Protein: APTX
Aprataxin (EC 3.6.1.71) (EC 3.6.1.72) (Forkhead-associated domain histidine triad-like protein) (FHA-HIT)

Gene: APTX
Organism: Homo sapiens
Interactions: 78
UniProt ID: Q7Z2E3

Gene Ontology (top 5):
GO:0000012 - single strand break repair
GO:0000785 - chromatin
GO:0003682 - chromatin binding
GO:0003684 - damaged DNA binding
GO:0003690 - double-stranded DNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

579713

XRCC1
DNA repair protein XRCC1

6

1

Small-scale

0.747

High

1033955

XRCC4
DNA repair protein XRCC4

6

1

Small-scale

0.735

High

455592

PARP1
Poly [ADP-ribose] polymerase 1

3

4

Small-scale

0.692

High

417828

DPOLB
DNA polymerase beta

3

1

High-throughput

0.667

High

1187459

PNMA1
Paraneoplastic antigen Ma1

2

2

High-throughput

0.654

High

836745

DNLI3
DNA ligase 3

2

3

Small-scale

0.611

High

1187482

PNMA3
Paraneoplastic antigen Ma3

2

2

High-throughput

0.606

High

369896

ESR1
Estrogen receptor

2

1

High-throughput

0.571

High

386993

P53
Cellular tumor antigen p53

1

0

Small-scale

0.561

High

1187461

FAD1
FAD synthase

2

1

High-throughput

0.553

High

301897

TRI37
E3 ubiquitin-protein ligase TRIM37

1

5

High-throughput

0.541

High

344304

AACT
Alpha-1-antichymotrypsin

1

3

High-throughput

0.536

High

396757

S10A8
Protein S100-A8

1

3

High-throughput

0.536

High

416462

S10A9
Protein S100-A9

1

4

High-throughput

0.536

High

596295

FILA
Filaggrin

1

2

High-throughput

0.536

High

611267

TGM1
Protein-glutamine gamma-glutamyltransferase K

1

1

High-throughput

0.536

High

667983

SPB3
Serpin B3

1

3

High-throughput

0.536

High

678468

S10A7
Protein S100-A7

1

4

High-throughput

0.536

High

836842

DNLI4
DNA ligase 4

1

3

High-throughput

0.536

High

901385

CH10
10 kDa heat shock protein, mitochondrial

1

2

High-throughput

0.536

High

993965

TGM3
Protein-glutamine gamma-glutamyltransferase E

1

1

High-throughput

0.536

High

996732

SSRP1
FACT complex subunit SSRP1

1

1

High-throughput

0.536

High

1087219

H2B2E
Histone H2B type 2-E

1

2

High-throughput

0.536

High

1187457

S1A7A
Protein S100-A7A

1

4

High-throughput

0.536

High

1187460

DR9C7
Short-chain dehydrogenase/reductase family 9C member 7

1

1

High-throughput

0.536

High

1187464

SPB12
Serpin B12

1

3

High-throughput

0.536

High

1187484

RBM8A
RNA-binding protein 8A

1

1

High-throughput

0.536

High

153018

IMPA2
Inositol monophosphatase 2

1

0

High-throughput

0.513

High

235926

HNRPQ
Heterogeneous nuclear ribonucleoprotein Q

1

0

High-throughput

0.513

High

345102

CYTA
Cystatin-A

1

0

High-throughput

0.513

High

396256

ARGI1
Arginase-1

1

0

High-throughput

0.513

High

414639

PTMA
Prothymosin alpha [Cleaved into: Prothymosin alpha, N-terminally processed; Thymosin alpha-1]

