Protein: FUMH
Fumarate hydratase, mitochondrial (Fumarase) (HsFH) (EC 4.2.1.2)

Gene: FUMH, FH
Organism: Homo sapiens
Interactions: 77
UniProt ID: P07954

Gene Ontology (top 5):
GO:0000050 - urea cycle
GO:0000821 - regulation of arginine metabolic process
GO:0004333 - fumarate hydratase activity
GO:0005634 - nucleus
GO:0005694 - chromosome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

464275

TTC19
Tetratricopeptide repeat protein 19, mitochondrial

2

3

High-throughput

0.606

High

464280

KLHL6
Kelch-like protein 6

2

1

High-throughput

0.606

High

464234

H2AZ
Histone H2A.Z

1

1

Small-scale

0.597

High

240525

PRKN
E3 ubiquitin-protein ligase parkin

2

3

High-throughput

0.584

High

464237

HSP7C
Heat shock cognate 71 kDa protein

2

2

Small-scale

0.584

High

164512

TNPO2
Transportin-2

2

0

High-throughput

0.580

High

180209

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

2

0

High-throughput

0.580

High

464245

SAT1
Diamine acetyltransferase 1

2

0

High-throughput

0.580

High

464260

DGCR6
Protein DGCR6

2

0

High-throughput

0.580

High

464270

CCD57
Coiled-coil domain-containing protein 57

2

0

High-throughput

0.580

High

464274

C102B
Coiled-coil domain-containing protein 102B

2

0

High-throughput

0.580

High

464292

CSTP1
Centriolar satellite-associated tubulin polyglutamylase complex regulator 1

