Protein: UB2J1
Ubiquitin-conjugating enzyme E2 J1 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme J1) (Non-canonical ubiquitin-conjugating enzyme 1) (NCUBE-1) (Yeast ubiquitin-conjugating enzyme UBC6 homolog E) (HsUBC6e)

Gene: UB2J1, UBE2J1
Organism: Homo sapiens
Interactions: 197
UniProt ID: Q9Y385

Gene Ontology (top 5):
GO:0000209 - protein polyubiquitination
GO:0000836 - Hrd1p ubiquitin ligase complex
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005789 - endoplasmic reticulum membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1287477

SYVN1
E3 ubiquitin-protein ligase synoviolin

6

20

Small-scale

0.949

High

243361

PRKN
E3 ubiquitin-protein ligase parkin

6

20

Small-scale

0.943

High

1107507

BIRC2
Baculoviral IAP repeat-containing protein 2

3

20

Small-scale

0.854

High

647687

UBA1
Ubiquitin-like modifier-activating enzyme 1

3

20

Small-scale

0.835

High

508874

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

3

20

Small-scale

0.834

High

1408215

RNF5
E3 ubiquitin-protein ligase RNF5

2

20

Small-scale

0.789

High

208593

PJA2
E3 ubiquitin-protein ligase Praja-2

1

20

High-throughput

0.698

High

799601

BRCA1
Breast cancer type 1 susceptibility protein

1

20

High-throughput

0.698

High

1248455

LRSM1
E3 ubiquitin-protein ligase LRSAM1

1

20

High-throughput

0.698

High

1404859

RING2
E3 ubiquitin-protein ligase RING2

1

20

High-throughput

0.698

High

1449086

TOPRS
E3 ubiquitin-protein ligase Topors

1

6

High-throughput

0.698

High

1414513

DERL1
Derlin-1

4

6

Small-scale

0.684

High

1458787

SE1L1
Protein sel-1 homolog 1

3

7

Small-scale

0.675

High

326113

UBR5
E3 ubiquitin-protein ligase UBR5

1

20

Small-scale

0.647

High

1380890

TRI63
E3 ubiquitin-protein ligase TRIM63

1

20

High-throughput

0.621

High

1125268

TRI25
E3 ubiquitin/ISG15 ligase TRIM25

1

20

Small-scale

0.618

High

1178116

RN151
RING finger protein 151

1

20

Small-scale

0.618

High

1358805

RN133
E3 ubiquitin-protein ligase RNF133

1

20

Small-scale

0.618

High

1391937

RN185
E3 ubiquitin-protein ligase RNF185

1

20

Small-scale

0.618

High

1417858

RNF26
E3 ubiquitin-protein ligase RNF26

1

20

Small-scale

0.618

High

1370217

CDS1
Phosphatidate cytidylyltransferase 1

2

2

High-throughput

0.606

High

1417784

SC11C
Signal peptidase complex catalytic subunit SEC11C

2

2

High-throughput

0.606

High

1428525

ELOV4
Very long chain fatty acid elongase 4

2

5

High-throughput

0.606

High

1434965

REEP4
Receptor expression-enhancing protein 4

2

3

High-throughput

0.606

High

1111756

STIM1
Stromal interaction molecule 1

2

0

High-throughput

0.585

High

417865

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

2

1

High-throughput

0.584

High

935327

TERA
Transitional endoplasmic reticulum ATPase

2

3

Small-scale

0.584

High

1491080

AUP1
Lipid droplet-regulating VLDL assembly factor AUP1

2

2

Small-scale

0.584

High

1110942

LAPM5
Lysosomal-associated transmembrane protein 5

2

0

High-throughput

0.580

High

1142977

EBP
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase

2

0

High-throughput

0.580

High

1207656

F209A
Protein FAM209A

2

0

High-throughput

0.580

High

1328229

JAGN1
Protein jagunal homolog 1

2

0

High-throughput

0.580

High

1491038

TMX2
Thioredoxin-related transmembrane protein 2

2

0

High-throughput

0.580

High

248254

NDK8
