Protein: GCN1
eIF-2-alpha kinase activator GCN1 (General control non-derepressible protein 1) (Translational activator GCN1)

Gene: GCN1
Organism: Saccharomyces cerevisiae S288C
Interactions: 220
UniProt ID: P33892

Gene Ontology (top 5):
GO:0001934 - positive regulation of protein phosphorylation
GO:0005739 - mitochondrion
GO:0005829 - cytosol
GO:0006417 - regulation of translation
GO:0006448 - regulation of translational elongation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

707879

GCN20
Protein GCN20

8

7

Small-scale

0.756

High

548524

GCN2
eIF-2-alpha kinase GCN2

5

7

Small-scale

0.720

High

707842

IMB2
Importin subunit beta-2

3

9

High-throughput

0.662

High

707920

GIR2
Protein GIR2

3

0

Small-scale

0.649

High

707949

RS10A
Small ribosomal subunit protein eS10A

2

5

Small-scale

0.631

High

707894

RBG2
Ribosome-interacting GTPase 2

4

10

Small-scale

0.626

High

490792

HSP71
Heat shock protein SSA1

3

14

High-throughput

0.624

High

493588

HSP72
Heat shock protein SSA2

3

14

High-throughput

0.624

High

635683

YIH1
Protein IMPACT homolog

2

1

Small-scale

0.614

High

406935

RS3
Small ribosomal subunit protein uS3

2

5

High-throughput

0.611

High

687681

BTAF1
TATA-binding protein-associated factor MOT1

2

3

High-throughput

0.588

High

691255

MYO4
Myosin-4

2

6

High-throughput

0.588

High

707885

SMC3
Structural maintenance of chromosomes protein 3

2

3

High-throughput

0.588

High

704615

PLSC
1-acyl-sn-glycerol-3-phosphate acyltransferase

3

2

High-throughput

0.587

High

707880

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

2

10

High-throughput

0.584

High

366065

HSP82
ATP-dependent molecular chaperone HSP82

2

13

High-throughput

0.571

High

510792

SSB1
Ribosome-associated molecular chaperone SSB1

2

17

High-throughput

0.571

High

707927

SXM1
Importin beta SMX1

2

4

High-throughput

0.571

High

707936

IMB1
Importin subunit beta-1

2

9

High-throughput

0.571

High

420482

RAD3
General transcription and DNA repair factor IIH helicase subunit XPD

2

0

High-throughput

0.563

High

707852

GGA2
ADP-ribosylation factor-binding protein GGA2

2

0

High-throughput

0.563

High

675929

XPO1
Exportin-1

2

3

High-throughput

0.558

High

707865

IMB4
Importin subunit beta-4

2

10

High-throughput

0.558

High

707958

RUVB2
RuvB-like protein 2

2

8

High-throughput

0.558

High

367919

EF1A
Elongation factor 1-alpha

2

7

Small-scale

0.552

High

680020

CCR4
CCR4-Not complex 3'-5'-exoribonuclease subunit Ccr4

2

1

High-throughput

0.549

High

707881

LSB3
LAS seventeen-binding protein 3

1

1

High-throughput

0.541

High

585289

MYO2
Myosin-2

2

6

High-throughput

0.537

High

707841

MAK5
ATP-dependent RNA helicase MAK5

2

16

High-throughput

0.537

High

707886

MTR4
ATP-dependent RNA helicase DOB1

2

11

High-throughput

0.537

High

707904

NAT10
RNA cytidine acetyltransferase

2

2

High-throughput

0.537

High

389884

VDAC1
Mitochondrial outer membrane protein porin 1

1

1

High-throughput

0.536

High

498488

METK1
S-adenosylmethionine synthase 1

1

1

High-throughput

0.536

High

575938

ADT2
ADP,ATP carrier protein 2

1

3

High-throughput

0.536

High

613666

RS3A2
Small ribosomal subunit protein eS1B

1

5

High-throughput

0.536

High

619552

MPCP
Mitochondrial phosphate carrier protein

1

5

High-throughput

0.536

High

657049

IDH2
Isocitrate dehydrogenase [NAD] subunit 2, mitochondrial

1

3

High-throughput

0.536

High

691221

MKK2
MAP kinase kinase MKK2/SSP33