2

0

High-throughput

0.580

High

464293

EXOS5
Exosome complex component RRP46

2

0

High-throughput

0.580

High

464239

PIM1
Serine/threonine-protein kinase pim-1

1

2

High-throughput

0.573

High

464241

ATF2
Cyclic AMP-dependent transcription factor ATF-2

1

1

High-throughput

0.536

High

464247

H2B1B
Histone H2B type 1-B

1

1

Small-scale

0.536

High

464254

H2B1C
Histone H2B type 1-C/E/F/G/I

1

1

Small-scale

0.536

High

464297

SAE1
SUMO-activating enzyme subunit 1

1

1

High-throughput

0.515

High

464253

H4
Histone H4

1

0

Small-scale

0.513

High

464257

H33
Histone H3.3

1

0

Small-scale

0.513

High

464264

IQCB1
IQ calmodulin-binding motif-containing protein 1

1

0

High-throughput

0.513

High

464284

H2A1H
Histone H2A type 1-H

1

0

Small-scale

0.513

High

464255

GRB2
Growth factor receptor-bound protein 2

1

2

High-throughput

0.508

High

185364

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

3

High-throughput

0.501

High

464248

MDHM
Malate dehydrogenase, mitochondrial

1

3

Small-scale

0.501

High

369811

CO3
Complement C3

1

0

Small-scale

0.493

High

464238

ODB2
Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial

1

0

High-throughput

0.493

High

332476

CCDB1
Cyclin-D1-binding protein 1

1

1

High-throughput

0.481

High

464256

PRKDC
DNA-dependent protein kinase catalytic subunit

1

0

Small-scale

0.480

High

464242

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.479

High

464244

CEBPB
CCAAT/enhancer-binding protein beta

1

1

High-throughput

0.479

High

464259

BIRC3
Baculoviral IAP repeat-containing protein 3

1

1

High-throughput

0.479

High

464262

HAPR1
HUWE1-associated protein modifying stress responses 1

1

1

High-throughput

0.479

High

464263

TNIP1
TNFAIP3-interacting protein 1

1

1

High-throughput

0.479

High

464268

EZH2
Histone-lysine N-methyltransferase EZH2

1

1

High-throughput

0.479

High

464273

FTM
Protein fantom

1

1

High-throughput

0.479

High

464277

FGD5
FYVE, RhoGEF and PH domain-containing protein 5

1

1

High-throughput

0.479

High

464278

TRI67
Tripartite motif-containing protein 67

1

3

High-throughput

0.479

High

464279

SERB1
SERPINE1 mRNA-binding protein 1

1

1

High-throughput

0.479

High

464285

NSD1
Histone-lysine N-methyltransferase, H3 lysine-36 specific

1

1

High-throughput

0.479

High

464286

DNJC7
DnaJ homolog subfamily C member 7

1

3

High-throughput

0.479

High

464287

ANM1
Protein arginine N-methyltransferase 1

1

1

High-throughput

0.479

High

464291

PKHA4
Pleckstrin homology domain-containing family A member 4

1

2

High-throughput

0.479

High

464298

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

464299

LZTS1
Leucine zipper putative tumor suppressor 1

1

3

High-throughput

0.479

High

464246

CDK2
Cyclin-dependent kinase 2

1

0

High-throughput

0.458

High

464249

RECQ1
ATP-dependent DNA helicase Q1

1

0

High-throughput

0.458

High

464251

BID
BH3-interacting domain death agonist

1

0

Small-scale

0.458

High

464252

IF6
Eukaryotic translation initiation factor 6

1

0

High-throughput

0.458

High

464261

IKKE
Inhibitor of nuclear factor kappa-B kinase subunit epsilon

1

0

High-throughput

0.458

High

464266

EEA1
Early endosome antigen 1

1

0

High-throughput

0.458

High

464267

TRIP4
Activating signal cointegrator 1

1

0

High-throughput

0.458

High

464269

E2F4
Transcription factor E2F4

1

0

High-throughput

0.458

High

464272

TET5C
Terminal nucleotidyltransferase 5C

1

0

High-throughput

0.458

High

464283

MAEL
Protein maelstrom homolog

1

0

Small-scale

0.458

High

464294

SIR7
NAD-dependent protein deacetylase sirtuin-7

1

0

High-throughput

0.458

High

464295

TLR7
Toll-like receptor 7

1

0

High-throughput

0.458

High

464296

ITSN2
Intersectin-2

1

0

High-throughput

0.458

High

464300

FND3A
Fibronectin type-III domain-containing protein 3A

1

0

High-throughput

0.458

High

464301

AAKB1
5'-AMP-activated protein kinase subunit beta-1

1

0

High-throughput

0.458

High

464240

CFTR
Cystic fibrosis transmembrane conductance regulator

1

1

High-throughput

0.445

High

464243

GDC
Solute carrier family 25 member 16

1

1

High-throughput

0.445

High

464271

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

1

High-throughput

0.445

High

464276

PKHA7
Pleckstrin homology domain-containing family A member 7

1

2

High-throughput

0.445

High

464281

TSC1
Hamartin

1

1

Small-scale

0.445

High

464290

S2532
Solute carrier family 25 member 32

1

1

High-throughput

0.445

High

105148

APRIO
Alternative prion protein

1

1

High-throughput

0.437

High

126966

APBB1
Amyloid beta precursor protein binding family B member 1

1

0

High-throughput

0.426

High

464236

TAU
Microtubule-associated protein tau

1

0

High-throughput

0.426

High

464258

LMNB2
Lamin-B2

2

0

High-throughput

0.316

High

464288

TX101
Testis-expressed protein 101

1

0

High-throughput

0.279

Low

352864

AGR2
Anterior gradient protein 2 homolog

1

0

High-throughput

0.269

Low

464235

S31C1
Spermatogenesis-associated protein 31C1

1

0

High-throughput

0.249

Low

464250

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.249

Low

464265

ACAP2
Arf-GAP with coiled-coil, ANK repeat and PH domain-containing protein 2

1

0

High-throughput

0.249

Low

464282

CLUA1
Clusterin-associated protein 1

1

0

High-throughput

0.249

Low

464289

ZDHC5
Palmitoyltransferase ZDHHC5

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025