Protein: ISCA2
Iron-sulfur cluster assembly 2 homolog, mitochondrial (HESB-like domain-containing protein 1)

Gene: ISCA2
Organism: Homo sapiens
Interactions: 75
UniProt ID: Q86U28

Gene Ontology (top 5):
GO:0005506 - iron ion binding
GO:0005739 - mitochondrion
GO:0005759 - mitochondrial matrix
GO:0016226 - iron-sulfur cluster assembly
GO:0042802 - identical protein binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1287728

ISCA1
Iron-sulfur cluster assembly 1 homolog, mitochondrial

3

7

Small-scale

0.847

High

1287717

ISCA2
Iron-sulfur cluster assembly 2 homolog, mitochondrial

2

7

Small-scale

0.778

High

1212515

CAF17
Iron-sulfur cluster assembly factor IBA57, mitochondrial

3

5

Small-scale

0.662

High

890662

RGS3
Regulator of G-protein signaling 3

3

1

High-throughput

0.604

High

907157

SUOX
Sulfite oxidase, mitochondrial

2

0

High-throughput

0.580

High

1287733

F124B
Protein FAM124B

2

0

High-throughput

0.580

High

1287718

THNS1
Threonine synthase-like 1

1

1

High-throughput

0.536

High

1287734

ACAD9
Complex I assembly factor ACAD9, mitochondrial

1

1

High-throughput

0.536

High

384691

CRYAB
Alpha-crystallin B chain

1

0

High-throughput

0.513

High

539359

ODB2
Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial

1

0

High-throughput

0.513

High

994282

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

1

0

High-throughput

0.513

High

1287729

RFIP5
Rab11 family-interacting protein 5

1

0

High-throughput

0.513

High

1287735

MTD2L
Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase 2, mitochondrial

1

0

High-throughput

0.513

High

246014

KIF1B
Kinesin-like protein KIF1B

1

0

High-throughput

0.493

High

228607

STRN
Striatin

1

2

High-throughput

0.489

High

326729

DUS14
Dual specificity protein phosphatase 14

1

1

High-throughput

0.489

High

692735

CALL3
Calmodulin-like protein 3

1

1

High-throughput

0.489

High

1092896

STRN3
Striatin-3

1

2

High-throughput

0.489

High

1287723

AP4AT
AP-4 complex accessory subunit Tepsin

1

1

High-throughput

0.489

High

1287727

SIKE1
Suppressor of IKBKE 1

1

1

High-throughput

0.489

High

1287737

STRN4
Striatin-4

1

2

High-throughput

0.489

High

1287739

FGOP2
FGFR1 oncogene partner 2

1

1

High-throughput

0.489

High

728319

AKT1
RAC-alpha serine/threonine-protein kinase

1

0

Small-scale

0.480

High

1193615

Q49AR9
ANKS1A protein

1

1

High-throughput

0.470

High

1286654

GLRX5
Glutaredoxin-related protein 5, mitochondrial

1

3

High-throughput

0.445

High

1287720

ANS1A
Ankyrin repeat and SAM domain-containing protein 1A

1

1

High-throughput

0.439

High

1287731

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.437

High

1287742

DS13B
Dual specificity protein phosphatase 13B

1

1

High-throughput

0.437

High

1287732

RNF41
E3 ubiquitin-protein ligase NRDP1

5

0

Small-scale

0.377

High

933859

GEM
GTP-binding protein GEM

2

0

High-throughput

0.316

High

949389

EIF3E
Eukaryotic translation initiation factor 3 subunit E

2

0

High-throughput

0.316

High

1287722

NTAQ1
Protein N-terminal glutamine amidohydrolase

2

0

High-throughput

0.316

High

1287724

GUCD1
Protein GUCD1

2

0

High-throughput

0.316

High

376996

ANF
Natriuretic peptides A

2

