Protein: NEP1
Ribosomal RNA small subunit methyltransferase NEP1 (EC 2.1.1.-) (18S rRNA (pseudouridine(1248)-N1)-methyltransferase) (18S rRNA Psi1248 methyltransferase) (Nucleolar protein EMG1 homolog) (Protein C2f) (Ribosome biogenesis protein NEP1)

Gene: NEP1, EMG1
Organism: Homo sapiens
Interactions: 99
UniProt ID: Q92979

Gene Ontology (top 5):
GO:0001824 - blastocyst development
GO:0003723 - RNA binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005694 - chromosome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1371099

NEP1
Ribosomal RNA small subunit methyltransferase NEP1

2

1

High-throughput

0.783

High

1004379

NOP14
Nucleolar protein 14

2

1

High-throughput

0.611

High

1334720

SERB1
SERPINE1 mRNA-binding protein 1

2

1

High-throughput

0.611

High

1161587

IF16
Gamma-interferon-inducible protein 16

2

0

High-throughput

0.585

High

1371114

ANLN
Anillin

2

0

High-throughput

0.585

High

1371110

ZN768
Zinc finger protein 768

2

0

High-throughput

0.580

High

177031

CE290
Centrosomal protein of 290 kDa

2

1

High-throughput

0.571

High

396657

ESR1
Estrogen receptor

2

1

High-throughput

0.571

High

223235

PRC1
Protein regulator of cytokinesis 1

2

0

High-throughput

0.561

High

589329

RFA2
Replication protein A 32 kDa subunit

2

0

High-throughput

0.559

High

696125

RFA1
Replication protein A 70 kDa DNA-binding subunit

2

0

High-throughput

0.559

High

768813

RFA3
Replication protein A 14 kDa subunit

2

0

High-throughput

0.559

High

998639

H31
Histone H3.1

2

0

High-throughput

0.559

High

1371108

3BHS7
3 beta-hydroxysteroid dehydrogenase type 7

2

1

High-throughput

0.553

High

134109

IPO5
Importin-5

1

1

High-throughput

0.536

High

1353350

IPO4
Importin-4

1

1

High-throughput

0.536

High

1371105

NOC4L
Nucleolar complex protein 4 homolog

1

1

High-throughput

0.536

High

1371109

ZN106
Zinc finger protein 106

1

1

High-throughput

0.536

High

564162

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.518

High

1059914

KHDR1
KH domain-containing, RNA-binding, signal transduction-associated protein 1

