Protein: MFN2
Mitofusin-2 (EC 3.6.5.-) (Transmembrane GTPase MFN2)

Gene: MFN2
Organism: Homo sapiens
Interactions: 153
UniProt ID: O95140

Gene Ontology (top 5):
GO:0001825 - blastocyst formation
GO:0003924 - GTPase activity
GO:0005525 - GTP binding
GO:0005739 - mitochondrion
GO:0005741 - mitochondrial outer membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

326585

MFN1
Mitofusin-1

5

5

Small-scale

0.925

High

326499

MFN2
Mitofusin-2

3

5

Small-scale

0.834

High

240352

PRKN
E3 ubiquitin-protein ligase parkin

10

5

Small-scale

0.754

High

326623

MARH5
E3 ubiquitin-protein ligase MARCHF5

8

3

Small-scale

0.751

High

326596

AKAP1
A-kinase anchor protein 1, mitochondrial

3

2

High-throughput

0.656

High

326580

MAVS
Mitochondrial antiviral-signaling protein

3

3

Small-scale

0.650

High

326540

TERA
Transitional endoplasmic reticulum ATPase

3

1

Small-scale

0.646

High

326613

GHITM
Growth hormone-inducible transmembrane protein

2

1

High-throughput

0.628

High

135431

DNM1L
Dynamin-1-like protein

1

1

High-throughput

0.618

High

326558

SQSTM
Sequestosome-1

2

1

High-throughput

0.584

High

326567

BAK
Bcl-2 homologous antagonist/killer

2

3

Small-scale

0.584

High

326598

S2546
Mitochondrial outer membrane protein SLC25A46

2

1

Small-scale

0.584

High

326609

TCHP
Trichoplein keratin filament-binding protein

2

2

Small-scale

0.584

High

326636

SAM50
Sorting and assembly machinery component 50 homolog

2

1

Small-scale

0.584

High

326624

MTCH1
Mitochondrial carrier homolog 1

2

3

High-throughput

0.571

High

326581

HUWE1
E3 ubiquitin-protein ligase HUWE1

2

0

Small-scale

0.559

High

326604

CI072
Guanine nucleotide exchange factor C9orf72

2

0

High-throughput

0.559

High

244830

TRAK2
Trafficking kinesin-binding protein 2

1

1

High-throughput

0.536

High

326569

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

2

Small-scale

0.515

High

326502

GLPA
Glycophorin-A

1

0

High-throughput

0.513

High

326586

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

0

High-throughput

0.513

High

326611

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

1

Small-scale

0.500

High

124703

AIP
AH receptor-interacting protein

1

2

High-throughput

0.479

High

127847

PSD11
26S proteasome non-ATPase regulatory subunit 11

1

1

High-throughput

0.479

High

165223

PSA7
Proteasome subunit alpha type-7

1

4

High-throughput

0.479

High

215229

TXNL1
Thioredoxin-like protein 1

1

2

High-throughput

0.479

High

276024

NIPS2
Protein NipSnap homolog 2

1

1

High-throughput

0.479

High

326504

NTRK1
High affinity nerve growth factor receptor

1

1

High-throughput

0.479

High

326506

TPM3
Tropomyosin alpha-3 chain

1

1

High-throughput

0.479

High

326507

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

1

3

High-throughput

0.479

High

326509

KAP2
cAMP-dependent protein kinase type II-alpha regulatory subunit

1

1

High-throughput

0.479

High

326511

PRS6A
26S proteasome regulatory subunit 6A

1

6

High-throughput

0.479

High

326512

PSB1
Proteasome subunit beta type-1

1

6

High-throughput

0.479

High

326515

PSA1
Proteasome subunit alpha type-1

1

3

High-throughput

0.479

High

326516

PSA2
Proteasome subunit alpha type-2

1

4

High-throughput

0.479

High

326517

PSA3
Proteasome subunit alpha type-3

1

3

High-throughput

0.479

High

326519

PSA5
Proteasome subunit alpha type-5

1

4

High-throughput

0.479

High

326520

PSB4
Proteasome subunit beta type-4

1

7

High-throughput

0.479

High

326521

PSB6
Proteasome subunit beta type-6

1

5

High-throughput

0.479

High

326522

PSB5
Proteasome subunit beta type-5

1

4

High-throughput

0.479

High

326524

KAP3
cAMP-dependent protein kinase type II-beta regulatory subunit

1

1

High-throughput

0.479

High

326525

STIP1
Stress-induced-phosphoprotein 1

1

1

High-throughput

0.479

High

326528

PRS7
26S proteasome regulatory subunit 7

1

4

High-throughput

0.479

High

326530

PRS6B
26S proteasome regulatory subunit 6B

1

4

High-throughput

0.479

High

326533

PSB3
Proteasome subunit beta type-3

1

5

High-throughput

0.479

High

326534

F10A1
Hsc70-interacting protein

1

1

High-throughput

0.479

High

326541

PSA6
Proteasome subunit alpha type-6

1

4

High-throughput

0.479

High

326543