1

17

High-throughput

0.536

High

707835

MAOM
NAD-dependent malic enzyme, mitochondrial

1

1

High-throughput

0.536

High

707847

SYNC
Asparagine--tRNA ligase, cytoplasmic

1

2

High-throughput

0.536

High

707861

FHP
Flavohemoprotein

1

2

High-throughput

0.536

High

707871

MOB1
DBF2 kinase activator protein MOB1

1

6

High-throughput

0.536

High

707873

LYS12
Homoisocitrate dehydrogenase, mitochondrial

1

3

High-throughput

0.536

High

707883

NMD5
Nonsense-mediated mRNA decay protein 5

1

9

High-throughput

0.536

High

707897

BRE5
UBP3-associated protein BRE5

1

10

High-throughput

0.536

High

707939

SWA2
Auxilin-like clathrin uncoating factor SWA2

1

9

High-throughput

0.536

High

707957

AHA1
Hsp90 co-chaperone AHA1

1

2

High-throughput

0.536

High

707963

TECR
Very-long-chain enoyl-CoA reductase

1

2

High-throughput

0.536

High

426373

PMM
Phosphomannomutase

1

0

High-throughput

0.513

High

540065

GFA1
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

1

0

High-throughput

0.513

High

707868

TPM2
Tropomyosin-2

1

4

High-throughput

0.494

High

707893

SDS23
Protein SDS23

1

4

High-throughput

0.494

High

707951

TGL5
Triacylglycerol lipase 5

1

1

High-throughput

0.494

High

356379

H4
Histone H4

1

4

High-throughput

0.489

High

360828

TBB
Tubulin beta chain

1

4

High-throughput

0.489

High

454268

TBA1
Tubulin alpha-1 chain

1

7

High-throughput

0.489

High

454587

TBA3
Tubulin alpha-3 chain

1

9

High-throughput

0.489

High

615137

BUR1
Serine/threonine-protein kinase BUR1

1

9

High-throughput

0.489

High

703541

UBC6
Ubiquitin-conjugating enzyme E2 6

1

6

High-throughput

0.489

High

707843

OLA1
Obg-like ATPase 1

1

8

High-throughput

0.489

High

707876

MPG1
Mannose-1-phosphate guanyltransferase

1

1

High-throughput

0.489

High

707877

LEM3
Phospholipid-transporting ATPase accessory subunit LEM3

1

1

High-throughput

0.489

High

707944

RBX1
RING-box protein HRT1

1

3

High-throughput

0.489

High

357980

RS17A
Small ribosomal subunit protein eS17A

1

4

High-throughput

0.479

High

383054

RL25
Large ribosomal subunit protein uL23

1

5

High-throughput

0.479

High

402925

ERF3
Eukaryotic peptide chain release factor GTP-binding subunit

1

9

Small-scale

0.479

High

405536

RL26A
Large ribosomal subunit protein uL24A

1

6

High-throughput

0.479

High

407832

RS13
Small ribosomal subunit protein uS15

1

5

High-throughput

0.479

High

413419

RS14A
Small ribosomal subunit protein uS11A

1

4

High-throughput

0.479

High

429193

SEC4
Ras-related protein SEC4

1

4

Small-scale

0.479

High

470967

RS22A
Small ribosomal subunit protein uS8A

1

5

High-throughput

0.479

High

472118

RL31A
Large ribosomal subunit protein eL31A

1

4

High-throughput

0.479

High

480585

RS8A
Small ribosomal subunit protein eS8A

1

5

High-throughput

0.479

High

543486

HSC82
ATP-dependent molecular chaperone HSC82

1

13

High-throughput

0.479

High

604976

XRN1
5'-3' exoribonuclease 1

1

2

Small-scale

0.479

High

607246

RFA1
Replication factor A protein 1

1

7

Small-scale

0.479

High

627891

SIS1
Protein SIS1

1

7

High-throughput

0.479

High

631782

RS2
Small ribosomal subunit protein uS5

1

6

High-throughput

0.479

High

700319

RSSA1
Small ribosomal subunit protein uS2A

1

8

High-throughput

0.479

High

700826

SMY2
Protein SMY2

1

2

High-throughput

0.479

High

706183

RS3A1
Small ribosomal subunit protein eS1A

1

5

High-throughput

0.479

High

707833

RS27A
