HitPredict

Interactor 1: KEAP1 (Q9Z2X8)
Kelch-like ECH-associated protein 1 (Cytosolic inhibitor of Nrf2) (INrf2)
Gene: KEAP1

Interactor 2: KEAP1 (Q9Z2X8)
Kelch-like ECH-associated protein 1 (Cytosolic inhibitor of Nrf2) (INrf2)
Gene: KEAP1

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.74 1.00 0.863

The method score is based on:

Property Details
Experiments 30261176, 20133743, 12145307
Identification Methods affinity chromatography technology, x-ray crystallography, molecular sieving, comigration in sds page, transmission electron microscopy
Interaction Type physical association, association, direct interaction

The annotation score is based on:

Property Details
Interacting Pfam domains BACK~BTB, BACK~Kelch_1, BTB~BTB, Kelch_1~Kelch_1
Common GO terms GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0001701 - in utero embryonic development
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0005783 - endoplasmic reticulum
and 20 others

more...
Homologous interactions 20

Homologous interactions (Top 20)

Color coding for hit scores

1 624
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Service provided by Combinatics, Japan

Last updated: 11Aug2025