HitPredict

Interactor 1: CUL3 (Q13618)
Cullin-3 (CUL-3)
Gene: CUL3

Interactor 2: KLHL6 (Q8WZ60)
Kelch-like protein 6
Gene: KLHL6

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.69	1.00	0.834

Property	Details
Experiments	28807996, 29695787, 37286065
Identification Methods	affinity chromatography technology, pull down
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	BACK~Cullin, BTB~Cullin
Common GO terms	GO:0005737 - cytoplasm GO:0031463 - Cul3-RING ubiquitin ligase complex GO:0043161 - proteasome-mediated ubiquitin-dependent protein catabolic process
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 768 Hs			1 621
+	Hs
		1113454 CUL3_HUMAN (1-768): 0: 943: 100.00		KLH24_HUMAN (18-607): 1.61e-167: 492: 43.94
+	Hs
		329059 CUL3_HUMAN (1-768): 0: 943: 100.00		KLHL2_HUMAN (21-608): 6.38e-157: 465: 29.09
+	Hs
		1114518 CUL3_HUMAN (1-768): 0: 943: 100.00		KLHL8_HUMAN (37-621): 2.93e-151: 451: 23.79
+	Hs
		1113682 CUL3_HUMAN (1-768): 0: 943: 100.00		KLH36_HUMAN (27-604): 1.53e-140: 424: 22.35
+	Hs
		1113719 CUL3_HUMAN (1-768): 0: 943: 100.00		KLH23_HUMAN (49-604): 8.09e-78: 259: 30.94
+	Hs
		161296 CUL3_HUMAN (1-768): 0: 943: 100.00		ENC1_HUMAN (62-581): 1.03e-74: 251: 29.96
+	Hs
		1113753 CUL3_HUMAN (1-768): 0: 943: 100.00		KBTB8_HUMAN (62-523): 2.23e-63: 221: 30.91
+	Hs
		1114054 CUL3_HUMAN (1-768): 0: 943: 100.00		KLHL5_HUMAN (403-613): 1.16e-55: 203: 24.54
+	Hs
		1113077 CUL3_HUMAN (1-768): 0: 943: 100.00		KEAP1_HUMAN (419-614): 6.27e-49: 182: 27.94
+	Hs
		1114520 CUL3_HUMAN (1-768): 0: 943: 100.00		KLHL9_HUMAN (435-620): 8.47e-48: 179: 21.54
+	Hs
		1114525 CUL3_HUMAN (1-768): 0: 943: 100.00		KLH13_HUMAN (435-620): 1.17e-47: 179: 21.54
+	Hs
		1114239 CUL3_HUMAN (1-768): 0: 943: 100.00		KLHL4_HUMAN (454-614): 1.38e-35: 144: 22.29
+	Hs
		1114459 CUL3_HUMAN (1-768): 0: 943: 100.00		KLH28_HUMAN (454-620): 8.77e-35: 141: 15.59
+	Hs
		1113274 CUL3_HUMAN (1-768): 0: 943: 100.00		KLH26_HUMAN (407-615): 6.28e-33: 136: 20.18
+	Hs
		1113267 CUL3_HUMAN (1-768): 0: 943: 100.00		KLH12_HUMAN (452-614): 4.51e-31: 129: 19.30
+	Hs
		1113399 CUL3_HUMAN (1-768): 0: 943: 100.00		KLH10_HUMAN (470-613): 3.04e-29: 124: 18.67
+	Hs
		1113453 CUL3_HUMAN (1-768): 0: 943: 100.00		KLH17_HUMAN (292-467): 6.89e-25: 111: 20.11
+	Hs
		320822 CUL3_HUMAN (1-768): 0: 943: 100.00		KLH18_HUMAN (497-621): 3.24e-24: 109: 21.21
+	Hs
		1114400 CUL3_HUMAN (1-768): 0: 943: 100.00		KLHL1_HUMAN (502-613): 7.91e-22: 102: 17.95
+	Hs
		1114259 CUL3_HUMAN (1-768): 0: 943: 100.00		KLH25_HUMAN (515-615): 5.76e-15: 80.2: 16.35