Protein: HBEGF
Proheparin-binding EGF-like growth factor [Cleaved into: Heparin-binding EGF-like growth factor (HB-EGF) (HBEGF) (Diphtheria toxin receptor) (DT-R)]

Gene: HBEGF
Organism: Homo sapiens
Interactions: 18
UniProt ID: Q99075

Gene Ontology (top 5):
GO:0005154 - epidermal growth factor receptor binding
GO:0005576 - extracellular region
GO:0005615 - extracellular space
GO:0005886 - plasma membrane
GO:0007165 - signal transduction

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

363751

EGFR
Epidermal growth factor receptor

4

19

Small-scale

0.683

High

762357

GPC1
Glypican-1 [Cleaved into: Secreted glypican-1]

2

1

High-throughput

0.611

High

591354

CD44
CD44 antigen

2

0

Small-scale

0.592

High

422954

A4
Amyloid-beta precursor protein

1

5

Small-scale

0.552

High

229561

NRDC
Nardilysin

1

0

Small-scale

0.537

High

283716

GPC4
Glypican-4

1

1

High-throughput

0.536

High

878080

AGRE5
Adhesion G protein-coupled receptor E5

1

1

High-throughput

0.536

High

1159817

OCLN
Occludin

1

0

High-throughput

0.513

High

686858

S10A4
Protein S100-A4

1

7

Small-scale

0.501

High

442452

GELS
Gelsolin

1

0

High-throughput

0.493

High

650373

FGFR3
Fibroblast growth factor receptor 3

1

0

High-throughput

0.493

High

697362

CD82
CD82 antigen

1

1

Small-scale

0.479

High

1145771

ERBB4
Receptor tyrosine-protein kinase erbB-4

1

19

Small-scale

0.479

High

404363

GCR
Glucocorticoid receptor

1

0

High-throughput

0.458

High

480386

MMP7
Matrilysin

1

0

Small-scale

0.458

High

1051409

ZBT16
Zinc finger and BTB domain-containing protein 16

2

0

Small-scale

0.332

High

832778

BCL6
B-cell lymphoma 6 protein

2

0

Small-scale

0.305

High

1403940

BAG1
BAG family molecular chaperone regulator 1

1

0

Small-scale

0.288

High


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Last updated: 11Aug2025