Putative nucleoside diphosphate kinase

2

0

High-throughput

0.559

High

1365538

EDEM1
ER degradation-enhancing alpha-mannosidase-like protein 1

2

0

Small-scale

0.559

High

762189

TRFR
Thyrotropin-releasing hormone receptor

2

1

High-throughput

0.553

High

946648

S26A5
Prestin

2

2

High-throughput

0.553

High

1186074

SOAT
Sodium-dependent organic anion transporter

2

1

High-throughput

0.553

High

1210330

MF14B
Hippocampus abundant transcript-like protein 1

2

5

High-throughput

0.553

High

1256860

GOT1A
Vesicle transport protein GOT1A

2

1

High-throughput

0.553

High

1339306

PKR2
Prokineticin receptor 2

2

1

High-throughput

0.553

High

1385814

T4S18
Transmembrane 4 L6 family member 18

2

1

High-throughput

0.553

High

1388147

T4S19
Transmembrane 4 L6 family member 19

2

1

High-throughput

0.553

High

1398495

TLCD4
TLC domain-containing protein 4

2

2

High-throughput

0.553

High

1449824

TM14B
Transmembrane protein 14B

2

2

High-throughput

0.553

High

1460424

HERC5
E3 ISG15--protein ligase HERC5

1

20

Small-scale

0.553

High

572293

TRI27
Zinc finger protein RFP

1

20

High-throughput

0.541

High

1388128

ERLEC
Endoplasmic reticulum lectin 1

1

2

High-throughput

0.536

High

1237594

Q6NR77
Ring finger protein 28

1

20

High-throughput

0.528

High

1490571

ERGI3
Endoplasmic reticulum-Golgi intermediate compartment protein 3

1

3

High-throughput

0.515

High

1418049

FUT8
Alpha-(1,6)-fucosyltransferase

1

0

High-throughput

0.513

High

230471

CREB3
Cyclic AMP-responsive element-binding protein 3

1

1

High-throughput

0.508

High

879767

MAPK2
MAP kinase-activated protein kinase 2

1

3

Small-scale

0.501

High

1368989

IOD2
Type II iodothyronine deiodinase

1

1

Small-scale

0.501

High

351993

S1PR4
Sphingosine 1-phosphate receptor 4

1

2

High-throughput

0.489

High

477482

CD63
CD63 antigen

1

1

High-throughput

0.489

High

1363169

CLC2B
C-type lectin domain family 2 member B

1

3

High-throughput

0.489

High

174157

AT2A1
Sarcoplasmic/endoplasmic reticulum calcium ATPase 1

1

1

High-throughput

0.479

High

224054

GET3
ATPase GET3

1

1

Small-scale

0.479

High

376128

RASK
GTPase KRas

1

1

High-throughput

0.479

High

386388

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

3

High-throughput

0.479

High

409544

HLAA
HLA class I histocompatibility antigen, A alpha chain

1

1

Small-scale

0.479

High

439886

INSR
Insulin receptor

1

4

High-throughput

0.479

High

466535

RHOC
Rho-related GTP-binding protein RhoC

1

8

High-throughput

0.479

High

548388

CP2C9
Cytochrome P450 2C9

1

4

High-throughput

0.479

High

581385

RAC2
Ras-related C3 botulinum toxin substrate 2

1

8

High-throughput

0.479

High

604284

CXA1
Gap junction alpha-1 protein

1

2

High-throughput

0.479

High

634705

LMNB1
Lamin-B1

1

3

High-throughput

0.479

High

658485

RS3
Small ribosomal subunit protein uS3

1

1

Small-scale

0.479

High

699279

CALX
Calnexin

1

2

High-throughput

0.479

High

774720

BASI
Basigin

1

3

High-throughput

0.479

High

902155

RAB9A
Ras-related protein Rab-9A

1

4

High-throughput

0.479

High

904211

BAP31
B-cell receptor-associated protein 31

1

1

High-throughput

0.479

High

951538

SC61B
Protein transport protein Sec61 subunit beta

1

1

High-throughput

0.479

High

953771

RAC3
Ras-related C3 botulinum toxin substrate 3

1

8

