Protein: SYSC
Serine--tRNA ligase, cytoplasmic (EC 6.1.1.11) (Seryl-tRNA synthetase) (SerRS) (Seryl-tRNA(Ser/Sec) synthetase)

Gene: SYSC, SARS1
Organism: Homo sapiens
Interactions: 102
UniProt ID: P49591

Gene Ontology (top 5):
GO:0000049 - tRNA binding
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0001514 - selenocysteine incorporation
GO:0002181 - cytoplasmic translation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

829394

SIR2
NAD-dependent protein deacetylase sirtuin-2

4

3

High-throughput

0.697

High

829386

FRPD2
FERM and PDZ domain-containing protein 2

3

1

High-throughput

0.667

High

829361

SYSC
Serine--tRNA ligase, cytoplasmic

1

14

Small-scale

0.647

High

829398

NOPC1
NOP protein chaperone 1

3

0

High-throughput

0.638

High

829390

TRI67
Tripartite motif-containing protein 67

1

8

High-throughput

0.618

High

322336

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

2

2

High-throughput

0.611

High

174715

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

2

7

Small-scale

0.595

High

226849

PRKN
E3 ubiquitin-protein ligase parkin

2

8

High-throughput

0.584

High

829379

KPCD1
Serine/threonine-protein kinase D1

2

1

High-throughput

0.571

High

829373

CAV1
Caveolin-1

2

0

High-throughput

0.547

High

336415

SODC
Superoxide dismutase [Cu-Zn]