0

High-throughput

0.313

High

1135351

SLMAP
Sarcolemmal membrane-associated protein

2

0

High-throughput

0.313

High

1201844

PKHG4
Puratrophin-1

2

0

High-throughput

0.313

High

1287265

DPP9
Dipeptidyl peptidase 9

2

0

High-throughput

0.313

High

1287730

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

2

0

High-throughput

0.313

High

177389

ARHGB
Rho guanine nucleotide exchange factor 11

1

0

High-throughput

0.279

Low

345194

ZMYM6
Zinc finger MYM-type protein 6

1

0

High-throughput

0.279

Low

488016

DPOLA
DNA polymerase alpha catalytic subunit

1

0

High-throughput

0.279

Low

502411

H2A1
Histone H2A type 1

1

0

High-throughput

0.279

Low

754575

S10A3
Protein S100-A3

1

0

High-throughput

0.279

Low

1168945

LONF2
LON peptidase N-terminal domain and RING finger protein 2

1

0

High-throughput

0.279

Low

1217337

STRP1
Striatin-interacting protein 1

1

0

High-throughput

0.279

Low

1236017

HPHL1
Ferroxidase HEPHL1

1

0

High-throughput

0.279

Low

1286427

DSG4
Desmoglein-4

1

0

High-throughput

0.279

Low

1287719

LRC15
Leucine-rich repeat-containing protein 15

1

0

High-throughput

0.279

Low

1287721

PBIR1
PPP2R1A-PPP2R2A-interacting phosphatase regulator 1

1

0

High-throughput

0.279

Low

1287725

OSBL9
Oxysterol-binding protein-related protein 9

1

0

High-throughput

0.279

Low

1287736

ISK5
Serine protease inhibitor Kazal-type 5

1

0

High-throughput

0.279

Low

1287738

ABC3C
DNA dC->dU-editing enzyme APOBEC-3C

1

0

High-throughput

0.279

Low

1287740

GAR1
H/ACA ribonucleoprotein complex subunit 1

1

0

High-throughput

0.279

Low

1287741

NARF
Nuclear prelamin A recognition factor

1

0

High-throughput

0.279

Low

1287744

PHOCN
MOB-like protein phocein

1

0

High-throughput

0.279

Low

1287745

HBS1L
HBS1-like protein

1

0

High-throughput

0.279

Low

1287746

CRBG1
Beta/gamma crystallin domain-containing protein 1

1

0

High-throughput

0.279

Low

47363

A0A6Q8PF08
Peripheral myelin protein 22

1

0

High-throughput

0.268

Low

109445

G5E9A7
DM1 locus, WD repeat containing

1

0

High-throughput

0.268

Low

301527

WFS1
Wolframin

1

0

High-throughput

0.268

Low

389848

TTHY
Transthyretin

1

0

High-throughput

0.268

Low

442383

GELS
Gelsolin

1

0

High-throughput

0.268

Low

650266

FGFR3
Fibroblast growth factor receptor 3

1

0

High-throughput

0.268

Low

702471

CLAT
Choline O-acetyltransferase

1

0

High-throughput

0.268

Low

705443

GRN
Progranulin

1

0

High-throughput

0.268

Low

1279597

SPRE1
Sprouty-related, EVH1 domain-containing protein 1

1

0

High-throughput

0.268

Low

106198

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

369263

ANT3
Antithrombin-III

1

0

High-throughput

0.249

Low

404829

PRIO
Major prion protein

1

0

High-throughput

0.232

Low

516680

VSIG8
V-set and immunoglobulin domain-containing protein 8

1

0

High-throughput

0.232

Low

733847

CDD
Cytidine deaminase

1

0

High-throughput

0.232

Low

1150446

NHRF2
Na(+)/H(+) exchange regulatory cofactor NHE-RF2

1

0

High-throughput

0.232

Low

1287726

S1PR3
Sphingosine 1-phosphate receptor 3

1

0

High-throughput

0.232

Low

1287743

T53G5
TP53-target gene 5 protein

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025