189

HS71B
Heat shock 70 kDa protein 1B

1

5

High-throughput

0.479

High

694897

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

5

High-throughput

0.479

High

879703

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

5

High-throughput

0.479

High

879709

KIF23
Kinesin-like protein KIF23

1

3

High-throughput

0.479

High

879740

ESR2
Estrogen receptor beta

1

7

High-throughput

0.479

High

879743

CHM4C
Charged multivesicular body protein 4c

1

1

High-throughput

0.479

High

879754

CHM4B
Charged multivesicular body protein 4b

1

1

High-throughput

0.479

High

606092

DESM
Desmin

1

0

Small-scale

0.460

High

879742

PINX1
PIN2/TERF1-interacting telomerase inhibitor 1

1

0

High-throughput

0.458

High

879745

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.458

High

879759

LYAR
Cell growth-regulating nucleolar protein

1

0

High-throughput

0.458

High

879717

TRI29
Tripartite motif-containing protein 29

1

4

Small-scale

0.457

High

105553

APRIO
Alternative prion protein

1

2

High-throughput

0.437

High

377456

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

1

High-throughput

0.437

High

712720

IL12A
Interleukin-12 subunit alpha

1

0

High-throughput

0.426

High

879727

H1FNT
Testis-specific H1 histone

1

0

High-throughput

0.426

High

879760

AATF
Protein AATF

1

0

Small-scale

0.426

High

879726

RBM43
RNA-binding protein 43

1

0

High-throughput

0.279

Low

879729

RSRC2
Arginine/serine-rich coiled-coil protein 2

1

0

High-throughput

0.279

Low

879750

TTPAL
Alpha-tocopherol transfer protein-like

1

0

High-throughput

0.279

Low

879751

MMTA2
Multiple myeloma tumor-associated protein 2

1

0

High-throughput

0.279

Low

879708

DEF6
Defensin-6

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025