Small ribosomal subunit protein eS27A

1

5

High-throughput

0.479

High

707846

RS20
Small ribosomal subunit protein uS10

1

5

High-throughput

0.479

High

707853

RPN10
26S proteasome regulatory subunit RPN10

1

4

High-throughput

0.479

High

707854

2A5D
Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform

1

16

High-throughput

0.479

High

707860

LAA1
AP-1 accessory protein LAA1

1

4

High-throughput

0.479

High

707869

MLP2
Protein MLP2

1

11

High-throughput

0.479

High

707878

UTP10
U3 small nucleolar RNA-associated protein 10

1

2

High-throughput

0.479

High

707889

RS12
Small ribosomal subunit protein eS12

1

3

High-throughput

0.479

High

707901

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

7

High-throughput

0.479

High

707910

NUM1
Nuclear migration protein NUM1

1

11

High-throughput

0.479

High

707912

RS15
Small ribosomal subunit protein uS19

1

4

High-throughput

0.479

High

707915

ESP1
Separin

1

3

High-throughput

0.479

High

707928

DHR1
Probable ATP-dependent RNA helicase DHR1

1

9

High-throughput

0.479

High

707946

MCA1
Metacaspase-1

1

1

High-throughput

0.479

High

707950

TMA46
Translation machinery-associated protein 46

1

4

High-throughput

0.479

High

707953

RIO1
Serine/threonine-protein kinase RIO1

1

3

High-throughput

0.479

High

707931

UTP14
U3 small nucleolar RNA-associated protein 14

1

1

High-throughput

0.470

High

707940

YP097
PX domain-containing protein YPR097W

1

0

Small-scale

0.460

High

707844

PHO88
SRP-independent targeting protein 3

1

0

High-throughput

0.458

High

707922

DOP1
Protein dopey

1

0

High-throughput

0.458

High

427225

ILVB
Acetolactate synthase catalytic subunit, mitochondrial

1

1

High-throughput

0.445

High

449999

HSP73
Heat shock protein SSA3

1

14

High-throughput

0.445

High

521183

EI2BD
Translation initiation factor eIF2B subunit delta

1

2

High-throughput

0.445

High

599446

VPS1
Vacuolar protein sorting-associated protein 1

1

2

High-throughput

0.445

High

605728

NPR1
Nitrogen permease reactivator protein

1

14

High-throughput

0.445

High

633097

MAS5
Mitochondrial protein import protein MAS5

1

9

High-throughput

0.445

High

688031

NDI1
Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial

1

2

High-throughput

0.445

High

690071

APE2
Aminopeptidase 2, mitochondrial

1

5

High-throughput

0.445

High

693619

UBP4
Ubiquitin carboxyl-terminal hydrolase 4

1

7

High-throughput

0.445

High

694409

HSP7F
Heat shock protein homolog SSE1

1

20

High-throughput

0.445

High

699630

DLD1
D-lactate dehydrogenase [cytochrome] 1, mitochondrial

1

1

High-throughput

0.445

High

705001

HSP78
Heat shock protein 78, mitochondrial

1

3

High-throughput

0.445

High

707830

MDJ1
DnaJ homolog 1, mitochondrial

1

10

High-throughput

0.445

High

707837

MCR1
NADH-cytochrome b5 reductase 2

1

2

High-throughput

0.445

High

707857

XDJ1
DnaJ protein homolog XDJ1

1

9

High-throughput

0.445

High

707864

PIC2
Mitochondrial phosphate carrier protein 2

1

3

High-throughput

0.445

High

707866

SSB2
Ribosome-associated molecular chaperone SSB2

1

17

High-throughput

0.445

High

707882

SA155
SIT4-associating protein SAP155

1

1

High-throughput

0.445

High

707891

RL4B
Large ribosomal subunit protein uL4B

1

4

High-throughput

0.445

High

707892

PHB2
Prohibitin-2

1

7

High-throughput

0.445

High

707900

JJJ1
J protein JJJ1

1

9

High-throughput

0.445

High

707902

RM22
Large ribosomal subunit protein uL22m

1

1