High-throughput

0.479

High

955778

CDC42
Cell division control protein 42 homolog

1

8

High-throughput

0.479

High

962657

RHOA
Transforming protein RhoA

1

9

High-throughput

0.479

High

1015929

RHOG
Rho-related GTP-binding protein RhoG

1

8

High-throughput

0.479

High

1105596

OS9
Protein OS-9

1

2

Small-scale

0.479

High

1125746

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

1

6

High-throughput

0.479

High

1238858

TECT3
Tectonic-3

1

1

High-throughput

0.479

High

1245158

RHDF2
Inactive rhomboid protein 2

1

1

High-throughput

0.479

High

1352408

RHBL4
Rhomboid-related protein 4

1

1

High-throughput

0.479

High

1381552

ERGI1
Endoplasmic reticulum-Golgi intermediate compartment protein 1

1

3

High-throughput

0.479

High

1383194

LRC59
Leucine-rich repeat-containing protein 59

1

15

High-throughput

0.479

High

1386425

FAF2
FAS-associated factor 2

1

3

Small-scale

0.479

High

1396000

DNJC1
DnaJ homolog subfamily C member 1

1

4

High-throughput

0.479

High

1400596

DERL3
Derlin-3

1

6

Small-scale

0.479

High

1401738

ERGI2
Endoplasmic reticulum-Golgi intermediate compartment protein 2

1

3

High-throughput

0.479

High

1412731

ESYT1
Extended synaptotagmin-1

1

1

High-throughput

0.479

High

1421185

LNP
Endoplasmic reticulum junction formation protein lunapark

1

1

High-throughput

0.479

High

1428322

DERL2
Derlin-2

1

6

Small-scale

0.479

High

1431297

DJC25
DnaJ homolog subfamily C member 25

1

3

High-throughput

0.479

High

1431799

3BHS7
3 beta-hydroxysteroid dehydrogenase type 7

1

1

High-throughput

0.479

High

1432683

GHITM
Growth hormone-inducible transmembrane protein

1

2

High-throughput

0.479

High

1452733

ELOV5
Very long chain fatty acid elongase 5

1

5

High-throughput

0.479

High

1462012

ALK
ALK tyrosine kinase receptor

1

14

High-throughput

0.479

High

1490711

DJC16
DnaJ homolog subfamily C member 16

1

2

High-throughput

0.479

High

418530

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

0

High-throughput

0.458

High

837915

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

0

High-throughput

0.458

High

847756

SSRA
Translocon-associated protein subunit alpha

1

0

High-throughput

0.458

High

880755

LMAN1
Protein ERGIC-53

1

0

High-throughput

0.458

High

1058735

CKAP4
Cytoskeleton-associated protein 4

1

0

High-throughput

0.458

High

1218708

OTU1
Ubiquitin thioesterase OTU1

1

0

Small-scale

0.458

High

1276382

ATG9A
Autophagy-related protein 9A

1

0

High-throughput

0.458

High

1288513

LBN
Limbin

1

0

High-throughput

0.458

High

1401261

PANX1
Pannexin-1

1

0

High-throughput

0.458

High

1404292

SEC62
Translocation protein SEC62

1

0

High-throughput

0.458

High

1454870

B3GA1
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1

1

0

High-throughput

0.458

High

1207912

S27A3
Long-chain fatty acid transport protein 3

1

1

High-throughput

0.445

High

1346839

ZNT5
Proton-coupled zinc antiporter SLC30A5

1

1

High-throughput

0.445

High

832662

AQP2
Aquaporin-2

1

10

Small-scale

0.439

High

1109099

AQP6
Aquaporin-6

1

12

High-throughput

0.439

High

126888

RHOD
Rho-related GTP-binding protein RhoD

1

9

High-throughput

0.437

High

189945

STX7
Syntaxin-7

1

1

High-throughput

0.437

High

218992

TGON2
Trans-Golgi network integral membrane protein 2

1

4

High-throughput

0.437

High