1

0

High-throughput

0.518

High

447281

NPM
Nucleophosmin

1

0

High-throughput

0.513

High

587168

ITF2
Transcription factor 4

1

0

High-throughput

0.513

High

693888

RL10
Large ribosomal subunit protein uL16

1

0

High-throughput

0.513

High

777309

AHR
Aryl hydrocarbon receptor

1

0

High-throughput

0.513

High

1136302

EMC2
ER membrane protein complex subunit 2

1

0

High-throughput

0.513

High

1225995

ICE2
Little elongation complex subunit 2

1

0

High-throughput

0.513

High

487606

PARP1
Poly [ADP-ribose] polymerase 1

1

0

High-throughput

0.493

High

422783

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.480

High

964406

SUMO2
Small ubiquitin-related modifier 2

1

0

High-throughput

0.480

High

260262

BRD4
Bromodomain-containing protein 4

1

1

High-throughput

0.479

High

285400

EED
Polycomb protein EED

1

1

High-throughput

0.479

High

346152

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

1

High-throughput

0.479

High

920162

PLK1
Serine/threonine-protein kinase PLK1

1

1

High-throughput

0.479

High

1008828

RED1
Double-stranded RNA-specific editase 1

1

1

High-throughput

0.479

High

1137913

TNIP1
TNFAIP3-interacting protein 1

1

1

High-throughput

0.479

High

1141250

BRD3
Bromodomain-containing protein 3

1

1

High-throughput

0.479

High

1207416

HABP4
Intracellular hyaluronan-binding protein 4

1

1

High-throughput

0.479

High

1366948

ESR2
Estrogen receptor beta

1

1

High-throughput

0.479

High

1371113

SMUF1
E3 ubiquitin-protein ligase SMURF1

1

2

High-throughput

0.479

High

1371116

AATF
Protein AATF

1

1

High-throughput

0.479

High

1371118

HECW2
E3 ubiquitin-protein ligase HECW2

1

2

High-throughput

0.479

High

1327372

ZCHC9
Zinc finger CCHC domain-containing protein 9

1

0

High-throughput

0.460

High

1335294

FA98A
Protein FAM98A

1

0

High-throughput

0.460

High

1337534

MCPH1
Microcephalin

1

0

Small-scale

0.460

High

218581

TGON2
Trans-Golgi network integral membrane protein 2

1

0

High-throughput

0.458

High

248026

NUPR1
Nuclear protein 1

1

0

High-throughput

0.458

High

272368

OBSL1
Obscurin-like protein 1

1

0

High-throughput

0.458

High

331208

KI20A
Kinesin-like protein KIF20A

1

0

High-throughput

0.458

High

372758

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.458

High

657652

GCSP
Glycine dehydrogenase

1

0

High-throughput

0.458

High

765173

IL13
Interleukin-13

1

0

Small-scale

0.458

High

766746

PHB1
Prohibitin 1

1

0

High-throughput

0.458

High

872606

SOX2
Transcription factor SOX-2

1

0

High-throughput

0.458

High

1029894

RUNX1
Runt-related transcription factor 1

1

0

High-throughput

0.458

High

1033740

PO5F1
POU domain, class 5, transcription factor 1

1

0

High-throughput

0.458

High

1092200

NFX1
Transcriptional repressor NF-X1

1

0

High-throughput

0.458

High

1108447

MTX1
Metaxin-1

1

0

High-throughput

0.458

High

1138470

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

0

High-throughput

0.458

High

1155628

EZH2
Histone-lysine N-methyltransferase EZH2

1

0

High-throughput

0.458

High

1156805

E2F4
Transcription factor E2F4

1

0

High-throughput

0.458

High

1241719

PRP8
Pre-mRNA-processing-splicing factor 8

1

0

High-throughput

0.458

High

1254921

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.458

High

1290631

ZCH18
Zinc finger CCCH domain-containing protein 18

1

0

High-throughput

0.458

High

1361201

DNJC9
DnaJ homolog subfamily C member 9

1

0

High-throughput

0.458

High

1370272

CSN5
COP9 signalosome complex subunit 5

1

0

High-throughput

0.458

High

1371101

DCPS
m7GpppX diphosphatase

1

0

High-throughput

0.458

High

1371103

RANB9
Ran-binding protein 9

1

0

High-throughput

0.458

High

1371107

DDA1
DET1- and DDB1-associated protein 1

1

0

High-throughput

0.458

High

1371111

ECT2
Protein ECT2

1

0

High-throughput

0.458

High

1371112

NANOG
Homeobox protein NANOG

1

0

High-throughput

0.458

High

1371115

SLX9
Ribosome biogenesis protein SLX9 homolog

1

0

Small-scale

0.458

High

1371117

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

1

0

High-throughput

0.458

High

1371119

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

1371120

TBK1
Serine/threonine-protein kinase TBK1

1

0

High-throughput

0.458

High

1371122

FBW1A
F-box/WD repeat-containing protein 1A

1

0

High-throughput

0.458

High

1371123

TRRAP
Transformation/transcription domain-associated protein

1

0

High-throughput

0.458

High

553727

ANXA3
Annexin A3

1

0

High-throughput

0.438

High

586328

ZEP1
Zinc finger protein 40

1

0

High-throughput

0.438

High

1054626

PSME1
Proteasome activator complex subunit 1

1

0

High-throughput

0.438

High

1198481

CEP55
Centrosomal protein of 55 kDa

1

0

High-throughput

0.438

High

1371100

NAA80
N-alpha-acetyltransferase 80

1

0

High-throughput

0.438

High

1371104

PSB7
Proteasome subunit beta type-7

1

0

High-throughput

0.438

High

1227200

A16L1
Autophagy-related protein 16-1

1

1

High-throughput

0.437

High

430201

JUN
Transcription factor Jun

1

0

High-throughput

0.426

High

1154892

NEDD8
Ubiquitin-like protein NEDD8

1

0

Small-scale

0.426

High

887084

CEBPA
CCAAT/enhancer-binding protein alpha

1

0

High-throughput

0.391

High

1371121

RHG26
Rho GTPase-activating protein 26

2

0

High-throughput

0.298

High

1371102

S2538
Mitochondrial glycine transporter

1

0

High-throughput

0.282

High

389466

FINC
Fibronectin

1

0

High-throughput

0.279

Low

416032

CP1A1
Cytochrome P450 1A1

1

0

High-throughput

0.279

Low

1163597

RTN1
Reticulon-1

1

0

High-throughput

0.279

Low

1273093

LIGO2
Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2

1

0

High-throughput

0.279

Low

1279118

GOGA7
Golgin subfamily A member 7

1

0

High-throughput

0.279

Low

1280207

MILR1
Allergin-1

1

0

High-throughput

0.279

Low

1371124

WIF1
Wnt inhibitory factor 1

1

0

High-throughput

0.279

Low

1371106

TIM21
Mitochondrial import inner membrane translocase subunit Tim21

1

0

High-throughput

0.269

Low

157705

CTRO
Citron Rho-interacting kinase

1

0

High-throughput

0.249

Low

569594

CATE
Cathepsin E

1

0

High-throughput

0.238

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025