1

0

High-throughput

0.513

High

683104

CASPE
Caspase-14

1

0

High-throughput

0.513

High

1134347

KPRP
Keratinocyte proline-rich protein

1

0

High-throughput

0.513

High

1173071

FBX50
F-box only protein 50

1

0

High-throughput

0.513

High

1187469

RNAS7
Ribonuclease 7

1

0

High-throughput

0.513

High

1187472

EAF6
Chromatin modification-related protein MEAF6

1

0

High-throughput

0.513

High

1187475

TYDP1
Tyrosyl-DNA phosphodiesterase 1

1

0

High-throughput

0.513

High

1187476

IL36G
Interleukin-36 gamma

1

0

High-throughput

0.513

High

231821

MABP1
Mitogen-activated protein kinase-binding protein 1

1

1

High-throughput

0.508

High

550406

ZEP1
Zinc finger protein 40

1

1

High-throughput

0.508

High

1137819

CE350
Centrosome-associated protein 350

1

1

High-throughput

0.508

High

1187458

CNTRB
Centrobin

1

1

High-throughput

0.508

High

1187474

PICK1
PRKCA-binding protein

1

1

High-throughput

0.508

High

1187481

ZN639
Zinc finger protein 639

1

1

High-throughput

0.508

High

198449

KLK10
Kallikrein-10

1

1

High-throughput

0.489

High

245818

CATL2
Cathepsin L2

1

1

High-throughput

0.489

High

453972

CATH
Pro-cathepsin H [Cleaved into: Cathepsin H mini chain; Cathepsin H

1

1

High-throughput

0.489

High

820327

SPB4
Serpin B4

1

3

High-throughput

0.489

High

1187480

CBPA4
Carboxypeptidase A4

1

1

High-throughput

0.489

High

362093

MBP
Myelin basic protein

1

0

High-throughput

0.486

High

1187470

TSYL2
Testis-specific Y-encoded-like protein 2

1

0

High-throughput

0.486

High

1187478

CACO1
Calcium-binding and coiled-coil domain-containing protein 1

1

0

High-throughput

0.486

High

714278

HSP74
Heat shock 70 kDa protein 4

1

4

Small-scale

0.479

High

799116

NKX21
Homeobox protein Nkx-2.1

1

3

High-throughput

0.479

High

917499

H4
Histone H4

1

1

High-throughput

0.479

High

1187479

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.479

High

268489

BAF
Barrier-to-autointegration factor

1

0

Small-scale

0.458

High

374439

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

High-throughput

0.458

High

1187466

CRBN
Protein cereblon

1

0

Small-scale

0.458

High

1187471

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.458

High

1187473

DDX21
Nucleolar RNA helicase 2

1

0

Small-scale

0.458

High

1187477

GRHL1
Grainyhead-like protein 1 homolog

1

4

High-throughput

0.445

High

72304

B3KVV6
cDNA FLJ41607 fis, clone CTONG3001370, highly similar to Homo sapiens alpha-2-macroglobulin-like 1

1

1

High-throughput

0.437

High

582359

NUCL
Nucleolin

1

0

Small-scale

0.426

High

66402

A2ML1
Alpha-2-macroglobulin-like protein 1

1

1

High-throughput

0.407

High

1187463

BAD
Bcl2-associated agonist of cell death

2

0

High-throughput

0.328

High

1187483

KIF3A
Kinesin-like protein KIF3A

2

0

High-throughput

0.328

High

259855

LX12B
Arachidonate 12-lipoxygenase, 12R-type

1

0

High-throughput

0.279

Low

588425

TYPH
Thymidine phosphorylase

1

0

High-throughput

0.279

Low

672685

CD6
T-cell differentiation antigen CD6

1

0

High-throughput

0.279

Low

787746

HUTH
Histidine ammonia-lyase

1

0

High-throughput

0.279

Low

945688

NGAL
Neutrophil gelatinase-associated lipocalin

1

0

High-throughput

0.279

Low

1102857

SMTL2
Smoothelin-like protein 2

1

0

High-throughput

0.279

Low

1187462

POF1B
Protein POF1B

1

0

High-throughput

0.279

Low

1187465

GSDMA
Gasdermin-A

1

0

High-throughput

0.279

Low

1187467

SORT
Sortilin

1

0

High-throughput

0.279

Low

1187468

SYT17
Synaptotagmin-17

1

0

High-throughput

0.265

Low


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Last updated: 15 Jul 2024