Protein: MARH6
E3 ubiquitin-protein ligase MARCHF6 (EC 2.3.2.27) (Doa10 homolog) (Membrane-associated RING finger protein 6) (Membrane-associated RING-CH protein VI) (MARCH-VI) (Protein TEB-4) (RING finger protein 176) (RING-type E3 ubiquitin transferase MARCHF6)

Gene: MARH6, MARCHF6
Organism: Homo sapiens
Interactions: 54
UniProt ID: O60337

Gene Ontology (top 5):
GO:0000835 - ER ubiquitin ligase complex
GO:0004842 - ubiquitin-protein transferase activity
GO:0005783 - endoplasmic reticulum
GO:0005789 - endoplasmic reticulum membrane
GO:0008270 - zinc ion binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

246291

ERG1
Squalene monooxygenase

5

1

Small-scale

0.707

High

246270

MARH6
E3 ubiquitin-protein ligase MARCHF6

2

12

Small-scale

0.626

High

246273

GLRA2
Glycine receptor subunit alpha-2

3

1

High-throughput

0.609

High

246318

AGRE2
Adhesion G protein-coupled receptor E2

2

1

High-throughput

0.606

High

246297

UB2J2
Ubiquitin-conjugating enzyme E2 J2

2

20

Small-scale

0.595

High

246316

ZDHC7
Palmitoyltransferase ZDHHC7

2

0

High-throughput

0.585

High

246312

GPR21
Probable G-protein coupled receptor 21

2

1

High-throughput

0.574

High

246304

IOD2
Type II iodothyronine deiodinase

2

0

Small-scale

0.569

High

246306

SPSB4
SPRY domain-containing SOCS box protein 4

1

1

High-throughput

0.536

High

246307

UBE2W
Ubiquitin-conjugating enzyme E2 W

1

20

High-throughput

0.536

High

246317

MARH4
E3 ubiquitin-protein ligase MARCHF4

1

11

High-throughput

0.536

High

246311

PLIN2
Perilipin-2

1

0

Small-scale

0.529

High

142122

NPT3
Sodium-dependent phosphate transport protein 3

1

0

High-throughput

0.513

High

246285

SEM1
26S proteasome complex subunit SEM1

1

0

Small-scale

0.513

High

246302

CKLF2
CKLF-like MARVEL transmembrane domain-containing protein 2

1

0

High-throughput

0.513

High

246272

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

9

Small-scale

0.501

High

246284

UB2G2
Ubiquitin-conjugating enzyme E2 G2

1

19

Small-scale

0.501

High

246287

UB2G1
Ubiquitin-conjugating enzyme E2 G1

1

19

Small-scale

0.501

High

246288

UB2D2
Ubiquitin-conjugating enzyme E2 D2

1

20

Small-scale

0.501

High

246289

AMPE
Glutamyl aminopeptidase

1

0

High-throughput

0.493

High

246279

P2RY2
P2Y purinoceptor 2

1

1

High-throughput

0.489

High

246281

GLRB
Glycine receptor subunit beta

1

1

High-throughput

0.489

High

246320

O10H1
Olfactory receptor 10H1

1

1

High-throughput

0.489

High

246283

VAMP7
Vesicle-associated membrane protein 7

1

5

High-throughput

0.479

High

246290

DHX9
ATP-dependent RNA helicase A

1

1

Small-scale

0.479

High

246300

RN149
E3 ubiquitin-protein ligase RNF149

1

2

High-throughput

0.479

High

246308

FAF2
FAS-associated factor 2

1

4

Small-scale

0.479

High

246310

SORT
Sortilin

1

1

High-throughput

0.479

High

246282

MTR1B
Melatonin receptor type 1B

1

1

High-throughput

0.464

High

246293

MSMO1
Methylsterol monooxygenase 1

1

0

Small-scale

0.460

High

246274

PRDX6
Peroxiredoxin-6

1

0

High-throughput

0.458

High

246275

PPARG
Peroxisome proliferator-activated receptor gamma

1

0

High-throughput

0.458

High

246276

FEN1
Flap endonuclease 1

1

0

High-throughput

0.458

High

246303

SPP
Signal peptide peptidase

1

0

Small-scale

0.458

High

246315

EMC7
Endoplasmic reticulum membrane protein complex subunit 7

1

0

High-throughput

0.458

High

246319

RRP44
Exosome complex exonuclease RRP44

1

0

High-throughput

0.458

High

246295

S27A4
Long-chain fatty acid transport protein 4

1

2

High-throughput

0.445

High

246305

CCD47
PAT complex subunit CCDC47

1

2

High-throughput

0.445

High

217574

TGON2
Trans-Golgi network integral membrane protein 2

1

1

High-throughput

0.437

High

246271

TYSY
Thymidylate synthase

1

2

High-throughput

0.437

High

246286

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

1

High-throughput

0.437

High

246313

S4A5
Electrogenic sodium bicarbonate cotransporter 4

1

0

High-throughput

0.426

High

246309

TXD15
Thioredoxin domain-containing protein 15

4

0

High-throughput

0.362

High

246280

5HT3A
5-hydroxytryptamine receptor 3A

2

0

High-throughput

0.328

High

246277

RGS2
Regulator of G-protein signaling 2

2

0

Small-scale

0.316

High

246278

BUD31
Protein BUD31 homolog

1

0

High-throughput

0.282

High

246292

KIF22
Kinesin-like protein KIF22

1

0

High-throughput

0.279

Low

246296

TMC4
Voltage-gated chloride channel TMC4

1

0

High-throughput

0.279

Low

246298

M4A15
Membrane-spanning 4-domains subfamily A member 15

1

0

High-throughput

0.279

Low

246299

KTAP2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit KCP2

1

0

High-throughput

0.279

Low

246301

OR2M7
Olfactory receptor 2M7

1

0

High-throughput

0.279

Low

246314

GPR88
G protein-coupled receptor 88

1

0

High-throughput

0.279

Low

246294

TRXR1
Thioredoxin reductase 1, cytoplasmic

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025