PRS4
26S proteasome regulatory subunit 4

1

4

High-throughput

0.479

High

326544

PRS8
26S proteasome regulatory subunit 8

1

6

High-throughput

0.479

High

326546

PRS10
26S proteasome regulatory subunit 10B

1

5

High-throughput

0.479

High

326548

TPM4
Tropomyosin alpha-4 chain

1

1

High-throughput

0.479

High

326553

FKBP4
Peptidyl-prolyl cis-trans isomerase FKBP4

1

3

High-throughput

0.479

High

326554

GOGA3
Golgin subfamily A member 3

1

2

High-throughput

0.479

High

326556

PSMD2
26S proteasome non-ATPase regulatory subunit 2

1

1

High-throughput

0.479

High

326559

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

1

3

High-throughput

0.479

High

326562

PSMD6
26S proteasome non-ATPase regulatory subunit 6

1

1

High-throughput

0.479

High

326563

KIF14
Kinesin-like protein KIF14

1

1

High-throughput

0.479

High

326564

EEA1
Early endosome antigen 1

1

1

High-throughput

0.479

High

326577

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.479

High

326587

MIRO2
Mitochondrial Rho GTPase 2

1

1

High-throughput

0.479

High

326589

NNRE
NAD(P)H-hydrate epimerase

1

1

Small-scale

0.479

High

326593

UBXN4
UBX domain-containing protein 4

1

1

High-throughput

0.479

High

326594

EDEM1
ER degradation-enhancing alpha-mannosidase-like protein 1

1

1

High-throughput

0.479

High

326599

S2538
Mitochondrial glycine transporter

1

1

Small-scale

0.479

High

326602

MYO19
Unconventional myosin-XIX

1

1

High-throughput

0.479

High

326605

PSB7
Proteasome subunit beta type-7

1

4

High-throughput

0.479

High

326606

PSMD1
26S proteasome non-ATPase regulatory subunit 1

1

1

High-throughput

0.479

High

326607

TTC1
Tetratricopeptide repeat protein 1

1

2

High-throughput

0.479

High

326608

NIPS1
Protein NipSnap homolog 1

1

1

High-throughput

0.479

High

326610

NAA15
N-alpha-acetyltransferase 15, NatA auxiliary subunit

1

1

High-throughput

0.479

High

326631

AMFR
E3 ubiquitin-protein ligase AMFR

1

3

Small-scale

0.479

High

326634

NUDC
Nuclear migration protein nudC

1

1

High-throughput

0.479

High

326635

TDRKH
Tudor and KH domain-containing protein

1

2

High-throughput

0.479

High

105003

APRIO
Alternative prion protein

1

0

High-throughput

0.458

High

133903

IPO5
Importin-5

1

0

High-throughput

0.458

High

192153

YKT6
Synaptobrevin homolog YKT6

1

0

High-throughput

0.458

High

326501

BAG2
BAG family molecular chaperone regulator 2

1

0

High-throughput

0.458

High

326508

BIP
Endoplasmic reticulum chaperone BiP

1

0

High-throughput

0.458

High

326510

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.458

High

326523

PUR8
Adenylosuccinate lyase

1

0

High-throughput

0.458

High

326527

MYH10
Myosin-10

1

0

High-throughput

0.458

High

326529

KPCI
Protein kinase C iota type

1

0

High-throughput

0.458

High

326531

MK09
Mitogen-activated protein kinase 9

1

0

Small-scale

0.458

High

326532

UB2R1
Ubiquitin-conjugating enzyme E2 R1

1

0

High-throughput

0.458

High

326536

AL3A2
Aldehyde dehydrogenase family 3 member A2

1

0

High-throughput

0.458

High

326537

PSMD7
26S proteasome non-ATPase regulatory subunit 7

1

0

High-throughput

0.458

High

326538

ATX3
Ataxin-3

1

0

High-throughput

0.458

High

326539

PSMD4
26S proteasome non-ATPase regulatory subunit 4

1

0

High-throughput

0.458

High

326542

UBE2N
Ubiquitin-conjugating enzyme E2 N

1

0

Small-scale

0.458

High

326545

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.458

High

326547

RBX1
E3 ubiquitin-protein ligase RBX1

1

0

High-throughput

0.458

High

326550

CLH1
Clathrin heavy chain 1

1

0

High-throughput

0.458

High

326552

OCRL
Inositol polyphosphate 5-phosphatase OCRL

1

0

High-throughput

0.458

High

326555

FADD
FAS-associated death domain protein

1

0

High-throughput

0.458

High

326560

NBR1
Next to BRCA1 gene 1 protein

1

0

High-throughput

0.458

High

326561

DIP2A
Disco-interacting protein 2 homolog A

1

0

High-throughput

0.458

High

326565

SMAD2
Mothers against decapentaplegic homolog 2

1

0

Small-scale

0.458

High

326566

CDC37
Hsp90 co-chaperone Cdc37

1

0

High-throughput

0.458

High

326571

UBR4
E3 ubiquitin-protein ligase UBR4

1

0

High-throughput

0.458

High

326572

VP13D
Intermembrane lipid transfer protein VPS13D