1

1

High-throughput

0.536

High

346228

MYC
Myc proto-oncogene protein

1

4

High-throughput

0.536

High

349189

RASH
GTPase HRas

1

1

High-throughput

0.536

High

386311

P53
Cellular tumor antigen p53

1

3

High-throughput

0.536

High

796055

MAGA9
Melanoma-associated antigen 9

1

2

High-throughput

0.536

High

829414

UBA5
Ubiquitin-like modifier-activating enzyme 5

1

1

High-throughput

0.536

High

829428

SAR1B
Small COPII coat GTPase SAR1B

1

2

High-throughput

0.536

High

829366

TERF1
Telomeric repeat-binding factor 1

1

0

High-throughput

0.518

High

147496

SOCS6
Suppressor of cytokine signaling 6

1

1

High-throughput

0.515

High

182325

PER1
Period circadian protein homolog 1

1

1

High-throughput

0.515

High

829403

LAR4B
La-related protein 4B

1

1

High-throughput

0.515

High

829411

ZKSC3
Zinc finger protein with KRAB and SCAN domains 3

1

1

High-throughput

0.515

High

829417

RASF1
Ras association domain-containing protein 1

1

2

High-throughput

0.515

High

829427

C170B
Centrosomal protein of 170 kDa protein B

1

1

High-throughput

0.515

High

829369

SUMO2
Small ubiquitin-related modifier 2

1

6

High-throughput

0.501

High

426601

H10
Histone H1.0

1

0

High-throughput

0.493

High

518288

ADT3
ADP/ATP translocase 3

1

0

High-throughput

0.493

High

63320

MET15
12S rRNA N4-methylcytidine

1

0

High-throughput

0.493

High

206337

LTOR5
Ragulator complex protein LAMTOR5

1

0

High-throughput

0.493

High

285155

DXO
Decapping and exoribonuclease protein

1

0

High-throughput

0.493

High

451778

ANXA4
Annexin A4

1

0

High-throughput

0.493

High

758152

CDN1A
Cyclin-dependent kinase inhibitor 1

1

0

High-throughput

0.493

High

829377

DPOA2
DNA polymerase alpha subunit B

1

0

High-throughput

0.493

High

829388

ADAL
Adenosine deaminase-like protein

1

0

High-throughput

0.493

High

829393

TAF8
Transcription initiation factor TFIID subunit 8

1

0

High-throughput

0.493

High

829397

PELI3
E3 ubiquitin-protein ligase pellino homolog 3

1

0

High-throughput

0.493

High

829413

ZN341
Zinc finger protein 341

1

0

High-throughput

0.493

High

829418

SRTD4
SERTA domain-containing protein 4

1

0

High-throughput

0.493

High

829425

SWP70
Switch-associated protein 70

1

0

High-throughput

0.493

High

118235

HAX1
HCLS1-associated protein X-1

1

1

High-throughput

0.479

High

162510

XPO1
Exportin-1

1

2

High-throughput

0.479

High

384484

NTRK1
High affinity nerve growth factor receptor

1

6

High-throughput

0.479

High

488164

HLAC
HLA class I histocompatibility antigen, C alpha chain

1

2

High-throughput

0.479

High

552219

RFA2
Replication protein A 32 kDa subunit

1

4

High-throughput

0.479

High

625232

CDK2
Cyclin-dependent kinase 2

1

3

High-throughput

0.479

High

650658

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

2

High-throughput

0.479

High

684514

STIP1
Stress-induced-phosphoprotein 1

1

8

High-throughput

0.479

High

724184

MSX2
Homeobox protein MSX-2

1

2

High-throughput

0.479

High

779016

CCNF
Cyclin-F

1

6

High-throughput

0.479

High

829362

MCM2
DNA replication licensing factor MCM2

1

1

High-throughput

0.479

High

829363

IMA5
Importin subunit alpha-5

1

3

Small-scale

0.479

High

829364

TXTP
Tricarboxylate transport protein, mitochondrial

1

1

High-throughput

0.479

High

829365

ATX3
Ataxin-3

1

1

High-throughput

0.479

High

829370

WDR5
WD repeat-containing protein 5

1

4

High-throughput

0.479

High

829371

H31
Histone H3.1

1

4

High-throughput

0.479

High

829374

BIRC3
Baculoviral IAP repeat-containing protein 3

1

3

High-throughput

0.479

High

829375

CUL3
Cullin-3

1

9

High-throughput

0.479

High

829376

CUL4A
Cullin-4A

1

9

High-throughput

0.479

High

829378

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

2

High-throughput

0.479

High

829380

CL16A
Protein CLEC16A

1

2

High-throughput

0.479

High

829382

FBX43
F-box only protein 43

1

1

Small-scale

0.479

High

829385

RN123
E3 ubiquitin-protein ligase RNF123

1

2

High-throughput

0.479

High

829396

RHG24
Rho GTPase-activating protein 24

1

2

High-throughput

0.479

High

829402

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

2

High-throughput

0.479

High

829404

CSN5
COP9 signalosome complex subunit 5

1

4

High-throughput

0.479

High

829405

CHM4C
Charged multivesicular body protein 4c

1

4

High-throughput

0.479

High

829408

DNJC2
DnaJ homolog subfamily C member 2

1

6

High-throughput

0.479

High

829409

DNJC7
DnaJ homolog subfamily C member 7

1

8

High-throughput

0.479

High

829410

SLF1
SMC5-SMC6 complex localization factor protein 1

1

4

High-throughput

0.479

High

829415

Q9H4D1
Protein kinase

1

4

High-throughput

0.479

High

829423

ABCF2
ATP-binding cassette sub-family F member 2

1

6

High-throughput

0.479

High

829424

ZRAN1
Ubiquitin thioesterase ZRANB1

1

4

High-throughput

0.479

High

829426

TNIK
TRAF2 and NCK-interacting protein kinase

1

2

High-throughput

0.479

High

829429

MTCH2
Mitochondrial carrier homolog 2

1

1

High-throughput

0.479

High

829384

TET5C
Terminal nucleotidyltransferase 5C

1

0

High-throughput

0.458

High

829400

NHLC2
NHL repeat-containing protein 2

1

0

High-throughput

0.458

High

829401

FBX22
F-box only protein 22

1

0

High-throughput

0.458

High

829416

DUS21
Dual specificity protein phosphatase 21

1

0

High-throughput

0.458

High

829422

TRM7
tRNA

1

0

High-throughput

0.458

High

401636

JUN
Transcription factor Jun

1

9

High-throughput

0.445

High

496563

TAU
Microtubule-associated protein tau

1

3

High-throughput

0.445

High

581546

VCAM1
Vascular cell adhesion protein 1

1

4

High-throughput

0.445

High

829367

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

3

High-throughput

0.445

High

829368

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

4

High-throughput

0.445

High

719959

RFA3
Replication protein A 14 kDa subunit

1

4

High-throughput

0.437

High

829383

RNFT1
E3 ubiquitin-protein ligase RNFT1

1

1

High-throughput

0.437

High

829389

LMBRL
Protein LMBR1L

1

3

High-throughput

0.437

High

829391

R3HCL
Coiled-coil domain-containing protein R3HCC1L

3

0

High-throughput

0.347

High

829407

DUS3L
tRNA-dihydrouridine(47) synthase [NAD(P)(+)]-like

3

0

High-throughput

0.347

High

829412

TINF2
TERF1-interacting nuclear factor 2

1

0

High-throughput

0.282

High

829419

POTE1
Protection of telomeres protein 1

1

0

High-throughput

0.282

High

829372

PRR3
Proline-rich protein 3

1

0

High-throughput

0.268

Low

829381

SPAS1
Spermatogenesis-associated serine-rich protein 1

1

0

High-throughput

0.268

Low

829392

SPT12
Spermatogenesis-associated protein 12

1

0

High-throughput

0.268

Low

829395

TMM61
Transmembrane protein 61

1

0

High-throughput

0.268

Low

829406

ASIC4
Acid-sensing ion channel 4

1

0

High-throughput

0.268

Low

829420

WBP1L
WW domain binding protein 1-like

1

0

High-throughput

0.268

Low

351731

SOMA
Somatotropin

1

0

High-throughput

0.249

Low

829387

BLT3A
Bridge-like lipid transfer protein family member 3A

1

0

High-throughput

0.249

Low

829399

EMC1
ER membrane protein complex subunit 1

1

0

High-throughput

0.249

Low

829421

MARH4
E3 ubiquitin-protein ligase MARCHF4

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024