562505

LAMP2
Lysosome-associated membrane glycoprotein 2

1

4

High-throughput

0.437

High

611427

PTN1
Tyrosine-protein phosphatase non-receptor type 1

1

1

High-throughput

0.437

High

631035

RAB4A
Ras-related protein Rab-4A

1

1

High-throughput

0.437

High

631584

RAB5A
Ras-related protein Rab-5A

1

1

High-throughput

0.437

High

820778

CEAM6
Cell adhesion molecule CEACAM6

1

1

High-throughput

0.437

High

895173

EMD
Emerin

1

1

High-throughput

0.437

High

901113

RAB5C
Ras-related protein Rab-5C

1

1

High-throughput

0.437

High

901696

RAB7A
Ras-related protein Rab-7a

1

4

High-throughput

0.437

High

1027244

REEP5
Receptor expression-enhancing protein 5

1

3

High-throughput

0.437

High

1087352

STX4
Syntaxin-4

1

1

High-throughput

0.437

High

1145187

RAB35
Ras-related protein Rab-35

1

1

High-throughput

0.437

High

1214608

ACBD5
Acyl-CoA-binding domain-containing protein 5

1

1

High-throughput

0.437

High

1252307

SYNE3
Nesprin-3

1

2

High-throughput

0.437

High

1286963

TM11B
Transmembrane protease serine 11B

1

6

High-throughput

0.437

High

1323054

CXD3
Gap junction delta-3 protein

1

2

High-throughput

0.437

High

1334072

DHB11
Estradiol 17-beta-dehydrogenase 11

1

2

High-throughput

0.437

High

1392505

TECT2
Tectonic-2

1

1

High-throughput

0.437

High

1448049

PXMP2
Peroxisomal membrane protein 2

1

1

High-throughput

0.437

High

1448859

TMPS4
Transmembrane protease serine 4

1

2

High-throughput

0.437

High

1453931

TM216
Transmembrane protein 216

1

1

High-throughput

0.437

High

1459637

SEC63
Translocation protein SEC63 homolog

1

1

High-throughput

0.437

High

1461859

CLC4E
C-type lectin domain family 4 member E

1

2

High-throughput

0.437

High

1462786

LAMP3
Lysosome-associated membrane glycoprotein 3

1

4

High-throughput

0.437

High

1380570

PIGT
GPI-anchor transamidase component PIGT

1

0

High-throughput

0.426

High

256200

S19A2
Thiamine transporter 1

1

1

High-throughput

0.407

High

539754

ACHB
Acetylcholine receptor subunit beta

1

1

High-throughput

0.407

High

663580

CMA1
Chymase

1

3

High-throughput

0.407

High

722667

CTR1
High affinity cationic amino acid transporter 1

1

2

High-throughput

0.407

High

870337

S6A12
Sodium- and chloride-dependent betaine transporter

1

2

High-throughput

0.407

High

1060406

SLC31
Amino acid transporter heavy chain SLC3A1

1

1

High-throughput

0.407

High

1211976

S35F1
Solute carrier family 35 member F1

1

2

High-throughput

0.407

High

1236386

MFSD5
Molybdate-anion transporter

1

2

High-throughput

0.407

High

1309011

S22A9
Organic anion transporter 7

1

2

High-throughput

0.407

High

1313885

S15A3
Solute carrier family 15 member 3

1

20

High-throughput

0.407

High

1356686

S22AH
Solute carrier family 22 member 17

1

2

High-throughput

0.407

High

1404979

S1PR3
Sphingosine 1-phosphate receptor 3

1

1

High-throughput

0.407

High

1460037

CLC2D
C-type lectin domain family 2 member D

1

3

High-throughput

0.407

High

1491051

KLK5
Kallikrein-5

1

4

High-throughput

0.407

High

1084028

SIA4A
CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 1

2

0

High-throughput

0.328

High

350326

LY66C
Lymphocyte antigen 6 complex locus protein G6c

2

0

High-throughput

0.316

High

549923

CD79A
B-cell antigen receptor complex-associated protein alpha chain

2

0

High-throughput