1

0

High-throughput

0.458

High

326579

LARP4
La-related protein 4

1

0

High-throughput

0.458

High

326591

CIP2A
Protein CIP2A

1

0

High-throughput

0.458

High

326597

GLMN
Glomulin

1

0

High-throughput

0.458

High

326600

KBP
KIF-binding protein

1

0

High-throughput

0.458

High

326616

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

326618

CYBP
Calcyclin-binding protein

1

0

High-throughput

0.458

High

326619

EXD2
Exonuclease 3'-5' domain-containing protein 2

1

0

High-throughput

0.458

High

326621

TM160
Transmembrane protein 160

1

0

High-throughput

0.458

High

326622

OCAD1
OCIA domain-containing protein 1

1

0

High-throughput

0.458

High

326627

HDAC6
Protein deacetylase HDAC6

1

0

Small-scale

0.458

High

326628

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

326632

PSD13
26S proteasome non-ATPase regulatory subunit 13

1

0

High-throughput

0.458

High

326633

NSF1C
NSFL1 cofactor p47

1

0

High-throughput

0.458

High

326637

MTCH2
Mitochondrial carrier homolog 2

1

3

High-throughput

0.445

High

326500

TTC4
Tetratricopeptide repeat protein 4

1

3

High-throughput

0.437

High

326549

RNF4
E3 ubiquitin-protein ligase RNF4

1

1

High-throughput

0.437

High

326584

NUDC3
NudC domain-containing protein 3

1

1

High-throughput

0.437

High

326614

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.437

High

326629

XPO7
Exportin-7

1

1

High-throughput

0.437

High

248818

GSDME
Gasdermin-E

1

0

High-throughput

0.426

High

326513

HEMH
Ferrochelatase, mitochondrial

1

0

High-throughput

0.426

High

326514

DNJB2
DnaJ homolog subfamily B member 2

1

0

High-throughput

0.426

High

326535

ERF
ETS domain-containing transcription factor ERF

1

0

High-throughput

0.426

High

326574

ARMC6
Armadillo repeat-containing protein 6

1

0

High-throughput

0.426

High

326612

DJC25
DnaJ homolog subfamily C member 25

1

1

High-throughput

0.407

High

326625

PP4RL
Putative serine/threonine-protein phosphatase 4 regulatory subunit 1-like

1

1

High-throughput

0.407

High

326551

REEP5
Receptor expression-enhancing protein 5

2

0

High-throughput

0.328

High

326582

VSIG1
V-set and immunoglobulin domain-containing protein 1

2

0

High-throughput

0.328

High

326503

THY1
Thy-1 membrane glycoprotein

1

0

High-throughput

0.279

Low

326526

CP2CJ
Cytochrome P450 2C19

1

0

High-throughput

0.279

Low

326630

CC018
Uncharacterized protein C3orf18

1

0

High-throughput

0.279

Low

207776

ZZEF1
Zinc finger ZZ-type and EF-hand domain-containing protein 1

1

0

High-throughput

0.249

Low

326518

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

326557

CTBP1
C-terminal-binding protein 1

1

0

High-throughput

0.249

Low

326568

ACTBL
Beta-actin-like protein 2

1

0

High-throughput

0.249

Low

326570

SNP47
Synaptosomal-associated protein 47

1

0

High-throughput

0.249

Low

326573

CRBG3
Very large A-kinase anchor protein

1

0

High-throughput

0.249

Low

326578

TPGS1
Tubulin polyglutamylase complex subunit 1

1

0

High-throughput

0.249

Low

326583

LRC49
Leucine-rich repeat-containing protein 49

1

0

High-throughput

0.249

Low

326588

KDF1
Keratinocyte differentiation factor 1

1

0

High-throughput

0.249

Low

326590

DIK2A
Divergent protein kinase domain 2A

1

0

Small-scale

0.249

Low

326592

SMCR8
Guanine nucleotide exchange protein SMCR8

1

0

High-throughput

0.249

Low

326601

CFA36
Cilia- and flagella-associated protein 36

1

0

High-throughput

0.249

Low

326603

VCIP1
Deubiquitinating protein VCPIP1

1

0

High-throughput

0.249

Low

326615

CSTP1
Centriolar satellite-associated tubulin polyglutamylase complex regulator 1

1

0

High-throughput

0.249

Low

326617

WDR41
WD repeat-containing protein 41

1

0

High-throughput

0.249

Low

326620

PIHD1
PIH1 domain-containing protein 1

1

0

High-throughput

0.249

Low

326626

IBTK
Inhibitor of Bruton tyrosine kinase

1

0

High-throughput

0.249

Low

326505

HEPS
Serine protease hepsin

1

0

High-throughput

0.232

Low

326575

NCEH1
Neutral cholesterol ester hydrolase 1

1

0

High-throughput

0.232

Low

326576

MOT12
Monocarboxylate transporter 12

1

0

High-throughput

0.232

Low

326595

LPAR1
Lysophosphatidic acid receptor 1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025