High-throughput

0.445

High

707905

APJ1
J domain-containing protein APJ1

1

9

High-throughput

0.445

High

707924

HMO1
High mobility group protein 1

1

7

High-throughput

0.445

High

707925

SNX41
Sorting nexin-41

1

3

High-throughput

0.445

High

707930

PUF6
Pumilio homology domain family member 6

1

2

High-throughput

0.445

High

707954

UTP23
rRNA-processing protein UTP23

1

1

High-throughput

0.445

High

707934

ISR1
Serine/threonine-protein kinase ISR1

1

0

High-throughput

0.438

High

340096

KPYK1
Pyruvate kinase 1

1

2

High-throughput

0.437

High

415937

DED1
ATP-dependent RNA helicase DED1

1

6

High-throughput

0.437

High

524249

CAF20
Cap-associated protein CAF20

1

3

High-throughput

0.437

High

606610

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

6

High-throughput

0.437

High

661808

TF2B
Transcription initiation factor IIB

1

5

High-throughput

0.437

High

687918

IMB3
Importin subunit beta-3

1

10

High-throughput

0.437

High

691013

HOG1
Mitogen-activated protein kinase HOG1

1

8

High-throughput

0.437

High

707831

SPT10
Protein SPT10

1

1

High-throughput

0.437

High

707832

SPT21
Protein SPT21

1

1

High-throughput

0.437

High

707834

CENPA
Histone H3-like centromeric protein CSE4

1

7

High-throughput

0.437

High

707836

SRPB
Signal recognition particle receptor subunit beta

1

2

High-throughput

0.437

High

707849

RPN1
26S proteasome regulatory subunit RPN1

1

6

High-throughput

0.437

High

707858

DHH1
ATP-dependent RNA helicase DHH1

1

11

High-throughput

0.437

High

707870

TM108
Protein TMA108

1

5

High-throughput

0.437

High

707875

RLP7
Ribosome biogenesis protein RLP7

1

6

High-throughput

0.437

High

707890

VATG
V-type proton ATPase subunit G

1

2

High-throughput

0.437

High

707896

YN8S
Phospholipid-transporting ATPase accessory subunit CRF1

1

1

High-throughput

0.437

High

707908

ACT
Actin

1

4

Small-scale

0.437

High

707911

CDC14
Tyrosine-protein phosphatase CDC14

1

20

Small-scale

0.437

High

707918

TOM1
E3 ubiquitin-protein ligase TOM1

1

5

High-throughput

0.437

High

707923

RUVB1
RuvB-like protein 1

1

8

High-throughput

0.437

High

707937

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

2

High-throughput

0.437

High

707945

SGO1
Shugoshin

1

2

High-throughput

0.437

High

707948

ESA1
Histone acetyltransferase ESA1

1

2

Small-scale

0.437

High

425010

DHE4
NADP-specific glutamate dehydrogenase 1

1

0

High-throughput

0.426

High

612223

HSP12
12 kDa heat shock protein

1

0

High-throughput

0.426

High

699092

YME2
Mitochondrial escape protein 2

1

0

High-throughput

0.426

High

707859

ILV3
Dihydroxy-acid dehydratase, mitochondrial

1

0

High-throughput

0.426

High

707872

SHQ1
Protein SHQ1

1

0

High-throughput

0.426

High

707895

MPA43
Protein MPA43

1

0

High-throughput

0.426

High

707932

COG8
Conserved oligomeric Golgi complex subunit 8

1

0

High-throughput

0.426

High

707863

RBG1
Ribosome-interacting GTPase 1

1

9

High-throughput

0.417

High

333752

ADH1
Alcohol dehydrogenase 1

1

2

High-throughput

0.407

High

339556

CDK1
Cyclin-dependent kinase 1

1

5

High-throughput

0.407

High

392378

H2A2
Histone H2A.2

1

6

High-throughput

0.407

High

399399

RLA0
Large ribosomal subunit protein uL10

1

3

High-throughput

0.407

High

555950

VATB
V-type proton ATPase subunit B

1

4

High-throughput

0.407

High

561229

APA1
Protein APA1 [Includes: Diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase 1

