Protein: RGRF1
Ras-specific guanine nucleotide-releasing factor 1 (Ras-GRF1) (Guanine nucleotide-releasing protein) (GNRP) (Ras-specific nucleotide exchange factor CDC25)

Gene: RGRF1, RASGRF1
Organism: Homo sapiens
Interactions: 19
UniProt ID: Q13972

Gene Ontology (top 5):
GO:0005085 - guanyl-nucleotide exchange factor activity
GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0007165 - signal transduction
GO:0007265 - Ras protein signal transduction

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

669130

ARBK1
Beta-adrenergic receptor kinase 1

1

4

High-throughput

0.698

High

692060

MARK3
MAP/microtubule affinity-regulating kinase 3

1

0

Small-scale

0.687

High

557294

SRC
Proto-oncogene tyrosine-protein kinase Src

1

19

Small-scale

0.647

High

1006388

SRPK2
SRSF protein kinase 2

1

1

High-throughput

0.647

High

374591

RASH
GTPase HRas

1

20

Small-scale

0.621

High

919953

PLK1
Serine/threonine-protein kinase PLK1

1

5

Small-scale

0.618

High

1098520

NMDE2
Glutamate receptor ionotropic, NMDA 2B

1

10

Small-scale

0.573

High

1119632

EHD4
EH domain-containing protein 4

1

6

High-throughput

0.541

High

1119631

RB33B
Ras-related protein Rab-33B

1

0

High-throughput

0.517

High

729821

1433B
14-3-3 protein beta/alpha

1

20

Small-scale

0.501

High

472728

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

1

High-throughput

0.494

High

886842

CEBPA
CCAAT/enhancer-binding protein alpha

1

3

High-throughput

0.494

High

292446

PALM
Paralemmin-1

1

0

High-throughput

0.493

High

731276

STIP1
Stress-induced-phosphoprotein 1

1

2

Small-scale

0.481

High

413806

P53
Cellular tumor antigen p53

1

3

Small-scale

0.479

High

990207

1433Z
14-3-3 protein zeta/delta

1

20

High-throughput

0.479

High

1119629

UBP48
Ubiquitin carboxyl-terminal hydrolase 48

1

1

Small-scale

0.479

High

1119630

NEB2
Neurabin-2

1

20

Small-scale

0.479

High

1028195

MDM2
E3 ubiquitin-protein ligase Mdm2

1

0

High-throughput

0.458

High


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Last updated: 11Aug2025