0.316

High

883455

CY561
Transmembrane ascorbate-dependent reductase CYB561

2

0

High-throughput

0.316

High

1387810

M4A6E
Membrane-spanning 4-domains subfamily A member 6E

2

0

High-throughput

0.316

High

1389674

MFSD3
Major facilitator superfamily domain-containing protein 3

2

0

High-throughput

0.316

High

1392024

PLPR2
Phospholipid phosphatase-related protein type 2

2

0

High-throughput

0.316

High

1396415

F210B
Protein FAM210B, mitochondrial

2

0

High-throughput

0.316

High

1438326

CLTRN
Collectrin

2

0

High-throughput

0.316

High

1449144

GKN1
Gastrokine-1

2

0

High-throughput

0.316

High

1451129

TMM51
Transmembrane protein 51

2

0

High-throughput

0.316

High

1491079

LYVE1
Lymphatic vessel endothelial hyaluronic acid receptor 1

2

0

High-throughput

0.316

High

1194726

GXLT1
Glucoside xylosyltransferase 1

2

0

High-throughput

0.313

High

1431641

CHST8
Carbohydrate sulfotransferase 8

2

0

High-throughput

0.313

High

182847

GP182
G-protein coupled receptor 182

1

0

High-throughput

0.279

Low

251131

B4GT3
Beta-1,4-galactosyltransferase 3

1

0

High-throughput

0.279

Low

833890

P2RY2
P2Y purinoceptor 2

1

0

High-throughput

0.279

Low

1380398

I22R2
Interleukin-22 receptor subunit alpha-2

1

0

High-throughput

0.279

Low

1419509

CNTP3
Contactin-associated protein-like 3

1

0

High-throughput

0.279

Low

1462140

AT1B4
Protein ATP1B4

1

0

High-throughput

0.279

Low

643155

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

0

High-throughput

0.269

Low

1398532

ZDH15
Palmitoyltransferase ZDHHC15

1

0

High-throughput

0.268

Low

1446084

S39A2
Zinc transporter ZIP2

1

0

High-throughput

0.268

Low

718747

FCERG
High affinity immunoglobulin epsilon receptor subunit gamma

1

0

High-throughput

0.251

Low

1207793

TMM31
Transmembrane protein 31

1

0

High-throughput

0.251

Low

291601

NU155
Nuclear pore complex protein Nup155

1

0

High-throughput

0.249

Low

630673

RAB3B
Ras-related protein Rab-3B

1

0

High-throughput

0.249

Low

1293220

TMM17
Transmembrane protein 17

1

0

High-throughput

0.249

Low

1293703

DYR2
Dihydrofolate reductase 2, mitochondrial

1

0

High-throughput

0.249

Low

1379915

KISSR
KiSS-1 receptor

1

0

Small-scale

0.249

Low

1382984

S2546
Mitochondrial outer membrane protein SLC25A46

1

0

High-throughput

0.249

Low

1436369

TMT1A
Thiol S-methyltransferase TMT1A

1

0

High-throughput

0.249

Low

1448183

ST7
Suppressor of tumorigenicity 7 protein

1

0

High-throughput

0.249

Low

1450146

OTULL
Inactive ubiquitin thioesterase OTULINL

1

0

High-throughput

0.249

Low

1490665

RXLT1
Ribitol-5-phosphate xylosyltransferase 1

1

0

High-throughput

0.249

Low

851246

ACHA4
Neuronal acetylcholine receptor subunit alpha-4

1

0

High-throughput

0.232

Low

946607

EVA1C
Protein eva-1 homolog C

1

0

High-throughput

0.232

Low

1230855

SL9A4
Sodium/hydrogen exchanger 4

1

0

High-throughput

0.232

Low

1333796

TM87A
Transmembrane protein 87A

1

0

High-throughput

0.232

Low

1359282

CA054
Uncharacterized protein C1orf54

1

0

High-throughput

0.232

Low

1359767

S13A3
Na(+)/dicarboxylate cotransporter 3

1

0

High-throughput

0.232

Low

1400643

B3A4
Anion exchange protein 4

1

0

High-throughput

0.232

Low

1452334

SCN3B
Sodium channel regulatory subunit beta-3

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025