1

1

High-throughput

0.407

High

576224

ERD2
ER lumen protein-retaining receptor

1

1

High-throughput

0.407

High

629327

MSH3
DNA mismatch repair protein MSH3

1

2

High-throughput

0.407

High

675722

RENT1
ATP-dependent helicase NAM7

1

2

High-throughput

0.407

High

693388

SMI1
Cell wall assembly regulator SMI1

1

1

High-throughput

0.407

High

704308

CBF5
H/ACA ribonucleoprotein complex subunit CBF5

1

3

High-throughput

0.407

High

705872

IXR1
Intrastrand cross-link recognition protein

1

6

High-throughput

0.407

High

707845

SRP68
Signal recognition particle subunit SRP68

1

2

High-throughput

0.407

High

707848

DBP8
ATP-dependent RNA helicase DBP8

1

10

High-throughput

0.407

High

707850

CIC1
Proteasome-interacting protein CIC1

1

3

High-throughput

0.407

High

707851

SSZ1
Ribosome-associated complex subunit SSZ1

1

10

High-throughput

0.407

High

707855

AKR1
Palmitoyltransferase AKR1

1

11

High-throughput

0.407

High

707856

TCPD
T-complex protein 1 subunit delta

1

1

High-throughput

0.407

High

707874

ICE2
Protein ICE2

1

1

High-throughput

0.407

High

707898

NOG2
Nucleolar GTP-binding protein 2

1

4

High-throughput

0.407

High

707906

TMEDA
Endoplasmic reticulum vesicle protein 25

1

1

High-throughput

0.407

High

707913

PDR12
ATP-dependent permease PDR12

1

1

High-throughput

0.407

High

707914

NOG1
Nucleolar GTP-binding protein 1

1

5

High-throughput

0.407

High

707917

SVL3
Styryl dye vacuolar localization protein 3

1

1

High-throughput

0.407

High

707919

SCS7
Ceramide very long chain fatty acid hydroxylase SCS7

1

3

High-throughput

0.407

High

707926

EIF3G
Eukaryotic translation initiation factor 3 subunit G

1

9

High-throughput

0.407

High

707929

UTP15
U3 small nucleolar RNA-associated protein 15

1

8

High-throughput

0.407

High

707933

RCO1
Transcriptional regulatory protein RCO1

1

10

High-throughput

0.407

High

707935

MRD1
Multiple RNA-binding domain-containing protein 1

1

6

High-throughput

0.407

High

707941

SSK1
Osmolarity two-component system protein SSK1

1

2

High-throughput

0.407

High

707942

SMC5
Structural maintenance of chromosomes protein 5

1

6

High-throughput

0.407

High

707943

BRX1
Ribosome biogenesis protein BRX1

1

5

High-throughput

0.407

High

707955

IES3
Ino eighty subunit 3

1

1

High-throughput

0.407

High

707956

ARP7
Actin-related protein 7

1

5

High-throughput

0.407

High

707959

NOP58
Nucleolar protein 58

1

7

High-throughput

0.407

High

707960

SET6
Potential protein lysine methyltransferase SET6

1

1

High-throughput

0.407

High

707961

H2AZ
Histone H2A.Z

1

8

High-throughput

0.407

High

707862

ECM1
Shuttling pre-60S factor ECM1

2

0

High-throughput

0.307

High

707888

LCF4
Long-chain-fatty-acid--CoA ligase 4

1

0

High-throughput

0.279

Low

707916

COFI
Cofilin

1

0

High-throughput

0.279

Low

707952

UPPS
Dehydrodolichyl diphosphate synthase complex subunit NUS1

1

0

High-throughput

0.279

Low

707839

SPC34
DASH complex subunit SPC34

1

0

High-throughput

0.269

Low

707838

PSG1
PMA1 stabilization in the Golgi protein 1 [Cleaved into: PSG1-N'; PSG1-C']

1

0

High-throughput

0.249

Low

707867

ELO3
Fatty acid elongase 3

1

0

High-throughput

0.249

Low

707884

MNN5
Alpha-1,2-mannosyltransferase MNN5

1

0

High-throughput

0.249

Low

707962

ATG44
Mitofissin

1

0

High-throughput

0.249

Low

707964

ENV10
SRP-independent targeting protein 2

1

0

High-throughput

0.249

Low

589478

ZRC1
Vacuolar zinc transporter ZRC1

1

0

High-throughput

0.232

Low

606326

SEC15
Exocyst complex component SEC15

1

0

High-throughput

0.232

Low

659146

LAC1
Ceramide synthase LAC1

1

0

High-throughput

0.232

Low

707840

GPT2
Glycerol-3-phosphate O-acyltransferase 2

1

0

High-throughput

0.232

Low

707887

YJY2
Uncharacterized protein YJR012C

1

0

High-throughput

0.232

Low

707899

CAF40
Protein CAF40

1

0

High-throughput

0.232

Low

707903

PFD4
Prefoldin subunit 4

1

0

High-throughput

0.232

Low

707907

DOS2
Protein DOS2

1

0

High-throughput

0.232

Low

707909

SEC5
Exocyst complex component SEC5

1

0

High-throughput

0.232

Low

707921

ARX1
Probable metalloprotease ARX1

1

0

High-throughput

0.232

Low

707938

RSC3
Chromatin structure-remodeling complex protein RSC3

1

0

High-throughput

0.232

Low

707947

AB140
tRNA(Thr)

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024