Protein: ZHX2
Zinc fingers and homeoboxes protein 2 (Alpha-fetoprotein regulator 1) (AFP regulator 1) (Regulator of AFP) (Zinc finger and homeodomain protein 2)

Gene: ZHX2
Organism: Homo sapiens
Interactions: 75
UniProt ID: Q9Y6X8

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0003677 - DNA binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1461324

ZHX1
Zinc fingers and homeoboxes protein 1

2

17

Small-scale

0.776

High

1433686

ZHX3
Zinc fingers and homeoboxes protein 3

1

15

Small-scale

0.680

High

1491867

ZHX2
Zinc fingers and homeoboxes protein 2

1

13

Small-scale

0.653

High

375063

RASH
GTPase HRas

3

8

Small-scale

0.647

High

1435658

DOCK5
Dedicator of cytokinesis protein 5

2

1

High-throughput

0.628

High

210155

CRX
Cone-rod homeobox protein

1

18

High-throughput

0.618

High

549362

SRF
Serum response factor

1

1

High-throughput

0.618

High

685403

PAX6
Paired box protein Pax-6

1

20

High-throughput

0.618

High

895829

LHX2
LIM/homeobox protein Lhx2

1

19

High-throughput

0.618

High

1379982

LHX4
LIM/homeobox protein Lhx4

1

17

High-throughput

0.618

High

1458652

LHX3
LIM/homeobox protein Lhx3

1

16

High-throughput

0.618

High

1066559

RBBP4
Histone-binding protein RBBP4

2

6

High-throughput

0.611

High

1451722

ABITM
Protein Abitram

2

0

High-throughput

0.602

High

1133771

NFIX
Nuclear factor 1 X-type

2

20

High-throughput

0.584

High

397354

ESR1
Estrogen receptor

2

13

High-throughput

0.571

High

822934

VHL
von Hippel-Lindau disease tumor suppressor

2

0

Small-scale

0.559

High

848760

MAGA9
Melanoma-associated antigen 9

1

1

High-throughput

0.536

High

1110232

HDAC1
Histone deacetylase 1

1

8

High-throughput

0.536

High

1368232

HDAC2
Histone deacetylase 2

1

8

High-throughput

0.536

High

1100654

DHRS2
Dehydrogenase/reductase SDR family member 2, mitochondrial

1

0

High-throughput

0.518

High

1436676

VRTN
Vertnin

1

0

High-throughput

0.513

High

927643

ATX1
Ataxin-1

1

5

High-throughput

0.508

High

423562

A4
Amyloid-beta precursor protein

1

1

High-throughput

0.501

High

691594

1433T
14-3-3 protein theta

1

6

Small-scale

0.501

High

348821

AIFM1
Apoptosis-inducing factor 1, mitochondrial

1

0

High-throughput

0.493

High

1436741

MTD2L
Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2, mitochondrial

1

1

High-throughput

0.489

High

143364

NFIB
Nuclear factor 1 B-type

1

20

High-throughput

0.479

High

240026

SOX15
Transcription factor SOX-15

1

20

High-throughput

0.479

High

260667

BRD4
Bromodomain-containing protein 4

1

8

High-throughput

0.479

High

339913

KLF8
Krueppel-like factor 8

1

20

High-throughput

0.479

High

474418

NFIC
Nuclear factor 1 C-type

1

20

High-throughput

0.479

High

626418

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

4

Small-scale

0.479

High

659715

NFYA
Nuclear transcription factor Y subunit alpha

1

1

Small-scale

0.479

High

675743

TYY1
Transcriptional repressor protein YY1

1

8

High-throughput

0.479

High

703223

TEAD1
Transcriptional enhancer factor TEF-1

1

4

High-throughput

0.479

High

714566

PML
Protein PML

1

3

High-throughput

0.479

High

739051

ELF1
ETS-related transcription factor Elf-1

1

12

High-throughput

0.479

High

776158

SOX5
Transcription factor SOX-5

1

20

High-throughput

0.479

High

776278

SOX6
Transcription factor SOX-6

1

20

High-throughput

0.479

High

834107

HNF4A
Hepatocyte nuclear factor 4-alpha

1

9

High-throughput

0.479

High

837114

ELK3
ETS domain-containing protein Elk-3

1

12

High-throughput

0.479

High

938525

PAX9
Paired box protein Pax-9

1

16

High-throughput

0.479

High

944774

KLF3
Krueppel-like factor 3

1

20

High-throughput

0.479

High

990935

1433Z
14-3-3 protein zeta/delta

1

6

Small-scale

0.479

High

995376

CSK2B
Casein kinase II subunit beta

1

5

High-throughput

0.479

High

1026795

NFKB2
Nuclear factor NF-kappa-B p100 subunit

1

4

Small-scale

0.479

High

1030051

RELB
Transcription factor RelB

1

3

Small-scale

0.479

High

1040097

PAX2
Paired box protein Pax-2

1

20

High-throughput

0.479

High

1045966

TF65
Transcription factor p65

1

3

Small-scale

0.479

High

1088139

NFIA
Nuclear factor 1 A-type

1

20

High-throughput

0.479

High

1089088

TP53B
TP53-binding protein 1

1

2

High-throughput

0.479

High

1118804

KLF5
Krueppel-like factor 5

1

20

High-throughput

0.479

High

1152771

ELF2
ETS-related transcription factor Elf-2

1

9

High-throughput

0.479

High

1159063

RBBP7
Histone-binding protein RBBP7

1

6

High-throughput

0.479

High

1332956

UBP38
Ubiquitin carboxyl-terminal hydrolase 38

1

1

Small-scale

0.479

High

1339079

NUP43
Nucleoporin Nup43

1

12

High-throughput

0.479

High

1346721

JOS2
Josephin-2

1

2

Small-scale

0.479

High

1367730

ESR2
Estrogen receptor beta

1

13

High-throughput

0.479

High

1371392

UBP13
Ubiquitin carboxyl-terminal hydrolase 13

1

2

Small-scale

0.479

High

1387668

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

1

High-throughput

0.479

High

1405469

FEV
Protein FEV

1

12

High-throughput

0.479

High

1405658

ELF4
ETS-related transcription factor Elf-4

1

12

High-throughput

0.479

High

1416979

KLF16
Krueppel-like factor 16

1

13

High-throughput

0.479

High

1491464

KLF12
Krueppel-like factor 12

1

19

High-throughput

0.479

High

273605

DJC13
DnaJ homolog subfamily C member 13

1

0

High-throughput

0.458

High

1120064

COTL1
Coactosin-like protein

1

0

High-throughput

0.458

High

1257903

UBP49
Ubiquitin carboxyl-terminal hydrolase 49

1

0

Small-scale

0.458

High

1258254

UBP50
Ubiquitin carboxyl-terminal hydrolase 50

1

0

Small-scale

0.458

High

1459607

PARP2
Poly [ADP-ribose] polymerase 2

1

2

Small-scale

0.445

High

520720

RRAS
Ras-related protein R-Ras

1

7

Small-scale

0.437

High

1333131

AT11C
Phospholipid-transporting ATPase IG

1

1

High-throughput

0.437

High

220430

LAT
Linker for activation of T-cells family member 1

1

0

High-throughput

0.282

High

1460891

NAGPA
N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase

1

0

High-throughput

0.282

High

1042610

TFF2
Trefoil factor 2

1

0

High-throughput

0.268

Low


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Last updated: 11Aug2025