Protein: IOD2
Type II iodothyronine deiodinase (EC 1.21.99.4) (5DII) (DIOII) (Type 2 DI) (Type-II 5'-deiodinase)

Gene: IOD2, DIO2
Organism: Homo sapiens
Interactions: 14
UniProt ID: Q92813

Gene Ontology (top 5):
GO:0001514 - selenocysteine incorporation
GO:0004800 - thyroxine 5'-deiodinase activity
GO:0005789 - endoplasmic reticulum membrane
GO:0005886 - plasma membrane
GO:0006590 - thyroid hormone generation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1353399

UBP33
Ubiquitin carboxyl-terminal hydrolase 33

3

1

Small-scale

0.616

High

970221

UB2G1
Ubiquitin-conjugating enzyme E2 G1

2

0

Small-scale

0.577

High

246304

MARH6
E3 ubiquitin-protein ligase MARCHF6

2

0

Small-scale

0.569

High

1368989

UB2J1
Ubiquitin-conjugating enzyme E2 J1

1

1

Small-scale

0.501

High

1368986

IOD2
Type II iodothyronine deiodinase

1

0

Small-scale

0.480

High

934944

TERA
Transitional endoplasmic reticulum ATPase

1

0

Small-scale

0.458

High

983915

RBX1
E3 ubiquitin-protein ligase RBX1

1

0

Small-scale

0.458

High

1147230

ELOB
Elongin-B

1

0

Small-scale

0.458

High

1368987

CUL5
Cullin-5

1

0

Small-scale

0.458

High

1368988

UBP20
Ubiquitin carboxyl-terminal hydrolase 20

1

1

Small-scale

0.437

High

1368990

WSB1
WD repeat and SOCS box-containing protein 1

3

0

Small-scale

0.346

High

933701

PSMD4
26S proteasome non-ATPase regulatory subunit 4

1

0

Small-scale

0.249

Low

1147084

ELOC
Elongin-C

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025